Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals infiltrating lobular carcinoma cells with a pleomorphic and classical subtype, demonstrating minimal formation of glandular structures, significantly deviating from normal tissue architecture with a tubule formation score of 3. The nuclei exhibit marked variability in size and shape, corresponding to a nuclear grade of 3. There is a moderate rate of cell division observed, reflected in a mitotic activity score of 2. Areas of lobular carcinoma in situ are noted, comprising less than 5% of the total tumor volume and displaying association with the invasive carcinoma. Notably, no definitive lymphovascular invasion is identified. Based on these observations, the diagnosis is invasive lobular carcinoma, nuclear grade 3, with a Nottingham score of 8/9 (3+3+2).


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals irregular clusters of epithelial cells infiltrating the stroma, forming glandular structures that moderately deviate from normal tissue architecture, with a glandular tubular differentiation score of 2. The nuclei exhibit moderate variability in size and shape, corresponding to a nuclear pleomorphism score of 2. There is a moderately high rate of cell division observed, with a mitotic count of 15 mitoses per 10 high power fields, scoring 3. Vascular invasion is not mentioned. Outside the tumor, the tissue shows fibrocystic changes and simple ductal hyperplasia. Based on these observations, the diagnosis is invasive ductal carcinoma, Nottingham Histologic Grade 2 (NHG2) with a total score of 7 (2+2+3) out of 9.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma with notable formation of glandular structures, retaining some resemblance to normal tissue architecture. The nuclei exhibit minimal variability in size and shape, and there is a low rate of cell division observed. Vascular invasion is not identified. Areas of in situ neoplastic cells are present, accounting for less than 5% of the tumor volume, displaying lobular patterns. Non-neoplastic breast parenchyma shows benign fibrocystic changes. Based on these observations, the diagnosis is infiltrating lobular carcinoma, Nottingham Grade I (tubules 3/3, nuclei 1/3, mitoses 1/3; total score 5/9).


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma, displaying a moderately deviated glandular structure formation characteristic of a moderately differentiated tumor. The nuclei exhibit variability in size and shape, corresponding to moderate nuclear pleomorphism. Additionally, there is a moderate rate of cell division observed. The invasion of lymph vessels is completely circumscribed, whereas necrosis and calcification are not notable. The presence of ductal hyperplasia and sclerotic intraductal papillomas is observed, surrounded by fibrocystic and proliferative changes. Based on these observations, the diagnosis is invasive ductal carcinoma, moderately differentiated, Nottingham Histologic Grade 2 (NHG2).


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals invasive ductal carcinoma with multifocality. The tumor cells present irregular clusters and infiltrative patterns within the stromal tissue. Tubular formation is minimal, significantly deviating from normal glandular architecture, corresponding to a tubule formation score of 3. The nuclei of the tumor cells exhibit marked variability in size and shape, indicative of severe nuclear pleomorphism with a nuclear grade of 3. There is a high rate of mitotic activity, consistent with a higher mitotic count score. Vascular invasion is extensive, and there are multiple foci of necrosis and calcifications, particularly within the areas of ductal carcinoma in situ (DCIS) which displays comedonecrosis prominently. Based on these observations, the diagnosis is invasive ductal carcinoma, moderately differentiated, Nottingham Histologic Grade 2 with a total score of 7 out of 9.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals neoplastic cells infiltrating the stroma, arranged predominantly in single-file linear patterns and loose clusters, characteristic of the lobular subtype, without significant glandular formation, indicative of a low grade with a total Nottingham score of 5 out of 9. Nuclear variation is minimal, with uniform, small, round nuclei, corresponding to a nuclear pleomorphism score of 1. The mitotic rate is low, with only one mitosis per 10 high power fields, contributing to a mitotic count score of 1. Vascular invasion is not observed. Based on these observations, the diagnosis is invasive lobular carcinoma, grade 1.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma with moderate formation of glandular structures, which deviate from the typical tissue architecture. The nuclei of these cells exhibit moderate variability in size and shape. Vascular invasion is absent. There are no observed areas of necrosis or calcification. Examined lymph nodes demonstrate sinus histiocytosis without evidence of metastasis. Based on these observations, the diagnosis is infiltrating ductal carcinoma, moderately differentiated, Nottingham Histologic Grade 2 (NHG2).


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals infiltrating ductal carcinoma characterized by irregular clusters of epithelial cells infiltrating the stroma and showing the formation of glandular structures that are scarcely differentiated from normal tissue architecture, corresponding to an architectural score of 3. The nuclei exhibit marked variability in size and shape, indicating a high degree of nuclear pleomorphism, with a score of 3. There is a high rate of cell division observed, reflected in a mitotic score of 3. Vascular invasion is present within the specimen. Ductal carcinoma in situ (DCIS) is also observed, exhibiting solid and comedo patterns with a nuclear grade of 3 and central necrosis present. Calcification is present within the tissue. Based on these observations, the diagnosis is infiltrating ductal carcinoma, grade 3.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals a histological pattern characterized by diffuse cell distribution and areas of necrosis. Cellular features include adenomatous differentiation, with glandular cells exhibiting signs of anisonucleosis, hyperchromatism, prominent nucleoli, and some multinucleated giant cells. A moderate degree of mitotic activity is noted. Vascular invasion and psammoma/calcification are present, along with mild lymphocytic infiltration and fibrosis. The structural pattern includes occasional alveolar formation and areas of cystic degeneration. Based on these observations, the diagnosis is infiltrating ductal carcinoma, moderately differentiated.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals infiltrating carcinoma cells exerting complete disruption of normal tissue architecture, with a high architectural score of 3 out of 3 indicating very poor tubular formation. The tumor cells display significant nuclear pleomorphism, showing marked variability in nuclear size and shape and earning a nuclear score of 3 out of 3. Additionally, mitotic activity is at a moderate level, with a mitotic score of 2 out of 3. The presence of calcification within the tissue is noted. Areas of ductal carcinoma in situ (DCIS) are also observed, displaying both solid and cribriform patterns, with a nuclear grade ranging from 2 to 3 and focal central necrosis. There is an extensive intraductal component present. Based on these observations, the diagnosis is infiltrating ductal carcinoma, grade 3.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals epithelial cells distributed in a diffuse and mosaic pattern, infiltrating the surrounding stroma with minimal formation of glandular structures, significantly deviating from normal tissue architecture. There are areas of necrosis, lymphocytic infiltration, and vascular invasion. The nuclei exhibit significant abnormalities, including aniso nucleosis, hyperchromatism, prominent nucleoli, and the presence of multinucleated giant cells, indicating poor nuclear differentiation. The rate of cell division is notably high. Cellular differentiation is poorly differentiated. Psammoma bodies (calcifications) are also observed. Based on these observations, the diagnosis is infiltrating ductal carcinoma, poorly differentiated with a nuclear grade of 3.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma with a well-defined architectural pattern, forming glandular structures that closely resemble normal tissue architecture, indicating a high degree of differentiation. The nuclei exhibit minimal variability in size and shape, reflecting limited nuclear pleomorphism. There is a low rate of cell division observed, suggesting a lower mitotic activity. Vascular invasion is not present. The intraductal components are circumscribed, synonymous with intraductal carcinoma in situ. Necrosis and calcifications are not observed in the evaluated slide. Based on these observations, the diagnosis is invasive ductal carcinoma, well differentiated, Nottingham Histologic Grade 1 (NHG1).


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals poorly differentiated epithelial cells infiltrating the stroma with minimal formation of glandular structures, significantly deviating from normal tissue architecture. The nuclei exhibit marked variability in size and shape, and there is a high rate of cell division observed. Vascular invasion is present, as well as focal areas containing intraductal components. Based on these observations, the diagnosis is poorly differentiated invasive ductal carcinoma with focal intraductal components and angioinvasion.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals metaplastic squamous cell carcinoma features. The neoplastic cells display squamous differentiation with keratinization and the formation of intercellular bridges. There is no evidence of glandular structures typical of normal breast tissue architecture. Vascular invasion is absent, and the lymph nodes exhibit sinus histiocytosis without metastatic infiltration. Based on these observations, the diagnosis is metaplastic squamous cell carcinoma.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma with minimal glandular formation, significantly deviating from normal tissue architecture. The nuclei display marked variability in size and shape, showing prominent pleomorphism. There is a high rate of cell division, indicating increased mitotic activity. Necrosis is present in some areas, and evidence of vascular invasion is noted. Based on these observations, the diagnosis is invasive ductal carcinoma, Nottingham grade 3 (of 3).


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals tumor cells infiltrating the surrounding stroma with minimal formation of glandular structures, significantly deviating from normal tissue architecture, and showing a poorly differentiated state with a tubule formation score of 3. The nuclei exhibit considerable size and shape variability, corresponding to a nuclear pleomorphism score of 3. There is a moderate rate of cell division observed, reflected by a mitotic count score of 2. Vascular invasion is not unequivocally present, and no necrosis or microcalcifications are observed. The intraductal component is noted to be less than 25% with prominent cancerization. Based on these observations, the diagnosis is infiltrating ductal carcinoma, no special type, Nottingham Grade III, poorly differentiated, with a total Nottingham score of 8/9.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals epithelial cells infiltrating the surrounding stroma with minimal formation of glandular structures, deviating significantly from normal tissue architecture, resulting in a glandular (tubular) differentiation score of 3. The nuclei exhibit moderate variability in size and shape, with a nuclear pleomorphism score of 2. There is a low rate of cell division observed, corresponding to a mitotic count score of 1. Vascular invasion and lymphatic invasion are not present. No necrosis is observed, and calcifications are not noted in the slide. Based on these observations, the diagnosis is invasive ductal carcinoma, Nottingham Histologic Grade 2 (NHG2) with a total score of 6 out of 9.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals tumor parenchyma with a hard gray-white sclerotic neoplasm exhibiting radially infiltrating borders. The presence of rare microcalcifications is noted. The morphology shows invasive tumor cells that are arranged in single files and loosely dispersed patterns, lacking well-formed glandular structures, which corresponds to a high tubular formation score of 3. There is minimal variability in nuclear size and shape, correlating with a nuclear pleomorphism score of 1. The mitotic activity is low, aligning with a mitotic rate score of 1. Lymphovascular invasion is not identified. Based on these observations, the diagnosis is invasive lobular carcinoma, Nottingham grade 1.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals dispersed epithelial cells infiltrating the stroma with a diffuse pattern. There is a notable presence of necrosis and mild lymphocytic infiltration. Vascular invasion is observed, and areas of the sample display cystic degeneration. Cellular differentiation shows an adenomatous nature with gland formation. Nuclear atypia includes prominent nucleoli and hyperchromatism, with occasional multinucleated giant cells, indicating high mitotic activity. Based on these observations, the diagnosis is invasive ductal carcinoma.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a mixed population of oligodendroglial and astrocytic cells, with the astrocytic component being predominant. The tumor exhibits increased cellularity, nuclear atypia, and frequent mitotic figures, consistent with a higher grade neoplasm. The nuclei display noticeable variability in size and shape, indicating significant pleomorphism. There is an absence of definite vascular proliferation or necrosis. Based on these observations, the diagnosis is oligoastrocytoma, grade 3 (WHO grade III), astrocytic predominant.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals diffuse infiltration by neoplastic glial cells with nuclear atypia. There is significant variability in nuclear size and shape, indicating pleomorphism. The tumor cells are irregularly distributed and integrated into the surrounding brain parenchyma. The presence of hypercellularity is evident, characteristic of a higher-grade astrocytic tumor. There is no vascular invasion or calcification observed, and necrosis is not specifically noted in the observations. Based on these observations, the diagnosis is diffuse astrocytoma, Grade III.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a mixture of neoplastic glial cells characteristic of an oligoastrocytoma, with a dominance of oligodendroglial components. The tumor displays moderate cellularity with observable nuclear atypia and notable mitotic activity, consistent with a World Health Organization (WHO) Grade 3 classification. There is evidence of nodularity and satellitosis within the tumor microenvironment. Based on these observations, the diagnosis is oligoastrocytoma, oligodendroglial dominant, WHO Grade 3.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a diffusely infiltrating glioma within the gray and white matter, characterized by mild to moderate hypercellularity. The tumor consists of cells predominantly exhibiting round to somewhat irregular nuclei with scant cytoplasmic processes. A notable feature is the presence of perinuclear halos around most cells. Mitotic activity is rare, with only occasional mitotic figures observed. Importantly, there is an absence of microvascular proliferation and necrosis within the examined tissue. Based on these observations, the diagnosis is oligodendroglioma, WHO grade II.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals moderate to heavy infiltration of glial cells with a predominantly oligodendroglial phenotype in the cerebrum. The neoplastic cells exhibit nuclear anaplastic features, characterized by a high mitotic rate of up to 13 mitoses per ten high power fields, indicating aggressive proliferative activity. A proliferation index of about 50% is noted in several active areas, highlighting increased cellular replication. The vascular profile shows focal microvascular mineralization without significant microvascular proliferation, and tumor necrosis is notably absent. The presence of microcalcifications is also observed. Based on these observations, the diagnosis is anaplastic oligodendroglioma.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a diffusely infiltrating tumor within the surrounding brain tissue. The tumor cells exhibit round to oval nuclei with coarse chromatin and irregular nuclear contours, accompanied by areas where the cytoplasm appears clear, displaying a characteristic fried egg appearance. A high mitotic activity is evident, with fifteen mitoses per ten high power fields. Notably, there are areas of hemorrhage and necrosis, alongside focal regions of microvascular proliferation. Based on these observations, the diagnosis is anaplastic oligodendroglioma (WHO Grade III).


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals a moderately hypercellular glial neoplasm with a composition that includes protoplasmic astrocytes, gemistocytes, microgemistocytes, and oligodendroglioma components. There is focal hypercellular clustering, and atypia is generally mild, with some areas showing moderate atypia. Only a few scattered mitotic figures are observed. Microvascular proliferation is present, but necrosis is absent. Notable features include focally prominent subpial accumulation and invasion into the subarachnoid space. Based on these observations, the diagnosis is anaplastic oligoastrocytoma, astrocytoma predominant.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals a moderately hypercellular glial neoplasm with a composition that includes protoplasmic astrocytes, gemistocytes, microgemistocytes, and oligodendroglioma components. There is focal hypercellular clustering, and atypia is generally mild, with some areas showing moderate atypia. Only a few scattered mitotic figures are observed. Microvascular proliferation is present, but necrosis is absent. Notable features include focally prominent subpial accumulation and invasion into the subarachnoid space. Based on these observations, the diagnosis is anaplastic oligoastrocytoma, astrocytoma predominant.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals densely packed, atypical astrocytic cells with increased mitotic activity and pleomorphic nuclei. There is evidence of hypercellularity, with a notable variation in the size and shape of the nuclei. The presence of microvascular proliferation is observed, and areas of necrosis are apparent. Based on these observations, the diagnosis is anaplastic astrocytoma WHO grade III.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a moderately cellular tumor composed predominantly of uniform round to oval cells with clear, perinuclear halos, often referred to as fried egg appearance. These cells are arranged in a delicate network of capillaries, creating a chicken-wire vascular pattern. There is no evidence of significant nuclear atypia or anaplasia, features that are consistent with low-grade behavior. Mitotic figures are scarce, and there is no observed vascular invasion or necrosis. An oligodendroglial pattern of tumor cells is present, with some areas demonstrating calcification, but no notable areas of hemorrhage or necrosis are observed. Based on these observations, the diagnosis is oligodendroglioma, grade II of IV on the WHO scale.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals a diffuse pattern of astrocytic neoplasia with a focal increase in cellularity. The presence of mitoses is noted, along with a proliferation index greater than 8%, suggesting increased cellular turnover and anaplasia. There is a lack of vascular invasion or calcification observed. The overall architectural disruption and cellular characteristics are indicative of an increased grade of malignancy. Based on these observations, the diagnosis is anaplastic astrocytoma WHO Grade III.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a mildly hypercellular glial neoplasm predominantly composed of cells with round to oval nuclei and scant glial processes. Classic differentiation features typical of oligodendroglioma are absent. Scattered moderately to markedly atypical cells are present throughout the sample. No mitotic figures are observed, and there is an absence of microvascular proliferation and necrosis. Based on these observations, the diagnosis is oligoastrocytoma, low grade, oligodendroglioma predominant.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals an infiltrative glial tumor characterized by high cellular uniformity, composed of cells with hyperchromatic, round nuclei surrounded by clear perinuclear haloes, which are a classic feature of oligodendroglial tumors. Prominent chicken-wire like vasculature is observed, providing supportive stroma for the tumor. Certain regions exhibit microcalcifications, indicative of focal mineral deposition within the neoplastic tissue. There is notable increased cellularity and localized mitotic activity, suggesting aggressive proliferation in some areas, although regions of overt tumor necrosis are absent. The absence of extensive necrosis correlates with regions showing increased mitotic activity. These pathological findings, including the IDH1 positivity and the combined 1p/19q chromosomal deletion status, signify the neoplasm's malignant transformation. Based on these observations, the diagnosis is anaplastic oligodendroglioma, WHO Grade III.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals an infiltration of neoplastic cells with oligodendroglial differentiation, showing uniform round nuclei with a clear perinuclear halo, consistent with a fried egg appearance. There is a predominance of oligodendroglial elements, and the cellularity is low, corresponding to a low-grade neoplasm. The tumor cells demonstrate minimal mitotic activity, indicating a slow proliferation rate. No evidence of vascular invasion, necrosis, or significant calcifications is observed. Based on these observations, the diagnosis is low-grade oligodendroglioma, predominance.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals diffuse infiltration of the neocortex by low-grade glial neoplasm, primarily located in the white matter. The predominant cellular pattern consists of cells with rounded nuclei, delicate and granular chromatin, inconspicuous nucleoli, and scarce cytoplasm, occasionally displaying perinuclear halos. These cells infiltrate the adjacent cortex up to layer I, with frequent neuronal satellitosis. A secondary cell component, with fewer cells, features irregular and sometimes elongated nuclei with dense chromatin and eosinophilic cytoplasm. The tumor exhibits areas of increased cellularity, alongside neuropil rarefaction and occasional microcysts. Mitotic figures are rare, and there is no evidence of microvascular proliferation or necrotic foci. Based on these observations, the diagnosis is oligoastrocytoma, grade II WHO.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals the presence of irregular clusters of atypical epithelial cells infiltrating the stroma. These cells demonstrate varying degrees of glandular differentiation, deviating from the normal tissue architecture, with evident invasion into the submucosal layer and extension through the muscularis propria into surrounding adipose tissue. The nuclei of the cells exhibit moderate pleomorphism, with noticeable variability in size and shape, indicating abnormal nuclear features. The mitotic activity appears moderate, suggesting an increased rate of cell division. There is evidence of necrosis within some areas of the neoplastic tissue, contributing to the cellular and architectural disruption. Vascular invasion is observed with tumor cells seen within blood vessels. Based on these observations, the diagnosis is adenocarcinoma.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a moderately differentiated mucinous adenocarcinoma characterized by clusters of malignant epithelial cells producing extracellular mucin. These tumor cells exhibit moderate glandular differentiation with some preservation of glandular architecture, though cellular atypia is evident. The nuclei show moderate variability in size and shape, consistent with a moderate degree of pleomorphism. Mitotic activity is not specified but aligns with moderate differentiation. There is evidence of circumscribed infiltration into the perirectal fatty tissue, and lymphovascular invasion is noted. Based on these observations, the diagnosis is mucinous adenocarcinoma, moderately differentiated (G2).


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals tubulopapillary formations of adenocarcinoma infiltrating through the muscularis mucosae, submucosa, and muscularis propria, extending into the adipose tissue. The neoplastic cells display a moderately differentiated architecture, classified as G2, showing tubulopapillary patterns with varying glandular formations and a mix of tubular and papillary morphologies. There is evidence of carcinomatous emboli, indicating vascular invasion. Necrosis is not mentioned in the microscopic description. Based on these observations, the diagnosis is adenocarcinoma tubulopapillare, moderately differentiated (G2).


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a moderately differentiated adenocarcinoma characterized by glandular structures that deviate from normal architecture. The neoplasm demonstrates an invasion extending through the muscularis propria into the subserosal adipose tissue without breaching the serosal surface. Notably, there is an absence of lymph-vascular invasion and perineural invasion. No evidence of treatment effect is observed. Tumor deposits are present, and additional microscopic findings include tubular adenoma. Based on these observations, the diagnosis is moderately differentiated adenocarcinoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a diffuse pattern of large B-cells that display non-cleaved nuclei, consistent in texture and morphology, indicative of a high-grade lymphoproliferative disorder. The architecture is effaced by sheets of atypical lymphoid cells, exhibiting significant nuclear pleomorphism and large nuclei with prominent nucleoli. There is no evidence of vascular invasion, calcification, or necrosis in the observed tissue. Based on these observations, the diagnosis is diffuse large B-cell lymphoma, non-cleaved (B-DLCL-NC).


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a diffuse infiltration by large lymphoid cells exhibiting centroblastic morphology, interspersed with smaller lymphocytes. The architecture includes a minimum area with lymphoid follicles, some of which show probable secondary colonization by the neoplastic cells. No vascular invasion, calcification, or significant necrosis is noted in the observed sections. Based on these observations, the diagnosis is diffuse large B-cell lymphoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a heterogenous tumor composition with distinct elements of nonseminomatous germ cell tumor, including 40% immature teratoma (MT), 30% embryonal carcinoma (EC), and 30% yolk sac tumor (YST). The presence of sporadic trophoblastic giant cells is noted. The tumor demonstrates angio-invasion, indicative of tumor cells invading blood vessels, and exhibits invasion into the rete testis. Additionally, involvement of the epididymis and adjacent paratesticular tissue is observed, suggesting local extension of the tumor. Based on these observations, the diagnosis is nonseminoma.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals a mixed germ cell tumor composed predominantly of yolk sac tumor (YST) elements (75%), embryonal carcinoma (18%), with minor components of mature teratoma and immature teratoma (5% each), and seminoma (5%). Scattered trophoblastic giant cells are also present. The architecture displays regions typical of yolk sac tumors with endodermal sinus patterns, embryonal carcinoma features including primitive epithelial cells in solid and tubular formations, and varying grades of differentiation in teratomatous areas. Vascular invasion is observed, suggesting aggressive behavior. Based on these observations, the diagnosis is nonseminoma.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a predominant presence of yolk sac tumor (YST) elements, accounting for more than 98% of the tumor composition. There is minimal presence of embryonal carcinoma (EC) elements, representing less than 1% of the tumor. The cellular architecture is predominantly characterized by microcystic and reticular patterns with occasional Schiller-Duval bodies. There is no evidence of vascular invasion, and no invasion into the rete testis is observed. Based on these observations, the diagnosis is nonseminoma.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals that the tumor cells are invading through the layers of the testicular tissue, extending into the epididymis and peri-testicular adipose tissue, as well as the spermatic cord. There is evidence of vascular invasion by the tumor, indicating the involvement of blood vessels in the vicinity. The tumor tissue shows a mottled appearance, with areas of softened necrosis and possible hemorrhage, comprising a significant portion of the tumor mass. No normal testicular tissue or epididymis is discernible in the observed tissue sections. Based on these observations, the diagnosis is mixed germ cell tumor.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a mixed germ cell tumor composed predominantly of embryonal carcinoma and yolk sac tumor components, with a histological distribution showing approximately 70% embryonal carcinoma and 30% yolk sac tumor. Notably, there are trophoblastic giant cells present. The embryonal carcinoma component demonstrates poorly formed glandular and papillary structures with highly pleomorphic nuclei and numerous mitotic figures. The yolk sac tumor component displays reticular and microcystic patterns, with periodic acid-Schiff (PAS)-positive hyaline globules visible within the cytoplasm. Vascular invasion is evident, indicating the presence of tumor cells within the blood vessels. There is no information provided regarding the invasion of the rete testis. Based on these observations, the diagnosis is nonseminoma.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals prostate adenocarcinoma with the presence of glandular structures that moderately deviate from normal tissue architecture, corresponding to a Gleason's pattern 3. There is evidence of a component of Gleason pattern 4, which indicates a more poorly differentiated area within the tumor. The nuclear morphology shows moderate variability in size and shape, but vascular invasion is not identified. However, perineural invasion is present, which involves cancer cells found in the space surrounding nerves within the prostate. High-grade prostatic intraepithelial neoplasia is also identified, suggesting a precursor lesion to the invasive carcinoma. Tumor foci are multicentric, indicating the presence of invasive carcinoma in multiple discrete locations within the prostate. The tumor invades into, but not beyond, the prostate capsule, and the seminal vesicles and bladder neck are not involved. Based on these observations, the diagnosis is adenocarcinoma with a Gleason Score of 3+4=7.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a proliferation of atypical glandular structures within the prostatic stroma, characterized by small, tightly packed acini with minimal glandular formation, consistent with a Gleason score of 3+3=6. The tumor cells exhibit mild nuclear atypia with slightly enlarged and irregular nuclei. A significant feature noted is the presence of perineural invasion, suggesting tumor cells encasing or infiltrating nerve fibers, although lymphatic invasion is not observed. There is no evidence of tumor extension beyond the prostatic capsule or into the seminal vesicles. Based on these observations, the diagnosis is adenocarcinoma of the prostate, without evidence of extraprostatic extension.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals glandular structures formed by epithelium infiltrating the prostatic stroma, with significant deviation from normal prostate architecture. The tumor is characterized by a Gleason score of 7, described as (4+3), indicating a primary pattern 4 and a secondary pattern 3, which corresponds to poorly formed glands with fused or cribriform structures and moderate glandular formation deviation. Nuclear pleomorphism is moderate, with visible nucleoli and increased nuclear size. A moderate to high number of mitotic figures are evident, indicating a relatively rapid rate of cell division. There is evidence of perineural and lymphovascular invasion, indicating that the tumor cells have infiltrated surrounding nerve fibers and vessels. Additionally, there is notable extensive extraprostatic extension, suggesting that the cancer has spread beyond the prostatic capsule. High-grade prostatic intraepithelial neoplasia is also present, indicating premalignant lesions within the gland. Based on these observations, the diagnosis is prostatic adenocarcinoma.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals small acinar structures infiltrating the stromal tissue, characteristic of the glandular architecture seen in prostatic adenocarcinoma. The tumor exhibits a homogeneous pattern with relatively uniform gland formations, consistent with a Gleason pattern 3, indicating moderate differentiation. The nuclei are moderately enlarged and the chromatin remains evenly distributed, with no significant atypical features. There is evidence of extensive perineural infiltration, a common feature in prostatic carcinomas. Notably, the slide also reveals extraprostatic extension, indicating tumor invasion beyond the prostatic capsule, and vascular invasion is not noted. Necrosis or calcification is not observed. Based on these observations, the diagnosis is prostatic adenocarcinoma, Gleason grade 3+3, score of 6.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals acinar-type prostatic adenocarcinoma presenting with moderately differentiated glandular structures (Gleason score of 4+3=7). The tumor shows a predominance of Gleason pattern 4 architecture, which comprises 50-60% of the sampled tumor volume. Multifocal carcinomatous perineural invasion is evident. There is an absence of angiolymphatic invasion. Non-neoplastic prostate tissue demonstrates nodular hyperplasia and focal glandular atrophy. Additionally, focal areas of high-grade prostatic intraepithelial neoplasia are noted. Based on these observations, the diagnosis is prostatic adenocarcinoma with a Gleason score of 7, histologic grade 4, indicating poorly differentiated/undifferentiated features.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals poorly differentiated adenocarcinoma characterized by malignant glandular structures with a Gleason score of 3+4=7, indicating a moderate to high degree of architectural distortion and nuclear atypia. The presence of tertiary Gleason pattern 6 suggests additional variations in tumor patterning. Extensive perineural invasion is observed, indicating that tumor cells are infiltrating the nerve sheaths, but no angiolymphatic invasion is detected. The carcinoma shows established extracapsular extension, signifying that the cancer has breached the prostate capsule and extends into the surrounding tissues. High-grade prostatic intraepithelial neoplasia is present, serving as a precursor lesion to invasive cancer. Based on these observations, the diagnosis is invasive poorly differentiated adenocarcinoma, Gleason score 3+4=7, with tertiary pattern 6.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals poorly differentiated prostatic adenocarcinoma characterized by glandular architecture that significantly deviates from the normal prostate tissue structure. The Gleason score is recorded as 4+3=7, indicating a predominance of poorly formed glandular patterns with fused glands and cribriform structures. A minor microscopic component of Gleason pattern 5, accounting for less than 1% of the tumor, suggests the presence of more aggressive, non-forming glandular structures. There is multifocal extracapsular extension of the tumor, indicating that the cancer cells have penetrated beyond the prostate capsule into surrounding tissues, particularly around regions such as the seminal vesicle and various parts of the prostate base and apex. Noteworthy is the observation of perineural invasion, where cancer cells are seen encircling or tracking along nerves. There are also areas showing high-grade prostatic intraepithelial neoplasia, which is a precursor lesion. Based on these observations, the diagnosis is prostatic adenocarcinoma, poorly differentiated, with a Gleason score of 4+3=7.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals malignant glandular formations with moderate differentiation, characteristic of prostatic adenocarcinoma. The tumor cells occupy three distinct regions within the prostate, demonstrating a Gleason pattern 3+4, indicative of irregular glandular structures, some of which merge with a cribriform appearance or exhibit individual cell necrosis. High-grade prostatic intraepithelial neoplasia (PIN) is present, characterized by architecturally crowded glandular structures with proliferative epithelial cells. Additionally, there is evidence of non-caseating necrotizing granulomatous inflammation within the periprostatic nodule. No vascular invasion or extraprostatic extension is noted. Based on these observations, the diagnosis is prostatic adenocarcinoma.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals well-formed glandular structures associated with small irregular acini. The tumor cells exhibit moderate nuclear pleomorphism and occasional prominent nucleoli. There is noticeable perineural invasion where the carcinoma encases nerve fibers. Microscopic evaluation also reveals invasion into the periprostatic adipose tissue at certain examined loci. High-grade prostatic intraepithelial neoplasia is observed in proximal areas without definitive vascular or lymphatic invasion. Based on these observations, the diagnosis is prostatic adenocarcinoma, Gleason grade 3+4 (combined score 7/10).


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals poorly-differentiated adenocarcinoma characterized by invasive malignant epithelial cells arising in Barrett's mucosa, with notable areas of high-grade dysplasia. The tumor cells exhibit submucosal invasion, marked nuclear pleomorphism, and irregular structural formation, reflecting poor differentiation. There is no evident vascular invasion within the observed section. Instead, fibrovascular tissue is noted without presence of lymphoid tissue. Importantly, areas adjacent to the tumor exhibit high-grade dysplastic changes, which correlate with the neoplastic transformation observed. Based on these observations, the diagnosis is adenocarcinoma, poorly differentiated.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals glandular structures formed by adenocarcinoma cells that are moderately to poorly differentiated, infiltrating the Barrett-epithelium. The architecture deviates significantly from normal tissue, indicating variable tubule formation. The adenocarcinoma cells exhibit moderate to marked nuclear pleomorphism, showing variability in nuclear size and morphology. There is noticeable mitotic activity, reflecting an increased rate of cell division. These features suggest a disruption in normal cellular organization and proliferation. Vascular invasion is not explicitly mentioned, nor are necrosis or calcifications observed in the description. Based on these observations, the diagnosis is moderate/poor differentiated adenocarcinoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals nests and sheets of squamous epithelial cells with moderate differentiation infiltrating the muscularis propria, showing moderate deviation from normal squamous tissue architecture. The nuclei exhibit slight to moderate variability in size and shape, indicative of nuclear pleomorphism. The mitotic activity appears moderate, correlating with a moderate rate of cell division. Lymph-vascular invasion is not identified. Perineural invasion is present, indicating tumor spread along nerve fibers. Based on these observations, the diagnosis is squamous cell carcinoma, moderately differentiated (Histologic Grade G2).


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals poorly differentiated epithelial cells with pronounced pleomorphism, exhibiting high variability in nuclear size and shape. The tumor is characterized by infiltrative nests and sheets of cells with minimal keratinization and lacks formation of organized glandular structures, indicative of high-grade cellular atypia. High mitotic activity is evident, suggesting a rapid rate of proliferation. Vascular invasion is not apparent from the observations. Necrosis is not observed in this sample. Based on these observations, the diagnosis is squamous non-keratinized carcinoma (G3).


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals the presence of invasive squamous cell carcinoma, characterized by the proliferation of atypical squamous cells infiltrating the underlying stroma. The tumor cells display moderate to well-differentiated features, as evidenced by varying degrees of keratinization and intercellular bridges. Specific microscopic features include distinctive nuclear pleomorphism with moderately variable nuclear size and shape. Furthermore, there is no evidence of vascular or perineural invasion, indicating a lack of tumor spread through lymphatic or neural routes on this slide. The tumor is found at a microscopic distance from the deep margin, indicating proximity to the margin. Based on these observations, the diagnosis is squamous cell carcinoma, invasive, moderately to well differentiated.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals irregularly shaped nests and cords of moderately differentiated squamous cells infiltrating the stroma. There is evidence of keratinization within the tumor islands, which is focal. The tumor cells display moderate nuclear pleomorphism with some variability in nuclear size and shape, consistent with a moderate rate of differentiation. Cell division, or mitotic activity, is evident but not excessive. There is clear vascular invasion, as tumor cells are seen penetrating vascular channels, but perineural and bone invasions are not identified. Necrotic areas are noted within the tumor tissue, indicating regions of cell death. The cancer is invasive, occupying a substantial portion of the observed mucosa and extending into the underlying muscular tissue with destruction of architecture. Based on these observations, the diagnosis is invasive moderately differentiated squamous cell carcinoma.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a moderately differentiated carcinoma characterized by infiltrative sheets and nests of malignant squamous cells. The tumor demonstrates extensive lymphovascular invasion, including involvement of large veins, and invades the bone of the maxilla. The carcinoma is seen undermining and eroding into the respiratory mucosa of the maxillary sinus, with invasion into the edge of a minor salivary gland. Numerous apoptotic neoplastic cells with vacuolar degeneration are present, and organizing thrombi are noted in many small veins. Importantly, a component of high-grade squamous intraepithelial neoplasia, also known as carcinoma in situ, is observable above the invasive carcinoma. Despite the extensive invasion into surrounding tissues, perineural invasion is not identified. Based on these observations, the diagnosis is invasive squamous carcinoma, moderately differentiated.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals invasive squamous cell carcinoma characterized by keratinizing cells with distinct cell borders and prominent intercellular bridges. The tumor cells exhibit moderate differentiation with noticeable keratin pearl formation, indicating the preservation of some squamous differentiation. Notably, there is no evidence of necrosis within the examined tissue. Vascular invasion is absent, while perineural invasion is identified, indicating the tumor's tendency to grow along nerve sheaths. Tumor cells infiltrate the medullary space, yet no in situ carcinoma or multicentricity is identified. The surrounding non-neoplastic squamous mucosa shows chronic inflammation. Based on these observations, the diagnosis is invasive squamous cell carcinoma, moderately differentiated.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals an invasive, focally keratinizing squamous cell carcinoma, which is moderately differentiated. The carcinoma is primarily observed in the right tonsil tissue, displaying characteristics of keratinization and moderate differentiation of squamous cells. Vascular invasion is present, as indicated by the positive identification of metastatic squamous cell carcinoma in two out of 31 lymph nodes in the neck level 1-4 dissection. There is no evidence of perineural invasion, and assessments for p16 and high-risk HPV types (16/18) are positive, suggesting an association with human papillomavirus. Based on these observations, the diagnosis is focally keratinizing squamous cell carcinoma, moderately differentiated.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals epithelial cells forming well to moderately differentiated squamous cell structures, indicating variations in differentiation. The tumor appears invasive and exhibits signs of perineural invasion, suggesting an aggressive pattern of growth into surrounding tissues. Examination of the lymph nodes identified the presence of metastatic squamous cell carcinoma with focal extranodal extension in one of the lymph nodes. The lymphovascular invasion is not identified in the examined specimen, indicating the absence of tumor cells within the vascular channels such as blood vessels and lymphatics. Based on these observations, the diagnosis is invasive well to moderately-differentiated squamous cell carcinoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a moderately differentiated keratinizing squamous cell carcinoma. The tumor is characterized by nests and islands of atypical squamous cells with evidence of keratinization. There is notable perineural invasion, where tumor cells are observed encasing nerve fibers, and vascular invasion is evident, indicating tumoral infiltration into the vascular channels. These cellular structures deviate significantly from normal tissue architecture, indicative of malignancy. Based on these observations, the diagnosis is invasive squamous cell carcinoma, moderately differentiated, keratinizing.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals invasive squamous cell carcinoma characterized by poorly differentiated cells with basaloid features. The carcinoma exhibits focal lymphovascular invasion, and adjacent areas show squamous cell carcinoma in situ. The tumor demonstrates a maximum depth of invasion of 9.0 mm into the underlying tissues, including soft tissue metastasis identified in a minor salivary gland. Necrosis and vascular invasion are noted, but there is no evidence of perineural invasion. Bone invasion is also noted, as seen in the mandibular sections. Based on these observations, the diagnosis is invasive poorly differentiated squamous cell carcinoma with basaloid features.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a well-circumscribed tumor composed of atypical cells characteristic of chromophobe renal cell carcinoma. The cells are arranged in solid sheets and have distinct cell borders with pale, eosinophilic cytoplasm. The nuclei are round and demonstrate hyperchromatic features with moderate nuclear pleomorphism, corresponding to a nuclear grade of 2 (out of 4). There is no evidence of sarcomatoid features, vascular invasion, capsular invasion, or infiltration into the perirenal adipose tissue and renal sinus. The tumor margins appear free of neoplastic cells. Based on these observations, the diagnosis is renal cell carcinoma, chromophobe type, nuclear grade 2 (of 4).


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals cells characteristic of chromophobe renal cell carcinoma, with most possessing eosinophilic cytoplasm. There are prominent areas of hemorrhage within the tumor. The nuclei exhibit features corresponding to a Fuhrman nuclear grade of 3, indicating significant nuclear size, shape variability, and prominent nucleoli. No evidence of vascular invasion or invasion into the perinephric adipose tissue, renal sinus adipose tissue, or renal structures is observed. Based on these observations, the diagnosis is chromophobe renal cell carcinoma.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals that the serous adenocarcinoma is characterized by high-grade papillary structures with areas of solid and glandular growth patterns. Tumor cells exhibit significant atypia with prominent nucleoli and high mitotic activity. Numerous psammoma bodies, which are concentrically calcified structures, are present throughout the specimen. There is widespread tumor necrosis and lymphovascular invasion, indicating aggressive behavior of the carcinoma. Reactive stromal changes, including fibrosis and secondary inflammation, are noted, suggesting a chronic inflammatory response. Additionally, foci of calcification are seen, which may correspond to previous necrotic or injured tissues. Based on these observations, the diagnosis is high-grade papillary serous carcinoma.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals the presence of significant vascular invasion by clusters of atypical cells, often arranged in irregular glandular structures. Calcifications are not observed within the examined tissues, but there are regions exhibiting necrosis, characterized by cellular debris and loss of viable cells. The tumor cells demonstrate a significant deviation from normal tissue architecture, with enlarged, irregular nuclei and prominent nucleoli, indicative of nuclear pleomorphism. The rate of cell division appears elevated, suggestive of a high mitotic index. Based on these observations, the diagnosis is invasive ductal carcinoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals the presence of infiltrating adenocarcinoma occupying more than 90% of the examined tissue. The tumor cells exhibit a Gleason score of 4+4=8, indicating poorly formed or fused glands with irregular patterns, and there is a presence of a tertiary pattern 5, suggesting single cells or solid sheets of cells with severe deviation from normal glandular structure. Based on these observations, the diagnosis is infiltrating adenocarcinoma.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals an epithelioid tumor consistent with metastatic melanoma, characterized by the presence of a large nodule that erodes the overlying small bowel mucosa and extends through the subserosal fat. The lesion ulcerates the small bowel mucosa and involves the entire thickness of the bowel wall, with an admixed lymphocytic infiltrate observed within the tumor. The margins of resection appear clear, indicating no residual tumor presence at the analyzed sections. Based on these observations, the diagnosis is metastatic melanoma.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals atypical melanocytic cells with significant pleomorphism, exhibiting large and irregularly shaped nuclei with prominent nucleoli. The tumor cells are organized in an infiltrative pattern extending into the deeper dermis. There is a presence of nodular aggregates as well. Areas of necrosis are evident within the tumor, and no vascular invasion is noted. Based on these observations, the diagnosis is melanoma, histological grade 3.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals an epithelioid malignant tumor with a high cellularity, making up approximately 90 percent of the tissue examined. The tumor cells display bizarre round to oval nuclei and a high nucleus-to-cytoplasm ratio. The cytoplasm is of moderate size. The mitotic count is noted at 6 mitoses per square millimeter, indicating a high rate of cell division. The growth pattern is sheet-like, and there is a presence of lymphocytic infiltrates, comprising around 5 percent of the tissue. Based on these observations, the diagnosis is consistent with a metastasis of a melanoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals clusters of abnormal melanocytic cells with atypical morphology that have extensively infiltrated throughout the lymph nodes, showing marked nuclear pleomorphism and hyperchromasia. The tumor cells exhibit variable degrees of pigmentation, consistent with melanoma, and there is conspicuous evidence of extranodal extension. Vascular invasion is observed, with the melanoma cells breaching the lymphatic channels, and there is a notable absence of glandular or epithelial structures, aligning with metastatic spread rather than primary lymph node pathology. Based on these observations, the diagnosis is metastatic melanoma.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals a circumscribed tumor nodule within the subcutis, comprised of large epithelioid cells, some of which contain intracytoplasmic pigment. Central areas of necrosis are prominent within the tumor mass. Surrounding the tumor, a peritumoral lymphocytic infiltrate is observed, along with inflammatory changes in the overlying epidermis and dermis. In addition to the nodule observation, the slide from the axillary region shows a lymph node extensively replaced by a pleomorphic epithelioid cell tumor with focal necrosis, consistent with metastatic spread. Based on these observations, the diagnosis is metastatic melanoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals metastatic melanoma characterized by the presence of melanoma cells involving subcutaneous tissue with extensive necrosis. There is focal melanin pigment evident within the tumor cells. The tumor borders exhibit a pushing pattern, indicating a locally aggressive growth pattern. In the lymph node sample, metastatic melanoma is identified with evidence of extracapsular extension, indicating that the tumor has invaded beyond the lymph node capsule. Exogenous black pigment, likely from a tattoo, is also present in one of the lymph nodes, but this is unrelated to the melanoma cells. Based on these observations, the diagnosis is metastatic melanoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals an epithelioid malignant tumor comprising approximately 80% of the examined tissue, with sparse connective tissue presence. The tumor cells are characterized by round to oval nuclei with granular chromatin and eosinophilic nucleoli, accompanied by a high nucleus-to-cytoplasm ratio. The cells display a mitotic count of 10 mitoses per square millimeter, indicative of a high cell division rate. The cytoplasm of the tumor cells is of moderate size, and the tumor exhibits a sheet-like growth pattern. Approximately 10% of the tumor tissue is necrotic. Lymphocytic infiltrates make up about 3% of the tissue cells. Based on these observations, the diagnosis is consistent with a metastasis of a melanoma.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals an epithelioid malignant tumor comprising approximately 95% of the tissue, with sparse connective tissue presence. The tumor cells exhibit round to oval nuclei with granular chromatin and have a high nucleocytoplasmic ratio. The cytoplasm is moderately pigmented, and there is a sheet-like growth pattern observed. A mitotic count reveals 8 mitoses per square millimeter, indicating a high rate of cell division. Presence of apoptotic cells and lymphocytic infiltrates constitute about 3% of the tissue cells, along with melanophages. Based on these observations, the diagnosis is a metastasis of a melanoma.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a circumscribed and encapsulated tumor composed of nests and clusters of cells (zellballen pattern) characteristic of pheochromocytoma, with moderate cellularity. The tumor cells possess an abundant eosinophilic cytoplasm and round to oval nuclei with finely stippled chromatin. There is no evidence of lymphovascular space invasion or malignancy-related architectural disruption observed. No necrosis, calcification, or significant mitotic activity is identified. Based on these observations, the diagnosis is pheochromocytoma.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals a malignant neoplasm consisting primarily of cells exhibiting variable size and shape, consistent with high-grade nuclear pleomorphism. The tumor shows extensive areas of central necrosis, surrounded by viable tumor cells with nodular architecture. Notably, there is focal lymphovascular invasion, indicating aggressive potential. The viable tumor tissue is predominantly located at the periphery, and areas of hemorrhage are present within the tumor mass. The tumor invades directly into the surrounding soft tissue, showing adherence to adjacent structures such as the kidney and pancreas. Tumor infiltration into adjacent soft tissue margins is evident, confirming invasion beyond the adrenal gland. Based on these observations, the diagnosis is malignant pheochromocytoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals cellular nests and clusters characteristic of pheochromocytoma, with cells displaying a rich chromatin pattern and moderate to ample cytoplasm. There is evidence of vascular invasion, indicated by microscopic foci where tumor cells infiltrate the lumens of blood vessels. The cellular architecture is further described by its tendency to be arranged in a zellballen pattern. The noted vascular invasion suggests potential aggressive behavior; however, further assessment would require clinical correlation. Based on these observations, the diagnosis is pheochromocytoma.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals a tumor with a solid nesting zellballen architecture, characterized by polygonal cells with indistinct cell borders and abundant basophilic cytoplasm. There is the presence of focal nuclear pleomorphism. Notably, stromal hemorrhage is observed, and vascular congestion indicates some level of degeneration. The tumor is partially encapsulated, as shown by an incomplete capsule, with no evidence of capsular invasion or extra-adrenal invasion. There is no lymphovascular involvement detected. Based on these observations, the diagnosis is pheochromocytoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals poorly differentiated neoplastic cells within the skeletal muscle, demonstrating a sclerosing pattern characteristic of dedifferentiated liposarcoma. Large areas of necrosis are present, and the tumor displays a malignant fibrous histiocytoma-like growth pattern. The dedifferentiated components predominate throughout, indicating aggressive tumor behavior with high-grade histological features. Based on these observations, the diagnosis is dedifferentiated liposarcoma.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a dominant dedifferentiated liposarcoma component characterized by undifferentiated round and plump spindle cell morphology. The presence of a hemangiopericytomatous-like pattern is noted, along with focal areas of well-differentiated/sclerosing liposarcoma. Approximately 30% of the tumor is comprised of necrotic and cystic areas. Extensive necrosis is evident, and there are no observable areas of calcification or vascular invasion on the slide. The tumor's architectural organization shows a lack of distinct structure, consistent with a dedifferentiated high-grade sarcoma, while some regions retain a better differentiation with increased fibrous stroma. Based on these observations, the diagnosis is dedifferentiated liposarcoma.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals the presence of spindle-shaped cells with elongated nuclei, exhibiting notable pleomorphism. These cells form interlacing fascicles and whorled patterns within the stromal matrix. There is evidence of nuclear atypia with variable nuclear size and prominent nucleoli, indicating abnormal cellular proliferation. Mitotic figures are readily observed, suggesting a heightened level of cellular division. Vascular invasion is not apparent within the examined tissue. No distinct zones of necrosis or calcification are observed. Based on these observations, the diagnosis is malignant peripheral nerve sheath tumor.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals a high-grade spindle cell neoplasm demonstrating elongated, spindle-shaped tumor cells with moderate to severe nuclear atypia, accompanied by frequent and atypical mitoses. The architecture consists of interlacing fascicles of these spindle cells, indicative of aggressive growth. Notably, the tumor cells are densely packed without discernible glandular or epithelial structures. Focal calcifications are present within the matrix surrounding the tumor cells. Despite the tumor's proximity to adjacent structures, there is no microscopic evidence of invasion into the left kidney, ureter, or adrenal gland. Areas of necrosis are observed within the tumor mass. Vascular invasion is not detected. Based on these observations, the diagnosis is high-grade spindle cell sarcoma consistent with leiomyosarcoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a neoplasm characterized by highly pleomorphic spindle-shaped and multinucleated tumor cells with significant nuclear atypia and frequent mitotic figures, reflecting a high-grade lesion. There is evidence of lymphovascular invasion as noted, and the tumor shows areas of necrosis, accounting for approximately 10% of the tissue examined. The tumor infiltrates surrounding soft tissue structures, including muscle and pleura. Notably, there is no calcification present. Based on these observations, the diagnosis is unclassified pleomorphic sarcoma, high grade.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a spindle cell proliferation consistent with a well to dedifferentiated liposarcoma. The well-differentiated component, making up less than 10% of the tumor, is characterized by a sclerosing subtype, while the non-lipogenic element resembles a low-grade spindle cell sarcoma. There is a notably high mitotic rate observed, although no pleomorphism or necrosis is evident. The tumor infiltrates fibro-adipose tissue, including the spermatic cord, and abuts the vas deferens. Based on these observations, the diagnosis is dedifferentiated liposarcoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals the presence of poorly differentiated tumor cells displaying a monomorphic spindle-shaped appearance. These cells are arranged in a haphazard pattern consistent with synovial sarcoma. The slide exhibits a high mitotic rate, with mitoses numbering up to 50 per 10 high power fields, indicating a high level of cellular proliferation. Focal lymphovascular invasion is evident, suggesting some degree of tumor spread into vascular structures, although no necrosis is identified within the tumor tissue. Additionally, there is an absence of calcification. The tumor tissues abut regions of hemorrhage and are in close proximity to cystic structures, although the specific relationships with these features are not detailed. Based on these observations, the diagnosis is poorly differentiated monophasic synovial sarcoma.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals exuberant granulation tissue with characteristic fibroblastic proliferation and myxoid changes, typical for a high-grade myxofibrosarcoma. No residual sarcoma tissue is identified in the examined section, suggesting a primarily reactive tissue response. The tissue is notably devoid of vascular invasion, calcification, necrosis, or significant atypia or pleomorphism within the granulation tissue. Based on these observations, the diagnosis is myxofibrosarcoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals a malignant fibrous histiocytoma characterized by hyxoid and pleomorphic areas. The cellular composition includes spindle-shaped and polygonal cells, exhibiting moderate to marked nuclear pleomorphism. These cells form storiform, whorled, or haphazardly arranged patterns within the fibrous stroma. Areas of increased cellularity contrast with regions displaying myxoid changes, where there is a gelatinous matrix. Mitotic figures are frequently observed, suggesting a high proliferative rate. No evidence of vascular invasion, calcification, or necrosis is noted. Based on these observations, the diagnosis is malignant fibrous histiocytoma.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals a proliferation of atypical spindle-shaped cells within a myxoid stroma, characteristic of a myxofibrosarcoma. The tumor displays a high degree of cellular pleomorphism and is infiltrative, breaching the surrounding stroma. There is a high mitotic activity with a mitotic count ranging between 10-30 figures per 10 high-power fields. Tumor necrosis is present and extensive, with necrotic areas comprising approximately 18-20% of the tumor section, indicative of aggressive behavior. Vascular invasion is not identified. Based on these observations, the diagnosis is myxofibrosarcoma, histologic grade 3 according to the FNCLCC grading system, reflecting poor tumor differentiation, high mitotic count, and significant necrosis.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals a proliferation of atypical spindle-shaped mesenchymal cells with marked pleomorphism and hyperchromatic nuclei. These cells infiltrate the surrounding tissue in an irregular fashion. Foci of necrosis are present, indicating rapid tumor growth and cell turnover. Mitoses are frequent, with numerous abnormal mitotic figures observed. Scattered within the tumor are areas of myxoid stromal change, contributing to a gelatinous appearance microscopically. Based on these observations, the diagnosis is malignant fibrous histiocytoma.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals features consistent with papillary thyroid carcinoma, notably with tall cell morphology. The observation includes clear evidence of vascular invasion, identified by tumor cells infiltrating blood vessels. There is nodular thyroid hyperplasia surrounding the carcinoma foci. Additional noted features include the presence of multinodal lesions across the thyroid gland lobes and isthmus, with one major nodule extending beyond the thyroid capsule, indicative of extrathyroidal extension. The carcinoma displays the conventional architecture and invasion patterns characteristic of papillary structures. Based on these observations, the diagnosis is papillary thyroid carcinoma with tall cell features.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals papillary structures with overlapping nuclei, nuclear grooves, and intranuclear inclusions, characteristic of a papillary carcinoma. The tumor appears well-differentiated, with no identified mitotic activity or necrosis. The carcinoma is confined within the thyroid parenchyma, with no evidence of extrathyroid extension or blood vessel invasion. The right lobe slide features a solitary papillary microcarcinoma, while the left lobe slide displays three foci of papillary carcinoma, including a classical type, a follicular variant, and a microcarcinoma. In the classical type, there is a focal capsular invasion, confirming the neoplastic process. Tumor encapsulation is observed, indicating complete surrounding by a fibrous capsule, except for the focal invasion observed in the classical variant. The thyroid parenchyma also exhibits nodular hyperplasia, with the absence of parathyroid gland tissues. Based on these observations, the diagnosis is papillary carcinoma, well-differentiated.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a well-differentiated papillary carcinoma displaying a diffuse sclerosing variant, characterized by the presence of psammoma bodies, which are concentrically calcified structures. There is evidence of extensive blood vessel invasion, suggesting aggressive behavior, although no mitotic activity or necrosis was identified. The thyroid tissue also exhibits features of chronic lymphocytic thyroiditis. Vascular invasion is extensive, but there is no extrathyroid extension noted to visceral structures. The presence of metastatic papillary thyroid carcinoma within lymph nodes indicates lymph node involvement, marked by psammoma bodies, but without extranodal extension. Based on these observations, the diagnosis is papillary thyroid carcinoma, diffuse sclerosing variant, well-differentiated.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a proliferation of well-formed papillary structures with fibrovascular cores. The epithelial cells lining these papillae demonstrate a distinct nuclear morphology characterized by overlapping nuclei, fine chromatin, and occasional nuclear grooves. In addition, some nuclei exhibit intranuclear inclusions. There is evidence of vascular invasion within the tumor. Calcification in the form of psammoma bodies is also noted. The tissue architecture includes focal areas where follicles are more prominent, indicating a follicular variant of the tumor. No necrosis is observed in the examined tissue. Based on these observations, the diagnosis is papillary carcinoma, follicular variant.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals the presence of papillary structures with fibrovascular cores infiltrating the stroma. Tumor cells exhibit overlapping nuclei with clear chromatin, displaying a ground glass or Orphan Annie eye appearance. Nuclear grooves and inclusions are also observed. There is evidence of venous and lymphatic invasion, as well as a focus of necrosis within the tumor. Based on these observations, the diagnosis is papillary carcinoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals the presence of thyroid follicular structures with branching papillary formations. The papillae are lined by neoplastic epithelial cells exhibiting characteristic nuclear features, including crowding, overlapping, and prominent nuclear grooves, with occasional intranuclear inclusions. The surrounding stroma lacks evidence of vascular invasion, and no necrosis or calcification is noted within the examined sample. Based on these observations, the diagnosis is papillary thyroid carcinoma, follicular variant.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals the presence of neoplastic epithelial cells exhibiting papillary formations typical of papillary carcinoma. The morphological analysis indicates a characteristic presence of branching and interconnected fronds of cells supported by fibrovascular cores. The nuclei of the tumor cells display a ground-glass appearance with overlapping features. Psammoma bodies, which are laminated calcific deposits, are identified within the tissue. Signs of Hashimoto's thyroiditis, such as lymphocytic infiltration and oncocytic changes in the thyroid parenchyma, are evident. Based on these observations, the diagnosis is papillary carcinoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals an encapsulated thyroid tumor with follicular and solid architecture. The tumor cells exhibit oncocytic or oxyphilic cytomorphology, characterized by abundant granular cytoplasm and large vesicular nuclei with prominent nucleoli. There is evidence of minimal tumor capsular invasion, indicating a breach of the capsule by tumor cells, though lymph-vascular invasion, perineural invasion, and extrathyroidal extension are not identified in the observed sample. The absence of these invasive features suggests local confinement of the tumor cells within the thyroid lobe. Based on these observations, the diagnosis is papillary carcinoma, oncocytic variant.


Question: What are the main observations in the whole slide histopathology image, and what is the likely diagnosis?

Microscopic observation of the pathology slide reveals the presence of neoplastic epithelial cells forming papillary structures with fibrovascular cores, characteristic of papillary architecture. The tumor is encapsulated with a focal area of capsular invasion, where the neoplastic cells extend into but do not penetrate through the capsule completely. Lymphovascular invasion is not observed within the examined sections, and there is no evidence of tumor extension beyond the thyroid capsule, indicating no extrathyroidal extension. Based on these observations, the diagnosis is papillary carcinoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals papillary structures with fibrovascular cores lined by epithelial cells exhibiting nuclear features characteristic of papillary thyroid carcinoma, such as overlapping nuclei, nuclear grooves, and clear 'Orphan Annie eye' appearance. These cells display mild nuclear pleomorphism and intranuclear inclusions. There is no evidence of vascular or capsular invasion. Necrosis or calcification is not observed. The tumor is confined within the thyroid tissue without multifocality. Based on these observations, the diagnosis is papillary thyroid carcinoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals moderately differentiated squamous cell carcinoma with moderately abnormal squamous cells forming clusters that demonstrate some degree of squamous differentiation. The cellular architecture shows notable keratinization, which is typical in squamous lesions. There is evidence of necrosis within the lesion, suggesting areas of central cellular death. Vascular invasion was not observed in the examined tissue sections. Based on these observations, the diagnosis is squamous cell carcinoma, moderately differentiated.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals moderately differentiated adenocarcinoma with focal areas of necrosis. The tumor exhibits papillary structures with areas showing significant calcification and necrosis in the center. Vascular invasion is prominent, as evidenced by the presence of tumor cells within the cervical stromal vessels. In situ carcinoma is identified in the examined area with notable architectural complexity. Based on these observations, the diagnosis is endometrioid adenocarcinoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals squamous epithelial cells exhibiting infiltrative growth patterns, with the formation of nests and sheets of cells that deviate from the normal tissue architecture. The squamous cells display moderate nuclear pleomorphism, characterized by variations in nuclear size and shape. Mitotic activity is notable, indicating a moderate rate of cell division. Extensive lymphovascular invasion is present, suggesting the potential for metastatic spread. Additionally, there is extensive involvement of the surrounding myometrial tissue. Based on these observations, the diagnosis is cervical squamous cell carcinoma, moderately differentiated.


Question: Briefly outline the characteristics and diagnostic findings of the whole slide histopathology image.

Microscopic observation of the pathology slide reveals glandular structures with a moderate degree of differentiation, characteristic of mucinous adenocarcinoma. The gland formation partially resembles normal tissue, with areas showing extensive necrosis within the tumor. Vascular invasion, calcification, and other structural alterations are not detailed in the observations provided. Based on these observations, the diagnosis is mucinous adenocarcinoma of endocervical type, moderately differentiated, with extensive necrosis.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals a tumor exhibiting a mass-forming growth pattern, predominantly of adenocarcinoma type, consistent with intrahepatic cholangiocarcinoma. The tumor shows well to moderately differentiated cellular morphology, corresponding to a histologic grade of 1-2 out of 4. Vascular invasion is evident, with tumor cells infiltrating portal vein branches and the vena cava. Perineural invasion is also identified. The tumor invades the liver capsule but does not extend through it. The stroma is prominently desmoplastic, and there is no significant necrosis, with the tumor being 90% viable. Background liver parenchyma displays cholestasis and moderate periportal inflammation without signs of cirrhosis. Based on these observations, the diagnosis is adenocarcinoma, consistent with intrahepatic cholangiocarcinoma, well to moderately differentiated (grade 1-2 of 4).


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a relatively well-circumscribed neoplasm demonstrating gland formation, characteristic of a mass-forming subtype. The tumor exhibits moderate nuclear pleomorphism, indicating variability in nuclear size and shape, which correlates with a histologic grade of 2 out of 4, reflecting moderate differentiation. There is focal necrosis observed, yet it comprises no more than 15% of the sampled tumor. The suspicion of lymphovascular invasion is noted, although not definitively confirmed, and there is no evidence of perineural or capsular invasion. The background liver tissue displays mild steatosis with minimal non-specific portal chronic inflammation. Based on these observations, the diagnosis is cholangiocarcinoma, moderately differentiated.


Question: Summarize the key features of the whole slide histopathology image and give a diagnosis.

Microscopic observation of the pathology slide reveals a malignant neoplasm characterized by the presence of both epithelial and mesenchymal components, consistent with a malignant mixed Mullerian tumor (carcinosarcoma). The tumor is arising within an endometrial polyp and shows superficial myometrial invasion, specifically measuring 0.5 mm in depth. The tumor does not display lymphovascular space invasion, and there is no involvement of the cervix or parametria. The surrounding tissues demonstrate changes such as adenomyosis and endometriosis, and a myometrial leiomyoma is present. Based on these observations, the diagnosis is malignant mixed Mullerian tumor (carcinosarcoma).


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals a malignant neoplasm characterized by a proliferation of epithelial elements with a predominantly glandular appearance, juxtaposed with a stromal component that is extensively malignant, featuring heterologous elements including rhabdoid cells. Despite the tumor's malignancy, there is no evidence of vascular invasion or necrosis, and the tumor lacks stromal invasion in the endocervix. Additionally, there is no observable muscular or stromal invasion in multiple sections of the tissue. Based on these observations, the diagnosis is malignant mixed Mullerian tumor, FIGO Grade 3.


Question: What does the whole slide histopathology image depict, and what is the diagnosis?

Microscopic observation of the pathology slide reveals a diffuse architectural pattern with tumor cells exhibiting nuclear features consistent with Fuhrman nuclear grading. The clear cells constitute less than 25% of the neoplasm. There are extensive areas of necrosis present, while the mitotic count is notably low with 0 mitoses observed in 10 high power fields, indicating a low proliferation rate. Capsular invasion and venous invasion are observed, confirming the aggressive nature of the neoplasm. Atypical mitoses are not detected, and sinusoidal invasion is also absent. Based on these observations, the diagnosis is adrenocortical carcinoma with a Weiss score of 4.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals that the adrenal tissue is predominantly replaced by a neoplastic infiltrate composed of solid sheets of highly pleomorphic cells exhibiting abundant eosinophilic cytoplasm. The nuclei are notably enlarged and vesicular with prominent nucleoli. Mitotic figures are numerous, including atypical forms, indicating a high rate of cell division. The tumor has an infiltrative border, invading both residual cortical and medullary tissue, though there is no evidence of penetration through the adrenal capsule. Extensive areas of necrosis and hemorrhage are observed, but there is no vascular space permeation. Based on these observations, the diagnosis is adrenal cortical carcinoma.


Question: What are the key features and diagnostic information that can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals features characteristic of adrenal cortical carcinoma, including pronounced nuclear atypia with significant pleomorphism, heightened mitotic activity, and areas of necrosis. There is notable vascular invasion and the presence of confluent growth patterns disrupting normal tissue architecture. Some regions exhibit intracytoplasmic vacuolization. These features align with a Weiss score of 6, indicating aggressive histological features under the Weiss criteria for adrenal cortical tumors. Based on these observations, the diagnosis is adrenal cortical carcinoma.


Question: Provide a concise report on the histopathological features and the diagnosis of the whole slide image.

Microscopic observation of the pathology slide reveals a proliferation of oxyphilic cells with abundant granular eosinophilic cytoplasm, consistent with an adrenal cortical tumor. The tumor demonstrates features such as increased mitotic activity, atypical mitoses, and areas of necrosis, contributing to a Weiss score of 5. These characteristics suggest a degree of cellular atypia and a potential for malignancy. Vascular invasion is not explicitly noted in the observations, but the cellular atypia and mitotic activity are significant morphologic findings. Based on these observations, the diagnosis is carcinoma with malignancy potential consistent with adrenal cortical carcinoma.


Question: Please describe the main features of the whole slide histopathology image and provide a diagnosis.

Microscopic observation of the pathology slide reveals large, polygonal tumor cells with abundant eosinophilic granular cytoplasm, characteristic of oncocytic features. There's a noted deviation from normal adrenal tissue architecture, where the organization into distinct cellular cords or nests is irregular. The nuclei are enlarged with prominent nucleoli, and there is moderate nuclear pleomorphism. The mitotic activity is notable, indicative of a higher rate of cellular proliferation. Vascular invasion is observed, with tumor thrombi present within small to medium-sized blood vessels. Additionally, areas of necrosis are present within the tumor. Based on these observations, the diagnosis is adrenal cortical carcinoma with oncocytic features, and the Weiss score is 5.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals lymphocyte-rich neoplasm predominantly of type B2, with encapsulation confined within the thymus, showing mixed characteristics of thymoma types B2 and B1. The structure of cells appears consistent with thymic epithelial cells, demonstrating some degree of atypia yet largely maintaining an organized architecture. Vascular invasion is not observed, and necrosis is absent within the examined tissue. The encapsulated nature of the neoplasm suggests no infiltration beyond its defined boundary. Based on these observations, the diagnosis is thymoma, mixed type B2/B1, predominantly B2 type.


Question: What morphological features and diagnostic conclusions can be derived from the whole slide histopathology image?

Microscopic observation of the pathology slide reveals the presence of a tumor characterized by the proliferation of epithelial cells that resemble normal thymic cortical and medullary features, consistent with WHO type B1 thymoma. These cells infiltrate the adjacent adipose tissue, indicating microscopic invasion. The tumor exhibits a well-defined interface with the surrounding fat, although cellular clustering within the adipose tissue suggests local invasiveness. No significant areas of necrosis are identified within the tumor structure. Based on these observations, the diagnosis is thymoma, WHO type B1.


Question: How would you summarize the morphological features and diagnosis in the whole slide histopathology image?

Microscopic observation of the pathology slide reveals the presence of a mass composed of neoplastic epithelial cells exhibiting a lobulated architecture within a fibrous stroma. The cells are arranged in densely packed, solid, and nodular formations, with evidence of substantial collagen deposition interspersed between them. Notably, there is no discernible vascular invasion, and necrosis was observed in some sections of the sample. The cellular components display moderate pleomorphism with vesicular nuclei, and occasional nucleoli are visible. Calcification or other mineral deposits are not apparent in the examined sections. Based on these observations, the diagnosis is thymoma.


Question: Please provide a brief description and diagnosis based on the whole slide histopathology image.

Microscopic observation of the pathology slide reveals a neoplasm characterized by a composition typical of WHO Type B1 thymoma, consisting predominantly of epithelial cells mixed with a prominent lymphocytic component. There is evidence of tumor invasion into the lung parenchyma. The tissue displays epithelial cells at the cauterized margin, confirmed by keratin staining. Lymphovascular invasion is not identified. Lymphoid follicular hyperplasia is also present. Based on these observations, the diagnosis is thymoma, WHO Type B1.