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"0e657c71-6632-4f28-bd18-df942ed7c0af", "image_id": 1, "image_name": "10109.png", "category_id": 5, "category_name": "Section", "bbox": [ 1102.453, 557.399, 270.8890000000001, 58.240999999999985 ], "priority": 3, "parents": [ 1 ], "children": [ 5 ], "area": 614506.199747, "iscrowd": 0, "segmentation": [], "text": "Abstract" }, { "id": 5, "strid": "da236d98-e599-4b2a-b590-adcd86856575", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 123.782, 636.672, 2237.758, 553.2719999999999 ], "priority": 4, "parents": [ 4 ], "children": [], "area": 78808.533504, "iscrowd": 0, "segmentation": [], "text": "Rationale: It has been known that the respiratory functions decline with age resulting in reduced quality of life. However, age-dependent molecular\nchanges in respiratory cells such as airway smooth muscle (ASM) cells are not established. There are data suggesting that aging develops a greater\ninflammatory and lower anti-oxidant response compared to young, but whether these differences actually translate into loss of cellular functions is\nunknown. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) along with mitochondrial homeostasis play fundamental roles in\nintracellular protein handling during inflammation. The UPR exists to improve protein folding for proper cellular homeostasis, and prevent cell damage\nfrom the accumulation of misfolded proteins. We investigated whether ER stress and mitochondrial homeostasis is changed with age in ASM cells.\nMethods & Results: ASM cells obtained from Young (12 months) and Aged (30 months) F344XBN rats were used to determine the ER stress markers at\nbaseline and after 24 to 120 hours of serum starvation using western blotting. Expression of hallmarks of UPR, BIP, and IRE1@ were measured in cell\nlysates obtained from Young and Aged ASM cells. MTT assay was used to measure the cell viability in ASM cells. Mitochondrial reactive oxygen species\n(ROS) generation was measured using a fluorescent assay. We found that ER stress or UPR hallmarks (BIP, IRE1) were induced in aged ASM cells\nwhen compared to Young. ROS generation was significantly higher in ASM cells from Old rats compared to Young. We also found greater cell death in\naged ASM cells at 72, 96 and 120 hours upon serum starvation when compared to Young. The induction of ER stress markers correlated with reduction\nof cell viability in aged ASM cells. Conclusions: Our results indicate that mitochondrial dysfunction along with increased ER stress/UPR in aged ASM\ncells contributes to reduced contractile responses of the airways with aging." }, { "id": 6, "strid": "7b4b981f-5ba0-4dd1-a6b7-8cecc6420563", "image_id": 1, "image_name": "10109.png", "category_id": 5, "category_name": "Section", "bbox": [ 525.459, 1241.395, 281.725, 65.01299999999992 ], "priority": 5, "parents": [ 1 ], "children": [ 8, 9, 7 ], "area": 652302.1753049999, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 7, "strid": "2ce29f08-8573-4825-a629-e593afce9a46", "image_id": 1, "image_name": "10109.png", "category_id": 4, "category_name": "List", "bbox": [ 125.98, 1334.275, 316.593, 43.728000000000065 ], "priority": 6, "parents": [ 6 ], "children": [], "area": 168091.96450000003, "iscrowd": 0, "segmentation": [] }, { "id": 8, "strid": "5596f9c7-6077-4b01-a3f2-d3f5fca9b6cf", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 270.817, 1401.91, 717.044, 491.336 ], "priority": 7, "parents": [ 6 ], "children": [], "area": 379661.06047, "iscrowd": 0, "segmentation": [] }, { "id": 9, "strid": "008a7890-8b87-4402-9141-621638413022", "image_id": 1, "image_name": "10109.png", "category_id": 4, "category_name": "List", "bbox": [ 128.743, 1926.707, 1098.772, 1273.615 ], "priority": 8, "parents": [ 6 ], "children": [], "area": 248050.039301, "iscrowd": 0, "segmentation": [] }, { "id": 10, "strid": "a5dcb7b2-9f80-48c4-81a5-a22757de9f35", "image_id": 1, "image_name": "10109.png", "category_id": 5, "category_name": "Section", "bbox": [ 1687.573, 1238.686, 239.73700000000008, 63.659000000000106 ], "priority": 9, "parents": [ 1 ], "children": [ 12, 17, 11, 20, 18, 22, 21, 15, 14, 23 ], "area": 2090373.049078, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 11, "strid": "74c4bd46-e2f9-4469-85bc-effbf85e28db", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 1275.321, 1384.733, 1062.8090000000002, 54.52800000000002 ], "priority": 10, "parents": [ 10 ], "children": [], "area": 1765979.074293, "iscrowd": 0, "segmentation": [], "text": "Aging ASM Cells Showed Reduced Cell Viability" }, { "id": 12, "strid": "4da3fbf3-a8c7-4881-b17c-8989113513e7", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1311.368, 1516.438, 958.5619999999999, 605.2309999999998 ], "priority": 11, "parents": [ 10 ], "children": [ 13 ], "area": 1988608.267184, "iscrowd": 0, "segmentation": [] }, { "id": 13, "strid": "ae86d187-55a2-49d7-9f2e-46085d4e81fd", "image_id": 1, "image_name": "10109.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1285.796, 2166.688, 1067.9169999999997, 203.98399999999992 ], "priority": 12, "parents": [ 12 ], "children": [], "area": 2785918.763648, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Young and aged rat ASM cells were subjected to serum deprivation from 24 h\nto 120 h and cell viability was measured using MTT assay. Relative cell viability (percent\nof control) was calculated using the equation: (mean OD of treated cells/mean OD of control\ncells) X 100. Primary airway smooth muscle cell cultures from 3-4 young and aged rats were\ncompared to each other at given time points. One Way ANOVA with multiple comparison\ntest (Bonferroni) was used, *p<0.05; **p<0.01." }, { "id": 14, "strid": "11d341a7-d2f4-42c0-b524-7322820668ab", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 1357.777, 2419.443, 897.2049999999999, 57.58699999999999 ], "priority": 13, "parents": [ 10 ], "children": [], "area": 3285064.058211, "iscrowd": 0, "segmentation": [], "text": "Increased ER Stress Markers With Aging" }, { "id": 15, "strid": "edcd42bc-a31d-4bf3-b8eb-99e74d0b9614", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1337.558, 2513.958, 968.848, 371.17300000000023 ], "priority": 14, "parents": [ 10 ], "children": [ 16 ], "area": 3362564.634564, "iscrowd": 0, "segmentation": [] }, { "id": 16, "strid": "79681b1c-d58c-4448-bf5b-949274392fcd", "image_id": 1, "image_name": "10109.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1287.51, 2934.628, 1069.631, 270.8359999999998 ], "priority": 15, "parents": [ 15 ], "children": [], "area": 3778362.89628, "iscrowd": 0, "segmentation": [], "text": "Figure 2. Young and aged rat airway smooth muscle cells were used to measure ER\nstress markers and untranslated protein response (UPR). Young and aged rat ASM\ncells at sub-confluence were serum starved (F12 + 1% ITS) for 24, 48, 72, 96 and 120\nhours and protein lysates were obtained to perform western blotting for ER stress\nmarkers, IRE1q@ and BiP (GRP78). As shown in the figure (Top) there was a time-\ndependent increase in ER stress markers with aging. Data shown above are\nrepresentative of 3-4 different animals. Expression of GAPDH was used as loading\ncontrol (bottom image)." }, { "id": 17, "strid": "a5600e8a-2e3a-4d6f-a4ac-b1e272e166e5", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 2528.671, 566.353, 2039.4290000000005, 48.813999999999965 ], "priority": 16, "parents": [ 10 ], "children": [], "area": 1432120.4068629998, "iscrowd": 0, "segmentation": [], "text": "Aging Increases Reactive Oxygen Species and Decreases Mitochondrial Membrane Potential" }, { "id": 18, "strid": "acd37db7-9ee3-4044-83d2-4a41261c5ae4", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2418.688, 634.982, 2218.9709999999995, 683.8209999999999 ], "priority": 17, "parents": [ 10 ], "children": [ 19 ], "area": 1535823.343616, "iscrowd": 0, "segmentation": [] }, { "id": 19, "strid": "d2391750-c3d2-439e-b74c-38edcdc55194", "image_id": 1, "image_name": "10109.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2486.096, 1331.982, 2207.0130000000004, 228.21000000000004 ], "priority": 18, "parents": [ 18 ], "children": [], "area": 3311435.1222719997, "iscrowd": 0, "segmentation": [], "text": "Figure 3. A). Effect of aging on mitochondrial reactive oxygen species (ROS) generation and mitochondrial functions in rat ASM cells. ROS was measured by confocal microscopy in\nyoung and aged cells at baseline and 48 hours after serum deprivation stained with Mitosox Red. Average cellular ROS levels were determined from 45-50 cells in triplicate dishes\nprepared from three different rat cell cultures. Histogram (Y-axis) shows normalized mitoSox fluroscenece intensity elevation in cellular ROS compared to time-matched, young rat\nASM cells. B). Effect of aging on mitochondrial trans-membrane potential (A,,). Young and aged rat ASM cells were loaded with JC-10 dye and the potential-dependent accumulation\nin the mitochondria (reduced AW,, indicated by a decrease in Red:Green fluorescence) measured directly using a plate reader. C). Oxygen consumption rate (OCR, an indicator of\nmitochondrial respiration) was measured at basal condition using Seahorse XF analyzer in young and aged ASM cells. Data represent the average values from triplicates of three\nindependent primary young and aged rat ASM cells. t-test, “p<0.05; **p<0.01." }, { "id": 20, "strid": "6418ac3a-31fa-4588-a617-c4f57ab5c041", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 2550.804, 1588.133, 888.1869999999999, 105.47199999999998 ], "priority": 19, "parents": [ 10 ], "children": [], "area": 4051016.008932, "iscrowd": 0, "segmentation": [], "text": "Altered Mitochondrial Dynamics in Aged\nAirway Smooth Muscle" }, { "id": 21, "strid": "cab956a3-e0e7-4393-8402-c4210e903525", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2444.22, 1682.315, 1068.2350000000001, 1531.851 ], "priority": 20, "parents": [ 10 ], "children": [], "area": 4111947.9693, "iscrowd": 0, "segmentation": [] }, { "id": 22, "strid": "870965c3-0aac-4513-843b-265d61c40e22", "image_id": 1, "image_name": "10109.png", "category_id": 3, "category_name": "Text", "bbox": [ 3615.911, 1589.493, 1027.1549999999997, 106.68100000000004 ], "priority": 21, "parents": [ 10 ], "children": [], "area": 5747465.223123, "iscrowd": 0, "segmentation": [], "text": "Role of Superoxide in Functional Properties of\nAirway Smooth Muscle" }, { "id": 23, "strid": "69557e1a-e3b4-4503-8093-cc66187e6a92", "image_id": 1, "image_name": "10109.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3571.42, 1673.521, 1073.228, 692.2140000000002 ], "priority": 22, "parents": [ 10 ], "children": [ 24 ], "area": 5976846.36982, "iscrowd": 0, "segmentation": [] }, { "id": 24, "strid": "f7cffab7-ee02-4aa5-9a36-5b2e608919be", "image_id": 1, "image_name": "10109.png", "category_id": 6, "category_name": "Caption", "bbox": [ 3523.017, 2378.566, 1173.6779999999999, 327.6970000000001 ], "priority": 23, "parents": [ 23 ], "children": [], "area": 8379728.453621998, "iscrowd": 0, "segmentation": [], "text": "Figure 4. A). Young and aged rat ASM cells were labeled with mitotracker green, live cell\nimaging was performed using confocal microscopy. B). To further investigate the ultrastructural\ndetails, transmission electron microscopy was performed in ASM cells from young and aged rats\n(aged rats demonstrated increased swelling of mitochondria). C). Mitochondrial dynamics\nproteins Drp1 and Opa1 were measured using at basal and 24 h in young and aged rat ASM\ncells. D). To determine the role of ROS in determining ASM function, mouse tracheal rings were\nused with +Xanthine/Xanthine Oxidase (X/XO) at 30 min, 4 h, 24 h and isometric force to\nmethacholine (MCh) was measured using myograph. In a select set of experiments, airways\nwere treated with X/XO for 4 h, allowed to recover in fresh buffer for 30 min, and contractile\nresponses to MCh were measured." }, { "id": 25, "strid": "b95456e5-f5ba-4b4e-bca5-f089a7576464", "image_id": 1, "image_name": "10109.png", "category_id": 5, "category_name": "Section", "bbox": [ 3546.905, 2732.59, 780.9580000000001, 69.65200000000004 ], "priority": 24, "parents": [ 1 ], "children": [ 26 ], "area": 9692237.13395, "iscrowd": 0, "segmentation": [], "text": "Summary & Conclusions" }, { "id": 26, "strid": "f9ac0b08-c523-40ec-b36a-508b924d3f70", "image_id": 1, "image_name": "10109.png", "category_id": 4, "category_name": "List", "bbox": [ 3529.872, 2820.066, 1170.935, 392.1399999999999 ], "priority": 25, "parents": [ 25 ], "children": [], "area": 9954472.011551999, "iscrowd": 0, "segmentation": [] }, { "id": 27, "strid": "fe61a33a-90e5-4b8a-8da1-23682442966c", "image_id": 2, "image_name": "10295.png", "category_id": 9, "category_name": "Root", "bbox": [ 11.71, 11.01, 63.6, 65.14999999999999 ], "priority": -1, "parents": [], "children": [ 28, 30, 36, 40, 44, 29, 42 ], "area": 128.9271, "iscrowd": 0, "segmentation": [] }, { "id": 28, "strid": "a7e3ae8c-dc5e-496f-b3ab-bb69cc137131", "image_id": 2, "image_name": "10295.png", "category_id": 1, "category_name": "Title", "bbox": [ 148.061, 48.619, 527.578, 100.701 ], "priority": 1, "parents": [ 27 ], "children": [], "area": 7198.577759000001, "iscrowd": 0, "segmentation": [], "text": "The AnaConDa® and Sevoflurane\nin the ICU\n\ndata on ambient pollution and staff exposure" }, { "id": 29, "strid": "10a61b68-af78-4150-ae96-621ae2913b6f", "image_id": 2, "image_name": "10295.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 126.964, 188.335, 417.35499999999996, 51.16499999999999 ], "priority": 2, "parents": [ 27 ], "children": [], "area": 23911.76494, "iscrowd": 0, "segmentation": [], "text": "tallied Re ela eh ald dad\nO. Thomas MD, Anesthesiologist-Intensivist\nDept. of Intensive Care, VieCuri Medical Center Venlo, the Netherlands" }, { "id": 30, "strid": "91de2b22-71e2-4dd5-924e-7d736ed7aa69", "image_id": 2, "image_name": "10295.png", "category_id": 5, "category_name": "Section", "bbox": [ 128.036, 280.077, 85.42700000000002, 12.468999999999994 ], "priority": 3, "parents": [ 27 ], "children": [ 31, 32, 34 ], "area": 35859.938772, "iscrowd": 0, "segmentation": [], "text": "introduction" }, { "id": 31, "strid": "91a1f7b0-2cfd-4d94-abc5-c1a50962bd2e", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 127.007, 296.694, 336.252, 204.47200000000004 ], "priority": 4, "parents": [ 30 ], "children": [], "area": 37682.21485800001, "iscrowd": 0, "segmentation": [], "text": "The AneConDe® {Sedana. Medical, Uppesia, Hwaden) ie a\nreflection filer that can be used to administer volatile\nanesthetics to intubated patients on a conventional ventilator\noutside the OR. We have recently implemented sevoflurane\nas a sedative in our ICU and found that litle data are\navailable on staff exposure and ambient pollution when using\nthe AnaConDa® (Fig. 1). A risk analyses was performed, as\nrequested by our occupational health service. We have\nmeasured ambient pollution, staff exposure and peak values\nof sevoflurane on all connection points of the AnaConDa®\nsystem and FlurAbsorb scavenger in a Critical Care setting\n(Fig. 2). Aim of this study was to quantity ambient pollution\nand statf exposure to sevoflurane while using the AnaConDa®\nea rete Le ecureERety ohcende:" }, { "id": 32, "strid": "2ac77e5f-219b-4a3e-a222-813b76f1ce5f", "image_id": 2, "image_name": "10295.png", "category_id": 2, "category_name": "Figure", "bbox": [ 133.919, 522.949, 123.85999999999999, 149.57100000000003 ], "priority": 5, "parents": [ 30 ], "children": [ 33 ], "area": 70032.807131, "iscrowd": 0, "segmentation": [] }, { "id": 33, "strid": "46c55203-5f0b-4d6c-83fc-52572f7595c6", "image_id": 2, "image_name": "10295.png", "category_id": 6, "category_name": "Caption", "bbox": [ 134.67, 673.389, 115.846, 8.955000000000041 ], "priority": 6, "parents": [ 32 ], "children": [], "area": 90685.29663, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 34, "strid": "06ea2595-7d79-4e93-8851-27f2bde80dfa", "image_id": 2, "image_name": "10295.png", "category_id": 2, "category_name": "Figure", "bbox": [ 263.488, 523.635, 188.606, 144.97800000000007 ], "priority": 7, "parents": [ 30 ], "children": [ 35 ], "area": 137971.53888, "iscrowd": 0, "segmentation": [] }, { "id": 35, "strid": "657abba3-8833-4933-83d1-da15acb5e888", "image_id": 2, "image_name": "10295.png", "category_id": 6, "category_name": "Caption", "bbox": [ 265.416, 673.094, 71.96499999999997, 9.172000000000025 ], "priority": 8, "parents": [ 34 ], "children": [], "area": 178649.91710400002, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 36, "strid": "bdc4b2b7-b7b1-4fe7-9d61-35d1f9e18df2", "image_id": 2, "image_name": "10295.png", "category_id": 5, "category_name": "Section", "bbox": [ 130.728, 705.647, 60.521000000000015, 13.211000000000013 ], "priority": 9, "parents": [ 27 ], "children": [ 39, 38, 37 ], "area": 92247.82101600002, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 37, "strid": "54863d16-3a54-4354-944b-69a55378f70c", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 128.499, 722.873, 327.6039999999999, 189.40200000000004 ], "priority": 10, "parents": [ 36 ], "children": [], "area": 92888.457627, "iscrowd": 0, "segmentation": [], "text": "Since pollution data are patient independent and relate to\nthe integrity of the breathing circuit, only one intubated\nsubject was used to perform sampling. Air sampling was\nperformed by an independent institute (RPS). A Miran\nSapphiRe portal ambient analyzer was used for realtime\nmeasurements on eight different connecting points of the\nbreathing circuit and AnaConDa\" system, including the\nFlurAbsorb scavenger. Charcoal sorbent tubes (SKC226-\n01) were used for stationary and personal measurements\nand were analyzed in a laboratory (OSHA 103 method),\nStationary 8 hour measurements were performed on two\ndifferent locations in an ICU room (fig 2). These\nmeasurements were repeated with new sampling tubes." }, { "id": 38, "strid": "4aa2eb02-4e71-4e57-97bf-30087fb5427a", "image_id": 2, "image_name": "10295.png", "category_id": 7, "category_name": "Table", "bbox": [ 131.593, 922.866, 323.937, 206.53600000000006 ], "priority": 11, "parents": [ 36 ], "children": [], "area": 121442.705538, "iscrowd": 0, "segmentation": [] }, { "id": 39, "strid": "7374a37a-f025-4d70-af3b-d555e4593867", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 481.67, 279.928, 217.83300000000003, 248.04200000000003 ], "priority": 12, "parents": [ 36 ], "children": [], "area": 134832.91976, "iscrowd": 0, "segmentation": [], "text": "ee een ne ee\nmeasure direct exposure during an 8-hour\nshift. This was repeated by a second nurse\non @ consecutive &-hour shift with a new\nsampling tube. In this way, a total of four\nstationary, two personal and eight real time\nmeasurements were performed.\nAnalyzers were calibrated before and after\nLaboratory analyses were\naccording to ISOINEN standards. The\nSwedish occupational exposure guidelines\nwere used as a reference, since no national\nguidelines are avaliable. The exposure limit\nis Spm (ime weighted average (TWA)\n42mglm’ over an Shour period), North\nAmerican quidelines are more strict, with a\nmaximum of 2pm, while in the United\nKingdom it is more. liberal, allowing\naane ements eet" }, { "id": 40, "strid": "afbe4b4e-2471-4971-b16e-3eae228b7a5f", "image_id": 2, "image_name": "10295.png", "category_id": 5, "category_name": "Section", "bbox": [ 482.97, 556.147, 44.90700000000004, 10.706999999999994 ], "priority": 13, "parents": [ 27 ], "children": [ 41 ], "area": 268602.31659000006, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 41, "strid": "4c158bfa-c380-4a7d-9946-644882ec73bb", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 482.692, 569.696, 217.67499999999995, 104.73699999999997 ], "priority": 14, "parents": [ 40 ], "children": [], "area": 274987.70163200004, "iscrowd": 0, "segmentation": [], "text": "Our results are summarized in table 1. Time\nweighted measurements are expressed as\na percentage of exposure limits (NEN 689\nmodel). An exceeding can be ruled out i\nconcentrations are <10% of exposure limits,\nWe clearly show that peak concentrations\nand TWA are far below the allowed\nneninalionel eemane irais," }, { "id": 42, "strid": "b6ebf97b-9456-4ded-85f8-c0e44c6e455d", "image_id": 2, "image_name": "10295.png", "category_id": 5, "category_name": "Section", "bbox": [ 482.68, 701.935, 65.75600000000003, 11.644000000000005 ], "priority": 15, "parents": [ 27 ], "children": [ 43 ], "area": 338809.98579999997, "iscrowd": 0, "segmentation": [], "text": "Discussion" }, { "id": 43, "strid": "d79438bd-b211-4ff6-bc9b-dc75228cd5b8", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 481.646, 716.916, 217.89799999999997, 115.88400000000001 ], "priority": 16, "parents": [ 42 ], "children": [], "area": 345299.723736, "iscrowd": 0, "segmentation": [], "text": "TNS GApORES 15 VOR S enesieics Shout\nbe reduced to a level as low as reasonably\nachievable’ (ALARA). Local differences in\nICU's necessitate quantification of exposure\nprior to routine use, in order to guarantee a\nsafe work environment. Furthermore,\nprotocols should be used to ensure a\nstandard way of care when using volatile\nanesthetics." }, { "id": 44, "strid": "816119af-4305-445f-a4b3-d5f7a46ff284", "image_id": 2, "image_name": "10295.png", "category_id": 5, "category_name": "Section", "bbox": [ 482.927, 861.613, 66.66600000000005, 11.057000000000016 ], "priority": 17, "parents": [ 27 ], "children": [ 45 ], "area": 416096.18125100003, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 45, "strid": "f7453ae3-e2d4-49d4-8637-c28ccbcea9e5", "image_id": 2, "image_name": "10295.png", "category_id": 3, "category_name": "Text", "bbox": [ 482.14, 875.891, 218.09699999999998, 119.21100000000001 ], "priority": 18, "parents": [ 44 ], "children": [], "area": 422302.08674, "iscrowd": 0, "segmentation": [], "text": "We concluded that sedation with\nsevoflurane and the AnaConDa® system\nwith the FlurAbsorb scavenger is safe in an\nICU setting. Occupational exposure is\nnegligible and meets _infornational\nstandards. These data highly contributed to\nstaff safely perception and awareness. Our\ndata may be helpful to those who want to\nfirgleanient-volallle srieethedion In ther GUL" }, { "id": 46, "strid": "53ca0a21-5b92-422e-8049-c7a337333a97", "image_id": 3, "image_name": "10301.png", "category_id": 9, "category_name": "Root", "bbox": [ 30.82, 18.49, 157.6, 115.58 ], "priority": -1, "parents": [], "children": [ 48, 49, 61, 59, 50, 52, 55, 47 ], "area": 569.8617999999999, "iscrowd": 0, "segmentation": [] }, { "id": 47, "strid": "7b47168e-a652-4662-9251-482d6755df66", "image_id": 3, "image_name": "10301.png", "category_id": 1, "category_name": "Title", "bbox": [ 89.379, 149.978, 1719.731, 269.406 ], "priority": 1, "parents": [ 46 ], "children": [], "area": 13404.883662000002, "iscrowd": 0, "segmentation": [], "text": "Genome Sequence Archive\n\na data repository for archiving sequence reads" }, { "id": 48, "strid": "35633ce6-1a03-4af7-a85e-cf1b133e32d4", "image_id": 3, "image_name": "10301.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 82.332, 474.055, 2188.437, 141.43599999999998 ], "priority": 2, "parents": [ 46 ], "children": [], "area": 39029.896259999994, "iscrowd": 0, "segmentation": [], "text": "Yanqing Wang, Junwei Zhu, Tingting Chen, Sisi Zhang, Wenming Zhao”\nBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, P.R. China" }, { "id": 49, "strid": "31790e7a-7b32-4218-a66d-c399ac50d7e2", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 89.768, 331.462, 1548.757, 87.20499999999998 ], "priority": 3, "parents": [ 46 ], "children": [], "area": 29754.680816, "iscrowd": 0, "segmentation": [], "text": "a data repository for archiving sequence reads" }, { "id": 50, "strid": "991a74fa-82d2-4c5a-b08d-2968b9ae6f42", "image_id": 3, "image_name": "10301.png", "category_id": 5, "category_name": "Section", "bbox": [ 581.338, 708.678, 344.544, 65.54700000000003 ], "priority": 4, "parents": [ 46 ], "children": [ 51 ], "area": 411981.45116399997, "iscrowd": 0, "segmentation": [], "text": "Instruction" }, { "id": 51, "strid": "98147df4-d077-4aa9-a6e1-7918a42163e1", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 68.311, 810.062, 1403.434, 667.2319999999999 ], "priority": 5, "parents": [ 50 ], "children": [], "area": 55336.145282000005, "iscrowd": 0, "segmentation": [], "text": "Genome Sequence Archive (GSA; http://bigd.big.ac.cn/gsa\nor http://gsa.big.ac.cn) is a data repository for archiving raw\nsequence data. As a core database resource of BIG Data\nCenter (http://bigd.big.ac.cn), GSA is built based on INSDC\ndata standards and structures and provides data archival\nservices for scientific communities not only in China but also\nthroughout the world. GSA accepts raw sequence reads\nproduced by a variety of sequencing platforms, stores both\nsequence reads and metadata, and provides free and\nunrestricted access to all publicly available data for worldwide\nscientific communities." }, { "id": 52, "strid": "78f300e5-ef8d-4e96-af84-ae7639b89a2d", "image_id": 3, "image_name": "10301.png", "category_id": 5, "category_name": "Section", "bbox": [ 250.365, 1528.174, 988.903, 78.13499999999999 ], "priority": 6, "parents": [ 46 ], "children": [ 53, 54 ], "area": 382601.28351000004, "iscrowd": 0, "segmentation": [], "text": "Data submission and retrieval" }, { "id": 53, "strid": "fc0b76c0-f1dc-49b3-a3dc-7f7afebd079b", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 66.534, 1648.366, 1398.228, 358.93499999999995 ], "priority": 7, "parents": [ 52 ], "children": [], "area": 109672.383444, "iscrowd": 0, "segmentation": [], "text": "Designed for compatibility, GSA follows INSDC data\nstandards and structures. All data are organized into four\nobjects, i.e., BioProject, BioSample, Experiment, and Run.\nBased on these standardized data objects, GSA not only\nfacilitates data submission and deposition, but also enables\ndata sharing and exchange." }, { "id": 54, "strid": "57676155-5fb6-47ff-b57f-09a22dc1688b", "image_id": 3, "image_name": "10301.png", "category_id": 2, "category_name": "Figure", "bbox": [ 88.107, 2031.719, 1338.071, 1137.848 ], "priority": 8, "parents": [ 52 ], "children": [], "area": 179008.665933, "iscrowd": 0, "segmentation": [] }, { "id": 55, "strid": "e0482828-6b62-48b0-adb0-51253ab919d1", "image_id": 3, "image_name": "10301.png", "category_id": 5, "category_name": "Section", "bbox": [ 249.262, 3223.285, 1031.996, 71.81700000000001 ], "priority": 9, "parents": [ 46 ], "children": [ 56, 57, 58 ], "area": 803442.46567, "iscrowd": 0, "segmentation": [], "text": "Data structure and organization" }, { "id": 56, "strid": "80265e93-711e-4277-9064-08e2d406e8df", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 71.192, 3327.148, 1397.454, 251.14800000000014 ], "priority": 10, "parents": [ 55 ], "children": [], "area": 236866.32041599997, "iscrowd": 0, "segmentation": [], "text": "GSA accepts data submissions from all over the world,\ncovers the spectrum of sequence reads generated by a\nvariety of sequencing platforms, and accommodates several\ncommonly used file formats, like FASTQ, BAM, and VCF." }, { "id": 57, "strid": "a9d962bc-d72a-4580-ba6b-5b706c9cde01", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 1521.005, 741.389, 1397.0730000000003, 477.2320000000001 ], "priority": 11, "parents": [ 55 ], "children": [], "area": 1127656.3759450002, "iscrowd": 0, "segmentation": [], "text": "Since its inception in August 2015, GSA presents a dramatic\nincrease on data submissions in terms of the numbers of\nBioProjects and BioSamples, Experiments, and Runs, as well\nas file size. As of December 2016, GSA houses a total of 198\nBioProjects, 8674 BioSamples, 9263 Experiments and 10,745\nRuns for more than 80 species, submitted by more than 160\ndata providers from a total of 39 institutions, and archives\nmore than 200 TBs of sequence data." }, { "id": 58, "strid": "d9240aeb-3c1d-404a-b803-167ac1829b58", "image_id": 3, "image_name": "10301.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1653.259, 1277.223, 1110.989, 1399.114 ], "priority": 12, "parents": [ 55 ], "children": [], "area": 2111580.419757, "iscrowd": 0, "segmentation": [] }, { "id": 59, "strid": "ed559d9d-011b-4de2-bd63-bfa5ea9b1eaa", "image_id": 3, "image_name": "10301.png", "category_id": 5, "category_name": "Section", "bbox": [ 2046.379, 2732.497, 335.83600000000024, 76.11599999999999 ], "priority": 13, "parents": [ 46 ], "children": [ 60 ], "area": 5591724.478363, "iscrowd": 0, "segmentation": [], "text": "Reference" }, { "id": 60, "strid": "5c204b28-51d3-4cba-8fba-825ad37da3f2", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 1519.139, 2836.882, 1401.381, 335.12699999999995 ], "priority": 14, "parents": [ 59 ], "children": [], "area": 4309618.084598, "iscrowd": 0, "segmentation": [], "text": "Yanqing Wang et al. GSA: Genome Sequence Archive.\nGenomics Proteomics Bioinformatics 2017, 15(1):14-18.\n\nBIG Data Center Members. The BIG Data Center: from\ndeposition to integration to translation. Nucleic Acids Res\n2017, 45(D1):D18-D24." }, { "id": 61, "strid": "a6d042bf-e1f2-4608-aace-0272c9de8670", "image_id": 3, "image_name": "10301.png", "category_id": 5, "category_name": "Section", "bbox": [ 1938.942, 3215.96, 549.3899999999999, 75.69399999999996 ], "priority": 15, "parents": [ 46 ], "children": [ 62 ], "area": 6235559.91432, "iscrowd": 0, "segmentation": [], "text": "Correspondence" }, { "id": 62, "strid": "4db2ad91-a408-479f-bb1b-48ef352fa046", "image_id": 3, "image_name": "10301.png", "category_id": 3, "category_name": "Text", "bbox": [ 1518.964, 3323.222, 1406.4390000000003, 246.78999999999996 ], "priority": 16, "parents": [ 61 ], "children": [], "area": 5047854.582008, "iscrowd": 0, "segmentation": [], "text": "We sincerely thank Prof. Jingchu Luo and Prof. Weimin Zhu\nfor their valuable suggestions and constructive discussions on\nthis work.\n\nIf have any question, please contact Yanqing Wang." }, { "id": 63, "strid": "82ea0859-4e0d-49db-806c-5724c03fed4b", "image_id": 4, "image_name": "10329.png", "category_id": 9, "category_name": "Root", "bbox": [ 13.17, 22.55, 63.36, 63.35000000000001 ], "priority": -1, "parents": [], "children": [ 65, 66, 72, 70, 76, 74, 64, 68, 79 ], "area": 296.9835, "iscrowd": 0, "segmentation": [] }, { "id": 64, "strid": "3dfdd099-c42b-41ba-992f-f1bc9c00280c", "image_id": 4, "image_name": "10329.png", "category_id": 1, "category_name": "Title", "bbox": [ 93.114, 44.982, 651.184, 35.623999999999995 ], "priority": 1, "parents": [ 63 ], "children": [], "area": 4188.453948, "iscrowd": 0, "segmentation": [], "text": "Update Notifications for Biological Databases" }, { "id": 65, "strid": "18d9bc86-be57-4391-b169-015a96c9616d", "image_id": 4, "image_name": "10329.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 282.409, 93.771, 297.26, 74.57000000000001 ], "priority": 2, "parents": [ 63 ], "children": [], "area": 26481.774339, "iscrowd": 0, "segmentation": [], "text": "Suzanne Paley and Peter D Karp\n‘SRI International, Menlo Park CA.\nBioCyc.org, EcoCyc.org, MetaCyc.org" }, { "id": 66, "strid": "00ccf8a2-2c0b-448b-8fd8-2d19472027e5", "image_id": 4, "image_name": "10329.png", "category_id": 5, "category_name": "Section", "bbox": [ 92.069, 195.546, 43.56699999999999, 23.35499999999999 ], "priority": 3, "parents": [ 63 ], "children": [ 67 ], "area": 18003.724674, "iscrowd": 0, "segmentation": [], "text": "Goal" }, { "id": 67, "strid": "65bb88b2-68d4-42c1-beba-0a553793fb39", "image_id": 4, "image_name": "10329.png", "category_id": 3, "category_name": "Text", "bbox": [ 193.567, 192.048, 555.334, 30.12100000000001 ], "priority": 4, "parents": [ 66 ], "children": [], "area": 37174.155216, "iscrowd": 0, "segmentation": [], "text": "To ensure that biologists get the greatest value from curated data collections by making them\naware of new information of particular interest to them as soon as it becomes available." }, { "id": 68, "strid": "45772309-cc01-4230-a5ba-440971cb8891", 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}, { "id": 80, "strid": "c5c1a5bf-5d02-4129-8ecd-fe3c1e22cfb7", "image_id": 4, "image_name": "10329.png", "category_id": 4, "category_name": "List", "bbox": [ 441.671, 900.672, 329.88899999999995, 155.35500000000002 ], "priority": 17, "parents": [ 79 ], "children": [], "area": 397800.702912, "iscrowd": 0, "segmentation": [] }, { "id": 81, "strid": "565ed524-9dc0-404c-bef8-11ec9e93fd17", "image_id": 5, "image_name": "10334.png", "category_id": 9, "category_name": "Root", "bbox": [ 2998.26, 92.35, 179.95999999999958, 125.47 ], "priority": -1, "parents": [], "children": [ 83, 88, 84, 82, 92 ], "area": 276889.311, "iscrowd": 0, "segmentation": [] }, { "id": 82, "strid": "7d3e9edf-def2-4d99-b47b-518b563dc8a3", "image_id": 5, "image_name": "10334.png", "category_id": 1, "category_name": "Title", "bbox": [ 50.236, 67.957, 2823.8, 171.981 ], "priority": 1, "parents": [ 81 ], "children": [], "area": 3413.8878519999994, "iscrowd": 0, "segmentation": [], "text": "Residue data and intrinsic disorder: extending InterPro functionality to improve\nprotein sequence annotation" }, { "id": 83, "strid": "3211b633-3665-4337-8425-16ee01797885", "image_id": 5, "image_name": "10334.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 47.832, 293.289, 1896.235, 155.625 ], "priority": 2, "parents": [ 81 ], "children": [], "area": 14028.599447999999, "iscrowd": 0, "segmentation": [], "text": "Alex Mitchell, Hsin-Yu Chang, Neil Rawlings, Lorna Richardson,\nAmaia Sangrador-Vegas & Robert D. Finn" }, { "id": 84, "strid": "9c4b03fb-a06f-47c8-b675-e884fa85858d", "image_id": 5, "image_name": "10334.png", "category_id": 5, "category_name": "Section", "bbox": [ 148.802, 745.27, 330.27, 53.932000000000016 ], "priority": 3, "parents": [ 81 ], "children": [ 86, 85 ], "area": 110897.66653999999, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 85, "strid": "4ece69ca-049d-4fad-980e-18245c108d0d", "image_id": 5, "image_name": "10334.png", "category_id": 3, "category_name": "Text", "bbox": [ 147.595, 814.604, 1463.148, 462.501 ], "priority": 4, "parents": [ 84 ], "children": [], "area": 120231.47738000001, "iscrowd": 0, "segmentation": [], "text": "InterPro = (http://www.ebi.ac.uk/interpro/) is a_ freely\navailable database used to classify protein sequences into\nfamilies and to predict the presence of important domains\nand sites. The resource is based around diagnostic\nsignatures, provided by different member databases,\nagainst which protein sequences are searched to\ndetermine their potential functions." }, { "id": 86, "strid": "acb13e50-88e1-4930-9946-0f12e5ea21b9", "image_id": 5, "image_name": "10334.png", "category_id": 2, "category_name": "Figure", "bbox": [ 121.172, 1333.171, 1486.903, 941.3440000000003 ], "priority": 5, "parents": [ 84 ], "children": [ 87 ], "area": 161542.996412, "iscrowd": 0, "segmentation": [] }, { "id": 87, "strid": "079f1257-0aed-4846-91bd-b67b2c2b0115", "image_id": 5, "image_name": "10334.png", "category_id": 6, "category_name": "Caption", "bbox": [ 139.41, 2305.997, 1463.113, 203.32900000000018 ], "priority": 6, "parents": [ 86 ], "children": [], "area": 321479.04176999995, "iscrowd": 0, "segmentation": [], "text": "Figure 1: Fourteen different member databases with differing methods of\nsignature production and biological focuses make up the InterPro\nresource. Databases with a Y provide some form of residue-specific\nannotation." }, { "id": 88, "strid": "0b87e26c-9a95-4d2e-86e3-8aa013d40c20", "image_id": 5, "image_name": "10334.png", "category_id": 5, "category_name": "Section", "bbox": [ 133.125, 2590.304, 835.554, 53.82499999999982 ], "priority": 7, "parents": [ 81 ], "children": [ 90, 89 ], "area": 344834.22000000003, "iscrowd": 0, "segmentation": [], "text": "Annotation of intrinsic disorder" }, { "id": 89, "strid": "25e4325d-e839-49a4-849a-c42dfe6c6926", "image_id": 5, "image_name": "10334.png", "category_id": 3, "category_name": "Text", "bbox": [ 135.072, 2654.598, 1467.109, 397.53899999999976 ], "priority": 8, "parents": [ 88 ], "children": [], "area": 358561.861056, "iscrowd": 0, "segmentation": [], "text": "InterPro has recently added prediction of intrinsically\ndisordered regions (IDRs) -— polypeptide segments that\nhave little or no three-dimensional structure - through\nintegration of MobiDB Lite. This tool combines eight\ndifferent prediction methods to generate consensus IDR\nannotations, focusing on long disordered regions." }, { "id": 90, "strid": "371b7111-2c9a-4f24-9ba5-71c6d75906ca", "image_id": 5, "image_name": "10334.png", "category_id": 2, "category_name": "Figure", "bbox": [ 133.738, 3108.269, 1488.583, 991.3610000000003 ], "priority": 9, "parents": [ 88 ], "children": [ 91 ], "area": 415693.67952199996, "iscrowd": 0, "segmentation": [] }, { "id": 91, "strid": "092fa1ef-0fd3-4e79-a468-ae356e82976a", "image_id": 5, "image_name": "10334.png", "category_id": 6, "category_name": "Caption", "bbox": [ 148.387, 4143.611, 1463.432, 158.53099999999995 ], "priority": 10, "parents": [ 90 ], "children": [], "area": 614858.005457, "iscrowd": 0, "segmentation": [], "text": "Figure 2: MobiDB Lite IDR annotations in InterPro. IDRs have a wide\nrange of potential functions, from acting as flexible linkers between\ndomains, to interacting with other proteins and modifying their activity." }, { "id": 92, "strid": "cb83ccc2-c172-42dd-ae01-01d6a2570291", "image_id": 5, "image_name": "10334.png", "category_id": 5, "category_name": "Section", "bbox": [ 1703.683, 747.528, 664.654, 52.797000000000025 ], "priority": 11, "parents": [ 81 ], "children": [ 99, 94, 96, 98, 93 ], "area": 1273550.745624, "iscrowd": 0, "segmentation": [], "text": "Residue-level annotation" }, { "id": 93, "strid": "759d5d59-3335-49dd-a9b1-a1438ae6cf2d", "image_id": 5, "image_name": "10334.png", "category_id": 3, "category_name": "Text", "bbox": [ 1702.457, 814.468, 1465.9929999999997, 328.783 ], "priority": 12, "parents": [ 92 ], "children": [], "area": 1386596.7478760001, "iscrowd": 0, "segmentation": [], "text": "Two recently added member databases, CDD and SLFD,\nprovide specific residue-level annotation, enabling\nidentification of important amino acids, such as those\ncomprising ligand-binding or active sites. These provide\nan additional tier to the annotations provided by InterPro." }, { "id": 94, "strid": "7a47d12e-fc2e-4c3e-bc00-e71000819d3d", "image_id": 5, "image_name": "10334.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1773.154, 1202.854, 1299.8340000000003, 740.5829999999999 ], "priority": 13, "parents": [ 92 ], "children": [ 95 ], "area": 2132845.3815160003, "iscrowd": 0, "segmentation": [] }, { "id": 95, "strid": "509a23b4-6759-4024-a784-c65e26dceaf6", "image_id": 5, "image_name": "10334.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1689.095, 1964.874, 1462.1700000000003, 103.33499999999981 ], "priority": 14, "parents": [ 94 ], "children": [], "area": 3318858.84903, "iscrowd": 0, "segmentation": [], "text": "Figure 3: CDD and SLFD profiles are annotated with residue information\nfor specific amino acids important for function, binding, etc." }, { "id": 96, "strid": "d2c2b60c-d945-4a20-a46f-cc2855af6bf6", "image_id": 5, "image_name": "10334.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1740.949, 2138.221, 1376.7850000000003, 637.3939999999998 ], "priority": 15, "parents": [ 92 ], "children": [ 97 ], "area": 3722533.7117290003, "iscrowd": 0, "segmentation": [] }, { "id": 97, "strid": "b23a0dc6-e5bb-41cc-af8c-471aaeb59f9a", "image_id": 5, "image_name": "10334.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1689.578, 2823.365, 1459.5390000000002, 105.09000000000015 ], "priority": 16, "parents": [ 96 ], "children": [], "area": 4770295.38997, "iscrowd": 0, "segmentation": [], "text": "Figure 4: When a sequence matches a relevant profile in InterProScan,\nthe appropriate matching amino acids are highlighted in the output." }, { "id": 98, "strid": "154a69c3-24cc-418b-adb7-817adac43be7", "image_id": 5, "image_name": "10334.png", "category_id": 3, "category_name": "Text", "bbox": [ 1702.709, 3002.663, 1465.8299999999997, 526.9479999999999 ], "priority": 17, "parents": [ 92 ], "children": [], "area": 5112661.3140670005, "iscrowd": 0, "segmentation": [], "text": "More specific functional annotation & increased\ncoverage\n\nThe new per-residue and IDR developments in InterPro\nenable greater coverage of sequence and residue space &\nmore richly-detailed annotation of protein sequences.\nSuch annotations will increasingly become available from\nInterPro as the residue information provided by other\nmember databases is deployed." }, { "id": 99, "strid": "754c0bf8-7753-44b2-9f22-ec81043922e2", "image_id": 5, "image_name": "10334.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1686.304, 3577.829, 1490.7640000000001, 508.5749999999998 ], "priority": 18, "parents": [ 92 ], "children": [ 100 ], "area": 6033307.354016, "iscrowd": 0, "segmentation": [] }, { "id": 100, "strid": "1753cf77-4efa-4beb-b19c-45b43c0df021", "image_id": 5, "image_name": "10334.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1704.147, 4121.751, 1458.797, 156.64300000000003 ], "priority": 19, "parents": [ 99 ], "children": [], "area": 7024069.601397, "iscrowd": 0, "segmentation": [], "text": "Figure 5: Coverage of UniProtKB: (A) sequences with residue annotation\nvia SFLD/CDD; (B) sequences with predicted IDRs; & (C) proportion of all\nUniProtKB amino acid residues predicted to fall within IDRs." }, { "id": 101, "strid": "8487bd9f-22de-4101-ba61-e481ab31c3d6", "image_id": 6, "image_name": "10362.png", "category_id": 9, "category_name": "Root", "bbox": [ 115, 70.12, 353.64, 239.21999999999997 ], "priority": -1, "parents": [], "children": [ 104, 122, 110, 120, 118, 126, 103, 124, 102 ], "area": 8063.8, "iscrowd": 0, "segmentation": [] }, { "id": 102, "strid": "faddd0af-5170-4328-a1e3-42ffce0e401b", "image_id": 6, "image_name": "10362.png", "category_id": 1, "category_name": "Title", "bbox": [ 607.712, 43.017, 2434.512, 238.829 ], "priority": 1, "parents": [ 101 ], "children": [], "area": 26141.947104000003, "iscrowd": 0, "segmentation": [], "text": "Cardiovascular response and serum IL-6 level\nIn concentric and eccentric exercise" }, { "id": 103, "strid": "d59cc79e-9148-493d-bf92-aecd04d10ff8", "image_id": 6, "image_name": "10362.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 445.925, 361.455, 2706.726, 187.46800000000002 ], "priority": 2, "parents": [ 101 ], "children": [], "area": 161181.820875, "iscrowd": 0, "segmentation": [], "text": "Mayank Agarwal’, Prof. Shraddha Singh’, Prof. Sunita Tiwari’, Dr. Jagdish Narayan’, Dr. Shivani Pandey”\n‘Department of Physiology, Department of Biochemistry, King George’s Medical University, Lucknow" }, { "id": 104, "strid": "465049c8-4113-4c96-bd2e-151fbca85368", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 619.539, 631.253, 671.922, 85.46400000000006 ], "priority": 3, "parents": [ 101 ], "children": [ 108, 105, 106 ], "area": 391085.852367, "iscrowd": 0, "segmentation": [], "text": "INTRODUCTION" }, { "id": 105, "strid": "0b57376b-f258-4e7c-af7b-63369be39067", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 17.061, 754.367, 1854.133, 1237.801 ], "priority": 4, "parents": [ 104 ], "children": [], "area": 12870.255387, "iscrowd": 0, "segmentation": [], "text": "Cardiovascular disease (CVD) has been a leading cause of morbidity and\nmortality in India; since 1990, its prevalence has increased by 23%\".\n\nThe higher levels of muscular strength are associated with a significantly\nbetter cardio-metabolic risk factor profile. Hence resistance exercise (RE)\nare strongly recommended for implementation in primary and secondary\nCVD prevention programs. Dynamic RE comprises of concentric (muscle\nshortening contractions) and eccentric (muscle lengthening contractions)\nphase (Fig. 1).\n\nContraction of the skeletal muscles promotes synthesis and secretion of\ncytokines and peptides from myocytes commonly termed as ‘myokines’.\nElevated plasma concentrations of muscle-derived interleukin-6 (IL-6)\npromotes a wide range of benefits in vascular reactivity, lipid and glucose\nmetabolism and the suppression of pro-inflammatory cytokines which may\nreduce the incidence of cardiovascular disease® (Fig. 2).\n\nThe present study aims at determining the cardiovascular response\nand serum IL-6 level in concentric and eccentric exercise." }, { "id": 106, "strid": "a53dc8e9-5e26-4aa4-a3d7-6f79f14de287", "image_id": 6, "image_name": "10362.png", "category_id": 2, "category_name": "Figure", "bbox": [ 17.223, 2175.776, 666.518, 873.5830000000001 ], "priority": 5, "parents": [ 104 ], "children": [ 107 ], "area": 37473.390047999994, "iscrowd": 0, "segmentation": [] }, { "id": 107, "strid": "c07a50b6-f6f2-4696-bf0e-e2f4b0b11ab5", "image_id": 6, "image_name": "10362.png", "category_id": 6, "category_name": "Caption", "bbox": [ 41.781, 2021.408, 652.556, 143.84299999999985 ], "priority": 6, "parents": [ 106 ], "children": [], "area": 84456.44764799999, "iscrowd": 0, "segmentation": [], "text": "Figure 1: Types of dynamic\nmuscle contraction" }, { "id": 108, "strid": "cd64928e-0c46-49a4-85c9-e773e142fffd", "image_id": 6, "image_name": "10362.png", "category_id": 2, "category_name": "Figure", "bbox": [ 689.826, 2171.48, 1186.758, 878.8809999999999 ], "priority": 7, "parents": [ 104 ], "children": [ 109 ], "area": 1497943.3624800001, "iscrowd": 0, "segmentation": [] }, { "id": 109, "strid": "7f21ea51-f981-419f-85ce-9650783412cb", "image_id": 6, "image_name": "10362.png", "category_id": 6, "category_name": "Caption", "bbox": [ 831.163, 2024.916, 999.884, 143.84300000000007 ], "priority": 8, "parents": [ 108 ], "children": [], "area": 1683035.257308, "iscrowd": 0, "segmentation": [], "text": "Figure 2: Possible effects of IL-6 released\nfrom contracting the skeletal muscle" }, { "id": 110, "strid": "5e8141df-6a46-42de-abc3-57c45b28325f", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 2549.842, 634.2, 383.11299999999983, 88.41100000000006 ], "priority": 9, "parents": [ 101 ], "children": [ 116, 111, 114, 112 ], "area": 1617109.7964, "iscrowd": 0, "segmentation": [], "text": "RESULTS" }, { "id": 111, "strid": "19ef33ca-a977-47a0-8294-149cf07a9b19", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 1922.554, 756.935, 1648.6890000000003, 220.85199999999998 ], "priority": 10, "parents": [ 110 ], "children": [], "area": 1455248.41199, "iscrowd": 0, "segmentation": [], "text": "Serum IL-6 level and cardiovascular response to concentric\nexercise (CE) was significantly higher (except DBP) than eccentric\nexercise (EE)." }, { "id": 112, "strid": "2c7d1670-384c-4fc8-8cc6-219d2b4e58a1", "image_id": 6, "image_name": "10362.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1946.877, 1104.022, 1590.5880000000002, 910.72 ], "priority": 11, "parents": [ 110 ], "children": [ 113 ], "area": 2149395.039294, "iscrowd": 0, "segmentation": [] }, { "id": 113, "strid": "cc3e6716-9bdc-44b7-8ea4-d9e2548494a5", "image_id": 6, "image_name": "10362.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1922.265, 996.965, 1645.4240000000002, 84.20099999999991 ], "priority": 12, "parents": [ 112 ], "children": [], "area": 1916430.9257250002, "iscrowd": 0, "segmentation": [], "text": "Fig. 3: Absolute change in blood pressure in response to CE and EE" }, { "id": 114, "strid": "7e3d699a-2fa1-4ad1-9483-1a4d31548a50", "image_id": 6, "image_name": "10362.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1931.656, 2225.297, 763.5839999999998, 799.0990000000002 ], "priority": 13, "parents": [ 110 ], "children": [ 115 ], "area": 4298508.301832, "iscrowd": 0, "segmentation": [] }, { "id": 115, "strid": "348a6aec-a1f0-44ed-a57e-161004607b13", "image_id": 6, "image_name": "10362.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1922.265, 2070.525, 652.5559999999998, 133.3180000000002 ], "priority": 14, "parents": [ 114 ], "children": [], "area": 3980097.7391250003, "iscrowd": 0, "segmentation": [], "text": "Figure 4: Absolute change\nin heart rate" }, { "id": 116, "strid": "155d04a1-74f0-4025-89ca-179597521c55", "image_id": 6, "image_name": "10362.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2753.587, 2240.518, 806.71, 786.415 ], "priority": 15, "parents": [ 110 ], "children": [ 117 ], "area": 6169461.238066, "iscrowd": 0, "segmentation": [] }, { "id": 117, "strid": "a532e3ee-2db6-49e0-8478-c83c59ef96f0", "image_id": 6, "image_name": "10362.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2813.39, 2081.05, 673.6060000000002, 122.79300000000012 ], "priority": 16, "parents": [ 116 ], "children": [], "area": 5854805.259500001, "iscrowd": 0, "segmentation": [], "text": "Figure 5: Absolute change\nin serum IL-6 level" }, { "id": 118, "strid": "07cac158-727f-4128-a0da-547e82d76c1b", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 62.551, 3121.491, 1119.87, 82.51699999999983 ], "priority": 17, "parents": [ 101 ], "children": [ 119 ], "area": 195252.38354100002, "iscrowd": 0, "segmentation": [], "text": "MATERIALS AND METHOD" }, { "id": 119, "strid": "98bc33f3-3ea3-4e2a-8305-f93619f00fb5", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 28.448, 3242.071, 1185.446, 1546.799 ], "priority": 18, "parents": [ 118 ], "children": [], "area": 92230.435808, "iscrowd": 0, "segmentation": [], "text": "The present non-randomised cross-over study\nwas conducted in the Exercise Physiology\nLaboratory, King George’s Medical University\n(KGMU), Lucknow after approval from the\nInstitutional Ethical Committee.\n\nTwenty-four apparently healthy males, aged 18-\n25 years, having body mass index (BMI) 18-23\nkg/m?,with sedentary lifestyle, voluntary\nparticipated in the study.\n\nAll participants done a session of concentric\nexercise (CE) for 45 minutes, followed by\neccentric exercise (EE) after a rest of 15 days.\n\nExercise was done on inclined (emphasised\nconcentric walk)/ declined (emphasised\neccentric walk) treadmill and with dumbbells.\n\nSystolic blood pressure (SBP), diastolic blood\npressure (DBP), mean arterial pressure (MAP),\npulse pressure (PP), heart rate (HR), and\nserum IL-6 level were measured/calculated just\nbefore and after the exercise sessions." }, { "id": 120, "strid": "ab49bc2b-ca2c-48f2-9fcb-bcfa52aa8308", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 1574.376, 3115.597, 580.5640000000001, 82.51699999999983 ], "priority": 19, "parents": [ 101 ], "children": [ 121 ], "area": 4905121.142472, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 121, "strid": "bc162304-cdc2-4223-b343-c31e61e5dae0", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 1271.086, 3229.073, 1164.6489999999997, 348.355 ], "priority": 20, "parents": [ 120 ], "children": [], "area": 4104429.483278, "iscrowd": 0, "segmentation": [], "text": "Based on our present findings, we may\nrecommend eccentric exercise training for\nreducing morbidity and mortality in elderly,\nfrail individuals or those at risk of\ncardiovascular diseases." }, { "id": 122, "strid": "6f144faa-7230-45cd-a7da-ea52fa69a2cc", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 1592.058, 3651.956, 536.3589999999999, 100.19900000000007 ], "priority": 21, "parents": [ 101 ], "children": [ 123 ], "area": 5814125.765448, "iscrowd": 0, "segmentation": [], "text": "DISCUSSION" }, { "id": 123, "strid": "4664df95-7ef8-4a3e-b833-9d32e65019f8", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 1273.686, 3772.403, 1146.4509999999998, 868.2869999999998 ], "priority": 22, "parents": [ 122 ], "children": [], "area": 4804856.887457999, "iscrowd": 0, "segmentation": [], "text": "The lesser recruitment and discharge rate of\nmotor units during eccentric contractions\nrelative to concentric contractions* performed\nwith a similar absolute load might be a\npotential explanation for lesser cardiovascular\nresponse to CE as compared to EE.\n\nExercise-induced IL-6 levels majorly depends\non exercise intensity, duration and\ncarbohydrate availability’. EE might have\ncaused less physical exertion resulting in less\nenergy expenditure as compared to CE.\nTherefore, EE induced a lower IL-6 response." }, { "id": 124, "strid": "f5971143-d0ed-4778-94cb-951cb189049d", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 2602.888, 3121.491, 848.7440000000001, 76.62300000000005 ], "priority": 23, "parents": [ 101 ], "children": [ 125 ], "area": 8124891.466008, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 125, "strid": "d31ebc1a-fb77-4c05-a08f-515bc3dc81b4", "image_id": 6, "image_name": "10362.png", "category_id": 3, "category_name": "Text", "bbox": [ 2500.727, 3239.472, 1050.2640000000001, 332.75700000000006 ], "priority": 24, "parents": [ 124 ], "children": [], "area": 8101035.096144, "iscrowd": 0, "segmentation": [], "text": "Future studies should involve various\npopulations for comparison, including\nathletes vs. non-athletes, females vs.\nmales and those of differing ages such as\nthe elderly vs. younger populations." }, { "id": 126, "strid": "90540df4-e216-4e4e-85e1-e4999a14472d", "image_id": 6, "image_name": "10362.png", "category_id": 5, "category_name": "Section", "bbox": [ 2747.292, 3651.956, 571.723, 82.51699999999983 ], "priority": 25, "parents": [ 101 ], "children": [ 127 ], "area": 10032989.503152, "iscrowd": 0, "segmentation": [], "text": "REFERENCES" }, { "id": 127, "strid": "29429134-3f07-428f-9d9d-d3a541e4fe33", "image_id": 6, "image_name": "10362.png", "category_id": 4, "category_name": "List", "bbox": [ 2492.928, 3764.604, 1055.4629999999997, 873.4869999999996 ], "priority": 26, "parents": [ 126 ], "children": [], "area": 9384886.720511999, "iscrowd": 0, "segmentation": [] }, { "id": 128, "strid": "b6a3d6a8-f78d-4e9f-bab7-e43f3a93d009", "image_id": 7, "image_name": "10382.png", "category_id": 9, "category_name": "Root", "bbox": [ 43.49, 15.43, 145.47, 145.47 ], "priority": -1, "parents": [], "children": [ 141, 135, 130, 129, 136, 131, 144, 133 ], "area": 671.0507, "iscrowd": 0, "segmentation": [] }, { "id": 129, "strid": "2df55bc2-19fd-4de0-b5af-36ae116bc818", "image_id": 7, "image_name": "10382.png", "category_id": 1, "category_name": "Title", "bbox": [ 254.084, 195.318, 1432.444, 290.004 ], "priority": 1, "parents": [ 128 ], "children": [], "area": 49627.178712, "iscrowd": 0, "segmentation": [], "text": "Retrospective analysis of trends in outcome following\nOut of Hospital Cardiac Arrest\nfrom a UK regional cardiac arrest centre,\nwith a focus on haematological parameters" }, { "id": 130, "strid": "09c740c4-ea4f-48c8-ad50-1a8e1e67e024", "image_id": 7, "image_name": "10382.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 409.865, 523.192, 1119.861, 45.11800000000005 ], "priority": 2, "parents": [ 128 ], "children": [], "area": 214438.08908, "iscrowd": 0, "segmentation": [], "text": "A. Skorko, M. Thomas. Bristol Royal Infirmary, Bristol, United Kingdom" }, { "id": 131, "strid": "9322d167-0668-440e-9402-cfa846f44ce6", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 844.608, 637.805, 252.9079999999999, 42.089000000000055 ], "priority": 3, "parents": [ 128 ], "children": [ 132 ], "area": 538695.2054399999, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 132, "strid": "41e18591-649a-4f16-bb8e-324aa442f7c9", "image_id": 7, "image_name": "10382.png", "category_id": 3, "category_name": "Text", "bbox": [ 113.902, 702.938, 1722.916, 418.4440000000001 ], "priority": 4, "parents": [ 131 ], "children": [], "area": 80066.044076, "iscrowd": 0, "segmentation": [], "text": "The Bristol Royal Infirmary is a tertiary centre for the management of out of hospital cardiac arrests (OHCA), covering a metropolitan population of\n1,000,000 in the South West of England. Since 2008 there has been a steady rise in the number of patients treated at our centre.\n\nAn ongoing matter for debate in the treatment of patients following OHCA is what the optimal antiplatelet drug strategy that should be delivered,\ngiven the concerns of both bleeding and clotting complications.\n\nThere is often reticence on the part of the intensive care teams to give full antiplatelet therapy to OHCA survivors, due to the perceived risk of\nbleeding. Studies vary in the rates of bleeding seen in this population, from 0 to 56% (1). However rates of acute in-stent thrombosis in this population\nare as high as 10%, compared to 2% in the acute ST elevation (STEMI) population(2).\n\nTherefore the need to balance the bleeding and thrombosis risks is of upmost importance.\n\nWe present the overall survival of patients treated following out of hospital cardiac arrest, alongside haematological parameters in the first 24 hours,\nin one UK centre over the period January 2009 to August 2016." }, { "id": 133, "strid": "6f3cbb5e-51c6-4b40-9c3b-1d2561642002", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 888.667, 1154.52, 161.81100000000004, 41.44800000000009 ], "priority": 5, "parents": [ 128 ], "children": [ 134 ], "area": 1025983.82484, "iscrowd": 0, "segmentation": [], "text": "Method" }, { "id": 134, "strid": "520f392f-bcb0-4ede-ab0b-e7a2f0ddb2e2", "image_id": 7, "image_name": "10382.png", "category_id": 3, "category_name": "Text", "bbox": [ 115.156, 1219.807, 1712.494, 293.42599999999993 ], "priority": 6, "parents": [ 133 ], "children": [], "area": 140468.09489200002, "iscrowd": 0, "segmentation": [], "text": "To understand why OHCA survivors may be at risk of bleeding and to try to quantify whether this impacts survival to hospital discharge, we\nretrospectively analysed laboratory parameters of coagulation (PT and APTT) and platelet count, alongside the haemoglobin value and stratified these\nby survival to hospital discharge.\n\nRoutinely collected data was used to identify patients for this analysis. Data was extracted for those coded as ‘Anoxic or ischaemic coma or\nencephalopathy’ with ‘Acute myocardial infarction’ or ‘Ventricular tachycardia or fibrillation’. Our electronic records began in December 2008 and\ncontinue to the present day. Data for 2016 is available up to and including August. Parameters of ‘status at hospital discharge’, lowest platelet count,\nAPTT and lowest haemoglobin within 24 hours of admission were extracted from the database." }, { "id": 135, "strid": "ff77f3c0-6db9-48c4-aec0-3419c709ebdd", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 895.181, 1547.228, 147.096, 45.48700000000008 ], "priority": 7, "parents": [ 128 ], "children": [], "area": 1385049.1082680002, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 136, "strid": "acefc230-3e06-4f49-b2a4-6844a48bbaa0", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 684.81, 1625.581, 569.52, 38.274000000000115 ], "priority": 8, "parents": [ 128 ], "children": [ 139, 137 ], "area": 1113214.1246099998, "iscrowd": 0, "segmentation": [], "text": "Rates of admission and survival" }, { "id": 137, "strid": "c3af23c1-eea0-4c61-a388-edea307b098e", "image_id": 7, "image_name": "10382.png", "category_id": 2, "category_name": "Figure", "bbox": [ 122.563, 1785.421, 927.83, 627.3170000000002 ], "priority": 9, "parents": [ 136 ], "children": [ 138 ], "area": 218826.554023, "iscrowd": 0, "segmentation": [] }, { "id": 138, "strid": "daa8fc32-4e5f-4e7e-ba8d-db41d13eee03", "image_id": 7, "image_name": "10382.png", "category_id": 6, "category_name": "Caption", "bbox": [ 249.53, 1723.906, 661.183, 58.21900000000005 ], "priority": 10, "parents": [ 137 ], "children": [], "area": 430166.26418, "iscrowd": 0, "segmentation": [], "text": "Figure 1: Number of OHCA patients admitted to the BRI and\nmortality rate by year (2009-2016)" }, { "id": 139, "strid": "dbe43955-2120-4bfa-a192-21cd5bda27a5", "image_id": 7, "image_name": "10382.png", "category_id": 7, "category_name": "Table", "bbox": [ 1083.105, 1936.725, 734.8820000000001, 484.1419999999998 ], "priority": 11, "parents": [ 136 ], "children": [ 140 ], "area": 2097676.5311249997, "iscrowd": 0, "segmentation": [] }, { "id": 140, "strid": "4de2ea9b-6b86-4e5a-8493-d2d80f8ad927", "image_id": 7, "image_name": "10382.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1091.807, 1728.072, 729.194, 178.519 ], "priority": 12, "parents": [ 139 ], "children": [], "area": 1886721.106104, "iscrowd": 0, "segmentation": [], "text": "Figure 1 demonstrates an upward trend in the number of\npatients been treated by our unit, at the same time as hospital\nmortality has shown a downward trend. The outcomes for\nsurvival in our unit are consistently below the national\n\naverage(3)." }, { "id": 141, "strid": "b01ed46d-73e4-458b-99b6-d63dbe94b953", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 561.397, 2468.079, 817.522, 43.21199999999999 ], "priority": 13, "parents": [ 128 ], "children": [ 142, 143 ], "area": 1385572.1463630002, "iscrowd": 0, "segmentation": [], "text": "Parameters of coagulation and platelet count" }, { "id": 142, "strid": "53e3a68a-aadf-4a9e-8dd8-2d66feb59375", "image_id": 7, "image_name": "10382.png", "category_id": 3, "category_name": "Text", "bbox": [ 116.411, 2544.049, 1684.953, 69.30200000000013 ], "priority": 14, "parents": [ 141 ], "children": [], "area": 296155.288139, "iscrowd": 0, "segmentation": [], "text": "Analysing the differences between survivors and non survivors as regards the coagulation parameters in the first 24 hours, demonstrates that there is\nno clinically significant difference in haemoglobin level, platelet counts, PT, or APTT parameters (see table above)." }, { "id": 143, "strid": "028f21d9-3a10-4166-a3e9-eea66e251158", "image_id": 7, "image_name": "10382.png", "category_id": 4, "category_name": "List", "bbox": [ 116.202, 2633.298, 1008.576, 130.5619999999999 ], "priority": 15, "parents": [ 141 ], "children": [], "area": 305994.494196, "iscrowd": 0, "segmentation": [] }, { "id": 144, "strid": "5edee22e-90d6-47ab-bed2-38e636f8c2fa", "image_id": 7, "image_name": "10382.png", "category_id": 5, "category_name": "Section", "bbox": [ 855.014, 2800.468, 225.1250000000001, 40.391999999999825 ], "priority": 16, "parents": [ 128 ], "children": [ 145 ], "area": 2394439.346552, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 145, "strid": "e637c674-b71f-45d6-be4c-2e674e91e224", "image_id": 7, "image_name": "10382.png", "category_id": 3, "category_name": "Text", "bbox": [ 113.991, 2866.477, 1707.336, 308.8249999999998 ], "priority": 17, "parents": [ 144 ], "children": [], "area": 326752.579707, "iscrowd": 0, "segmentation": [], "text": "Our data demonstrates that absolute platelet count, haemoglobin, PT and APTT in the first 24 hours do not differ between survivors and non-survivors\nof OHCA. Abnormalities in platelet count or coagulation markers within the first 24 hours of admission do not explain differences between survivors\nand non survivors of OHCA.\n\nHowever, absolute values do not give an indication as to the function of platelets or of the coagulation cascade. An analysis of platelet function and\nthe coagulation cascade as a whole may provide better insights into the risks of bleeding in this population.\n\nWe therefore propose to carry out a prospective analysis of thromoelastometric coagulation assessment and platelet inhibition, and correlate this with\nbleeding events and administration of antiplatelet therapy." }, { "id": 146, "strid": "74f39814-61b2-4460-b45b-feeb123b19d7", "image_id": 8, "image_name": "10418.png", "category_id": 9, "category_name": "Root", "bbox": [ 7.21, 43.58, 35.56, 53.34 ], "priority": -1, "parents": [], "children": [ 151, 167, 149, 148, 154, 147 ], "area": 314.2118, "iscrowd": 0, "segmentation": [] }, { "id": 147, "strid": "744fba02-f59f-41ed-a046-faa97409a5ef", "image_id": 8, "image_name": "10418.png", "category_id": 1, "category_name": "Title", "bbox": [ 64.033, 33.911, 451.70399999999995, 19.457 ], "priority": 1, "parents": [ 146 ], "children": [], "area": 2171.423063, "iscrowd": 0, "segmentation": [], "text": "Blood tests in the intensive care uni necessary cost" }, { "id": 148, "strid": "b2e41a19-f76c-4c5f-a7f4-7b1c5f65297f", "image_id": 8, "image_name": "10418.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 63.49, 63.666, 453.33899999999994, 13.879999999999995 ], "priority": 2, "parents": [ 146 ], "children": [], "area": 4042.15434, "iscrowd": 0, "segmentation": [], "text": "E Cumber; | Channon; A Wong: John Radcliffe Hospital, Oxford, United Kingdom" }, { "id": 149, "strid": "45127812-4ea1-4306-bdc9-ac2a0ec643ba", "image_id": 8, "image_name": "10418.png", "category_id": 5, "category_name": "Section", "bbox": [ 77.149, 107.904, 67.108, 14.025999999999996 ], "priority": 3, "parents": [ 146 ], "children": [ 150 ], "area": 8324.685696, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 150, "strid": "5505ce65-029f-4d5e-88dc-ba799778588a", "image_id": 8, "image_name": "10418.png", "category_id": 4, "category_name": "List", "bbox": [ 73.475, 128.344, 683.257, 112.643 ], "priority": 4, "parents": [ 149 ], "children": [], "area": 9430.0754, "iscrowd": 0, "segmentation": [] }, { "id": 151, "strid": "6eb856e5-b9d3-4f64-ad49-8ef9e79e0e40", "image_id": 8, "image_name": "10418.png", "category_id": 5, "category_name": "Section", "bbox": [ 72.629, 279.733, 50.40400000000001, 12.22199999999998 ], "priority": 5, "parents": [ 146 ], "children": [ 153, 152 ], "area": 20316.728057, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 152, "strid": "56fc4ee7-26d1-4e33-b3da-74ac1ef15378", "image_id": 8, "image_name": "10418.png", "category_id": 4, "category_name": "List", "bbox": [ 70.809, 296.702, 213.88999999999996, 59.27800000000002 ], "priority": 6, "parents": [ 151 ], "children": [], "area": 21009.171918, "iscrowd": 0, "segmentation": [] }, { "id": 153, "strid": "d8e07c24-ad8a-4b96-ae53-ea803fe97874", "image_id": 8, "image_name": "10418.png", "category_id": 4, "category_name": "List", "bbox": [ 418.877, 272.906, 354.704, 76.144 ], "priority": 7, "parents": [ 151 ], "children": [], "area": 114314.046562, "iscrowd": 0, "segmentation": [] }, { "id": 154, "strid": "21cd5863-5821-484d-9824-159be1391a93", "image_id": 8, "image_name": "10418.png", "category_id": 5, "category_name": "Section", "bbox": [ 73.349, 375.055, 40.318, 11.814999999999998 ], "priority": 8, "parents": [ 146 ], "children": [ 159, 163, 165, 157, 155, 161 ], "area": 27509.909195, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 155, "strid": "762665b0-6da7-44f5-b99c-22b916ab229a", "image_id": 8, "image_name": "10418.png", "category_id": 2, "category_name": "Figure", "bbox": [ 55.307, 396.655, 343.26, 205.62200000000007 ], "priority": 9, "parents": [ 154 ], "children": [ 156 ], "area": 21937.798085, "iscrowd": 0, "segmentation": [] }, { "id": 156, "strid": "c40a2de6-5094-40f7-98cb-177b4f8fb0fc", "image_id": 8, "image_name": "10418.png", "category_id": 6, "category_name": "Caption", "bbox": [ 73.441, 608.131, 297.813, 14.986999999999966 ], "priority": 10, "parents": [ 155 ], "children": [], "area": 44661.748771, "iscrowd": 0, "segmentation": [], "text": "Figure 1 Average number of investigations per day and their annual cost" }, { "id": 157, "strid": "a3d870c4-59ed-4783-9207-9f91a9d53da1", "image_id": 8, "image_name": "10418.png", "category_id": 2, "category_name": "Figure", "bbox": [ 54.665, 652.804, 345.032, 222.336 ], "priority": 11, "parents": [ 154 ], "children": [ 158 ], "area": 35685.53066, "iscrowd": 0, "segmentation": [] }, { "id": 158, "strid": "e5e691e6-97cd-4d5e-b7aa-77c9b0d39fa0", "image_id": 8, "image_name": "10418.png", "category_id": 6, "category_name": "Caption", "bbox": [ 69.462, 883.552, 309.089, 29.998000000000047 ], "priority": 12, "parents": [ 157 ], "children": [], "area": 61373.289024000005, "iscrowd": 0, "segmentation": [], "text": "‘Figure 2 Qualitative feedback from survey of AICU MDT stoff on frequency\nibeetinaions" }, { "id": 159, "strid": "39d144b7-b91b-4e0e-a88a-5d0552612576", "image_id": 8, "image_name": "10418.png", "category_id": 2, "category_name": "Figure", "bbox": [ 49.951, 940.673, 360.538, 188.64100000000008 ], "priority": 13, "parents": [ 154 ], "children": [ 160 ], "area": 46987.557023, "iscrowd": 0, "segmentation": [] }, { "id": 160, "strid": "12c19e98-68eb-4ce2-91c1-0ebe33411254", "image_id": 8, "image_name": "10418.png", "category_id": 6, "category_name": "Caption", "bbox": [ 73.329, 1140.896, 236.75799999999998, 13.603000000000065 ], "priority": 14, "parents": [ 159 ], "children": [], "area": 83660.76278399999, "iscrowd": 0, "segmentation": [], "text": "Figure 3 Clotting results throughout patient MGP MetaGénoPolis, INRA, Université Paris-Saclay, 78350 Jouy en Josas, France ©CentraleSupélec, Université Paris-Saclay, 92290 Chatenay-Malabry, France ¢King’s College London, Centre for Host-Microbiome Interactions, London, UK" }, { "id": 186, "strid": "9c4860b9-96d1-43f5-855d-9150d0cef529", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 473.532, 574.782, 395.95700000000005, 70.654 ], "priority": 3, "parents": [ 183 ], "children": [ 187 ], "area": 272177.670024, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 187, "strid": "355381cc-6ffb-4da4-b70a-1e8531c5529f", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 94.989, 685.119, 1157.211, 947.8550000000001 ], "priority": 4, "parents": [ 186 ], "children": [], "area": 65078.768691000005, "iscrowd": 0, "segmentation": [], "text": "Metagenomic shotgun sequencing is a culture-free technology that\nallows strain-level characterization of complex microbial communities.\n\nRecent analysis pipelines can capture intra-species gene content\nvariability and SNPs within and between metagenomic samples. [1,2,3]\n\nHowever, these tools rely on sparse reference genomes databases which\nlimit the scope of the analysis.\n\nNielsen et al. [4] showed that genomes of microbial organisms can be\nreconstituted by binning co-abundant genes obtained from de novo\nmetagenomics assembly. This method groups core genes and highly\nprevalent accessory genes but misses rare accessory genes or assigns them\nto small separated clusters. Moreover, Pearson correlation used to detect\nrelated genes is highly sensitive to outliers and may miss some relevant\nrelations.\n\nWe propose a new method that reconstitutes species pangenomes by\nbinning co-abundant genes across metagenomic samples. It distinguishes\ncore genes from accessory and shared genes even when rarely observed.\nThe method relies on a new robust score that is only limited by the number\nof reads mapped on a gene and its prevalence across samples." }, { "id": 188, "strid": "fdc15e7f-537c-4bfe-8ea4-b87eef825242", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 526.32, 1754.642, 300.145, 70.24700000000007 ], "priority": 5, "parents": [ 183 ], "children": [ 189, 191 ], "area": 923503.1774400001, "iscrowd": 0, "segmentation": [], "text": "Rationale" }, { "id": 189, "strid": "8c4cef2c-c7ae-4c10-a239-8aeea403ec0e", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 97.65, 1889.374, 1154.376, 772.0820000000001 ], "priority": 6, "parents": [ 188 ], "children": [ 190 ], "area": 184497.37110000002, "iscrowd": 0, "segmentation": [] }, { "id": 190, "strid": "28e193a4-6b01-4d44-845a-b3eba8c7a5d0", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 113.935, 2704.459, 947.393, 40.603000000000065 ], "priority": 7, "parents": [ 189 ], "children": [], "area": 308132.536165, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Simple model illustrating the rationale behind the method" }, { "id": 191, "strid": "c988dd86-bba7-4b4c-ac2d-ea84394d808b", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 107.906, 2748.528, 1104.707, 357.4290000000001 ], "priority": 8, "parents": [ 188 ], "children": [], "area": 296582.662368, "iscrowd": 0, "segmentation": [], "text": "5 samples carry different strains from the same species. Three core genes (red, blue,\norange) are present in all the strains. Two accessory genes (green, purple) are present\nonly in some strains. The abundance of the species in each sample ranges from 1 to 3\ncopies.\n\nAfter shotgun sequencing, a raw gene abundance matrix is built.\n\nA strict proportionality relationship is expected between two core genes, the\nproportionality coefficient being equal to the ratio of their length. In contrast, such\nrelationship between a core and an accessory gene should be observed only in the\nsubset of samples where the accessory gene is present." }, { "id": 192, "strid": "8390c72e-8160-4d27-9785-680c2bde6858", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 2154.695, 574.179, 282.8789999999999, 69.56000000000006 ], "priority": 9, "parents": [ 183 ], "children": [ 201, 197, 193, 195, 199, 203 ], "area": 1237180.620405, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 193, "strid": "2d17bb45-a02b-4601-8835-b9064808265f", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1428.067, 679.054, 751.2339999999999, 503.352 ], "priority": 10, "parents": [ 192 ], "children": [ 194 ], "area": 969734.6086179999, "iscrowd": 0, "segmentation": [] }, { "id": 194, "strid": "0ab9c2d8-8b88-4c25-9bd6-5927b1d943a1", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1416.578, 1190.273, 529.7640000000001, 88.2940000000001 ], "priority": 11, "parents": [ 193 ], "children": [], "area": 1686114.545794, "iscrowd": 0, "segmentation": [], "text": "Figure 2. structuration of MSPs\n(Metagenomic Species Pan-genomes)" }, { "id": 195, "strid": "23450ca2-fc81-4acb-bfab-79f94933bb04", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2328.536, 706.878, 849.8800000000001, 472.9989999999999 ], "priority": 12, "parents": [ 192 ], "children": [ 196 ], "area": 1645990.870608, "iscrowd": 0, "segmentation": [] }, { "id": 196, "strid": "16d88554-93c3-47d0-bc4e-5d442588e50a", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2337.575, 1191.795, 835.748, 86.77199999999993 ], "priority": 13, "parents": [ 195 ], "children": [], "area": 2785910.197125, "iscrowd": 0, "segmentation": [], "text": "Figure 3.a. Illustration of a core gene in the MSP\ncorresponding to R. bromii" }, { "id": 197, "strid": "9fb1541f-ac6f-4784-b1c5-9e115bde2d5f", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1400.244, 1316.465, 852.4100000000001, 478.058 ], "priority": 14, "parents": [ 192 ], "children": [ 198 ], "area": 1843372.2174599997, "iscrowd": 0, "segmentation": [] }, { "id": 198, "strid": "d66db996-aaa8-4f8b-80ee-ed6b8c401f63", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1408.148, 1805.576, 832.3509999999999, 88.02500000000009 ], "priority": 15, "parents": [ 197 ], "children": [], "area": 2542518.233248, "iscrowd": 0, "segmentation": [], "text": "Figure 3.b. Illustration of an accessory gene in the MSP\ncorresponding to R. bromii" }, { "id": 199, "strid": "f8ec4e07-a02e-45d5-8fcc-b2af67c74e53", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2323.477, 1316.465, 854.9389999999999, 475.528 ], "priority": 16, "parents": [ 192 ], "children": [ 200 ], "area": 3058776.1488049994, "iscrowd": 0, "segmentation": [] }, { "id": 200, "strid": "542edc08-0043-4d84-a3fa-9cdaa0daf7ee", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2338.88, 1806.871, 834.94, 85.43599999999992 ], "priority": 17, "parents": [ 199 ], "children": [], "area": 4226054.44448, "iscrowd": 0, "segmentation": [], "text": "Figure 3.c. Illustration of a shared accessory gene in the\nMSP corresponding to R. bromii" }, { "id": 201, "strid": "c77634f3-f958-4133-8ff3-add371210061", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1672.876, 1928.127, 1252.1049999999998, 724.634 ], "priority": 18, "parents": [ 192 ], "children": [ 202 ], "area": 3225517.383252, "iscrowd": 0, "segmentation": [] }, { "id": 202, "strid": "5bb83901-e281-405e-b8bc-20a561fbc774", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1695.435, 2674.354, 990.172, 48.95600000000013 ], "priority": 19, "parents": [ 201 ], "children": [], "area": 4534193.373989999, "iscrowd": 0, "segmentation": [], "text": "Figure 4. Workflow for Metagenomics Species Pan-genomes generation" }, { "id": 203, "strid": "182a13cc-1e80-4e54-901c-67195c40669c", "image_id": 10, "image_name": "10488.png", "category_id": 4, "category_name": "List", "bbox": [ 1449.829, 2729.729, 1691.6919999999998, 380.69000000000005 ], "priority": 20, "parents": [ 192 ], "children": [], "area": 3957640.2663409994, "iscrowd": 0, "segmentation": [] }, { "id": 204, "strid": "b856c749-887c-4dbb-b154-d70d8e2ab328", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 3874.53, 575.049, 223.32100000000037, 64.38099999999997 ], "priority": 21, "parents": [ 183 ], "children": [ 205, 211, 209, 206, 208 ], "area": 2228044.60197, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 205, "strid": "be574a45-9999-43b2-9a9a-ceea632c9c84", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 3349.325, 690.399, 1274.4920000000002, 428.2130000000001 ], "priority": 22, "parents": [ 204 ], "children": [], "area": 2312370.6306749997, "iscrowd": 0, "segmentation": [], "text": "The method has been implemented as a C++ multithreaded program. It can process\nlarge datasets of thousands of samples and millions of genes in few hours on a\nregular single node server..\n\nWe used it to structure the integrated catalog of reference genes of the human gut\nmicrobiome (IGC) [5]. Among the 9.9 million genes, 4.7 million with enough mapped\nreads and enough prevalence across the 1267 samples were kept.\n\n1068 Metagenomic Species Pan-genomes (MSP) with at least 200 genes in their core\ngenes set were discovered." }, { "id": 206, "strid": "d51dc466-d7a7-42a9-ab24-45942b66a7a2", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3351.229, 1145.075, 639.1240000000003, 425.4580000000001 ], "priority": 23, "parents": [ 204 ], "children": [ 207 ], "area": 3837408.547175, "iscrowd": 0, "segmentation": [] }, { "id": 207, "strid": "acbe101b-7b5c-4c12-a4e3-52da660821cc", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 4040.879, 1245.508, 559.5320000000002, 81.53199999999993 ], "priority": 24, "parents": [ 206 ], "children": [], "area": 5032947.121532, "iscrowd": 0, "segmentation": [], "text": "Figure 5. Lowest taxonomic rank\nassigned to MSPs" }, { "id": 208, "strid": "fa8313b6-5f15-4c1a-98a2-51a16b3c0bd1", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 4043.177, 1327.834, 554.2469999999998, 120.40200000000004 ], "priority": 25, "parents": [ 204 ], "children": [], "area": 5368667.888618001, "iscrowd": 0, "segmentation": [], "text": "Taxonomic annotation of MSPs was\nperformed by comparing core genes\nagainst KEGG GENES and RefSeq." }, { "id": 209, "strid": "3587bef7-b8a1-403a-bf70-1ecd36ca54ed", "image_id": 10, "image_name": "10488.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3324.989, 1630.51, 719.7170000000001, 491.057 ], "priority": 26, "parents": [ 204 ], "children": [ 210 ], "area": 5421427.81439, "iscrowd": 0, "segmentation": [] }, { "id": 210, "strid": "8f5d957b-80e7-446b-b904-4f2db4fbf69f", "image_id": 10, "image_name": "10488.png", "category_id": 6, "category_name": "Caption", "bbox": [ 4050.471, 1675.548, 594.7019999999998, 84.72900000000004 ], "priority": 27, "parents": [ 209 ], "children": [], "area": 6786758.583108, "iscrowd": 0, "segmentation": [], "text": "Figure 6. composition of MSPs matching\nknown species" }, { "id": 211, "strid": "36ae22aa-ebaa-427e-9f4c-27d2a66d8434", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 4051.137, 1759.689, 594.0489999999995, 245.779 ], "priority": 28, "parents": [ 204 ], "children": [], "area": 7128741.216393, "iscrowd": 0, "segmentation": [], "text": "The method discovered very few new genes\nfor well-characterized species like E. coli that\nhave thousands of sequenced strains.\nHowever, many previously unknown\naccessory genes genes were discovered for\nspecies with just a few representatives." }, { "id": 212, "strid": "506f2ebf-e635-4195-b906-e66923eb6000", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 3809.008, 2227.556, 355.6090000000004, 74.08500000000004 ], "priority": 29, "parents": [ 183 ], "children": [ 213 ], "area": 8484778.624448, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 213, "strid": "992c58e1-94e5-457c-b07c-7baf8ef71504", "image_id": 10, "image_name": "10488.png", "category_id": 3, "category_name": "Text", "bbox": [ 3346.225, 2337.459, 1270.7069999999999, 280.76200000000017 ], "priority": 30, "parents": [ 212 ], "children": [], "area": 7821663.742275, "iscrowd": 0, "segmentation": [], "text": "Our approach enables an efficient and informative reconstitution of pan-genomes\nfrom shotgun metagenomic data without referring to genomes from isolated\nstrains. It gives an overview of the genetic variation of microbes in a given\necosystem. Identification of core genes sets and accessory modules can be used for\na more accurate counting of microbes abundance and their optional functional\nunits." }, { "id": 214, "strid": "60601ff6-ac69-4b0c-b742-a3d876361d55", "image_id": 10, "image_name": "10488.png", "category_id": 5, "category_name": "Section", "bbox": [ 3815.723, 2712.131, 349.0779999999995, 76.36099999999988 ], "priority": 31, "parents": [ 183 ], "children": [ 215 ], "area": 10348740.635713, "iscrowd": 0, "segmentation": [], "text": "References" }, { "id": 215, "strid": "109bfe70-aba5-42d7-941c-192cb0e1be86", "image_id": 10, "image_name": "10488.png", "category_id": 4, "category_name": "List", "bbox": [ 3351.435, 2823.882, 1195.726, 283.25199999999995 ], "priority": 32, "parents": [ 214 ], "children": [], "area": 9464056.97067, "iscrowd": 0, "segmentation": [] }, { "id": 216, "strid": "7fa18c2a-3ed5-4029-a58d-1e8d9e5c95c2", "image_id": 11, "image_name": "10629.png", "category_id": 9, "category_name": "Root", "bbox": [ 2376.89, 108.93, 198.09000000000015, 186.76 ], "priority": -1, "parents": [], "children": [ 217, 236, 238, 226, 232, 222, 218, 219 ], "area": 258914.6277, "iscrowd": 0, "segmentation": [] }, { "id": 217, "strid": "132e75a4-91c2-4f1e-8672-03d40aecb4ad", "image_id": 11, "image_name": "10629.png", "category_id": 1, "category_name": "Title", "bbox": [ 204.089, 184.82, 2054.586, 302.867 ], "priority": 1, "parents": [ 216 ], "children": [], "area": 37719.72898, "iscrowd": 0, "segmentation": [], "text": "A crisis of protection and safe passage:\nviolence experienced by migrants/refugees travelling\nalong the Western Balkan corridor to Northern Europe" }, { "id": 218, "strid": "a7210153-6318-4ede-ade9-1c7655fdf29e", "image_id": 11, "image_name": "10629.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 153.029, 576.004, 2158.4, 207.159 ], "priority": 2, "parents": [ 216 ], "children": [], "area": 88145.316116, "iscrowd": 0, "segmentation": [], "text": "'Médecins Sans Frontiéres *International Union Against TB and Lung Disease; 7London School of Hygiene and Tropical Medicine." }, { "id": 219, "strid": "a189018a-4397-4f01-9aa7-eef7f03b33f2", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 688.639, 907.708, 307.605, 57.18799999999999 ], "priority": 3, "parents": [ 216 ], "children": [ 221, 220 ], "area": 625083.129412, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 220, "strid": "50df78d6-b317-47a5-a87e-f966f0e97290", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 158.173, 1015.683, 1356.895, 141.76499999999987 ], "priority": 4, "parents": [ 219 ], "children": [], "area": 160653.627159, "iscrowd": 0, "segmentation": [], "text": "To curb the influx of migrants/refugees, during 2015 and 2016, European\ncountries instituted restrictive migration policies often characterized by building\nof razor-wire border fences and border closures." }, { "id": 221, "strid": "e80e9fc0-fbb7-4177-a9d1-662437c1681c", "image_id": 11, "image_name": "10629.png", "category_id": 2, "category_name": "Figure", "bbox": [ 148.488, 1193.562, 1379.58, 1182.0990000000002 ], "priority": 5, "parents": [ 219 ], "children": [], "area": 177229.634256, "iscrowd": 0, "segmentation": [] }, { "id": 222, "strid": "0bc56c0d-0908-44a7-8650-ef3f4f606ae8", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 1785.517, 909.159, 423.048, 55.813999999999965 ], "priority": 6, "parents": [ 216 ], "children": [ 224, 225, 223 ], "area": 1623318.850203, "iscrowd": 0, "segmentation": [], "text": "Study objectives" }, { "id": 223, "strid": "03e2cccb-7841-41f9-bd60-7879a022cbaf", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 1585.624, 1027.355, 796.9469999999999, 186.7840000000001 ], "priority": 7, "parents": [ 222 ], "children": [], "area": 1628998.74452, "iscrowd": 0, "segmentation": [], "text": "Among migrants/refugees who received mental\nhealth care, and who were traveling along the\n\nBalkan route to Northern Europe we report\non:" }, { "id": 224, "strid": "6c0a5826-db25-4cc3-80ab-6197d6ba4ad4", "image_id": 11, "image_name": "10629.png", "category_id": 4, "category_name": "List", "bbox": [ 1589.231, 1275.958, 817.6900000000003, 440.721 ], "priority": 8, "parents": [ 222 ], "children": [], "area": 2027792.008298, "iscrowd": 0, "segmentation": [] }, { "id": 225, "strid": "0dda4923-eebf-43ff-84c3-9c749af42f15", "image_id": 11, "image_name": "10629.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1586.418, 1751.118, 815.5260000000001, 619.268 ], "priority": 9, "parents": [ 222 ], "children": [], "area": 2778005.115324, "iscrowd": 0, "segmentation": [] }, { "id": 226, "strid": "c64911da-b5bf-47f9-808f-282d1f786783", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 2677.899, 911.286, 221.5079999999998, 42.11800000000005 ], "priority": 10, "parents": [ 216 ], "children": [ 228, 231, 229, 230, 227 ], "area": 2440331.8681139997, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 227, "strid": "febc31ca-ac7a-4025-ad0b-362c4e0af115", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 2464.137, 1027.109, 551.953, 47.59999999999991 ], "priority": 11, "parents": [ 226 ], "children": [], "area": 2530937.2899329998, "iscrowd": 0, "segmentation": [], "text": "Design: A cross-sectional study" }, { "id": 228, "strid": "249fad42-bb2c-4563-81a8-f511680b7461", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 2464.137, 1110.155, 545.8759999999997, 45.57400000000007 ], "priority": 12, "parents": [ 226 ], "children": [], "area": 2735574.011235, "iscrowd": 0, "segmentation": [], "text": "Period: July 2015 and June 2016" }, { "id": 229, "strid": "0e713de1-f8fc-416e-a454-91ec5901f9de", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 2464.137, 1194.214, 563.0929999999998, 239.01099999999997 ], "priority": 13, "parents": [ 226 ], "children": [], "area": 2942706.903318, "iscrowd": 0, "segmentation": [], "text": "Site:\n\nMédecins sans Frontieres (MSF)\nmental health clinics in Serbia — a\nmain transit hub to European\ncountries." }, { "id": 230, "strid": "442de04c-df5f-424e-9e10-f6adcbe19d4d", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 2462.112, 1477.786, 559.0419999999999, 246.0999999999999 ], "priority": 14, "parents": [ 226 ], "children": [], "area": 3638474.644032, "iscrowd": 0, "segmentation": [], "text": "Mental health clinics:\nConducted according to MSF\nguidelines by experienced\npsychologists\n\nSupported by cultural mediators." }, { "id": 231, "strid": "73a69638-cb74-41d0-9da4-020d1d5ad176", "image_id": 11, "image_name": "10629.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2448.832, 1752.56, 671.835, 617.6169999999997 ], "priority": 15, "parents": [ 226 ], "children": [], "area": 4291725.00992, "iscrowd": 0, "segmentation": [] }, { "id": 232, "strid": "795b580f-fd13-4102-a0c3-347addd58ddb", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 970.639, 2482.44, 183.6439999999999, 42.81899999999996 ], "priority": 16, "parents": [ 216 ], "children": [ 235, 234, 233 ], "area": 2409553.07916, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 233, "strid": "585d6562-a23a-4051-a119-3080cec62b11", "image_id": 11, "image_name": "10629.png", "category_id": 4, "category_name": "List", "bbox": [ 153.831, 2590.828, 1796.402, 348.8879999999999 ], "priority": 17, "parents": [ 232 ], "children": [], "area": 398549.66206799995, "iscrowd": 0, "segmentation": [] }, { "id": 234, "strid": "dd43ba9b-f13a-456e-8168-1afc217e9240", "image_id": 11, "image_name": "10629.png", "category_id": 2, "category_name": "Figure", "bbox": [ 151.934, 2954.227, 1400.582, 782.212 ], "priority": 18, "parents": [ 232 ], "children": [], "area": 448847.525018, "iscrowd": 0, "segmentation": [] }, { "id": 235, "strid": "9d987790-6074-4c1a-b381-71e2c2c40f51", "image_id": 11, "image_name": "10629.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1667.029, 3213.203, 1444.6259999999997, 526.7599999999998 ], "priority": 19, "parents": [ 232 ], "children": [], "area": 5356502.583887, "iscrowd": 0, "segmentation": [] }, { "id": 236, "strid": "e74baffa-1ac3-4a89-9bfd-86ccc361224b", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 2416.386, 2483.808, 311.25, 42.5920000000001 ], "priority": 20, "parents": [ 216 ], "children": [ 237 ], "area": 6001838.877888, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 237, "strid": "84476a93-33ce-4132-9499-207b5bf8a1b7", "image_id": 11, "image_name": "10629.png", "category_id": 4, "category_name": "List", "bbox": [ 2031.844, 2592.085, 1082.9920000000002, 548.7150000000001 ], "priority": 21, "parents": [ 236 ], "children": [], "area": 5266712.35474, "iscrowd": 0, "segmentation": [] }, { "id": 238, "strid": "00fc5021-70fe-44e9-a2b7-48a6880f1a2d", "image_id": 11, "image_name": "10629.png", "category_id": 5, "category_name": "Section", "bbox": [ 775.028, 3857.352, 1731.1009999999999, 65.13000000000011 ], "priority": 22, "parents": [ 216 ], "children": [ 239 ], "area": 2989555.805856, "iscrowd": 0, "segmentation": [], "text": "Testimonies of two migrants who experienced intentional violence" }, { "id": 239, "strid": "a1085a1d-ac74-4b9b-87b5-84bc42eae759", "image_id": 11, "image_name": "10629.png", "category_id": 3, "category_name": "Text", "bbox": [ 208.881, 3969.992, 2869.78, 489.4430000000002 ], "priority": 23, "parents": [ 238 ], "children": [], "area": 829255.8989520001, "iscrowd": 0, "segmentation": [], "text": "“| tried to cross the border with a group of migrants. There were five policemen on the Hungarian side who threatened us not to try to cross the border. We lit a fire and sat around\nabout 2km on the Serbian side.We thought we were safe. The policemen with five big dogs crossed to the Serbian side and chased us. They pushed us on the ground (including\nwomen) and kicked us with boots on our face and body. The dogs attacked and bit us too.The police then sprayed pepper spray in our eyes and threw our things into the fire. Some of\nthe women were thrown in the nearby water. One of the policemen was very big and strong and he kept throwing people around.The one that beat me did not stop until | stopped\nmoving and pretended to be dead.”\n\n“I suffered from severe injuries caused by a mine explosion many years ago in Afghanistan that left me physically disabled and with impaired sight. | was travelling with a young relative\nwho was an accompanying aid to me.We had been on the road for about five months. | got treated by MSF in Serbia and received a medical certificate of disability.! was among 10\npeople who crossed the Hungarian border and were caught by Hungarian police who beat us with their sticks, kicked us with boots also used pepper spray.We were also beaten by\ncivilians.”" }, { "id": 240, "strid": "029cccb1-84b2-49d0-8333-d2908b0a7eee", "image_id": 12, "image_name": "10639.png", "category_id": 9, "category_name": "Root", "bbox": [ 350.95, 17.85, 244.49000000000007, 236.34 ], "priority": -1, "parents": [], "children": [ 251, 241, 243, 247, 249, 263, 242, 261, 245 ], "area": 6264.4575, "iscrowd": 0, "segmentation": [] }, { "id": 241, "strid": "9111df70-e1b3-4a62-b763-b1a782b9933b", "image_id": 12, "image_name": "10639.png", "category_id": 1, "category_name": "Title", "bbox": [ 647.116, 87.958, 2139.39, 354.294 ], "priority": 1, "parents": [ 240 ], "children": [], "area": 56919.029127999995, "iscrowd": 0, "segmentation": [], "text": "Inequities in access to maternal and child\nhealthcare and poor outcomes in rural Sierra\nLeone: findings of mixed methods study" }, { "id": 242, "strid": "c6981e0b-3e98-4de6-afbb-62f69d1ee8e9", "image_id": 12, "image_name": "10639.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 89.407, 554.163, 3194.517, 266.547 ], "priority": 2, "parents": [ 240 ], "children": [], "area": 49546.051341, "iscrowd": 0, "segmentation": [], "text": "J Elston (1), K Danis (2), N Gray (3), K West (4) B Stringer (4) K Lokuge (5), B Back (6) A.S Jimmisa (7) A Biankoe (7), MO Sanko (7),\nA | Carrion Martin (8), D S Kazungu (8) | Ait-Bouziad (4) P Masters (4) S Sang (8), R J Southgate (4), G Caleo (4)\n\n1. Field Epidemiology Training Programme (FETP), Public Health England, UK; 2.European Programme for Interventional Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC),\nStockholm, Sweden; 3.Médecins Sans Frontiéres (MSF), London, UK; 4. MSF, London, UK; 5. National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National\nUniversity, Canberra, Australia; 6. The Royal Free Hospital, London; 7.District Health Management Team, Ministry of Health and Sanitation, Tonkolili, Sierra Leone; 8.MSF, Amsterdam, The Netherlands" }, { "id": 243, "strid": "2c9e89d7-d47b-4dfb-8330-5f138584ce79", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 72.029, 917.894, 318.392, 55.807000000000016 ], "priority": 3, "parents": [ 240 ], "children": [ 244 ], "area": 66114.986926, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 244, "strid": "cdfe346c-fb0c-4254-9c7b-d2eb2ef247c1", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 68.409, 983.178, 1314.063, 640.6550000000001 ], "priority": 4, "parents": [ 243 ], "children": [], "area": 67258.22380200001, "iscrowd": 0, "segmentation": [] }, { "id": 245, "strid": "33e9ca0e-6787-49a4-96dc-4f754853aaed", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 72.158, 1755.351, 102.10699999999999, 43.99299999999994 ], "priority": 5, "parents": [ 240 ], "children": [ 246 ], "area": 126662.61745800001, "iscrowd": 0, "segmentation": [], "text": "Aim" }, { "id": 246, "strid": "475353b3-382e-4f70-9912-ffec4d972cb9", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 74.034, 1818.308, 1337.167, 261.22199999999975 ], "priority": 6, "parents": [ 245 ], "children": [], "area": 134616.61447200002, "iscrowd": 0, "segmentation": [] }, { "id": 247, "strid": "a7e816fe-4e6a-4a94-b931-172aeb99da57", "image_id": 12, "image_name": "10639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 117.554, 2162.36, 1233.386, 786.114 ], "priority": 7, "parents": [ 240 ], "children": [ 248 ], "area": 254194.06744, "iscrowd": 0, "segmentation": [] }, { "id": 248, "strid": "0b9c5b17-2814-47c8-988a-b9e259fd4aca", "image_id": 12, "image_name": "10639.png", "category_id": 6, "category_name": "Caption", "bbox": [ 33.069, 2103.176, 1314.708, 51.503999999999905 ], "priority": 8, "parents": [ 247 ], "children": [], "area": 69549.927144, "iscrowd": 0, "segmentation": [], "text": "Figure 1: A caregiver and her children in Tonkolili © James Elston" }, { "id": 249, "strid": "220c981d-11e2-4eef-b931-014476c3064a", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 79.284, 3041.111, 193.459, 46.92399999999998 ], "priority": 9, "parents": [ 240 ], "children": [ 250 ], "area": 241111.44452400002, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 250, "strid": "e6426b74-8f3e-4cce-8556-63b725228824", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 79.358, 3102.109, 1321.079, 634.098 ], "priority": 10, "parents": [ 249 ], "children": [], "area": 246177.16602200002, "iscrowd": 0, "segmentation": [] }, { "id": 251, "strid": "257384b0-2a09-4af3-94db-a4cd404476e8", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 82.047, 3825.947, 196.244, 49.447000000000116 ], "priority": 11, "parents": [ 240 ], "children": [ 253, 257, 254, 258, 255, 252, 259 ], "area": 313907.473509, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 252, "strid": "dfadad16-cb0c-47a7-965f-8b5579b74866", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 81.017, 3888.014, 1319.882, 158.38599999999997 ], "priority": 12, "parents": [ 251 ], "children": [], "area": 314995.230238, "iscrowd": 0, "segmentation": [] }, { "id": 253, "strid": "04780134-756d-4d5c-ad79-d886d69402d8", "image_id": 12, "image_name": "10639.png", "category_id": 7, "category_name": "Table", "bbox": [ 73.291, 4068.29, 1352.074, 536.9660000000003 ], "priority": 13, "parents": [ 251 ], "children": [], "area": 298169.04238999996, "iscrowd": 0, "segmentation": [] }, { "id": 254, "strid": "22bb2f42-8906-4dc4-a20c-0d3718d74f49", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 88.645, 4610.196, 1274.339, 107.47599999999966 ], "priority": 14, "parents": [ 251 ], "children": [], "area": 408670.82441999996, "iscrowd": 0, "segmentation": [] }, { "id": 255, "strid": "85e7ec1f-7971-46c9-8890-1f9865f8c23a", "image_id": 12, "image_name": "10639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1534.43, 951.269, 1627.361, 880.788 ], "priority": 15, "parents": [ 251 ], "children": [ 256 ], "area": 1459655.69167, "iscrowd": 0, "segmentation": [] }, { "id": 256, "strid": "3c2f475a-c672-41de-9cd5-66c08f0c61e0", "image_id": 12, "image_name": "10639.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1617.918, 894.97, 1258.6900000000003, 50.58899999999994 ], "priority": 16, "parents": [ 255 ], "children": [], "area": 1447988.07246, "iscrowd": 0, "segmentation": [], "text": "Figure 2: Place of birth and availability of skilled assistance" }, { "id": 257, "strid": "aa773322-7ee5-4188-a6e2-234b4f19d828", "image_id": 12, "image_name": "10639.png", "category_id": 4, "category_name": "List", "bbox": [ 1535.879, 1838.975, 1695.967, 270.1700000000001 ], "priority": 17, "parents": [ 251 ], "children": [], "area": 2824443.0840249998, "iscrowd": 0, "segmentation": [] }, { "id": 258, "strid": "114e2023-c1aa-4250-b932-bf5c74a8f45c", "image_id": 12, "image_name": "10639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1495.789, 2102.172, 1790.0910000000001, 702.4410000000003 ], "priority": 18, "parents": [ 251 ], "children": [], "area": 3144405.753708, "iscrowd": 0, "segmentation": [] }, { "id": 259, "strid": "3819ccff-e8ba-4a05-801f-2457577ac8e7", "image_id": 12, "image_name": "10639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1511.807, 2935.777, 1799.517, 966.9650000000001 ], "priority": 19, "parents": [ 251 ], "children": [ 260 ], "area": 4438328.219039001, "iscrowd": 0, "segmentation": [] }, { "id": 260, "strid": "412f6dee-3883-4ea4-a043-d22b4d89a82d", "image_id": 12, "image_name": "10639.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1631.851, 2832.352, 1419.4630000000002, 50.070000000000164 ], "priority": 20, "parents": [ 259 ], "children": [], "area": 4621976.443552, "iscrowd": 0, "segmentation": [], "text": "Figure 3: Summary of barriers from survey and in depth-interviews" }, { "id": 261, "strid": "f96ef1b3-d386-4f17-a6b5-df7ee2ebc499", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 1518.767, 4023.438, 904.8150000000003, 50.153999999999996 ], "priority": 21, "parents": [ 240 ], "children": [ 262 ], "area": 6110664.860946001, "iscrowd": 0, "segmentation": [], "text": "Conclusion and recommendations" }, { "id": 262, "strid": "408dbfec-dfb2-4341-bdf5-160702da492d", "image_id": 12, "image_name": "10639.png", "category_id": 3, "category_name": "Text", "bbox": [ 1515.387, 4082.374, 1778.8820000000003, 368.3289999999997 ], "priority": 22, "parents": [ 261 ], "children": [], "area": 6186376.488737999, "iscrowd": 0, "segmentation": [], "text": "Health outcomes are poor in both areas and under5 mortality rate rurally is close to the\nemergency threshold. A high proportion of women give birth at home without assistance.\nFindings indicate inequity in access to maternal and child healthcare. Focus must be given\nto improving healthcare delivered at primary healthcare level in rural Sierra Leone.\nHealthcare has to be accessible, free of charge and of good quality. To further increase\naccessibility community health worker networks need to be strengthened, along with\nmaternal death surveillance" }, { "id": 263, "strid": "e9dfdb09-2c32-4dc2-b043-c24cf8868b88", "image_id": 12, "image_name": "10639.png", "category_id": 5, "category_name": "Section", "bbox": [ 1516.904, 4588.237, 519.4670000000001, 57.1840000000002 ], "priority": 23, "parents": [ 240 ], "children": [ 264 ], "area": 6959915.058248, "iscrowd": 0, "segmentation": [], "text": "Acknowledgements" }, { "id": 264, "strid": "1a4b6e50-726a-41e4-9a20-9901ce665038", "image_id": 12, "image_name": "10639.png", "category_id": 3, "category_name": "Text", "bbox": [ 1517.067, 4653.417, 1759.7960000000003, 99.83399999999983 ], "priority": 24, "parents": [ 263 ], "children": [], "area": 7059545.367939001, "iscrowd": 0, "segmentation": [], "text": "We would like to thank the our study teams and colleagues in the project for their support,\nand, most importantly, the communities of Tonkolili for participating in this study." }, { "id": 265, "strid": "305ce5be-7b82-4912-b306-f56c688a3e32", "image_id": 13, "image_name": "10655.png", "category_id": 9, "category_name": "Root", "bbox": [ 65.31, 61.17, 244.49, 220.03999999999996 ], "priority": -1, "parents": [], "children": [ 289, 268, 277, 273, 267, 270, 281, 266 ], "area": 3995.0127, "iscrowd": 0, "segmentation": [] }, { "id": 266, "strid": "a253fb5f-46ea-44bb-9d39-73f521d30e08", "image_id": 13, "image_name": "10655.png", "category_id": 1, "category_name": "Title", "bbox": [ 563.369, 98.581, 2275.566, 88.509 ], "priority": 1, "parents": [ 265 ], "children": [], "area": 55537.47938900001, "iscrowd": 0, "segmentation": [], "text": "ls Oxford Nanopore Technology Ready for Clinical Diagnostics?" }, { "id": 267, "strid": "9fd39cfc-a54d-4aaf-a163-dcb82db7b16d", "image_id": 13, "image_name": "10655.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 916.662, 197.456, 1567.5400000000002, 138.547 ], "priority": 2, "parents": [ 265 ], "children": [], "area": 181000.411872, "iscrowd": 0, "segmentation": [], "text": "GR Taylor, Kesia Brown, Andrew Bond & Michael Yau\nViapath Clinical Genetics Labs, Guy’s Hospital, London UK" }, { "id": 268, "strid": "36eb4459-6f00-4ce7-9931-3493f0a74775", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 81.79, 482.665, 237.42699999999996, 49.541 ], "priority": 3, "parents": [ 265 ], "children": [ 269 ], "area": 39477.17035000001, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 269, "strid": "2d24dc61-6c55-4328-abd5-df665c5bff75", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 75.358, 545.064, 1482.146, 895.5950000000001 ], "priority": 4, "parents": [ 268 ], "children": [], "area": 41074.932912, "iscrowd": 0, "segmentation": [], "text": "Bridging the “valley of death” between scientific and technological\ninnovation and clinical implementation is a cultural challenge for many\norganizations, including the NHS. Nanopore sequencing is a good\nexample of a potentially disruptive genomics technology that looks likely\nto converge with mainstream clinical genomics in the near future. Since\nthe technology is packaged in a range of products from the relatively\nsmall scale (Gigabase) O.N. Minion to the Terabase-scale Promethion,\nservice developers have the opportunity to cross the valley of death\nusing a “rope bridge” prior to investing in major infrastructure.\n\nOur objective is to validate diagnostic services using Oxford Nanopore’s\nMinion in the first instance and to evaluate the cost and performance\ncompared to existing sequencing technology in areas such as tumour\nDNA sequencing (and circulating tumour DNA), virology, microbiology,\ngenetics and HLA-typing. To facilitate this we are developing R&D\ncollaborations and securing grant funding and commercial backing." }, { "id": 270, "strid": "f01549dc-12bf-494e-b7a5-dd91b94f82d8", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 78.313, 1486.538, 184.824, 43.791999999999916 ], "priority": 5, "parents": [ 265 ], "children": [ 271, 272 ], "area": 116415.250394, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 271, "strid": "5bf9cd92-d37f-4b97-add7-cfb738e348ee", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 72.528, 1546.1, 1489.75, 1253.518 ], "priority": 6, "parents": [ 270 ], "children": [], "area": 112135.5408, "iscrowd": 0, "segmentation": [], "text": "The scale of the Minion enables direct access to small genomes, but for\nGigabase genomes, enrichment in required to target the sequencing\ncapacity to the region of interest. In the studies reported here we used\nlong PCR to generate fragments in the range 3.5 to 16 Kb. Barcode and\nsequencing adapters were added by ligation. Targets were the HLA-B\nlocus, BRCA1, BRCA2, SMN1 and LDLR. The reads (2D and 1D) were\ncalled locally and converted to fastq using Poretools (Loman et al.).\nBarcode sorting used EPI2Z2ME. Fastq read length was measured using\nAWK; cat bc12.fastq | awk '{if(NR9%64==2) print length($1)}! | sort -n | uniq -c > bc12_length.txt\n\nand plotted using R:\nreads<-read.csv(file=\"bc12_length.txt\", sep=\"\", header=FALSE)\nplot (reads$V2,reads$V1,type=\"I\",xlab=\"bc12 (bases)\",ylab=\"occurences\",col=\"blue\", xlim=c(0,18000), ylim=c(0,100))\n\nRead mapping used either BWA, BLAT or GraphSeq. We selected a\ngenomic region including BRAF and and aligned reads of length 200\nbases to 200 kilobases with simulated error rates of phred 10 to phred\n40 to hg19 using GraphSeq, BLAT and BWA. FASTA files of length 200kbp\nto 200bp were generated from hg19 using samtools faidx, with starting\npositions of chr7: 140431813 (BRAF). We simulated error rates the\nrange phred 10 to phred 40 and examined the effect of error rate and\nread length on the ability to identify a point mutation.\n\nSamples\n\nThis presentation reports a series of BRCA1 and BRCA2 cases:" }, { "id": 272, "strid": "0240aacb-77ef-497f-b1a2-0b827a2e6531", "image_id": 13, "image_name": "10655.png", "category_id": 7, "category_name": "Table", "bbox": [ 72.167, 2820.603, 1472.992, 821.5889999999999 ], "priority": 7, "parents": [ 270 ], "children": [], "area": 203554.45670100002, "iscrowd": 0, "segmentation": [] }, { "id": 273, "strid": "024c33e9-ba4f-40e4-a675-99df764b29b8", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 79.014, 3734.909, 418.325, 53.32999999999993 ], "priority": 8, "parents": [ 265 ], "children": [ 274, 275 ], "area": 295110.099726, "iscrowd": 0, "segmentation": [], "text": "Sequenced products" }, { "id": 274, "strid": "f4a15d35-ba10-4ac7-b4af-3f3da41de2d2", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 76.785, 3795.622, 1476.98, 240.48799999999983 ], "priority": 9, "parents": [ 273 ], "children": [], "area": 291446.83527, "iscrowd": 0, "segmentation": [], "text": "The product size distribution for the BRCA1 and BRCA2 series was as\nexpected, with some small products also sequenced. Most products\nwere unique is length and in content, indicating that sequencing errors\nare common." }, { "id": 275, "strid": "69ab00b9-016f-44c5-bd45-e69bc0e38750", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 61.549, 4128.328, 1488.7, 345.35199999999986 ], "priority": 10, "parents": [ 273 ], "children": [ 276 ], "area": 254094.46007200002, "iscrowd": 0, "segmentation": [] }, { "id": 276, "strid": "409893c4-02d9-4f37-bf9f-bdc10b1c0c14", "image_id": 13, "image_name": "10655.png", "category_id": 6, "category_name": "Caption", "bbox": [ 271.055, 4537.171, 1063.765, 82.6890000000003 ], "priority": 11, "parents": [ 275 ], "children": [], "area": 1229822.885405, "iscrowd": 0, "segmentation": [], "text": "Figure 1\nRead length: pooled BRCA1 & BRCA2 (green) BRCA2 (blue) and BRCA1 (purple)" }, { "id": 277, "strid": "d9125b28-8762-4e5a-a7a3-c7564fc0514d", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 1685.395, 462.73, 453.3960000000002, 48.488999999999976 ], "priority": 12, "parents": [ 265 ], "children": [ 279, 278 ], "area": 779882.82835, "iscrowd": 0, "segmentation": [], "text": "Results: read mapping" }, { "id": 278, "strid": "f5096d6b-9a09-4cd8-89fb-baba2a7a79ab", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 1680.006, 521.422, 1482.689, 296.48199999999997 ], "priority": 13, "parents": [ 277 ], "children": [], "area": 875992.0885320001, "iscrowd": 0, "segmentation": [], "text": "Each tool successfully mapped synthetic reads with error rates of up to\n10%, but the genomic indexes used by GraphMap were rather large, and\nso in further studies we used BWA or BLAT. Using the mpileup consensus\noption it was possible to call the variants in NA12878 correctly with no\nfalse positives using read depths of 500 with 2D reads (figure 2)" }, { "id": 279, "strid": "dd499f56-7146-49dc-b911-11a1e736bae3", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1679.745, 876.352, 1619.821, 151.3470000000001 ], "priority": 14, "parents": [ 277 ], "children": [ 280 ], "area": 1472047.8902399999, "iscrowd": 0, "segmentation": [] }, { "id": 280, "strid": "3b5c10f6-c994-48b4-b0f9-bcdad2ff9225", "image_id": 13, "image_name": "10655.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2014.286, 1045.229, 914.509, 78.88699999999994 ], "priority": 15, "parents": [ 279 ], "children": [], "area": 2105390.1414940003, "iscrowd": 0, "segmentation": [], "text": "Figure 2\nHigh sensitivity and specificty achieved using mpileup re-alignmant" }, { "id": 281, "strid": "1b06ba55-9b87-4165-96e3-6ee29e41beda", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 1733.304, 1139.611, 456.797, 50.30799999999999 ], "priority": 16, "parents": [ 265 ], "children": [ 282, 283, 287, 285 ], "area": 1975292.3047440003, "iscrowd": 0, "segmentation": [], "text": "Results: variant calling" }, { "id": 282, "strid": "313b0e0f-52ce-4b96-a37e-ad37f78a6ba0", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 1725.876, 1201.329, 1494.28, 409.05399999999986 ], "priority": 17, "parents": [ 281 ], "children": [], "area": 2073344.889204, "iscrowd": 0, "segmentation": [], "text": "Variant identification protocols are in development: in a small control\nseries using 1D reads there is evidence or recurrent false postives\ncaused by insertions or deletions being reported non-randomly. We are\nable to identify true positives, but although the accuracy of 1D reads is\nof the order of 95%, the errors appear to be less random that seen with\n2D reads, and so consensus reads are not able to remove all of the\nerrors." }, { "id": 283, "strid": "4ad9ffe2-f578-4c22-9917-3b4737db851b", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1672.95, 1620.976, 1592.6410000000003, 760.3960000000002 ], "priority": 18, "parents": [ 281 ], "children": [ 284 ], "area": 2711811.7992000002, "iscrowd": 0, "segmentation": [] }, { "id": 284, "strid": "3fe1639d-d57a-458c-a276-c5795bce5530", "image_id": 13, "image_name": "10655.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2102.535, 2416.536, 701.8670000000002, 76.60500000000002 ], "priority": 19, "parents": [ 283 ], "children": [], "area": 5080851.518759999, "iscrowd": 0, "segmentation": [], "text": "Figure 3\nVisualisation of the E1493fs variant in a BRCA2 case" }, { "id": 285, "strid": "e892ad8e-d754-42ee-a7f1-bc7c66682895", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1664.967, 2529.061, 1588.65, 467.0149999999999 ], "priority": 20, "parents": [ 281 ], "children": [ 286 ], "area": 4210803.105987, "iscrowd": 0, "segmentation": [] }, { "id": 286, "strid": "9c7f7560-92cc-4f20-8875-61396c167b81", "image_id": 13, "image_name": "10655.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2280.59, 3008.672, 391.3069999999998, 80.7460000000001 ], "priority": 21, "parents": [ 285 ], "children": [], "area": 6861547.2764800005, "iscrowd": 0, "segmentation": [], "text": "Figure 4\nExon 13-14 deletion in LDLR" }, { "id": 287, "strid": "e560b031-674c-4163-b8d3-64a2173a51af", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1672.95, 3099.857, 1572.6829999999998, 467.0149999999999 ], "priority": 22, "parents": [ 281 ], "children": [ 288 ], "area": 5185905.76815, "iscrowd": 0, "segmentation": [] }, { "id": 288, "strid": "046dacb9-8010-4da6-80f5-f56915277bd4", "image_id": 13, "image_name": "10655.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2313.716, 3617.371, 318.183, 71.83800000000019 ], "priority": 23, "parents": [ 287 ], "children": [], "area": 8369569.160635999, "iscrowd": 0, "segmentation": [], "text": "Figure 5\nExon 7 deletion in LDLR" }, { "id": 289, "strid": "d1ea3489-e80c-4cc6-a1bd-6f72df23a970", "image_id": 13, "image_name": "10655.png", "category_id": 5, "category_name": "Section", "bbox": [ 1768.924, 3734.546, 1028.118, 52.21399999999994 ], "priority": 24, "parents": [ 265 ], "children": [ 290, 291 ], "area": 6606128.048504, "iscrowd": 0, "segmentation": [], "text": "Results: improving Q-scores using consensus reads" }, { "id": 290, "strid": "bfc5e611-01e8-417e-b1b4-6812f2bf8bf2", "image_id": 13, "image_name": "10655.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1716.554, 3812.147, 1462.212, 514.0039999999999 ], "priority": 25, "parents": [ 289 ], "children": [], "area": 6543756.181438, "iscrowd": 0, "segmentation": [] }, { "id": 291, "strid": "3fb2b970-bce2-4777-a1fe-6148d66cc1cd", "image_id": 13, "image_name": "10655.png", "category_id": 3, "category_name": "Text", "bbox": [ 1747.433, 4414.932, 1485.493, 234.10300000000007 ], "priority": 26, "parents": [ 289 ], "children": [], "area": 7714797.8695559995, "iscrowd": 0, "segmentation": [], "text": "In conclusion, random error rates are tractable by either consensus\nalignment and oversequencing. Provided systematic errors can be\navoided, as with 2D sequencing, nanopore sequencing can deliver\nunique tools for clinical use and point of care testing." }, { "id": 292, "strid": "b3719a1e-cb7d-4fd1-9594-5e46f90db913", "image_id": 14, "image_name": "10723.png", "category_id": 9, "category_name": "Root", "bbox": [ 58.38, 65.08, 71.80000000000001, 71.79 ], "priority": -1, "parents": [], "children": [ 307, 304, 305, 293, 301, 294, 295, 316 ], "area": 3799.3704000000002, "iscrowd": 0, "segmentation": [] }, { "id": 293, "strid": "481c0d30-a2d5-4180-bd32-9fbdfd50af75", "image_id": 14, "image_name": "10723.png", "category_id": 1, "category_name": "Title", "bbox": [ 140.332, 109.734, 4196.432, 304.542 ], "priority": 1, "parents": [ 292 ], "children": [], "area": 15399.191687999999, "iscrowd": 0, "segmentation": [], "text": "The Role of Exercises in Osteoporotic Fracture Prevention and Current Care Gaps\nWhere Are We Now? Recent Updates" }, { "id": 294, "strid": "5e36c5f4-598b-4e66-b442-2eb1bd5c0e64", "image_id": 14, "image_name": "10723.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 1559.874, 495.12, 1348.82, 468.27 ], "priority": 2, "parents": [ 292 ], "children": [], "area": 772324.81488, "iscrowd": 0, "segmentation": [], "text": "Helen Senderovich (MD MCFP (COE), (PC))!:2>\",\nHenry Tang\", Samuel Belmont (BMSc)\"\n\n'Baycrest Health Sciences, Faculty of Medicine,\nUniversity of Toronto, Toronto, Canada;\n3Department of Family and Community Medicine,\nDivision of Palliative Care." }, { "id": 295, "strid": "64f56b67-8331-4440-ab43-ea2d42d296ba", "image_id": 14, "image_name": "10723.png", "category_id": 5, "category_name": "Section", "bbox": [ 657.201, 485.776, 269.418, 57.13500000000005 ], "priority": 3, "parents": [ 292 ], "children": [ 297, 296, 298, 300, 299 ], "area": 319252.472976, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 296, "strid": "808f954b-c267-44c5-94d7-f4dc98844dec", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 95.127, 610.602, 1370.511, 207.663 ], "priority": 4, "parents": [ 295 ], "children": [], "area": 58084.736454, "iscrowd": 0, "segmentation": [], "text": "Introduction\nThe primary non-pharmacological management recommended for patients\n\nwith osteoporosis (OP) is exercise, but whether it should be high force, resistive,\nor other means can be obscure." }, { "id": 297, "strid": "f98b4e33-4f69-4845-a738-0d8901cb2576", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 96.079, 859.365, 1390.498, 215.24299999999994 ], "priority": 5, "parents": [ 295 ], "children": [], "area": 82566.92983499999, "iscrowd": 0, "segmentation": [], "text": "Objective\n\nTo describe the role of exercises in osteoporotic fracture prevention, identify\neffects and potential risks of high-force exercises, detect the optimal exercises to\ncombat OP, and explore the challenges that might arise from interventions." }, { "id": 298, "strid": "45361919-c939-4b7a-af3f-ab9c605aae9d", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 97.243, 1109.142, 1381.711, 381.9200000000001 ], "priority": 6, "parents": [ 295 ], "children": [], "area": 107856.295506, "iscrowd": 0, "segmentation": [], "text": "Methods\n\nA MEDLINE, and a Cochrane databases search was conducted on the role of\nexercises in preventing osteoporotic fractures from 1989 onwards, leading to 40\nresults, including op-ed pieces, qualitative studies, randomized clinical trials\n(RCTs) (n = 5),and RCT follow up studies (n = 1). Articles deemed relevant to the\nobjective hands were analyzed and summarized. Data on effects of Vitamin D\nand Calcium supplementation was later gathered from different sources as well." }, { "id": 299, "strid": "43cceeed-978a-42ae-a4e4-a38b200a18ec", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 98.246, 1526.533, 1381.801, 437.23 ], "priority": 7, "parents": [ 295 ], "children": [], "area": 149975.761118, "iscrowd": 0, "segmentation": [], "text": "Results\n\nHigh-intensity, resistive strength training provided the maximum benefit in\nincreasing Bone Mineral Density (BMD) levels, muscle mass and reduction in\nfracture, while posture and balance exercises only improved mobility. High force\nexercises did not increase fractures, and were associated with increases in BMD.\nInterventions including exercises, Vitamin D and calcium intake had limited\neffect when used as single interventions, while Vitamin D and calcium intake\nmay potentially cause increases of Cardiovascular events." }, { "id": 300, "strid": "3bc84ec6-001a-43b1-a000-615f181cf27e", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 96.957, 1998.297, 1379.458, 214.88799999999992 ], "priority": 8, "parents": [ 295 ], "children": [], "area": 193748.88222899998, "iscrowd": 0, "segmentation": [], "text": "Conclusion\n\nA long term regular exercise programme designed to improve postural stability,\nmobility, and mechanical efficiency, alongside Vitamin D and dietary Calcium\nintake is most effective in preventing OP and reducing osteoporotic fractures." }, { "id": 301, "strid": "3af219cd-6fa4-4acd-980c-a04a72a651e4", "image_id": 14, "image_name": "10723.png", "category_id": 5, "category_name": "Section", "bbox": [ 603.445, 2273.281, 380.0880000000001, 69.2170000000001 ], "priority": 9, "parents": [ 292 ], "children": [ 303, 302 ], "area": 1371800.0530450002, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 302, "strid": "f6081eba-6a8b-4f3f-805f-8a91b79affa4", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 97.357, 2399.11, 1356.741, 154.3420000000001 ], "priority": 10, "parents": [ 301 ], "children": [], "area": 233570.15227000002, "iscrowd": 0, "segmentation": [], "text": "Osteoporosis (OP) is an incurable weakening of bone structure due to loss of\ntissue from mineral deficiency in the elderly.' It is the leading cause of death in\nthe elderly due to its high incidence rate.”" }, { "id": 303, "strid": "2d5ec061-dcd7-40c3-ab18-c1443712e256", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 93.992, 2566.983, 1394.173, 696.058 ], "priority": 11, "parents": [ 301 ], "children": [], "area": 241275.86613600003, "iscrowd": 0, "segmentation": [] }, { "id": 304, "strid": "53b1b433-fb91-4b2d-b95e-0aa866e1c1c8", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1586.608, 1090.375, 1300.206, 1330.591 ], "priority": 12, "parents": [ 292 ], "children": [], "area": 1729997.6979999999, "iscrowd": 0, "segmentation": [] }, { "id": 305, "strid": "ebce571f-98e7-4955-8c16-595e1f57f4a8", "image_id": 14, "image_name": "10723.png", "category_id": 5, "category_name": "Section", "bbox": [ 1788.37, 2520.219, 900.19, 70.5039999999999 ], "priority": 13, "parents": [ 292 ], "children": [ 306 ], "area": 4507084.05303, "iscrowd": 0, "segmentation": [], "text": "Effects of High Force Exercise" }, { "id": 306, "strid": "20e34a89-1ffe-4f22-bfc6-b84a63de9276", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 1546.073, 2644.905, 1373.927, 488.4850000000001 ], "priority": 14, "parents": [ 305 ], "children": [], "area": 4089216.2080650004, "iscrowd": 0, "segmentation": [], "text": "The immediate step to take for anybody to strengthen bone health is to\nundergo regular vigorous exercise. Among other things, it has been found that\nexercises may help to maintain mobility, physicality, BMD, muscle, strength and\nbalance.’ Together, these benefits have attributed to a small but statistically\nsignificant reduction in falls, particularly when the exercise program specifically\ninvolves balance and lower body strength training, which is may be associated\nwith a reduction up to 40% in hip fractures.* Despite concern from many\nosteoporotic patients that exercise increases the risk of fractures, data suggests\ninjury rate actually decline, and severe damage is non-existent.'*" }, { "id": 307, "strid": "d6764540-99a7-442c-98c6-e9c490953470", "image_id": 14, "image_name": "10723.png", "category_id": 5, "category_name": "Section", "bbox": [ 3268.661, 483.976, 836.1869999999999, 70.005 ], "priority": 15, "parents": [ 292 ], "children": [ 311, 313, 310, 309, 314, 308, 315, 312 ], "area": 1581953.4761360001, "iscrowd": 0, "segmentation": [], "text": "Effective Types of Exercises" }, { "id": 308, "strid": "e213c49f-f372-466a-a42c-f08a115a6432", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 2986.933, 608.679, 908.9749999999999, 436.94999999999993 ], "priority": 16, "parents": [ 307 ], "children": [], "area": 1818083.391507, "iscrowd": 0, "segmentation": [], "text": "Strength Training\n\nThe most effective form of exercise,6 strength\ntraining increases muscle mass, which is often an\nissue in the elderly; by age 70 people are expected\nto lose between 50%-55% of their max muscle mass.\nStrength training may also increase BMD in certain\nparts of the body, including the spine and hip bone,\nreducing fracture risk.”" }, { "id": 309, "strid": "f8053d35-aa10-43fe-a586-d199c42484b9", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3930.699, 615.729, 437.9050000000002, 437.72900000000004 ], "priority": 17, "parents": [ 307 ], "children": [], "area": 2420245.364571, "iscrowd": 0, "segmentation": [] }, { "id": 310, "strid": "0316c337-da91-4edc-81d7-5825bef6515e", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2987.287, 1103.82, 458.52, 443.49199999999996 ], "priority": 18, "parents": [ 307 ], "children": [], "area": 3297427.1363399997, "iscrowd": 0, "segmentation": [] }, { "id": 311, "strid": "d97a3d22-4a6a-4c45-85ce-aa66ff48c2cf", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 3477.59, 1123.036, 913.8429999999998, 430.568 ], "priority": 19, "parents": [ 307 ], "children": [], "area": 3905458.7632400002, "iscrowd": 0, "segmentation": [], "text": "Posture Training\n\nPosture training involves proper alignment and\npositioning of various body parts, especially the\nspine. The aim of posture training is to strengthen\nmuscles along the back and the hip, the areas most\naffected by OP, and improve alignment of the spine\nSo small twists and loads upon the vertebrae will not\nresult in fractures.®" }, { "id": 312, "strid": "e3951385-e996-41cd-9f36-c99c177101e1", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 2989.502, 1630.189, 886.9699999999998, 319.73299999999995 ], "priority": 20, "parents": [ 307 ], "children": [], "area": 4873453.275878, "iscrowd": 0, "segmentation": [], "text": "Balance Training\n\nBalance training exercises are those that work to\nimprove balance and reduce falls, by enhancing leg\nmuscles. Results have demonstrated greater\nmobility, and improved functional and static\nbalance.?" }, { "id": 313, "strid": "c040dcdd-2acb-4407-9fd6-16f3ac22bbb2", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3937.822, 1565.24, 440.3069999999998, 445.876 ], "priority": 21, "parents": [ 307 ], "children": [], "area": 6163636.5072800005, "iscrowd": 0, "segmentation": [] }, { "id": 314, "strid": "24ee684a-7686-4dd8-a774-3e763b9cc926", "image_id": 14, "image_name": "10723.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2982.438, 2038.082, 429.90200000000004, 417.26700000000005 ], "priority": 22, "parents": [ 307 ], "children": [], "area": 6078453.203916, "iscrowd": 0, "segmentation": [] }, { "id": 315, "strid": "b8f56e6e-ab06-4057-91d9-d5f5fa2ca250", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 3473.984, 2035.192, 914.6380000000004, 375.97800000000007 ], "priority": 23, "parents": [ 307 ], "children": [], "area": 7070224.444928, "iscrowd": 0, "segmentation": [], "text": "Aerobic Training\n\nAerobic training is any physical activity that\nincreases heart and breathing rate, and can be\nperformed continuously for periods of time. The\npurpose of aerobic training is to strengthen the\nheart and lungs, and increase muscle mass and BMD,\nwhich reduces chance of fractures.!°" }, { "id": 316, "strid": "f958c879-b607-4e5d-a168-ba4124e9279b", "image_id": 14, "image_name": "10723.png", "category_id": 5, "category_name": "Section", "bbox": [ 3382.428, 2518.045, 605.355, 60.75799999999981 ], "priority": 24, "parents": [ 292 ], "children": [ 317, 318 ], "area": 8517105.91326, "iscrowd": 0, "segmentation": [], "text": "References/Contact" }, { "id": 317, "strid": "210fa55c-8d2a-42d0-9366-d2a41c64344b", "image_id": 14, "image_name": "10723.png", "category_id": 4, "category_name": "List", "bbox": [ 2993.758, 2648.017, 1383.0609999999997, 557.3049999999998 ], "priority": 25, "parents": [ 316 ], "children": [], "area": 7927522.077885999, "iscrowd": 0, "segmentation": [] }, { "id": 318, "strid": "d98ae117-9f7b-438d-8d9a-375efa46bea0", "image_id": 14, "image_name": "10723.png", "category_id": 3, "category_name": "Text", "bbox": [ 2993.868, 3242.723, 721.531, 31.744000000000142 ], "priority": 26, "parents": [ 316 ], "children": [], "area": 9708284.622564, "iscrowd": 0, "segmentation": [], "text": "For inquiry: please contact Dr. H. Senderovich at hsenderovich@baycrest.org" }, { "id": 319, "strid": "49d69896-b3ff-4b6a-8735-5e333e4a660f", "image_id": 15, "image_name": "10783.png", "category_id": 9, "category_name": "Root", "bbox": [ 9.03, 379.35, 267.58000000000004, 54.72999999999996 ], "priority": -1, "parents": [], "children": [ 331, 321, 326, 324, 322, 334, 320 ], "area": 3425.5305, "iscrowd": 0, "segmentation": [] }, { "id": 320, "strid": "e96472c0-2ed2-4056-b808-9cb044c87af9", "image_id": 15, "image_name": "10783.png", "category_id": 1, "category_name": "Title", "bbox": [ 966.0, 61.913, 1663.024, 77.88599999999998 ], "priority": 1, "parents": [ 319 ], "children": [], "area": 59807.958, "iscrowd": 0, "segmentation": [], "text": "Pernicious Anemia in African Americans" }, { "id": 321, "strid": "c1692af0-fe1c-4a34-8892-2b31fc6af124", "image_id": 15, "image_name": "10783.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 626.077, 175.137, 2370.001, 137.851 ], "priority": 2, "parents": [ 319 ], "children": [], "area": 109649.247549, "iscrowd": 0, "segmentation": [], "text": "ANTONY IRUNGU BSc *, UCHE IKE BSc *, ANITA LWANGA MD ?.\n1.ROSS UNIVERSITY SCHOOL OF MEDICINE, 2. DEPARTMENT OF INTERNAL MEDICINE AT MOUNT SINAI HOSPITAL" }, { "id": 322, "strid": "d8ff9206-e724-4ce0-9b3b-7ab918194d6f", "image_id": 15, "image_name": "10783.png", "category_id": 5, "category_name": "Section", "bbox": [ 520.224, 392.586, 223.13199999999995, 48.41500000000002 ], "priority": 3, "parents": [ 319 ], "children": [ 323 ], "area": 204232.65926400002, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 323, "strid": "8b2459d4-e52d-4b51-86c5-518931b127f4", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 89.469, 458.855, 1078.982, 589.931 ], "priority": 4, "parents": [ 322 ], "children": [], "area": 41053.297995, "iscrowd": 0, "segmentation": [], "text": "Pernicious anemia, an autoimmune disorder characterized\nby the inability to absorb Vitamin B12, can be caused by\ndecreased production of intrinsic factor (IF), antibodies\nagainst parietal cells, antibodies against IF, chronic atrophic\ngastritis or a gastrectomy. Traditionally pernicious anemia\nwas thought to affect elderly individuals of Northern\nEuropean descent, however, a study done at Cook County\nHospital, in between 1931 to 1942, found that 93 out of\n1000 patients diagnosed with pernicious anemia were\nAfrican American. Other studies have also demonstrate that\npernicious anemia affects individuals of all ethnic groups." }, { "id": 324, "strid": "65910a1a-24e4-4559-abf1-ae63d721c4b4", "image_id": 15, "image_name": "10783.png", "category_id": 5, "category_name": "Section", "bbox": [ 528.562, 1072.311, 198.67500000000007, 46.59500000000003 ], "priority": 5, "parents": [ 319 ], "children": [ 325 ], "area": 566782.8467819999, "iscrowd": 0, "segmentation": [], "text": "Objectives" }, { "id": 325, "strid": "ea183872-e326-4e82-b66a-0062117cf0ef", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 80.696, 1134.316, 1063.631, 162.28600000000006 ], "priority": 6, "parents": [ 324 ], "children": [], "area": 91534.763936, "iscrowd": 0, "segmentation": [], "text": "Our objective is to encourage clinicians to consider\npernicious anemia, in their differential, as a cause of\nVitamin B 12 deficiency in individuals of African descent." }, { "id": 326, "strid": "9ac6019c-20e5-445c-a326-48ae9d1a195d", "image_id": 15, "image_name": "10783.png", "category_id": 5, "category_name": "Section", "bbox": [ 518.214, 1343.479, 223.87599999999998, 42.89499999999998 ], "priority": 7, "parents": [ 319 ], "children": [ 330, 329, 327, 328 ], "area": 696209.6265060001, "iscrowd": 0, "segmentation": [], "text": "Case Report" }, { "id": 327, "strid": "9e8ee1da-1976-410e-8c22-c919c01e33b4", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 89.023, 1413.019, 1086.639, 904.1699999999998 ], "priority": 8, "parents": [ 326 ], "children": [], "area": 125791.190437, "iscrowd": 0, "segmentation": [], "text": "Mr. H a 73 year old African American male presented with\ncomplaints of bilateral lower extremity weakness, dizziness\nthat occurred for 1 or 2 minutes after stood up, frequent falls\nand burning sensation from his mid shins to the bottom of\nhis feet. He symptoms had progressed over the last year. He\ndenied, nausea, vomiting, chills, fevers, loss of\nconsciousness, spinning sensation, or tinnitus. He had a past\nmedical history of hypertension and iron deficiency anemia.\nHe did not take medications, have allergies, drink alcohol,\nsmoke or use recreational drugs. His diet consisted mostly\nhot dogs because of limited finances. His vital signs were\nwithin normal limits except for positive orthostatic blood\npressure. His physical exam was unremarkable except for\nchronic non healing lesions on his lower legs, weakness in\nhis hip, knees and ankles, loss of conscious proprioception,\nloss of sensation in his feet, ataxic gait, and a positive\nBabinski sign." }, { "id": 328, "strid": "bf802991-b7f4-4d8a-ac97-339461c5cc59", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 1247.401, 406.222, 1100.9130000000002, 271.9390000000001 ], "priority": 9, "parents": [ 326 ], "children": [], "area": 506721.729022, "iscrowd": 0, "segmentation": [], "text": "His hemoglobin was 7.6 mg/dL, his MCV was 114 um 3 ,\nhis Vitamin B 12 was < 50 pb/mL, while intrinsic factor was\npositive. His brain and neck MRI were negative for signs of\nmyelopathy. He was referred to a Gastroenterologist for an\nesophagogastroduodenoscopy but was lost to follow up." }, { "id": 329, "strid": "345805e1-7340-44c0-8a8b-181f64775e84", "image_id": 15, "image_name": "10783.png", "category_id": 7, "category_name": "Table", "bbox": [ 1318.894, 701.758, 958.258, 586.9559999999999 ], "priority": 10, "parents": [ 326 ], "children": [], "area": 925544.415652, "iscrowd": 0, "segmentation": [] }, { "id": 330, "strid": "75b5c233-b988-45ca-98d8-d277a31958bf", "image_id": 15, "image_name": "10783.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1237.839, 1326.252, 1121.8779999999997, 539.7539999999999 ], "priority": 11, "parents": [ 326 ], "children": [], "area": 1641686.4494279998, "iscrowd": 0, "segmentation": [] }, { "id": 331, "strid": "d9ca46e9-dc0d-453d-a676-b0624fe2a5c9", "image_id": 15, "image_name": "10783.png", "category_id": 5, "category_name": "Section", "bbox": [ 1706.574, 1906.56, 194.721, 40.64599999999996 ], "priority": 12, "parents": [ 319 ], "children": [ 333, 332 ], "area": 3253685.72544, "iscrowd": 0, "segmentation": [], "text": "Discussion" }, { "id": 332, "strid": "b467a86a-d021-4654-8d7d-009f745fd69b", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 1259.096, 1962.589, 1078.7490000000003, 371.1970000000001 ], "priority": 13, "parents": [ 331 ], "children": [], "area": 2471087.9595439998, "iscrowd": 0, "segmentation": [], "text": "In Caucasians, the average age of onset of pernicious\nanemia in is in the 60s, , while in those of African descent it\nis in the 50s, and has a female predominance. In our patient,\nand most individuals of African descent, pernicious anemia\nis caused by antibodies against IF, rather than antibodies\nagainst parietal cells, as is the case in individuals of\nEuropean descent." }, { "id": 333, "strid": "3b06253b-d8ee-4121-a097-19fc157875dc", "image_id": 15, "image_name": "10783.png", "category_id": 3, "category_name": "Text", "bbox": [ 2423.908, 417.434, 1067.9940000000001, 1004.99 ], "priority": 14, "parents": [ 331 ], "children": [], "area": 1011821.612072, "iscrowd": 0, "segmentation": [], "text": "African Americans with pernicious anemia demonstrate a\nlower incidence of anti-parietal cell antibodies with the\npresence of IF antibodies or absence anti-parietal cell\nantibodies compared to individuals of European descent.\nFailure to recognize and treat pernicious anemia can lead to\nirreversible neurological deficits and disability. One tragic\ncase, in the literature we reviewed, is that of a 29 year\nfemale whose macrocytosis and paresthesia were ignored\nfor 7 months. A diagnosis of pernicious anemia was\neventually made, after she developed subacute combined\ndegeneration. This was most likely due to outdated\ninformation regarding the racial incidence and age group\nthat is susceptible to pernicious anemia. In accurate\ninformation regarding pernicious anemia may cause\nclinicians to overlook this diagnosis in patients of African\ndescent, particularly young adults. Pernicious anemia is\ntreated with 1000 ug of intramuscular Vitamin B12 daily\nfor 7 days, then 1000 ug weekly for 4 weeks, then 1000 ug\nmonthly for life." }, { "id": 334, "strid": "71af0df9-d0d5-4a97-8b83-4ecc8719bb43", "image_id": 15, "image_name": "10783.png", "category_id": 5, "category_name": "Section", "bbox": [ 2852.197, 1439.12, 235.10199999999986, 44.31600000000003 ], "priority": 15, "parents": [ 319 ], "children": [ 335 ], "area": 4104653.74664, "iscrowd": 0, "segmentation": [], "text": "Bibliography" }, { "id": 335, "strid": "9ae447e9-34af-4dab-8ad2-3db68b9a7baa", "image_id": 15, "image_name": "10783.png", "category_id": 4, "category_name": "List", "bbox": [ 2425.204, 1511.246, 1089.3740000000003, 705.9989999999998 ], "priority": 16, "parents": [ 334 ], "children": [], "area": 3665079.8441840005, "iscrowd": 0, "segmentation": [] }, { "id": 336, "strid": "33311f05-58f0-4b72-a1f9-426509f593c7", "image_id": 16, "image_name": "10786.png", "category_id": 9, "category_name": "Root", "bbox": [ 418.18, 60.36, 160.54000000000002, 149.07999999999998 ], "priority": -1, "parents": [], "children": [ 341, 352, 343, 337, 339, 356, 354, 338, 345 ], "area": 25241.3448, "iscrowd": 0, "segmentation": [] }, { "id": 337, "strid": "ef86fb62-3575-4a30-bd7f-aaab0d78ba3a", "image_id": 16, "image_name": "10786.png", "category_id": 1, "category_name": "Title", "bbox": [ 655.057, 79.644, 2296.08, 258.989 ], "priority": 1, "parents": [ 336 ], "children": [], "area": 52171.359708, "iscrowd": 0, "segmentation": [], "text": "Merging two grape genome assemblies iteratively\nimproves the quality" }, { "id": 338, "strid": "d501b711-521a-4fd1-8b49-038d9547c5f6", "image_id": 16, "image_name": "10786.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 511.416, 349.515, 2570.304, 217.63800000000003 ], "priority": 2, "parents": [ 336 ], "children": [], "area": 178747.56324, "iscrowd": 0, "segmentation": [], "text": "Zhixiu LuS, Sagar Patel\", Anne Fennell*, and Erliang Zeng® *\n§ Department of Computer Science and * Department of Biology, University of South Dakota, Vermillion, SD, USA\n* Department of Agronomy, Horticulture, and Plant Science, South Dakota State University, Brookings, SD, USA" }, { "id": 339, "strid": "7baa8d9e-30b7-401e-b9a6-5797f7c807e1", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 774.932, 620.605, 271.87300000000005, 43.875999999999976 ], "priority": 3, "parents": [ 336 ], "children": [ 340 ], "area": 480926.67386000004, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 340, "strid": "4f9c800c-409e-4fab-b41d-1a94e057b36c", "image_id": 16, "image_name": "10786.png", "category_id": 4, "category_name": "List", "bbox": [ 63.406, 670.517, 1701.119, 219.05399999999997 ], "priority": 4, "parents": [ 339 ], "children": [], "area": 42514.800902, "iscrowd": 0, "segmentation": [] }, { "id": 343, "strid": "d104a084-b236-4593-8c3a-bae4b3799465", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 2593.165, 622.302, 201.23199999999997, 49.754999999999995 ], "priority": 5, "parents": [ 336 ], "children": [ 344 ], "area": 1613731.76583, "iscrowd": 0, "segmentation": [], "text": "Objective" }, { "id": 344, "strid": "19c3fcaf-83d7-494c-bc90-841b312580ba", "image_id": 16, "image_name": "10786.png", "category_id": 4, "category_name": "List", "bbox": [ 1843.463, 678.411, 1685.331, 242.735 ], "priority": 6, "parents": [ 343 ], "children": [], "area": 1250625.577293, "iscrowd": 0, "segmentation": [] }, { "id": 341, "strid": "c5d618d3-08b0-4ae6-9531-0d50ac2f2f66", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 491.62, 979.916, 851.1910000000001, 57.0379999999999 ], "priority": 7, "parents": [ 336 ], "children": [ 342 ], "area": 481746.30392000003, "iscrowd": 0, "segmentation": [], "text": "Workflow for Vitis vinifera cv. Sultanina" }, { "id": 342, "strid": "bdd6cebe-3289-4e3c-9f19-4ad4d10991a9", "image_id": 16, "image_name": "10786.png", "category_id": 2, "category_name": "Figure", "bbox": [ 57.826, 1057.509, 1711.863, 2088.164 ], "priority": 8, "parents": [ 341 ], "children": [], "area": 61151.515434, "iscrowd": 0, "segmentation": [] }, { "id": 345, "strid": "3fca6257-b85b-4348-8703-985a4744dcba", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 2614.173, 975.011, 163.63900000000012, 41.462999999999965 ], "priority": 9, "parents": [ 336 ], "children": [ 348, 346, 350 ], "area": 2548847.430903, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 346, "strid": "661a96a8-880a-4730-865b-498218a33f3f", "image_id": 16, "image_name": "10786.png", "category_id": 7, "category_name": "Table", "bbox": [ 1881.988, 1036.674, 1624.0509999999997, 783.6990000000001 ], "priority": 10, "parents": [ 345 ], "children": [ 347 ], "area": 1951008.027912, "iscrowd": 0, "segmentation": [] }, { "id": 347, "strid": "91d63564-5367-4b3d-ae8b-73c069a46594", "image_id": 16, "image_name": "10786.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1897.725, 1829.815, 1603.5930000000003, 113.30600000000004 ], "priority": 11, "parents": [ 346 ], "children": [], "area": 3472485.670875, "iscrowd": 0, "segmentation": [], "text": "Table 1. Comparison of published ALLPATHS-LG assembly with our PLATANUS assembly and merged assemblies by Assemblathon script. “Improved\nALLPATHS-LG assembly” was obtained using ALLPATHS-LG assembly as initial assembly, and then merged with PLATANUS assembly by MetaAssembler\niteratively till convergence. “Improved PLATANUS assembly” was obtained using PLATANUS assembly as initial assembly, and then merged with\nALLPATHS-LG assembly by MetaAssembler iteratively till convergence." }, { "id": 348, "strid": "1b69551c-6198-4321-bc45-57575e157fc0", "image_id": 16, "image_name": "10786.png", "category_id": 7, "category_name": "Table", "bbox": [ 1888.283, 1998.2, 1609.8870000000002, 682.9819999999997 ], "priority": 12, "parents": [ 345 ], "children": [ 349 ], "area": 3773167.0905999998, "iscrowd": 0, "segmentation": [] }, { "id": 349, "strid": "64ad1449-603f-471a-83c3-17d4fd4e952c", "image_id": 16, "image_name": "10786.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1886.709, 2692.198, 1608.314, 58.22699999999986 ], "priority": 13, "parents": [ 348 ], "children": [], "area": 5079394.196382, "iscrowd": 0, "segmentation": [], "text": "Table 2. Mapping results of mRNA, EST with > 90% identity and > 70% coverage. BAC with > 90% identity and > 90% coverage and reference genome with\n> 95% identity with published ALLPATHS-LG assembly, our PLATANUS assembly, and our merged PLATANUS assembly." }, { "id": 350, "strid": "e16b570c-a134-416b-ab38-f643049da07d", "image_id": 16, "image_name": "10786.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1886.709, 2794.488, 1598.872, 860.81 ], "priority": 14, "parents": [ 345 ], "children": [ 351 ], "area": 5272385.659992, "iscrowd": 0, "segmentation": [] }, { "id": 351, "strid": "f1a46350-5036-49e5-9a5d-2ba7b68c0b28", "image_id": 16, "image_name": "10786.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1896.151, 3664.74, 1598.872, 58.22699999999986 ], "priority": 15, "parents": [ 350 ], "children": [], "area": 6948900.41574, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Assembly QUAST cumulative length plot. Scaffolds lengths of published ALLPATHS-LG assembly, PLATANUS assembly, and their improved merged\nones are shown. On the x-axis, scaffolds are ordered from the largest to smallest. The y-axis gives the size of the x largest scaffolds in the assembly." }, { "id": 352, "strid": "3e027556-ade3-4e33-a9cc-f67f90f27bdd", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 2535.904, 3788.232, 246.82900000000018, 45.48999999999978 ], "priority": 16, "parents": [ 336 ], "children": [ 353 ], "area": 9606592.681728, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 353, "strid": "320cdf04-299d-4fe1-b7a7-0f4d6309c63a", "image_id": 16, "image_name": "10786.png", "category_id": 4, "category_name": "List", "bbox": [ 1838.295, 3886.028, 1682.136, 469.87000000000035 ], "priority": 17, "parents": [ 352 ], "children": [], "area": 7143665.84226, "iscrowd": 0, "segmentation": [] }, { "id": 356, "strid": "417f27a7-dd49-4c6c-8ac8-f045a3ca1d0a", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 773.685, 3242.702, 251.7539999999999, 50.35100000000011 ], "priority": 18, "parents": [ 336 ], "children": [ 357 ], "area": 2508829.89687, "iscrowd": 0, "segmentation": [], "text": "References" }, { "id": 357, "strid": "0c65884f-f689-4990-beed-6f243ccaaff2", "image_id": 16, "image_name": "10786.png", "category_id": 4, "category_name": "List", "bbox": [ 73.931, 3329.232, 1703.28, 662.5169999999998 ], "priority": 19, "parents": [ 356 ], "children": [], "area": 246133.450992, "iscrowd": 0, "segmentation": [] }, { "id": 354, "strid": "9dc8524f-081e-4583-a200-596e9b9e8c9b", "image_id": 16, "image_name": "10786.png", "category_id": 5, "category_name": "Section", "bbox": [ 695.992, 4146.348, 447.01800000000003, 50.96299999999974 ], "priority": 20, "parents": [ 336 ], "children": [ 355 ], "area": 2885825.037216, "iscrowd": 0, "segmentation": [], "text": "Acknowledgements" }, { "id": 355, "strid": "b485de99-c8cc-40a1-9d17-26ee88c1b4ec", "image_id": 16, "image_name": "10786.png", "category_id": 4, "category_name": "List", "bbox": [ 75.609, 4202.574, 1678.109, 157.6869999999999 ], "priority": 21, "parents": [ 354 ], "children": [], "area": 317752.41756599996, "iscrowd": 0, "segmentation": [] }, { "id": 358, "strid": "75eb142d-67f9-4d16-a40f-2218c6412586", "image_id": 17, "image_name": "10942.png", "category_id": 9, "category_name": "Root", "bbox": [ 103.17, 82.88, 231.03999999999996, 188.25 ], "priority": -1, "parents": [], "children": [ 377, 359, 360, 368, 363, 361 ], "area": 8550.7296, "iscrowd": 0, "segmentation": [] }, { "id": 359, "strid": "ed943870-39d1-4ac2-8fce-9a49f1db0d85", "image_id": 17, "image_name": "10942.png", "category_id": 1, "category_name": "Title", "bbox": [ 524.991, 39.101, 2000.7020000000002, 246.385 ], "priority": 1, "parents": [ 358 ], "children": [], "area": 20527.673091, "iscrowd": 0, "segmentation": [], "text": "Computing cluster with virtual machines\n\nin bioinformatic" }, { "id": 360, "strid": "94c7b329-f3e7-4377-b86a-f0b2bbbb002b", "image_id": 17, "image_name": "10942.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 900.766, 326.518, 1927.4719999999998, 194.95800000000003 ], "priority": 2, "parents": [ 358 ], "children": [], "area": 294116.312788, "iscrowd": 0, "segmentation": [], "text": "Jonathan Lorenzo!, Sandrine Perrin!, Awa Sepou Ngailo!, Bryan Brancotte!; Mohamed\n\nBedri!, Christophe Blanchet! et Jean-Francois Gibrat+\n1 IFB-core, CNRS, INRA, INSERM, Inria, CEA, Université Paris-Saclay, 91190 Gif-sur-Yvette, France\nContact: jonathan.lorenzo@france-bioinformatique.fr" }, { "id": 361, "strid": "06f6f29c-8630-4870-9567-baf9905e94cf", "image_id": 17, "image_name": "10942.png", "category_id": 5, "category_name": "Section", "bbox": [ 171.707, 546.173, 226.365, 48.24199999999996 ], "priority": 3, "parents": [ 358 ], "children": [ 362 ], "area": 93781.727311, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 362, "strid": "941e409c-4b09-4616-ad44-d02802f6e19b", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 39.873, 612.487, 3060.495, 480.381 ], "priority": 4, "parents": [ 361 ], "children": [], "area": 24421.694150999996, "iscrowd": 0, "segmentation": [], "text": "The BioDataCloud project tends towards the use of a cloud-computing system suitable for efficient production of high-value data in the area of plant biotechnology.\nWith the cloud, we can adapt our needs in terms of calculation by specifying the number of processors and associated memory size, but also in terms of storage by\nspecifying the desired size for the associated virtual disks.\n\nAs part of this project, a collaboration between the IFB-CORE and the project partners was established to use the cloud of IFB to integrate and test a « de novo genomic\nassembly » pipeline. This pipeline may need more resources than a single VM can bring at maximum. Therefore, it is useful to create a Virtual Computing Cluster that\ncan include many virtual machines (VMs) and be scheduled by systems like RabbitWQ, SGE, Torque/Maui or Spark. The configuration is done with a script to set up the\ncluster settings to the different VMs (one master and several compute nodes). The script also manages the installation of the data sharing system (NFS or SSH/SCP). All\nthis, helps the user to deploy a complete virtual computing cluster in one command. The ultimate objectives are to simplify the creation of a compute cluster using a\ngraphical interface, to achieve continuous integration of new versions of the pipeline and to use Docker containers (see poster 111) for each tools of the pipeline." }, { "id": 363, "strid": "8a7828d1-961b-4cee-88eb-5e62a2093d2c", "image_id": 17, "image_name": "10942.png", "category_id": 5, "category_name": "Section", "bbox": [ 91.751, 1191.665, 1036.658, 61.52299999999991 ], "priority": 5, "parents": [ 358 ], "children": [ 365, 366, 364, 367 ], "area": 109336.455415, "iscrowd": 0, "segmentation": [], "text": "Integrate pipeline (Appliance developer)" }, { "id": 364, "strid": "a1f4a554-19fb-4e74-ac92-845208236674", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 43.944, 1281.073, 1114.12, 799.8819999999998 ], "priority": 6, "parents": [ 363 ], "children": [], "area": 56295.47191200001, "iscrowd": 0, "segmentation": [] }, { "id": 365, "strid": "67c85d87-3412-41aa-af2b-4d00c9730f39", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 1234.399, 1350.799, 627.915, 183.93499999999995 ], "priority": 7, "parents": [ 363 ], "children": [], "area": 1667424.9348009997, "iscrowd": 0, "segmentation": [], "text": "Step 1\nCreate/Modify compute node:\nAdd usefull tools" }, { "id": 366, "strid": "d233f042-59b4-4add-9185-ccbc165a53c1", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 43.739, 2113.381, 951.522, 687.3490000000002 ], "priority": 8, "parents": [ 363 ], "children": [], "area": 92437.171559, "iscrowd": 0, "segmentation": [] }, { "id": 367, "strid": "0ec64d87-ba93-4f06-8f2c-857975e845b7", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 31.965, 2846.95, 1161.03, 602.076 ], "priority": 9, "parents": [ 363 ], "children": [], "area": 91002.75675, "iscrowd": 0, "segmentation": [] }, { "id": 368, "strid": "544aa7c9-8a75-430c-8a92-43c37f782cf4", "image_id": 17, "image_name": "10942.png", "category_id": 5, "category_name": "Section", "bbox": [ 2043.877, 1190.646, 455.17999999999984, 58.60699999999997 ], "priority": 10, "parents": [ 358 ], "children": [ 370, 376, 375, 371, 369, 372, 373, 374 ], "area": 2433533.974542, "iscrowd": 0, "segmentation": [], "text": "Start your cluster" }, { "id": 369, "strid": "3f6736a9-0bb2-486d-8438-2662fd19672d", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1972.129, 1264.856, 1068.3289999999997, 238.88100000000009 ], "priority": 11, "parents": [ 368 ], "children": [], "area": 2494459.198424, "iscrowd": 0, "segmentation": [] }, { "id": 370, "strid": "98a01697-ac90-444a-9430-7bc9c789e5c5", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1937.092, 1501.019, 1163.873, 880.9840000000002 ], "priority": 12, "parents": [ 368 ], "children": [], "area": 2907611.8967480003, "iscrowd": 0, "segmentation": [] }, { "id": 371, "strid": "ebb41f2d-e328-488f-a4f3-35e5e426de54", "image_id": 17, "image_name": "10942.png", "category_id": 4, "category_name": "List", "bbox": [ 1214.776, 1987.555, 620.4359999999999, 305.39599999999996 ], "priority": 13, "parents": [ 368 ], "children": [], "area": 2414434.1126800003, "iscrowd": 0, "segmentation": [] }, { "id": 372, "strid": "aca3a7a8-b760-4d93-824b-ff12330fbf04", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 1297.099, 2413.529, 652.5069999999998, 60.86499999999978 ], "priority": 14, "parents": [ 368 ], "children": [], "area": 3130586.052371, "iscrowd": 0, "segmentation": [], "text": "Finalize the configuration" }, { "id": 373, "strid": "8228a0e4-7bb0-4f5b-93e0-dab03d9d8fa5", "image_id": 17, "image_name": "10942.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1222.0, 2493.997, 1241.9679999999998, 544.0219999999999 ], "priority": 15, "parents": [ 368 ], "children": [], "area": 3047664.334, "iscrowd": 0, "segmentation": [] }, { "id": 374, "strid": "98ed57ba-d39c-442f-baff-0dcc17e5a357", "image_id": 17, "image_name": "10942.png", "category_id": 4, "category_name": "List", "bbox": [ 2397.737, 2668.28, 671.6639999999998, 380.94399999999996 ], "priority": 16, "parents": [ 368 ], "children": [], "area": 6397833.682360001, "iscrowd": 0, "segmentation": [] }, { "id": 375, "strid": "22e00249-9997-4163-82fa-b120ba4a5369", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 1584.093, 3188.351, 1128.896, 83.28999999999996 ], "priority": 17, "parents": [ 368 ], "children": [], "area": 5050644.500643, "iscrowd": 0, "segmentation": [], "text": "Pipeline ready to assemble the reads" }, { "id": 376, "strid": "08ec6446-ca21-46dd-9674-fa05d47f6558", "image_id": 17, "image_name": "10942.png", "category_id": 4, "category_name": "List", "bbox": [ 1279.843, 3372.669, 1733.3929999999998, 245.72699999999986 ], "priority": 18, "parents": [ 368 ], "children": [], "area": 4316486.810967, "iscrowd": 0, "segmentation": [] }, { "id": 377, "strid": "df496fc9-7896-4c09-8204-0c158c637b8a", "image_id": 17, "image_name": "10942.png", "category_id": 5, "category_name": "Section", "bbox": [ 322.47, 3477.795, 551.802, 63.10500000000002 ], "priority": 19, "parents": [ 358 ], "children": [ 381, 382, 379, 380, 378 ], "area": 1121484.5536500001, "iscrowd": 0, "segmentation": [], "text": "Cluster mode : principle" }, { "id": 378, "strid": "41747198-2053-4a01-b5bf-8f6e6b1027b4", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 388.299, 3836.005, 193.44499999999994, 179.17700000000013 ], "priority": 20, "parents": [ 377 ], "children": [], "area": 1489516.905495, "iscrowd": 0, "segmentation": [], "text": "Cluster\nReady in\n2 mins" }, { "id": 379, "strid": "3ebbf659-f104-44b8-b22e-539daf2838e5", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 746.931, 3718.65, 1683.342, 182.9720000000002 ], "priority": 21, "parents": [ 377 ], "children": [], "area": 2777574.96315, "iscrowd": 0, "segmentation": [], "text": "E. Coli dataset WK mer Lehi\nGenome Size: 4.8M Genome Size: 12.1M" }, { "id": 380, "strid": "973538aa-eea1-4d3c-afc1-6ade9364db73", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 812.278, 3964.356, 1479.459, 250.93300000000045 ], "priority": 22, "parents": [ 377 ], "children": [], "area": 3220159.1629680004, "iscrowd": 0, "segmentation": [], "text": "5 nodes of 4CPU-16GB\n\n45min ( vs 1h05 * ) 2h ( vs 3h30 * )" }, { "id": 381, "strid": "89154862-7b66-4bb8-b11b-6169fc860bdf", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 545.662, 4254.497, 2033.6030000000003, 133.308 ], "priority": 23, "parents": [ 377 ], "children": [], "area": 2321517.3420140003, "iscrowd": 0, "segmentation": [], "text": "Acknowledgement: Emeric Sevin (GenOuest and CBiB) for the bioinformatics pipeline and\nbenchmarks. Marie Grosjean (formerly IFB-core) for the initial work on the cloud IFB." }, { "id": 382, "strid": "0f1b502e-0e9e-4385-b632-2b207eaf2547", "image_id": 17, "image_name": "10942.png", "category_id": 3, "category_name": "Text", "bbox": [ 2587.106, 3836.275, 470.49900000000025, 235.25 ], "priority": 24, "parents": [ 377 ], "children": [], "area": 9924850.070150001, "iscrowd": 0, "segmentation": [], "text": "* On a standard\nworkstation:\n4 core / 16Go RAM" }, { "id": 383, "strid": "a6a80044-e0fe-483a-b3b2-b7b391f0c230", "image_id": 18, "image_name": "10947.png", "category_id": 9, "category_name": "Root", "bbox": [ 140.5, 228.41, 207.85000000000002, 160.91 ], "priority": -1, "parents": [], "children": [ 413, 411, 386, 403, 390, 385, 406, 384, 398 ], "area": 32091.605, "iscrowd": 0, "segmentation": [] }, { "id": 384, "strid": "3a83c024-0d75-4f5b-a57d-19a628d7edee", "image_id": 18, "image_name": "10947.png", "category_id": 1, "category_name": "Title", "bbox": [ 231.373, 95.49, 4384.586, 108.837 ], "priority": 1, "parents": [ 383 ], "children": [], "area": 22093.80777, "iscrowd": 0, "segmentation": [], "text": "Instructor presence, visual attention, and learning in educational video: Content difficulty matters." }, { "id": 385, "strid": "8c8bc8dc-880f-40cd-9b14-7edb01ce3e8e", "image_id": 18, "image_name": "10947.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 1286.717, 222.973, 1935.4190000000003, 115.60300000000001 ], "priority": 2, "parents": [ 383 ], "children": [], "area": 286903.149641, "iscrowd": 0, "segmentation": [], "text": "Jiahui Wang', Pavlo Antonenko!, Ethan Fieldman?" }, { "id": 386, "strid": "eebaf22c-a41c-4620-9fdc-532b63154b75", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 115.542, 447.938, 374.8159999999999, 62.786 ], "priority": 3, "parents": [ 383 ], "children": [ 389, 387, 388 ], "area": 51755.652396, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 387, "strid": "328567e0-b636-407c-8926-33a049449d9d", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 115.298, 535.931, 1343.922, 292.571 ], "priority": 4, "parents": [ 386 ], "children": [], "area": 61791.77243800001, "iscrowd": 0, "segmentation": [], "text": "In an effort to reach more students, educators work to design engaging\nonline learning experiences, particularly in the form of online videos.\nWhile many instructional videos feature a picture-in-picture view of\ninstructor, it is not clear how instructor presence influences learners’\nvisual attention and what it contributes to learning and affect." }, { "id": 388, "strid": "a9dec867-688d-4d71-a3e0-2585b2d2c77b", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 110.541, 845.152, 1374.845, 608.9279999999999 ], "priority": 5, "parents": [ 386 ], "children": [], "area": 93423.947232, "iscrowd": 0, "segmentation": [] }, { "id": 389, "strid": "760e1462-5928-4018-98c9-b561ad1fbb1f", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 118.597, 1467.258, 1335.866, 227.06299999999987 ], "priority": 6, "parents": [ 386 ], "children": [], "area": 174012.397026, "iscrowd": 0, "segmentation": [], "text": "The objective of the current study is to explore how instructor\npresence in mathematics instructional video influence learning,\nvisual attention distribution and perceptions for easy and difficult\nmathematics topics." }, { "id": 390, "strid": "b32f9876-9712-4407-ba11-15e194f08fcb", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 101.301, 1802.583, 380.524, 65.375 ], "priority": 7, "parents": [ 383 ], "children": [ 393, 395, 391, 392, 397, 394, 396 ], "area": 182603.460483, "iscrowd": 0, "segmentation": [], "text": "Methodology" }, { "id": 391, "strid": "ee93426f-9eef-40c6-aa49-2eb55579e122", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 238.7, 1903.626, 553.8299999999999, 334.1859999999999 ], "priority": 8, "parents": [ 390 ], "children": [], "area": 454395.52619999996, "iscrowd": 0, "segmentation": [] }, { "id": 392, "strid": "1d45dccb-d8c3-4b9c-b58a-ae2e83e5af8f", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 951.134, 1901.784, 360.78099999999995, 335.51200000000017 ], "priority": 9, "parents": [ 390 ], "children": [], "area": 1808851.4230560001, "iscrowd": 0, "segmentation": [] }, { "id": 393, "strid": "aca673a2-6351-4171-b9f3-c8a6debbc260", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 116.044, 2286.598, 1378.856, 46.08100000000013 ], "priority": 10, "parents": [ 390 ], "children": [], "area": 265345.978312, "iscrowd": 0, "segmentation": [], "text": "Example Video Screenshot with instructor Presence and Experimental setup" }, { "id": 394, "strid": "4ec732f9-27a3-48b6-949c-c35143158295", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 122.434, 2376.986, 1205.962, 114.17399999999998 ], "priority": 11, "parents": [ 390 ], "children": [], "area": 291023.903924, "iscrowd": 0, "segmentation": [], "text": "Participants: Thirty-six undergraduate students (age 18-21, 21\nfemale)" }, { "id": 395, "strid": "312e4561-d340-4fe1-af8b-a29dafdcc34e", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 120.055, 2553.004, 1322.515, 104.6590000000001 ], "priority": 12, "parents": [ 390 ], "children": [], "area": 306500.89522, "iscrowd": 0, "segmentation": [], "text": "Apparatus: SR Research Eyelink 1000 Plus system (desktop-mount)\nand Screen Recorder" }, { "id": 396, "strid": "4b891554-ea13-45c4-8658-ef09cd0358fa", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 120.801, 2714.12, 1309.876, 336.0160000000001 ], "priority": 13, "parents": [ 390 ], "children": [], "area": 327868.41012, "iscrowd": 0, "segmentation": [], "text": "Materials: Similar Triangles represented an easy mathematics topic\nand Trigonometric Function - a difficult mathematics topic. The two\nvideos with instructor presence were designed by Algebra Nation™.\nThe two videos without instructor presence were made by Khan\nAcademy™. Each participant watched two videos, either with or\nwithout instructor." }, { "id": 397, "strid": "e66a73dc-d926-4fe2-8080-fb2d7d6f5a7f", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 90.651, 3071.76, 1400.214, 428.05600000000004 ], "priority": 14, "parents": [ 390 ], "children": [], "area": 278458.11576, "iscrowd": 0, "segmentation": [] }, { "id": 398, "strid": "da085be3-7315-4690-bcfb-78906d356a0e", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 1626.22, 440.328, 527.0249999999999, 85.61799999999994 ], "priority": 15, "parents": [ 383 ], "children": [ 401, 400, 399, 402 ], "area": 716070.20016, "iscrowd": 0, "segmentation": [], "text": "Results: Learning" }, { "id": 399, "strid": "10a46e3f-9da2-4a71-b97a-00c3949a1863", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1680.513, 577.24, 580.3020000000001, 470.66499999999996 ], "priority": 16, "parents": [ 398 ], "children": [], "area": 970059.32412, "iscrowd": 0, "segmentation": [] }, { "id": 400, "strid": "48440281-b4e7-4c8a-a7b5-a01f28717c81", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 1619.123, 1085.758, 710.8530000000001, 238.16599999999994 ], "priority": 17, "parents": [ 398 ], "children": [], "area": 1757975.7502340002, "iscrowd": 0, "segmentation": [] }, { "id": 401, "strid": "adbfe873-c60c-4c82-9b5b-51d961ff0ac2", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2508.406, 566.053, 592.906, 469.2220000000001 ], "priority": 18, "parents": [ 398 ], "children": [], "area": 1419890.741518, "iscrowd": 0, "segmentation": [] }, { "id": 402, "strid": "54e9fa24-dd01-44d2-8ced-8a03ae451de3", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 2476.366, 1087.313, 699.502, 232.84400000000005 ], "priority": 19, "parents": [ 398 ], "children": [], "area": 2692584.944558, "iscrowd": 0, "segmentation": [] }, { "id": 403, "strid": "568e60d1-2a3e-4c98-ac20-374f9bc74744", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 1632.924, 1409.485, 1091.7399999999998, 65.68599999999992 ], "priority": 20, "parents": [ 383 ], "children": [ 405, 404 ], "area": 2301581.8841399997, "iscrowd": 0, "segmentation": [], "text": "Results: Visual Attention Distribution" }, { "id": 404, "strid": "30ceecf7-67a3-4264-bb4c-223865a963df", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1787.912, 1485.656, 1152.3009999999997, 868.1410000000001 ], "priority": 21, "parents": [ 403 ], "children": [], "area": 2656222.190272, "iscrowd": 0, "segmentation": [] }, { "id": 405, "strid": "89e0def4-9cde-458f-844a-b0e75c931f3f", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 1650.721, 2379.648, 1511.049, 580.607 ], "priority": 22, "parents": [ 403 ], "children": [], "area": 3928134.926208, "iscrowd": 0, "segmentation": [] }, { "id": 406, "strid": "93b4411b-2b1d-48bc-a528-4fb127db8b35", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 3298.203, 447.894, 592.1240000000003, 73.423 ], "priority": 23, "parents": [ 383 ], "children": [ 407, 410, 408, 409 ], "area": 1477245.334482, "iscrowd": 0, "segmentation": [], "text": "Results: Perceptions" }, { "id": 407, "strid": "45b1750f-47a1-4047-a5ab-049a851a7141", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3337.142, 577.688, 579.5070000000001, 465.84299999999996 ], "priority": 24, "parents": [ 406 ], "children": [], "area": 1927826.8876959998, "iscrowd": 0, "segmentation": [] }, { "id": 408, "strid": "139a7a67-9564-4aa2-952b-dc3af61d278b", "image_id": 18, "image_name": "10947.png", "category_id": 2, "category_name": "Figure", "bbox": [ 4001.736, 578.147, 565.1869999999999, 459.13 ], "priority": 25, "parents": [ 406 ], "children": [], "area": 2313591.6631920002, "iscrowd": 0, "segmentation": [] }, { "id": 409, "strid": "50c0d9b3-c21e-45ff-9dee-70ff11ce25f1", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 3304.096, 1068.18, 1353.4270000000001, 164.47900000000004 ], "priority": 26, "parents": [ 406 ], "children": [], "area": 3529369.2652800004, "iscrowd": 0, "segmentation": [], "text": "Average rating on scales of perceived learning, satisfaction, and mental\neffort for easy topic and difficult topic (* p < .05). For mental effort\nquestion, 1= very, very low mental effort; 9 = very, very high mental effort." }, { "id": 410, "strid": "fe897d09-7c79-4c18-be7b-52b8b1308614", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 3319.869, 1270.254, 1337.9879999999998, 340.7080000000001 ], "priority": 27, "parents": [ 406 ], "children": [], "area": 4217076.876726, "iscrowd": 0, "segmentation": [] }, { "id": 411, "strid": "c0e6346d-4441-40b9-909d-66eed5dd7603", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 3280.231, 1725.783, 314.7449999999999, 68.24099999999999 ], "priority": 28, "parents": [ 383 ], "children": [ 412 ], "area": 5660966.895873, "iscrowd": 0, "segmentation": [], "text": "Discussion" }, { "id": 412, "strid": "d56893be-c1b0-4a12-9c01-528d4a45e89a", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 3292.398, 1829.818, 1387.2780000000002, 528.4889999999998 ], "priority": 29, "parents": [ 411 ], "children": [], "area": 6024489.123564, "iscrowd": 0, "segmentation": [] }, { "id": 413, "strid": "4b01cd6f-0f14-43ba-ab5b-84b784907ca1", "image_id": 18, "image_name": "10947.png", "category_id": 5, "category_name": "Section", "bbox": [ 3282.778, 2441.518, 324.9699999999998, 60.1880000000001 ], "priority": 30, "parents": [ 383 ], "children": [ 416, 414, 415 ], "area": 8014961.577004, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 414, "strid": "1d48dbdf-e8ae-4c0b-8349-738d109185fa", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 3282.002, 2557.709, 860.2549999999997, 53.00199999999995 ], "priority": 31, "parents": [ 413 ], "children": [], "area": 8394406.053418, "iscrowd": 0, "segmentation": [], "text": "Instructor presence in Mathematics video:" }, { "id": 415, "strid": "f8cc852e-d05e-4097-85cc-503136658ccb", "image_id": 18, "image_name": "10947.png", "category_id": 4, "category_name": "List", "bbox": [ 3274.556, 2641.861, 1427.2580000000003, 534.335 ], "priority": 32, "parents": [ 413 ], "children": [], "area": 8650921.788716, "iscrowd": 0, "segmentation": [] }, { "id": 416, "strid": "da5b4d21-b7e6-456c-b23b-4833b3252f26", "image_id": 18, "image_name": "10947.png", "category_id": 3, "category_name": "Text", "bbox": [ 3320.673, 3251.246, 1314.3589999999995, 221.01200000000017 ], "priority": 33, "parents": [ 413 ], "children": [], "area": 10796324.808558, "iscrowd": 0, "segmentation": [], "text": "Future research could test the efficacy of instructor presence in other\nlearning contexts and with different populations of learners. It is also\nimperative to understand how learners with individual differences\nrespond to instructor presence in online videos." }, { "id": 417, "strid": "f6c2cef0-23ee-4bdc-bdde-61b91f38c10f", "image_id": 19, "image_name": "10963.png", "category_id": 9, "category_name": "Root", "bbox": [ 66.59, 74.74, 120.82, 199.63 ], "priority": -1, "parents": [], "children": [ 420, 423, 419, 443, 418, 441, 430 ], "area": 4976.9366, "iscrowd": 0, "segmentation": [] }, { "id": 418, "strid": "d746506f-3c00-48a1-b999-7a9ecf98cae0", "image_id": 19, "image_name": "10963.png", "category_id": 1, "category_name": "Title", "bbox": [ 1084.703, 112.69, 2889.506, 122.394 ], "priority": 1, "parents": [ 417 ], "children": [], "area": 122235.18106999999, "iscrowd": 0, "segmentation": [], "text": "Temporal Properties of Mirror-Symmetry Perception" }, { "id": 419, "strid": "690e563c-bedc-44fc-a4f8-69986c54fd6a", "image_id": 19, "image_name": "10963.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 1433.231, 270.346, 2192.3010000000004, 124.50900000000001 ], "priority": 2, "parents": [ 417 ], "children": [], "area": 387468.267926, "iscrowd": 0, "segmentation": [], "text": "Rebecca J. Sharman & Elena Gheorghiu\nUniversity of Stirling, Faculty of Natural Sciences, Department of Psychology, Stirling, FK9 4LA, Scotland" }, { "id": 420, "strid": "0371937e-3fce-46c3-a614-66462febe0df", "image_id": 19, "image_name": "10963.png", "category_id": 5, "category_name": "Section", "bbox": [ 114.745, 489.786, 431.582, 67.714 ], "priority": 3, "parents": [ 417 ], "children": [ 422, 421 ], "area": 56200.49457, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 421, "strid": "e25219fa-ba88-46eb-8bb7-222fb9a01037", "image_id": 19, "image_name": "10963.png", "category_id": 3, "category_name": "Text", "bbox": [ 88.468, 600.984, 1377.766, 205.87599999999998 ], "priority": 4, "parents": [ 420 ], "children": [], "area": 53167.852512000005, "iscrowd": 0, "segmentation": [], "text": "The human visual system has specialised mechanisms for\nencoding mirror-symmetry. Recent studies suggest that temporal\ndynamics contribute to mirror-symmetry perception (Sharman &\nGheorghiu 2017). Here we investigate:" }, { "id": 422, "strid": "23745662-1645-42ec-ad26-e74d478d84eb", "image_id": 19, "image_name": "10963.png", "category_id": 4, "category_name": "List", "bbox": [ 90.491, 811.615, 1418.963, 256.69600000000014 ], "priority": 5, "parents": [ 420 ], "children": [], "area": 73443.852965, "iscrowd": 0, "segmentation": [] }, { "id": 423, "strid": "1e1bf62f-3f3a-46e3-8690-4c553b7c96b1", "image_id": 19, "image_name": "10963.png", "category_id": 5, "category_name": "Section", "bbox": [ 91.266, 1141.098, 307.903, 81.02700000000004 ], "priority": 6, "parents": [ 417 ], "children": [ 424, 428, 429, 427, 426, 425 ], "area": 104143.450068, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 424, "strid": "abf09a5b-fee9-4405-8263-3117ba0ed9c2", "image_id": 19, "image_name": "10963.png", "category_id": 4, "category_name": "List", "bbox": [ 75.584, 1267.946, 1455.714, 462.73 ], "priority": 7, "parents": [ 423 ], "children": [], "area": 95836.430464, "iscrowd": 0, "segmentation": [] }, { "id": 425, "strid": "cca917ba-1725-454a-a571-be8548128284", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 83.446, 1739.359, 704.649, 490.6100000000001 ], "priority": 8, "parents": [ 423 ], "children": [], "area": 145142.551114, "iscrowd": 0, "segmentation": [] }, { "id": 426, "strid": "ba39304e-66f4-44b7-851f-72dca9fd4b61", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 818.051, 1739.482, 706.1919999999999, 491.1460000000002 ], "priority": 9, "parents": [ 423 ], "children": [], "area": 1422984.989582, "iscrowd": 0, "segmentation": [] }, { "id": 427, "strid": "956fcddf-c87b-4b07-b23c-6bb277408852", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 83.768, 2242.533, 704.617, 494.2220000000002 ], "priority": 10, "parents": [ 423 ], "children": [], "area": 187852.504344, "iscrowd": 0, "segmentation": [] }, { "id": 428, "strid": "2b6bb159-cbba-44d1-b0d6-90b328c71b6d", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 818.389, 2241.751, 703.7219999999999, 495.30999999999995 ], "priority": 11, "parents": [ 423 ], "children": [], "area": 1834624.3591390003, "iscrowd": 0, "segmentation": [] }, { "id": 429, "strid": "9cf51ba1-ccc7-4e00-b528-8190985205dc", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 188.125, 2748.4, 1283.975, 496.72699999999986 ], "priority": 12, "parents": [ 423 ], "children": [], "area": 517042.75, "iscrowd": 0, "segmentation": [] }, { "id": 430, "strid": "666d8067-e6d3-409a-aad0-548049dcd7b0", "image_id": 19, "image_name": "10963.png", "category_id": 5, "category_name": "Section", "bbox": [ 1616.38, 488.661, 259.6600000000001, 69.20999999999998 ], "priority": 13, "parents": [ 417 ], "children": [ 431, 433, 437, 432, 434, 439, 440, 436, 435 ], "area": 789861.8671800001, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 431, "strid": "695a1d9d-d6d2-456b-a521-6cf8f22b1eef", "image_id": 19, "image_name": "10963.png", "category_id": 3, "category_name": "Text", "bbox": [ 1956.265, 626.555, 582.6319999999998, 108.31700000000001 ], "priority": 14, "parents": [ 430 ], "children": [], "area": 1225707.617075, "iscrowd": 0, "segmentation": [], "text": "Sustained Presentation\nAverage Across Participants" }, { "id": 432, "strid": "892aa17b-252c-4965-947b-4c806fa14f21", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1607.547, 757.853, 1284.768, 899.764 ], "priority": 15, "parents": [ 430 ], "children": [], "area": 1218284.316591, "iscrowd": 0, "segmentation": [] }, { "id": 433, "strid": "46dd726a-b41b-4983-9160-094aad542c28", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1898.584, 1691.133, 701.5290000000002, 527.9359999999999 ], "priority": 16, "parents": [ 430 ], "children": [], "area": 3210758.055672, "iscrowd": 0, "segmentation": [] }, { "id": 434, "strid": "c1bd9d39-6f06-4561-a312-2a4690061cee", "image_id": 19, "image_name": "10963.png", "category_id": 4, "category_name": "List", "bbox": [ 1603.886, 2257.99, 1294.688, 308.99699999999984 ], "priority": 17, "parents": [ 430 ], "children": [], "area": 3621558.54914, "iscrowd": 0, "segmentation": [] }, { "id": 435, "strid": "b3079b60-7111-40c3-a7fd-7295a45258ce", "image_id": 19, "image_name": "10963.png", "category_id": 3, "category_name": "Text", "bbox": [ 3661.876, 625.695, 583.7690000000002, 106.88400000000001 ], "priority": 18, "parents": [ 430 ], "children": [], "area": 2291217.50382, "iscrowd": 0, "segmentation": [], "text": "Transient Presentation\nAverage Across Participants" }, { "id": 436, "strid": "00d4d1b8-7c3e-4448-ba30-c2f6f9245f29", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2963.079, 757.577, 1917.8830000000003, 920.441 ], "priority": 19, "parents": [ 430 ], "children": [], "area": 2244760.4995830003, "iscrowd": 0, "segmentation": [] }, { "id": 437, "strid": "224e0d0f-93c3-482b-85a1-b469c790dd1f", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3177.415, 1775.488, 704.1219999999998, 582.6180000000002 ], "priority": 20, "parents": [ 430 ], "children": [ 438 ], "area": 5641462.20352, "iscrowd": 0, "segmentation": [] }, { "id": 438, "strid": "4dbeb1d5-4fc4-4df9-901a-d4db0268eb4f", "image_id": 19, "image_name": "10963.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2962.672, 1694.18, 552.1990000000001, 67.58699999999999 ], "priority": 21, "parents": [ 437 ], "children": [], "area": 5019299.64896, "iscrowd": 0, "segmentation": [], "text": "Order 1 - Image 1 followed by image 2\nOrder 2 - Image 2 followed by image 1" }, { "id": 439, "strid": "fe0f981f-790d-4163-aeb5-dc7d0ceae9c5", "image_id": 19, "image_name": "10963.png", "category_id": 2, "category_name": "Figure", "bbox": [ 4030.344, 1775.924, 701.192, 583.3690000000001 ], "priority": 22, "parents": [ 430 ], "children": [], "area": 7157584.637856, "iscrowd": 0, "segmentation": [] }, { "id": 440, "strid": "63d12682-0042-4ffa-ba70-12889a409521", "image_id": 19, "image_name": "10963.png", "category_id": 4, "category_name": "List", "bbox": [ 2961.364, 2371.255, 1919.4699999999998, 206.0010000000002 ], "priority": 23, "parents": [ 430 ], "children": [], "area": 7022149.19182, "iscrowd": 0, "segmentation": [] }, { "id": 441, "strid": "760f644d-5055-4dbf-b76e-848cffe13ba3", "image_id": 19, "image_name": "10963.png", "category_id": 5, "category_name": "Section", "bbox": [ 1616.171, 2638.183, 415.78, 67.69599999999991 ], "priority": 24, "parents": [ 417 ], "children": [ 442 ], "area": 4263754.857293, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 442, "strid": "debcaf77-34a6-41d6-a90d-65ac785b69df", "image_id": 19, "image_name": "10963.png", "category_id": 4, "category_name": "List", "bbox": [ 1611.442, 2746.112, 3163.183, 282.0920000000001 ], "priority": 25, "parents": [ 441 ], "children": [], "area": 4425200.213504001, "iscrowd": 0, "segmentation": [] }, { "id": 443, "strid": "2a6e6abb-18fa-492d-ab6a-e20965d73e39", "image_id": 19, "image_name": "10963.png", "category_id": 3, "category_name": "Text", "bbox": [ 1601.358, 3088.849, 2132.879, 150.73300000000017 ], "priority": 26, "parents": [ 417 ], "children": [], "area": 4946353.056942, "iscrowd": 0, "segmentation": [], "text": "References & Acknowledgements\nSharman, R.J. & Gheorghiu, E. (2017) The role of motion and number of element locations in mirror symmetry perception. Scientific Reports. 7, 45679.\n\n \n\nThis research was supported by a Wellcome Trust Investigator grant (WT106969/Z/15/Z) given to EG." }, { "id": 444, "strid": "95e366aa-e2fd-4816-9e7d-3a90107ac52a", "image_id": 20, "image_name": "10983.png", "category_id": 9, "category_name": "Root", "bbox": [ 552.78, 372.43, 254.84000000000003, 162.17000000000002 ], "priority": -1, "parents": [], "children": [ 476, 459, 453, 445, 446, 447, 464, 467 ], "area": 205871.8554, "iscrowd": 0, "segmentation": [] }, { "id": 445, "strid": "cd1752f4-f5b4-4de1-9b03-99942dd528d0", "image_id": 20, "image_name": "10983.png", "category_id": 1, "category_name": "Title", "bbox": [ 664.976, 68.685, 4356.746, 268.977 ], "priority": 1, "parents": [ 444 ], "children": [], "area": 45673.876560000004, "iscrowd": 0, "segmentation": [], "text": "Eye movement signatures of decision making and hand movement accuracy\nin a go/nogo manual interception task" }, { "id": 446, "strid": "bf3f1259-5393-4ecb-8df2-94d2452bed95", "image_id": 20, "image_name": "10983.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 900.894, 366.644, 3832.5469999999996, 170.399 ], "priority": 2, "parents": [ 444 ], "children": [], "area": 330307.37973600003, "iscrowd": 0, "segmentation": [], "text": "Miriam Spering'? & Jolande Fooken?\n\n1Dept. Ophthalmology & Visual Sciences, 2Graduate Program in Neuroscience, ?Center for Brain Health; University of British Columbia, Vancouver, Canada" }, { "id": 447, "strid": "8b3c2c2f-acc7-4e98-82b4-be204820e730", "image_id": 20, "image_name": "10983.png", "category_id": 5, "category_name": "Section", "bbox": [ 555.495, 632.433, 766.369, 81.10900000000004 ], "priority": 3, "parents": [ 444 ], "children": [ 450, 452, 448, 451, 449 ], "area": 351313.369335, "iscrowd": 0, "segmentation": [], "text": "Research Question" }, { "id": 448, "strid": "dc8cbeae-ebbc-4c61-8a2f-5d8eee26c0c4", "image_id": 20, "image_name": "10983.png", "category_id": 4, "category_name": "List", "bbox": [ 92.678, 755.459, 1699.3630000000003, 280.5659999999999 ], "priority": 4, "parents": [ 447 ], "children": [], "area": 70014.429202, "iscrowd": 0, "segmentation": [] }, { "id": 449, "strid": "297eadf6-4fab-4c13-9460-fe86bd8b53c7", "image_id": 20, "image_name": "10983.png", "category_id": 4, "category_name": "List", 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"11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 4409.391, 723.624, 346.15800000000036, 63.21199999999999 ], "priority": 19, "parents": [ 495 ], "children": [], "area": 3190741.152984, "iscrowd": 0, "segmentation": [], "text": "Accuracy (in %)" }, { "id": 497, "strid": "9062db30-7d76-4fb7-9a58-4dbad6842dad", "image_id": 21, "image_name": "11066.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3659.61, 819.936, 1354.7369999999996, 558.1749999999998 ], "priority": 20, "parents": [ 495 ], "children": [], "area": 3000645.98496, "iscrowd": 0, "segmentation": [] }, { "id": 498, "strid": "20797bf8-1899-4f51-991a-5d58521122d3", "image_id": 21, "image_name": "11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 5114.001, 946.443, 347.97699999999986, 281.20900000000006 ], "priority": 21, "parents": [ 495 ], "children": [], "area": 4840110.448443, "iscrowd": 0, "segmentation": [], "text": "Accuracy is\nincreaed by 65%\n(19 percentage\npoints) with visual\nenhancement\n(p<0.001)" }, { "id": 499, "strid": "6e04d1c5-7d67-44ec-a471-7aaf3bb9a4c1", "image_id": 21, "image_name": "11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 4284.813, 1427.598, 585.9449999999997, 53.174999999999955 ], "priority": 22, "parents": [ 495 ], "children": [], "area": 6116990.4691739995, "iscrowd": 0, "segmentation": [], "text": "Response time (in seconds)" }, { "id": 500, "strid": "f0741663-a647-4c50-9fbe-4ed928e80c11", "image_id": 21, "image_name": "11066.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3659.61, 1514.747, 1348.9230000000002, 558.175 ], "priority": 23, "parents": [ 495 ], "children": [], "area": 5543383.26867, "iscrowd": 0, "segmentation": [] }, { "id": 501, "strid": "29eeaccf-d607-4f58-852d-042f37978b41", "image_id": 21, "image_name": "11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 5117.236, 1626.276, 337.1319999999996, 288.251 ], "priority": 24, "parents": [ 495 ], "children": [], "area": 8322038.093136, "iscrowd": 0, "segmentation": [], "text": "Response time is\nincreased by 65%\n(27 seconds)\nwith visual\nenhancement\n(p<0.001)" }, { "id": 502, "strid": "9f9a10e1-ba59-4209-97de-ed490f720ea7", "image_id": 21, "image_name": "11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 4307.158, 2142.224, 550.1090000000004, 53.11999999999989 ], "priority": 25, "parents": [ 495 ], "children": [], "area": 9226897.239392001, "iscrowd": 0, "segmentation": [], "text": "Speed-Accuracy Tradeoff" }, { "id": 503, "strid": "daf6791b-6c2a-473f-a884-14f1bbdb31e4", "image_id": 21, "image_name": "11066.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3664.042, 2233.754, 1318.6439999999998, 520.8379999999997 ], "priority": 26, "parents": [ 495 ], "children": [], "area": 8184568.473668, "iscrowd": 0, "segmentation": [] }, { "id": 504, "strid": "c84daaa2-c64d-450f-b51b-813e6e84349a", "image_id": 21, "image_name": "11066.png", "category_id": 3, "category_name": "Text", "bbox": [ 5064.967, 2344.632, 401.9369999999999, 288.27199999999993 ], "priority": 27, "parents": [ 495 ], "children": [], "area": 11875483.707144, "iscrowd": 0, "segmentation": [], "text": "Half of the patients\nbenefit greatly from\nour system with a\nsubstantial accuracy\nincrease paired with\na small time increase" }, { "id": 505, "strid": "7de1607c-6029-4844-a057-91b2610d6053", "image_id": 21, "image_name": "11066.png", "category_id": 5, "category_name": "Section", "bbox": [ 4300.383, 2818.46, 581.5680000000002, 81.6550000000002 ], "priority": 28, "parents": [ 477 ], "children": [ 506 ], "area": 12120457.47018, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 506, "strid": "e08f933c-fa33-4115-a3ae-2ace27773a3f", "image_id": 21, "image_name": "11066.png", "category_id": 4, "category_name": "List", "bbox": [ 3696.549, 2980.987, 1794.7840000000006, 425.0329999999999 ], "priority": 29, "parents": [ 505 ], "children": [], "area": 11019364.513863001, "iscrowd": 0, "segmentation": [] }, { "id": 507, "strid": "02a5ba57-f13d-409a-877d-74bd84252774", "image_id": 22, "image_name": "11122.png", "category_id": 9, "category_name": "Root", "bbox": [ 4271.14, 97.96, 236.39999999999964, 231.15000000000003 ], "priority": -1, "parents": [], "children": [ 530, 510, 509, 519, 508, 515, 522 ], "area": 418400.87440000003, "iscrowd": 0, "segmentation": [] }, { "id": 508, "strid": "692744c2-a2ac-49ee-b9c1-d9f69d21bf8d", "image_id": 22, "image_name": "11122.png", "category_id": 1, "category_name": "Title", "bbox": [ 80.027, 44.964, 3948.674, 388.585 ], "priority": 1, "parents": [ 507 ], "children": [], "area": 3598.3340279999998, "iscrowd": 0, "segmentation": [], "text": "C: automatic prediction of quality and\ne visual reporting of MRI scans" }, { "id": 509, "strid": "7d4cda72-0ee3-4697-b805-63c33851439e", "image_id": 22, "image_name": "11122.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 32.556, 482.016, 4249.58, 127.04400000000004 ], "priority": 2, "parents": [ 507 ], "children": [], "area": 15692.512896, "iscrowd": 0, "segmentation": [], "text": "Oscar Esteban’, Krzysztof Gorgolewski?, Russell Poldrack’ - ‘Dept. of Psychology, Stanford University, US" }, { "id": 510, "strid": "9a0867ba-f311-41a5-8e74-9798f24a736c", "image_id": 22, "image_name": "11122.png", "category_id": 5, "category_name": "Section", "bbox": [ 40.118, 718.005, 710.604, 458.45400000000006 ], "priority": 3, "parents": [ 507 ], "children": [ 511, 513, 512, 514 ], "area": 28804.924590000002, "iscrowd": 0, "segmentation": [], "text": "QA - ASSESSMENT\nQC - CONTROL\n\nVISUAL INSPECTION" }, { "id": 511, "strid": "21f2a71a-8df4-4468-8da4-7030355120c5", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 122.583, 1213.665, 652.603, 589.1990000000001 ], "priority": 4, "parents": [ 510 ], "children": [], "area": 148774.696695, "iscrowd": 0, "segmentation": [] }, { "id": 512, "strid": "fd0b86f4-3142-4c4a-b8f9-166a67b80a0c", "image_id": 22, "image_name": "11122.png", "category_id": 4, "category_name": "List", "bbox": [ 840.941, 679.424, 1045.352, 333.62300000000005 ], "priority": 5, "parents": [ 510 ], "children": [], "area": 571355.497984, "iscrowd": 0, "segmentation": [] }, { "id": 513, "strid": "fca8f496-40ff-4724-b239-32145bfaeda3", "image_id": 22, "image_name": "11122.png", "category_id": 3, "category_name": "Text", "bbox": [ 830.399, 1091.478, 1059.4300000000003, 161.29700000000003 ], "priority": 6, "parents": [ 510 ], "children": [], "area": 906362.2397220001, "iscrowd": 0, "segmentation": [], "text": "... IS time consuming, and prone\nto inter- and intra- rater variabilities" }, { "id": 514, "strid": "5197d049-331f-40e7-94b6-2f7f52dc48db", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 925.193, 1283.255, 535.0730000000001, 477.85400000000004 ], "priority": 7, "parents": [ 510 ], "children": [], "area": 1187258.543215, "iscrowd": 0, "segmentation": [] }, { "id": 515, "strid": "d1c4a9c7-4f76-4f09-b3b0-6ecd4a674741", "image_id": 22, "image_name": "11122.png", "category_id": 5, "category_name": "Section", "bbox": [ 741.008, 1880.985, 1087.012, 85.34400000000005 ], "priority": 8, "parents": [ 507 ], "children": [ 517, 516 ], "area": 1393824.93288, "iscrowd": 0, "segmentation": [], "text": "AUTOMATED PREDICTION" }, { "id": 516, "strid": "74d88258-4c33-4d28-a3ac-f61f2e39a9f2", "image_id": 22, "image_name": "11122.png", "category_id": 3, "category_name": "Text", "bbox": [ 86.712, 2068.693, 1758.928, 624.6660000000002 ], "priority": 9, "parents": [ 515 ], "children": [], "area": 179380.50741600004, "iscrowd": 0, "segmentation": [], "text": "Data: 1098 rs-fMRI scans from ABIDE [1], manual QA ratings (accept/reject)\nof two experts [2] (reject fractions - rater 1: 4.64%; rater 2: 5.83%).\n\nMethods: nested cross-validation (scikit-learn) with AUC (area under the\ncurve) scoring. Stratified 6-Fold split and grid search in the inner loop.\nOuter loop uses a stratified 5-Fold. Run permutation (5000 rep.) testing.\n\nModels: SVC (support vector machines classifier) and RFC (random-forests\nclassifier). Preprocessing: with and without site-wise standardization." }, { "id": 517, "strid": "b0addb1e-4793-4152-94ee-08a946ec3717", "image_id": 22, "image_name": "11122.png", "category_id": 7, "category_name": "Table", "bbox": [ 86.993, 2893.044, 1736.985, 199.95100000000002 ], "priority": 10, "parents": [ 515 ], "children": [ 518 ], "area": 251674.57669199997, "iscrowd": 0, "segmentation": [] }, { "id": 518, "strid": "74b25416-edbe-4acd-b939-5bd312291afb", "image_id": 22, "image_name": "11122.png", "category_id": 6, "category_name": "Caption", "bbox": [ 102.176, 2817.994, 1664.799, 67.51299999999992 ], "priority": 11, "parents": [ 517 ], "children": [], "area": 287931.354944, "iscrowd": 0, "segmentation": [], "text": "Table 1. Cross-validation results. The best performing classifier was RFC-nzs, with the following hyperparameters (estimators/minimum samples per split/maximum\ndepth): rater 1 (18/2/5); and rater 2 (11/2/7). The reported score is roc_auc (area under the curve of the receiver-operator characteristic)." }, { "id": 519, "strid": "0bc4875d-d8f5-4b6e-a4ed-678965c78a59", "image_id": 22, "image_name": "11122.png", "category_id": 5, "category_name": "Section", "bbox": [ 3109.096, 743.31, 866.3980000000001, 85.88599999999997 ], "priority": 12, "parents": [ 507 ], "children": [ 520, 521 ], "area": 2311022.1477599996, "iscrowd": 0, "segmentation": [], "text": "W/ DESIGN" }, { "id": 520, "strid": "00856bc6-6e7b-43b0-ac7a-c17ffadd96e7", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2040.28, 710.4, 1037.046, 1001.927 ], "priority": 13, "parents": [ 519 ], "children": [], "area": 1449414.912, "iscrowd": 0, "segmentation": [] }, { "id": 521, "strid": "ec902e1e-2477-4beb-a873-3905b72ba66d", "image_id": 22, "image_name": "11122.png", "category_id": 4, "category_name": "List", "bbox": [ 3120.102, 852.356, 1390.8720000000003, 842.5930000000001 ], "priority": 14, "parents": [ 519 ], "children": [], "area": 2659437.6603119997, "iscrowd": 0, "segmentation": [] }, { "id": 522, "strid": "87fa74ba-2608-4572-a5fa-900bbc2cbffd", "image_id": 22, "image_name": "11122.png", "category_id": 5, "category_name": "Section", "bbox": [ 1992.13, 1869.656, 1665.7759999999998, 102.36599999999999 ], "priority": 15, "parents": [ 507 ], "children": [ 529, 524, 526, 528, 523, 525, 527 ], "area": 3724597.8072800003, "iscrowd": 0, "segmentation": [], "text": "GROUP & INDIVIDUAL VISUAL REPORTS" }, { "id": 523, "strid": "4be4fa87-201e-403b-b4c9-18ec76bf6fcf", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1979.489, 2052.028, 823.3200000000002, 901.0320000000002 ], "priority": 16, "parents": [ 522 ], "children": [], "area": 4061966.853692, "iscrowd": 0, "segmentation": [] }, { "id": 524, "strid": "c020151d-3ba6-4f0a-beac-cb3fdac242ca", "image_id": 22, "image_name": "11122.png", "category_id": 3, "category_name": "Text", "bbox": [ 2025.552, 2967.538, 754.1800000000001, 148.779 ], "priority": 17, "parents": [ 522 ], "children": [], "area": 6010902.530975999, "iscrowd": 0, "segmentation": [], "text": "Group and individual reports\nMRIQC speeds up manual assessment with the\ncombination of group and individual reports." }, { "id": 525, "strid": "37e9483d-043d-478a-89a2-9888ff2d3707", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2838.102, 2065.733, 1092.828, 676.777 ], "priority": 18, "parents": [ 522 ], "children": [], "area": 5862760.958766, "iscrowd": 0, "segmentation": [] }, { "id": 526, "strid": "7edd5f01-1fd0-4f3b-a14f-5faede5db87e", "image_id": 22, "image_name": "11122.png", "category_id": 3, "category_name": "Text", "bbox": [ 2922.702, 2784.87, 922.4319999999998, 324.37300000000005 ], "priority": 19, "parents": [ 522 ], "children": [], "area": 8139345.118740001, "iscrowd": 0, "segmentation": [], "text": "The fMRI summary plot\n\nIndividual reports consist of several sections that help\nevaluate different quality aspects. One section is the\nfMRI summary plot that shows the estimated head\nmotion, DVARS, spikes, etc. Other visual elements to aid\ninspection are mosaic views of volumes." }, { "id": 527, "strid": "2f14f087-e187-4fc7-98ae-95fd5bf0c320", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3985.843, 2068.983, 597.116, 319.96000000000004 ], "priority": 20, "parents": [ 522 ], "children": [], "area": 8246641.407669, "iscrowd": 0, "segmentation": [] }, { "id": 528, "strid": "69648a11-2921-4e1d-91f9-6a41bf429ff0", "image_id": 22, "image_name": "11122.png", "category_id": 2, "category_name": "Figure", "bbox": [ 3986.986, 2499.017, 596.0199999999995, 317.99800000000005 ], "priority": 21, "parents": [ 522 ], "children": [], "area": 9963545.792761998, "iscrowd": 0, "segmentation": [] }, { "id": 529, "strid": "ccf95e5f-9653-4ea0-949c-2fdb1dae6445", "image_id": 22, "image_name": "11122.png", "category_id": 3, "category_name": "Text", "bbox": [ 3992.573, 2879.307, 583.0130000000004, 237.817 ], "priority": 22, "parents": [ 522 ], "children": [], "area": 11495843.386911, "iscrowd": 0, "segmentation": [], "text": "Quality Assessment\n\nWe modified our reconstruction\nprotocol after discovering signal\nleakage from the eyes using MRIQC." }, { "id": 530, "strid": "7ae1745b-e9ff-47a4-9b9a-917baf1fc719", "image_id": 22, "image_name": "11122.png", "category_id": 4, "category_name": "List", "bbox": [ 19.301, 3187.389, 1550.161, 105.69300000000021 ], "priority": 23, "parents": [ 507 ], "children": [], "area": 61519.795089, "iscrowd": 0, "segmentation": [] }, { "id": 531, "strid": "ed3a6cb8-683b-43f9-a849-b881677fb1e5", "image_id": 23, "image_name": "11157.png", "category_id": 9, "category_name": "Root", "bbox": [ 19.72, 37.29, 183.04, 211.20000000000002 ], "priority": -1, "parents": [], "children": [ 552, 532, 538, 534, 550, 553, 541, 536, 533 ], "area": 735.3588, "iscrowd": 0, "segmentation": [] }, { "id": 532, "strid": "ecd1c0f1-0c42-4bd5-8802-e42e8e02738d", "image_id": 23, "image_name": "11157.png", "category_id": 1, "category_name": "Title", "bbox": [ 209.153, 161.422, 2507.751, 105.43199999999999 ], "priority": 1, "parents": [ 531 ], "children": [], "area": 33761.895566, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 533, "strid": "9d880ed8-76f2-4a98-aed3-4a1600ce491a", "image_id": 23, "image_name": "11157.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 81.014, 298.866, 2761.155, 232.93499999999995 ], "priority": 2, "parents": [ 531 ], "children": [], "area": 24212.330123999996, "iscrowd": 0, "segmentation": [], "text": "Stefan Panaiotov', Georgi Filevski?, Michele Equestre’, Elena Nikolova’, Victoria Levterova', lvan Simeonovski',\n\nElizabeta Bachiyska', Maria Nikolova', Reni Kalfin®\n‘National Center of Infectious and Parasitic Diseases, Janko Sakasov 26, Sofia 1504, Bulgaria, ?First Town’s Hospital, Patriarch Eftimii 37, Sofia 1000, Bulgaria, “Istituto\nSuperiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy, 4Institute of Experimental Morphology, Pathology and Anthropology, Bulgarian Academy of Sciences, Acad. G.\nBonchev Str. 25, Sofia 1113, Bulgaria, ‘Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 23, Sofia 1113, Bulgaria" }, { "id": 534, "strid": "50b9d263-9282-4b4d-86cd-a5b839acaa20", "image_id": 23, "image_name": "11157.png", "category_id": 5, "category_name": "Section", "bbox": [ 284.85, 693.478, 427.298, 73.17399999999998 ], "priority": 3, "parents": [ 531 ], "children": [ 535 ], "area": 197537.2083, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 535, "strid": "2f03c87a-89d1-4f24-ae16-5d3e461b0ecb", "image_id": 23, "image_name": "11157.png", "category_id": 3, "category_name": "Text", "bbox": [ 95.053, 824.842, 834.813, 1040.641 ], "priority": 4, "parents": [ 534 ], "children": [], "area": 78403.706626, "iscrowd": 0, "segmentation": [], "text": "Current assays for determining the presence of M.\ntuberculosis infection, such as an interferon gamma\nrelease assay (IGRA) or tuberculin skin test (TST),\ncannot predict which infected individuals will develop\nactive tuberculosis.\n\nDormant latent bacteria remain undetected by\nconventional culture methods. Therefore, these\n“invisible” bacteria represent a diagnostic target, which\nif successfully detected may improve tuberculosis\ncontrol hindered by LTBI.\n\nIn 1993 Emil Kalfin cultured blood of healthy individuals\nin BHI broth supplemented with vitamin K and 100% of\nblood cultures were positive for organisms which he\nnamed Chlamydia-Like Microorganisms.\n\nDomingue, G. (1987), Nikkari, S. (2001), McLaughlin, R.\n(2002), Moriyama (2008), Damgaard, C. (2015), Paise,\nS. (2016) also questioned the existence of a blood\nmicrobiome in healthy individuals. Zak, D. (2016)\nattempted to demonstrate that host blood RNA\nsignatures can predict progression to active TB in\nlatently infected individuals.\n\nMarkova, N. (2015, 2017) showed that mycobacterial L-\nforms persist in the blood of BCG vaccinated people\nand suggest that reproductive filterable L-bodies of\nBCG origin are able to pass in the blood circulation of\nthe fetus by vertical transmission." }, { "id": 536, "strid": "5be7efdc-be8a-422b-9482-138e1bf1a24d", "image_id": 23, "image_name": "11157.png", "category_id": 5, "category_name": "Section", "bbox": [ 301.82, 1934.725, 316.474, 62.71100000000001 ], "priority": 5, "parents": [ 531 ], "children": [ 537 ], "area": 583938.6995, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 537, "strid": "34a440ce-a86b-4aaf-9069-4f3bf049e121", "image_id": 23, "image_name": "11157.png", "category_id": 3, "category_name": "Text", "bbox": [ 100.585, 2053.946, 833.677, 203.66100000000006 ], "priority": 6, "parents": [ 536 ], "children": [], "area": 206596.15840999997, "iscrowd": 0, "segmentation": [], "text": "To test resuscitation of dormant blood microbiota and M.\ntuberculosis in blood samples by culturing,\nmicroscopy analysis, physico-chemical analysis,\nDNA isolation and sequencing analysis in healthy\nindividuals and with latent TB infection." }, { "id": 538, "strid": "b5e581f1-41cf-44e1-aeb1-1c0f12f5b6d7", "image_id": 23, "image_name": "11157.png", "category_id": 5, "category_name": "Section", "bbox": [ 148.525, 2346.857, 719.534, 59.13200000000006 ], "priority": 7, "parents": [ 531 ], "children": [ 539, 540 ], "area": 348566.935925, "iscrowd": 0, "segmentation": [], "text": "Materials\n\n& Methods" }, { "id": 539, "strid": "dd67abca-cd25-4be9-89e0-2bd7640a266c", "image_id": 23, "image_name": "11157.png", "category_id": 3, "category_name": "Text", "bbox": [ 99.105, 2476.181, 867.825, 280.9920000000002 ], "priority": 8, "parents": [ 538 ], "children": [], "area": 245401.918005, "iscrowd": 0, "segmentation": [], "text": "Blood was collected from healthy and IGRA(+) volunteers\nusing BD Vacutainer K3E 5 ml tubes. For culturing we\nused Brain Hearth Infusion (BHI) broth (Difco, BD)\nsupplemented with vitamin K 1 mg/ml, 10% (D+) sucrose,\n0.25% sodium citrate and 0.2% yeastolate (Difco, BD).\nGrowth at 43°C was detected at 24 h, but 72 h was\noptimal growing time (Figure 1)." }, { "id": 540, "strid": "97711fb4-ae9f-4128-80c5-86dcd4d62945", "image_id": 23, "image_name": "11157.png", "category_id": 4, "category_name": "List", "bbox": [ 97.193, 2757.912, 869.768, 796.3600000000001 ], "priority": 9, "parents": [ 538 ], "children": [], "area": 268049.741016, "iscrowd": 0, "segmentation": [] }, { "id": 541, "strid": "4e1c7895-ba49-4145-a6ab-f5b66fa49d94", "image_id": 23, "image_name": "11157.png", "category_id": 5, "category_name": "Section", "bbox": [ 1277.863, 698.439, 259.8589999999999, 57.313999999999965 ], "priority": 10, "parents": [ 531 ], "children": [ 544, 548, 542, 546 ], "area": 892509.355857, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 542, "strid": "45910a44-af46-4d82-8bd9-781a9b4b0896", "image_id": 23, "image_name": "11157.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1054.371, 873.46, 716.5439999999999, 520.4380000000001 ], "priority": 11, "parents": [ 541 ], "children": [ 543 ], "area": 920950.8936600002, "iscrowd": 0, "segmentation": [] }, { "id": 543, "strid": "89c6538b-f685-4e90-957c-bfb341820cb6", "image_id": 23, "image_name": "11157.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1010.044, 1404.215, 833.7890000000001, 399.365 ], "priority": 12, "parents": [ 542 ], "children": [], "area": 1418318.9354599998, "iscrowd": 0, "segmentation": [], "text": "Figure 1 | Microscopic examinations of blood\nmicrobiome (liquid culture). a, Gram stained blood\nmicrobiota of cultured human blood at 43 °C for 48 h, 10\nx 100. Several morphological forms could be observed.\nb, ‘dense body’ of Gram positively stained microbial\ncore structure surrounded by Gram negative coat. c,\nThe ‘dense body’ could divide by simple budding, and/or\nd, produce in chains Gram negatively stained ‘primary\ncells’. Green bar 10um. e, f, TEM division by budding\nand chain forming. g, TEM of ‘primary cell’." }, { "id": 544, "strid": "8e705765-d182-470e-b2c3-0a56e3d02b1b", "image_id": 23, "image_name": "11157.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1082.19, 1821.966, 696.4969999999998, 528.1390000000001 ], "priority": 13, "parents": [ 541 ], "children": [ 545 ], "area": 1971713.38554, "iscrowd": 0, "segmentation": [] }, { "id": 545, "strid": "3ea0c325-9279-40e6-9836-ef5e1152dbf2", "image_id": 23, "image_name": "11157.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1014.327, 2379.24, 831.1789999999999, 158.10500000000002 ], "priority": 14, "parents": [ 544 ], "children": [], "area": 2413327.3714799997, "iscrowd": 0, "segmentation": [], "text": "Figire 2 | Colonies of blood microbiota on agar\nplate. a, Growth on agar plate for 30 days at 43 °C. b,\nZoom in of the sector plate. c, Gram_ stained\npreparation. d, Zoom in sector. Gree bar 10m." }, { "id": 546, "strid": "472f557b-062e-4a24-882d-4c1953a0ba8f", "image_id": 23, "image_name": "11157.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1149.848, 2547.296, 654.4470000000001, 469.5 ], "priority": 15, "parents": [ 541 ], "children": [ 547 ], "area": 2929003.2110079997, "iscrowd": 0, "segmentation": [] }, { "id": 547, "strid": "98a3af74-0d4e-40b6-8c61-b25b84357edd", "image_id": 23, "image_name": "11157.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1033.592, 3052.147, 866.923, 442.27800000000025 ], "priority": 16, "parents": [ 546 ], "children": [], "area": 3154674.7220240002, "iscrowd": 0, "segmentation": [], "text": "Figure 3 | Physico-chemical properties of the blood\nmicrobiota. a, Gram stained blood microbiota grown on\nagar for 30 days at 43 °C. b, c, Disintegration of the\nsample with ultrasound (MSE, UK) for 1 h. Cells with\nstreptococcal appearance of 0.1-0.2 pm dominate. d,\nUncultured blood sample after gamma irradiation with\n25+25 KGy dose. e, 25+25 KGy irradiated sample\ncultured for 14 days at 43 °C. f, Sector zoom in. g, h, i,\nBlood microbiota treated with 10% KOH, (h) with 10%\nNaOH - Gram negatively stained microbial structures are\nnot seen and (i) with 10% CH,COOH for 30 min at 37 °C" }, { "id": 548, "strid": "b3674147-9ee2-4f4f-aa4a-5a6ec0f78268", "image_id": 23, "image_name": "11157.png", "category_id": 7, "category_name": "Table", "bbox": [ 1900.044, 843.418, 1028.7660000000003, 1444.121 ], "priority": 17, "parents": [ 541 ], "children": [ 549 ], "area": 1602531.310392, "iscrowd": 0, "segmentation": [] }, { "id": 549, "strid": "beffbb51-57b6-4bca-8292-df40da99f435", "image_id": 23, "image_name": "11157.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1907.939, 665.732, 957.8509999999999, 158.76700000000005 ], "priority": 18, "parents": [ 548 ], "children": [], "area": 1270176.046348, "iscrowd": 0, "segmentation": [], "text": "Table 1. 16S rDNA genes and ITS2 region targeted\nmetagenomic sequencing data. Confirmed bacterial and fungi\n\nphyla and genera in the blood of two healthy individuals of blood\ngroup A and B." }, { "id": 550, "strid": "3205d259-7999-402c-a1a5-9fbf2fd62d6b", "image_id": 23, "image_name": "11157.png", "category_id": 5, "category_name": "Section", "bbox": [ 2148.176, 2366.53, 490.2040000000002, 65.91899999999987 ], "priority": 19, "parents": [ 531 ], "children": [ 551 ], "area": 5083722.94928, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 551, "strid": "8b70fe35-7e8e-4de9-8bec-63437232c797", "image_id": 23, "image_name": "11157.png", "category_id": 3, "category_name": "Text", "bbox": [ 1958.702, 2504.826, 911.3199999999999, 697.3450000000003 ], "priority": 20, "parents": [ 550 ], "children": [], "area": 4906207.695852, "iscrowd": 0, "segmentation": [], "text": "The dormant blood microbiota are innate of the\nhealthy humans. On the bases of the 16S rRNA\ngenes and ITS2 sequencing results we identified\nOTUs similarity with 25 bacterial genera belonging\nto 4 phyla and 10 fungi genera (predominantly\nAlternaria, Epicoccum, Monographella, Malassezia,\nFilobasidium and others) belonging to 2 phyla. For\nthe first time we confirm presence of fungi in the\nblood of healthy individuals. Resuscitation of the\nLTBI blood microbiome is_ highly challenging.\nPreliminary results suggest that using vitamin K to\nreanimate the dormant bacteria may enable\nquantitative detection of the dormant M. tuberculosis\npopulation in patients with LTBI and holds promise\nfor becoming a predictive tool for LTBI dynamics." }, { "id": 552, "strid": "fea00729-5614-49ef-aa71-62105d3372dc", "image_id": 23, "image_name": "11157.png", "category_id": 4, "category_name": "List", "bbox": [ 1978.416, 3257.102, 930.5739999999998, 366.59000000000015 ], "priority": 21, "parents": [ 531 ], "children": [], "area": 6443902.7104319995, "iscrowd": 0, "segmentation": [] }, { "id": 553, "strid": "2368e6a3-4ce4-45ec-b8d9-919295e1f611", "image_id": 23, "image_name": "11157.png", "category_id": 3, "category_name": "Text", "bbox": [ 984.133, 3588.182, 949.374, 78.33100000000013 ], "priority": 22, "parents": [ 531 ], "children": [], "area": 3531248.316206, "iscrowd": 0, "segmentation": [], "text": "Acknowledgements: This project has received funding from\nthe National Science Fund of Bulgaria GA: H-01-4/16.12.2016" }, { "id": 554, "strid": "c87de30d-65a6-422e-9bae-cdbb4eaa5b9f", "image_id": 24, "image_name": "11299.png", "category_id": 9, "category_name": "Root", "bbox": [ 186.37, 107.5, 171.14, 179.29000000000002 ], "priority": -1, "parents": [], "children": [ 555, 557, 561, 569, 564, 563, 570, 559, 556, 567 ], "area": 20034.775, "iscrowd": 0, "segmentation": [] }, { "id": 555, "strid": "1dc7b99a-059b-42f0-b491-d937f9426cfa", "image_id": 24, "image_name": "11299.png", "category_id": 1, "category_name": "Title", "bbox": [ 460.117, 262.538, 2626.269, 180.55600000000004 ], "priority": 1, "parents": [ 554 ], "children": [], "area": 120798.19694600001, "iscrowd": 0, "segmentation": [], "text": "GOBLET Standards Committee:" }, { "id": 556, "strid": "992caa85-30ce-4a23-8ba0-a9ed19f2d9cb", "image_id": 24, "image_name": "11299.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 455.894, 478.478, 2789.2929999999997, 353.632 ], "priority": 2, "parents": [ 554 ], "children": [], "area": 218135.249332, "iscrowd": 0, "segmentation": [], "text": "our activities and forward vision\n\nSonika Tyagi, Maria Victoria Schneider?, Sarah L. Morgan’, Michael Charleston?>, Patricia M. Palagi®,\nJudit Kumuthini’, Gabriella Rustici® and Teresa K. Attwood?\n\ntMonash Bioinformatics Platform, Monash University, AU; 7AGRF, AU; 7EMBL-ABR, AU; 7EMBL-EBI, UK; °University of Tasmania,\nAU; °SIB Swiss Institute of Bioinformatics; 7\"CPGR, ZA; ®University of Cambridge, UK; °University of Manchester, UK" }, { "id": 557, "strid": "598274b6-6a63-4f9c-852a-20b044290c33", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 157.248, 876.652, 252.55900000000003, 53.652000000000044 ], "priority": 3, "parents": [ 554 ], "children": [ 558 ], "area": 137851.773696, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 558, "strid": "6de4caf1-4d94-4d99-97c9-90d2d9f12049", "image_id": 24, "image_name": "11299.png", "category_id": 3, "category_name": "Text", "bbox": [ 147.679, 960.636, 3284.097, 423.299 ], "priority": 4, "parents": [ 557 ], "children": [], "area": 141865.763844, "iscrowd": 0, "segmentation": [], "text": "Recognising the importance of internationally-recognised standards in data-driven science, GOBLET’s?\nStandards Committee is contributing to the open science data life-cycle by helping both to develop standards\nfor annotating training materials and events?, and to raise awareness of life-science data standards (including\nFAIR principles) through training provision. Here, we introduce some of the Committee’s work and review\n\npreliminary results of our standards-awareness survey." }, { "id": 559, "strid": "06cb21a9-c183-4963-9542-346fa3e69058", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 129.185, 1458.438, 853.922, 58.46499999999992 ], "priority": 5, "parents": [ 554 ], "children": [ 560 ], "area": 188408.31303000002, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 560, "strid": "4ace452c-e001-4cda-80ae-415c7e0c22aa", "image_id": 24, "image_name": "11299.png", "category_id": 4, "category_name": "List", "bbox": [ 119.399, 1556.058, 1509.2060000000001, 303.405 ], "priority": 6, "parents": [ 559 ], "children": [], "area": 185791.769142, "iscrowd": 0, "segmentation": [] }, { "id": 561, "strid": "718074ef-9d68-45dd-81ff-6a1b858288a4", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 1841.415, 1459.124, 389.14400000000023, 55.827 ], "priority": 7, "parents": [ 554 ], "children": [ 562 ], "area": 2686852.82046, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 562, "strid": "f431bc8e-035b-40b5-9357-73151a9115ab", "image_id": 24, "image_name": "11299.png", "category_id": 3, "category_name": "Text", "bbox": [ 1832.905, 1548.031, 1626.0380000000002, 777.1239999999998 ], "priority": 8, "parents": [ 561 ], "children": [], "area": 2837393.760055, "iscrowd": 0, "segmentation": [], "text": "Standards are fundamental to the data life-cycle.\nNumerous standards exist in the life sciences (from\ndata collection to annotation, preservation and\npublication), all playing vital roles for data sharing and\nreuse. We are currently surveying awareness of\nstandards and their adoption in the life sciences.\nHere, we present the initial results, highlighting an\nalarming lack of standards awareness, about their\nimportance, what they are and when to use them." }, { "id": 563, "strid": "e6eacc99-e08a-4432-a3b9-e5843c967520", "image_id": 24, "image_name": "11299.png", "category_id": 2, "category_name": "Figure", "bbox": [ 112.53, 1957.556, 1591.171, 809.5430000000001 ], "priority": 9, "parents": [ 554 ], "children": [], "area": 220283.77668, "iscrowd": 0, "segmentation": [] }, { "id": 564, "strid": "496fcf5e-b611-4a88-960b-de3793495dc2", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 1827.508, 2415.176, 617.4379999999999, 67.21000000000004 ], "priority": 10, "parents": [ 554 ], "children": [ 566, 565 ], "area": 4413753.4614079995, "iscrowd": 0, "segmentation": [], "text": "Preliminary Findings" }, { "id": 565, "strid": "dbdb7ce3-e363-4229-b81a-4a31863aa606", "image_id": 24, "image_name": "11299.png", "category_id": 4, "category_name": "List", "bbox": [ 1807.796, 2508.83, 1667.363, 574.5639999999999 ], "priority": 11, "parents": [ 564 ], "children": [], "area": 4535452.83868, "iscrowd": 0, "segmentation": [] }, { "id": 566, "strid": "eb8337b2-dec5-474d-a100-6cce42b9b48a", "image_id": 24, "image_name": "11299.png", "category_id": 3, "category_name": "Text", "bbox": [ 1814.007, 3115.307, 1607.0949999999998, 311.05099999999993 ], "priority": 12, "parents": [ 564 ], "children": [], "area": 5651188.705149, "iscrowd": 0, "segmentation": [], "text": "So far, we have received limited responses to the survey in\ngeneral, and to the topic of training material standards in\nparticular; nevertheless, the latter was listed amongst the\ntop priority standards to be developed (data not shown)." }, { "id": 567, "strid": "c2086d58-1586-4358-800b-663e70d7d0f3", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 117.397, 2850.228, 1091.473, 70.74299999999994 ], "priority": 13, "parents": [ 554 ], "children": [ 568 ], "area": 334608.21651600004, "iscrowd": 0, "segmentation": [], "text": "Future Activities, Moving Forward" }, { "id": 568, "strid": "bc905acf-02d3-4c3d-9a57-44884e3b7171", "image_id": 24, "image_name": "11299.png", "category_id": 4, "category_name": "List", "bbox": [ 105.617, 2940.576, 1599.428, 800.8710000000001 ], "priority": 14, "parents": [ 567 ], "children": [], "area": 310574.815392, "iscrowd": 0, "segmentation": [] }, { "id": 569, "strid": "044c4009-915c-4557-84f1-22d32cde1abc", "image_id": 24, "image_name": "11299.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1844.974, 3512.528, 1594.6160000000002, 936.7469999999998 ], "priority": 15, "parents": [ 554 ], "children": [], "area": 6480522.834271999, "iscrowd": 0, "segmentation": [] }, { "id": 570, "strid": "e8c35bf9-eb23-4b10-9220-410d7c4ddee7", "image_id": 24, "image_name": "11299.png", "category_id": 5, "category_name": "Section", "bbox": [ 142.599, 3796.809, 322.392, 46.94399999999996 ], "priority": 16, "parents": [ 554 ], "children": [ 571 ], "area": 541421.166591, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 571, "strid": "bf22cd59-98e5-405b-a777-498f9112e8d8", "image_id": 24, "image_name": "11299.png", "category_id": 4, "category_name": "List", "bbox": [ 122.041, 3862.845, 1588.292, 595.4000000000001 ], "priority": 17, "parents": [ 570 ], "children": [], "area": 471425.466645, "iscrowd": 0, "segmentation": [] }, { "id": 572, "strid": "9b1e48f9-39c6-4486-ad1f-45c422f0983a", "image_id": 25, "image_name": "11354.png", "category_id": 9, "category_name": "Root", "bbox": [ 80.45, 72.03, 277.37, 208.03 ], "priority": -1, "parents": [], "children": [ 575, 586, 574, 590, 573, 581, 577 ], "area": 5794.8135, "iscrowd": 0, "segmentation": [] }, { "id": 573, "strid": "213064de-2f87-4b16-b22f-866da48cba77", "image_id": 25, "image_name": "11354.png", "category_id": 1, "category_name": "Title", "bbox": [ 556.859, 54.556, 2630.68, 304.374 ], "priority": 1, "parents": [ 572 ], "children": [], "area": 30379.999604, "iscrowd": 0, "segmentation": [], "text": "QCFALLSequencing" }, { "id": 574, "strid": "f419329b-1ede-46c6-b7b6-547ca6c4eb5f", "image_id": 25, "image_name": "11354.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 359.806, 360.805, 2812.767, 352.724 ], "priority": 2, "parents": [ 572 ], "children": [], "area": 129819.80382999999, "iscrowd": 0, "segmentation": [], "text": "Steven Wingett', Felix Krueger’, Philip Ewels* and Simon Andrews'\n‘Bioinformatics Group, The Babraham Institute, Cambridge CB22 3AT, UK\n“Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm\nUniversity, Stockholm 106 91, Sweden" }, { "id": 575, "strid": "9d93f9d4-485b-4121-ad1f-20d7a57437bd", "image_id": 25, "image_name": "11354.png", "category_id": 5, "category_name": "Section", "bbox": [ 601.607, 810.949, 434.953, 65.19200000000001 ], "priority": 3, "parents": [ 572 ], "children": [ 576 ], "area": 487872.59504299995, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 576, "strid": "d9021361-2cf1-4083-b7f8-9da9b41430c1", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 37.569, 941.543, 1542.597, 1314.9859999999999 ], "priority": 4, "parents": [ 575 ], "children": [], "area": 35372.828967, "iscrowd": 0, "segmentation": [], "text": "Reaching valid conclusions from DNA sequencing experiments\nrequires accurate results and a thorough understanding of the data,\nyet we often see researchers misinterpreting artefacts as genuine\nfindings and consequently presenting incorrect conclusions and\n\nwasting time chasing false leads.\n\nPerhaps more frustrating still is the fact that many different\nresearchers are being adversely affected by the same artefacts, or\nmaking similar mistakes when interpreting DNA sequencing results.\nAt present, there is a lack of resources available to help scientists\navoid these pitfalls, and an unmet need for a freely available central\nresource clearly documenting the most commonly encountered and\n\nproblematic issues affecting those undertaking DNA sequencing.\n\nTo address these problems, we developed the website QC Fail." }, { "id": 577, "strid": "9a8497fb-6165-43f4-9380-9ad52fdd3454", "image_id": 25, "image_name": "11354.png", "category_id": 5, "category_name": "Section", "bbox": [ 719.593, 2308.617, 196.47199999999998, 69.29199999999992 ], "priority": 5, "parents": [ 572 ], "children": [ 578, 579, 580 ], "area": 1661264.632881, "iscrowd": 0, "segmentation": [], "text": "Aims" }, { "id": 578, "strid": "d1949188-2910-44d3-ac68-3d9eb94e0282", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 37.709, 2448.674, 1539.611, 774.8789999999999 ], "priority": 6, "parents": [ 577 ], "children": [], "area": 92337.04786600001, "iscrowd": 0, "segmentation": [], "text": "When we encounter a sequencing problem which may be of interest\nto the wider life sciences community, we record our experiences on\nthe QC Fail website. Each article typically discusses how a problem\nwas identified, whether we determined the cause and what measures\nshould be taken to improve the situation. In addition, we make\navailable example datasets for people to download and analyse\nthemselves and perhaps use in the development of processing or\nQC tools. These datasets should also prove useful for teaching\n\npurposes. This poster summarises two recently published stories." }, { "id": 579, "strid": "14021107-2dac-428c-b76e-79bcd0eb7490", "image_id": 25, "image_name": "11354.png", "category_id": 2, "category_name": "Figure", "bbox": [ 39.776, 3270.499, 766.035, 607.1990000000001 ], "priority": 7, "parents": [ 577 ], "children": [], "area": 130087.368224, "iscrowd": 0, "segmentation": [] }, { "id": 580, "strid": "be70b95e-d6c4-43cb-b904-dc55bee52704", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 828.017, 3268.889, 760.9370000000001, 512.3630000000003 ], "priority": 8, "parents": [ 577 ], "children": [], "area": 2706695.6631130003, "iscrowd": 0, "segmentation": [], "text": "QC Fail website screenshot\n\nAs we encounter new sequencing-related problems we\npost our experiences on the website. We allow visitors\nto comment on our stories and share their experiences\nwith our readers. The site now hosts a wealth of\ninformation on how to improve experiments, and\nprovides a great way for researchers to get in contact\nwith people who may have already encountered a\n\nproblem similar to their own." }, { "id": 581, "strid": "1f1df8b4-c2d1-4784-9001-f67496d5990b", "image_id": 25, "image_name": "11354.png", "category_id": 5, "category_name": "Section", "bbox": [ 1982.008, 809.292, 1011.5179999999998, 79.87699999999995 ], "priority": 9, "parents": [ 572 ], "children": [ 584, 582, 585, 583 ], "area": 1604023.218336, "iscrowd": 0, "segmentation": [], "text": "Story 1 - DNA contamination" }, { "id": 582, "strid": "5d26724e-7bb5-4449-8f35-9c5945c4c1b9", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 1704.245, 939.826, 1556.993, 594.665 ], "priority": 10, "parents": [ 581 ], "children": [], "area": 1601693.76137, "iscrowd": 0, "segmentation": [], "text": "Problem: Cross mapping artefacts owing to DNA contamination from\n“foreign” species.\n\nSolution: Validate the sample is as expected using tools such as\nFastQ Screen to map sequences against a panel of reference\ngenomes. In the example below, the supposedly human sample was\ncontaminated with E. coli DNA. Researchers should troubleshoot\n\ntheir protocols to identify and remove such contaminants." }, { "id": 583, "strid": "5ebdb3b4-45ce-4443-9606-1ad483cae5c5", "image_id": 25, "image_name": "11354.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1705.247, 1592.57, 1043.785, 538.5399999999997 ], "priority": 11, "parents": [ 581 ], "children": [], "area": 2715725.21479, "iscrowd": 0, "segmentation": [] }, { "id": 584, "strid": "342827d8-acaf-4674-b426-c15e786a0d4a", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 2778.536, 1601.008, 485.0529999999999, 448.885 ], "priority": 12, "parents": [ 581 ], "children": [], "area": 4448458.364288, "iscrowd": 0, "segmentation": [], "text": "Output from FastQ Screen\n\nThe graph shows the result of\nmapping reads against the\nexpected human genome and four\npotential sources of\ncontamination. Unexpectedly, just\nover 60% of the reads mapped\n\nonly to the E. coli genome." }, { "id": 585, "strid": "9af4d86c-fab6-4461-8734-b13861e12d0d", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 1717.405, 2182.709, 1495.334, 37.15299999999979 ], "priority": 13, "parents": [ 581 ], "children": [], "area": 3748595.3501449996, "iscrowd": 0, "segmentation": [], "text": "The tool FastQ Screen may be downloaded from : http://www.bioinformatics.babraham.ac.uk/projects" }, { "id": 586, "strid": "a3a1ff54-a058-4d3a-a253-5f8e6b9bf19c", "image_id": 25, "image_name": "11354.png", "category_id": 5, "category_name": "Section", "bbox": [ 1800.473, 2310.02, 1372.676, 77.59000000000015 ], "priority": 14, "parents": [ 572 ], "children": [ 589, 587, 588 ], "area": 4159128.6394599997, "iscrowd": 0, "segmentation": [], "text": "Story 2 - patterned flow cell duplicates" }, { "id": 587, "strid": "cda1dcc4-eddc-4291-bf76-4e9908c8d3b8", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 1704.214, 2448.778, 1560.234, 863.835 ], "priority": 15, "parents": [ 586 ], "children": [], "area": 4173241.7504919996, "iscrowd": 0, "segmentation": [], "text": "Problem: Although the new Illumina patterned flow cells generate\nmany more sequence reads than the previous generation design, a\nsignificant proportion of such reads may be duplicates. These\nartefacts, specific to this new patterned design, reduce sequencing\ndepth and could skew experimental results.\n\nSolution: These duplicates are positioned in close proximity to one\nanother on a flowcell and so may be removed using a distance filter\n(similar to the removal of “optical duplicates” performed by tools such\nas Picard, but requiring an increased minimum allowed separation\n\ndistance)." }, { "id": 588, "strid": "4a68a584-f6b6-4ad1-b358-22840b422089", "image_id": 25, "image_name": "11354.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1722.925, 3340.197, 892.9619999999998, 539.0230000000001 ], "priority": 16, "parents": [ 586 ], "children": [], "area": 5754908.916225, "iscrowd": 0, "segmentation": [] }, { "id": 589, "strid": "23cecaac-bae4-4313-a2f0-8671cd295e0d", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 2632.724, 3337.629, 630.0250000000001, 456.89699999999993 ], "priority": 17, "parents": [ 586 ], "children": [], "area": 8787055.971396001, "iscrowd": 0, "segmentation": [], "text": "Plot showing the spatial separation of\nduplicates relative to one another\n\nOne read is set at the origin, and the relative\nposition of its duplicate is determined using\nthe co-ordinate system recorded in the FASTQ\nfile. The plot reveals the ordered array of\nindividual nanowells integral to this new\n\ntechnology." }, { "id": 590, "strid": "f3ef6220-e875-498e-92ef-2a94dbc7231a", "image_id": 25, "image_name": "11354.png", "category_id": 5, "category_name": "Section", "bbox": [ 1317.533, 3915.491, 669.7139999999999, 102.99400000000014 ], "priority": 18, "parents": [ 572 ], "children": [ 591 ], "area": 5158788.603703, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 591, "strid": "f11e90f4-885f-442a-af49-e6e6fc0a4ae0", "image_id": 25, "image_name": "11354.png", "category_id": 3, "category_name": "Text", "bbox": [ 42.553, 4070.867, 3210.33, 235.41600000000017 ], "priority": 19, "parents": [ 590 ], "children": [], "area": 173227.603451, "iscrowd": 0, "segmentation": [], "text": "The QC Fail website already provides an invaluable resource to help other scientists plan, perform and analyse sequencing experiments. Our\nbioinformatics facility is continuing to develop the site as we, and our readers, encounter interesting sequencing problems. Although the stories\n\ncurrently focus on sequencing-related matters, we intend to report new technology trends as they develop." }, { "id": 623, "strid": "d84bc615-ad56-4155-940e-27df360905c6", "image_id": 27, "image_name": "11403.png", "category_id": 9, "category_name": "Root", "bbox": [ 165.51, 130.12, 356.62, 316.99 ], "priority": -1, "parents": [], "children": [ 626, 625, 635, 630, 629, 624, 640, 645, 638, 632, 634, 636, 642, 631, 639, 633, 637, 628, 641 ], "area": 21536.1612, "iscrowd": 0, "segmentation": [] }, { "id": 624, "strid": "8b469a1a-5da6-428b-8d9c-bb296ca0aeef", "image_id": 27, "image_name": "11403.png", "category_id": 1, "category_name": "Title", "bbox": [ 790.76, 123.248, 2020.265, 263.976 ], "priority": 1, "parents": [ 623 ], "children": [], "area": 97459.58848, "iscrowd": 0, "segmentation": [], "text": "NGL Viewer & Library\nVersatile molecular graphics on the web" }, { "id": 625, "strid": "151c8749-2ef8-46a8-9b21-6582bd02469d", "image_id": 27, "image_name": "11403.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 1343.767, 452.034, 910.3509999999999, 61.398000000000025 ], "priority": 2, "parents": [ 623 ], "children": [], "area": 607428.372078, "iscrowd": 0, "segmentation": [], "text": "Alexander S. Rose, Stephen K. Burley" }, { "id": 626, "strid": "767e55a6-7ecf-400c-9c8f-1f61f794b056", "image_id": 27, "image_name": "11403.png", "category_id": 5, "category_name": "Section", "bbox": [ 675.113, 788.235, 225.34500000000003, 48.63099999999997 ], "priority": 3, "parents": [ 623 ], "children": [ 627 ], "area": 532147.6955550001, "iscrowd": 0, "segmentation": [], "text": "Overview" }, { "id": 627, "strid": "95a8182b-4d25-4e95-ad45-466d2d76717f", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 318.121, 888.776, 938.8660000000001, 492.59399999999994 ], "priority": 4, "parents": [ 626 ], "children": [], "area": 282738.30989599996, "iscrowd": 0, "segmentation": [], "text": "Interactive visualization, annotation and sharing of\nlarge macromolecular complexes is more important\nthan ever but is becoming challenging as experimental\ntechniques advance at an unprecedented rate. The\nweb can provide easy access to the resulting\nvisualizations for all interested parties, including\ncolleagues, collaborators, reviewers and educators.\nHerein, we utilize the web-based NGL library to provide\n3D visualization of experimental and computational\ndata integrated with general molecular graphics." }, { "id": 628, "strid": "7812c988-c1d0-40b3-8ffc-aa85030c9b0c", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1465.452, 784.397, 1194.144, 800.9500000000002 ], "priority": 5, "parents": [ 623 ], "children": [], "area": 1149496.1524440001, "iscrowd": 0, "segmentation": [] }, { "id": 629, "strid": "0dab12ea-5272-4fec-b426-379d1f37f46d", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 2892.023, 795.237, 371.5160000000001, 707.2489999999999 ], "priority": 6, "parents": [ 623 ], "children": [], "area": 2299843.694451, "iscrowd": 0, "segmentation": [], "text": "Format support\n\nStructure:\nmmCIF,\nPDB/PQR,\nGRO, SDF,\nMOL2, MMTF\n\nTrajectory: PSF & DCD, TOP\n& TRR/XTC, PRMTOP &\nNCTRAJ\n\nVolume: MRC/MAP/CCP4,\nDSN6/BRIX, CUBE,\nDX/DXBIN, XPLOR/CNS\nSurface: OBJ, PLY\n\nGeneral: CSV, JSON,\nMSGPACK, TXT, XML" }, { "id": 630, "strid": "2fe0c6d5-d8ca-4be9-aac8-c47bdca24316", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 341.492, 1774.131, 805.4760000000001, 214.423 ], "priority": 7, "parents": [ 623 ], "children": [], "area": 605851.543452, "iscrowd": 0, "segmentation": [], "text": "Working with molecules\n\nThe Structure class provides iterators for the\nmolecular hierarchy and data access via proxies" }, { "id": 631, "strid": "f418696a-5fa8-45aa-b20b-fa5cf1ab7be4", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 293.142, 2050.987, 940.2559999999999, 390.39699999999993 ], "priority": 8, "parents": [ 623 ], "children": [], "area": 601230.431154, "iscrowd": 0, "segmentation": [] }, { "id": 632, "strid": "3cd4a891-948a-402c-baa0-f2e32e030eaf", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 1406.048, 1774.392, 898.78, 264.72399999999993 ], "priority": 9, "parents": [ 623 ], "children": [], "area": 2494880.322816, "iscrowd": 0, "segmentation": [], "text": "The molecular world is but a stage\n\nThere is one object to rule them all, the Stage. To\ndraw on the canvas follow the central dogma of NGL\n“Stage -> Component -> Representation’." }, { "id": 633, "strid": "41a9df6f-312b-4df0-b0f9-7a0a68a73a29", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1344.644, 2180.014, 1035.579, 261.067 ], "priority": 10, "parents": [ 623 ], "children": [], "area": 2931342.7450160002, "iscrowd": 0, "segmentation": [] }, { "id": 634, "strid": "0310cf8f-93f4-4312-929b-224e55795135", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 2498.7, 1775.863, 789.9520000000002, 311.54200000000014 ], "priority": 11, "parents": [ 623 ], "children": [], "area": 4437348.878099999, "iscrowd": 0, "segmentation": [], "text": "Animation & user interaction\n\nAnimation controls to orient the whole scene\nor individual components. Mouse controls to\nbind actions to mouse and keyboard, including\nclicking or hovering atoms or other elements" }, { "id": 635, "strid": "2339adf0-31ba-4fc7-9243-b8523f00e652", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2481.795, 2204.691, 825.915, 239.1260000000002 ], "priority": 12, "parents": [ 623 ], "children": [], "area": 5471591.100345, "iscrowd": 0, "segmentation": [] }, { "id": 636, "strid": "8c3c0711-ed59-406a-9776-47be7f700e76", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 302.972, 2656.255, 907.815, 280.8609999999999 ], "priority": 13, "parents": [ 623 ], "children": [], "area": 804770.88986, "iscrowd": 0, "segmentation": [], "text": "Volume Data\n\nVolumetric data can be rendered as isosurfaces, point\nclouds or volume slices. Moreover, volume data can\nbe used for coloring structures and other volumes." }, { "id": 637, "strid": "fd69f3be-b22b-40a9-b8a4-36a89f884b16", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 299.847, 3049.423, 915.9300000000001, 738.2510000000002 ], "priority": 14, "parents": [ 623 ], "children": [], "area": 914360.3382809999, "iscrowd": 0, "segmentation": [] }, { "id": 638, "strid": "2fa3d6f7-36bf-4bdb-91cc-804c94de8d87", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 1481.681, 2657.161, 809.9670000000001, 269.98900000000003 ], "priority": 15, "parents": [ 623 ], "children": [], "area": 3937064.967641, "iscrowd": 0, "segmentation": [], "text": "Molecular Data & Coloring\n\nMolecular data can be displayed as balls, sticks,\ncartoons, surfaces and labels or with specialized\nrepresentations such as hyperballs and ropes." }, { "id": 639, "strid": "94f1ed8e-8ad1-4b8f-b8e1-30689537d036", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1454.974, 3047.251, 997.644, 756.9380000000001 ], "priority": 16, "parents": [ 623 ], "children": [], "area": 4433670.976474, "iscrowd": 0, "segmentation": [] }, { "id": 640, "strid": "52e06a19-a564-4830-b1a7-bd70ac8357b4", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 2671.208, 2655.686, 567.4090000000001, 363.4859999999999 ], "priority": 17, "parents": [ 623 ], "children": [], "area": 7093889.688688001, "iscrowd": 0, "segmentation": [], "text": "Custom Shapes\n\nA variety of shapes, including\nsphere, cylinder, ellipsoid, cone,\narrow, label, and mesh, are\navailable for custom rendering of\nuser data" }, { "id": 641, "strid": "b5e014c0-1107-4a25-93ef-6b7c6157e6d0", "image_id": 27, "image_name": "11403.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2681.259, 3046.574, 596.6500000000001, 761.7539999999999 ], "priority": 18, "parents": [ 623 ], "children": [], "area": 8168653.956666, "iscrowd": 0, "segmentation": [] }, { "id": 642, "strid": "68370634-7653-4ef1-928e-868b4c2ad3be", "image_id": 27, "image_name": "11403.png", "category_id": 5, "category_name": "Section", "bbox": [ 615.987, 4027.477, 776.8350000000002, 61.90299999999979 ], "priority": 19, "parents": [ 623 ], "children": [ 643, 644 ], "area": 2480873.4747989997, "iscrowd": 0, "segmentation": [], "text": "Funding and acknowledgements" }, { "id": 643, "strid": "1c8f8722-45c8-4af4-a25f-b653deac28b7", "image_id": 27, "image_name": "11403.png", "category_id": 4, "category_name": "List", "bbox": [ 322.168, 4139.948, 534.456, 179.60499999999956 ], "priority": 20, "parents": [ 642 ], "children": [], "area": 1333758.7672640001, "iscrowd": 0, "segmentation": [] }, { "id": 644, "strid": "f43ff634-3b6b-4b99-b2d1-015432bed0d5", "image_id": 27, "image_name": "11403.png", "category_id": 4, "category_name": "List", "bbox": [ 1033.499, 4138.68, 656.508, 190.9979999999996 ], "priority": 21, "parents": [ 642 ], "children": [], "area": 4277321.64132, "iscrowd": 0, "segmentation": [] }, { "id": 645, "strid": "07bd0322-fdce-45fd-a09f-4d55e5d18b90", "image_id": 27, "image_name": "11403.png", "category_id": 5, "category_name": "Section", "bbox": [ 2352.157, 4026.019, 483.259, 63.78699999999981 ], "priority": 22, "parents": [ 623 ], "children": [ 646 ], "area": 9469828.772983, "iscrowd": 0, "segmentation": [], "text": "Software availability" }, { "id": 646, "strid": "efd2327a-5dc4-4089-87ab-97c15c07a880", "image_id": 27, "image_name": "11403.png", "category_id": 3, "category_name": "Text", "bbox": [ 1947.358, 4153.176, 894.4550000000002, 170.47199999999975 ], "priority": 23, "parents": [ 645 ], "children": [], "area": 8087720.509008001, "iscrowd": 0, "segmentation": [], "text": "NGL Viewer & Library (https://github.com/arose/ngl)\nAS Rose & PW Hildebrand.\n\nNGL Viewer: a web application for molecular visualization.\nNucl. Acids Res. (1 July 2015) 43 (W1). doi:10.1093/nar/gkv402" }, { "id": 647, "strid": "eecb1e82-01dc-4138-b786-2d35642bad58", "image_id": 28, "image_name": "11411.png", "category_id": 9, "category_name": "Root", "bbox": [ 167, 153.33, 270.43, 208.02 ], "priority": -1, "parents": [], "children": [ 660, 658, 654, 648, 662, 652, 649, 650, 656 ], "area": 25606.11, "iscrowd": 0, "segmentation": [] }, { "id": 648, "strid": "1d196ca6-30b3-4b4c-a704-822095c703b9", "image_id": 28, "image_name": "11411.png", "category_id": 1, "category_name": "Title", "bbox": [ 266.808, 464.709, 3111.453, 309.516 ], "priority": 1, "parents": [ 647 ], "children": [], "area": 123988.078872, "iscrowd": 0, "segmentation": [], "text": "Microsatellite instability profiling\n\nof TCGA colorectal adenocarcinomas using Common Workflow Language pipeline" }, { "id": 649, "strid": "8abefe4e-2642-47ee-8333-ddb829b9728a", "image_id": 28, "image_name": "11411.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 1461.433, 1010.435, 714.0590000000002, 70.5909999999999 ], "priority": 2, "parents": [ 647 ], "children": [], "area": 1476683.053355, "iscrowd": 0, "segmentation": [], "text": "Nikola Tesi¢, Marko Kalini¢" }, { "id": 650, "strid": "14dc8ed7-ac40-48b0-bf07-0cbe65d980ed", "image_id": 28, "image_name": "11411.png", "category_id": 5, "category_name": "Section", "bbox": [ 775.004, 1381.049, 256.2679999999999, 55.409000000000106 ], "priority": 3, "parents": [ 647 ], "children": [ 651 ], "area": 1070318.499196, "iscrowd": 0, "segmentation": [], "text": "ABSTRACT" }, { "id": 651, "strid": "4d22ae77-5c68-400d-87db-81f2aaa8fcc0", "image_id": 28, "image_name": "11411.png", "category_id": 3, "category_name": "Text", "bbox": [ 183.972, 1496.485, 1426.789, 600.267 ], "priority": 4, "parents": [ 650 ], "children": [], "area": 275311.33842, "iscrowd": 0, "segmentation": [], "text": "Microsatellite instability (MSI) is an important factor for classifying certain cancer types, it\nhas been shown to be associated with prognosis, and it can be used as a biomarker for\ntreatment selection. Here, we present a portable and reproducible Common Workflow\nLanguage (CWL) implementation of MS/sensor tool and JobSTR toolkit, we will show how\nto use MS/sensor and /JobSTR, and we will see how JobSTR deals with PCR noise and how\nit can silence it. Finally, we present results obtained using the aforementioned tools on\nmore than 600 TCGA colorectal adenocarcinoma cases, as well as our further analysis\nand interpretation of the results. Out of 592 cases that had MSI classification on GDC\nportal, MSIsensor predicted the MSI status correctly for 580 of them with F-score 0.93\nusing tumor and normal samples, while results obtained using lobSTR enabled us to\ncorrectly predict the MSI status in 584 cases with F-score 0.96 using tumor and normal\nsamples, and 581 cases with F-score 0.94 using tumor only." }, { "id": 652, "strid": "fab65f5d-eb35-4547-8844-6b13ddcff39d", "image_id": 28, "image_name": "11411.png", "category_id": 5, "category_name": "Section", "bbox": [ 2488.074, 1376.432, 353.2339999999999, 57.718000000000075 ], "priority": 5, "parents": [ 647 ], "children": [ 653 ], "area": 3424664.671968, "iscrowd": 0, "segmentation": [], "text": "BACKGROUND" }, { "id": 653, "strid": "229e84ae-96ab-4d01-b656-efab81bf9e2f", "image_id": 28, "image_name": "11411.png", "category_id": 3, "category_name": "Text", "bbox": [ 1941.677, 1479.811, 1419.863, 662.6029999999998 ], "priority": 6, "parents": [ 652 ], "children": [], "area": 2873314.9830469997, "iscrowd": 0, "segmentation": [], "text": "Microsatellite instability (MSI) refers to widespread somatic changes in the number of\nrepeats at microsatellite loci in the genome. MSI typically reflects defects in the DNA\nmismatch repair machinery, which are a hallmark of certain types of cancer. This workflow\nenables profiling MSI using WXS or WGS data. It uses BWA-MEM for read alignment,\nlobSTR for calling microsatellite variants, and MSlsensor for quantifying microsatellite\ninstability (see Fig. 1).\n\nBecause of lobSTR, there is also a preparatory workflow for training of PCR stutter and\nstep models that are later used in the main pipeline by lobSTR to silence the PCR noise.\nThis is done only once for data that comes from the same sequencing platform and the\nsame data submitting center, and it is done on the largest normal male sample. After that,\nthe main workflow can be used with both tumor only data and tumor-normal pairs. In the\ncase of tumor only, MSlsensor will be skipped." }, { "id": 654, "strid": "94ee7f53-5d6b-4a5b-88c2-62281e53a199", "image_id": 28, "image_name": "11411.png", "category_id": 5, "category_name": "Section", "bbox": [ 622.885, 2673.932, 593.3410000000001, 60.027000000000044 ], "priority": 7, "parents": [ 647 ], "children": [ 655 ], "area": 1665552.1338199999, "iscrowd": 0, "segmentation": [], "text": "Validation of the workflow" }, { "id": 655, "strid": "c8e8310b-6573-4929-9321-76fc13d2e180", "image_id": 28, "image_name": "11411.png", "category_id": 3, "category_name": "Text", "bbox": [ 165.758, 2773.207, 1500.668, 706.4679999999998 ], "priority": 8, "parents": [ 654 ], "children": [], "area": 459681.245906, "iscrowd": 0, "segmentation": [], "text": "The workflow was validated by profiling 592 colorectal adenocarcinomas for which\ninformation about MSI status is present on the GDC portal. There were three approaches that\nwere made possible by this workflow - using MSlsensor results from tumor-normal samples,\nusing lobSTR results from tumor-normal samples and using lobSTR results from tumor only\nsamples.\n\nFor MSlsensor, MSI score (percent of somatic changes of microsatellite length) was\nconsidered, and everything above the limit of 3.5 (proposed in MS/sensor: microsatellite\ninstability detection using paired tumor-normal sequence data, Niu et al.) was considered as\nMSI, while everything below was considered as MSS (see Fig. 2 for results). For lobSTR output\nVCFs, total number of differences from reference genome and total increase and decrease of\nlength (due to different number of microsatellite core repetitions) in relation to reference\ngenome were calculated. Based on that, using leave-one-out, SVM predictions were made for\nremaining samples (see Figures 3 and 4 for results)." }, { "id": 656, "strid": "dc405797-cc73-4fc0-95c3-2b830177c4d8", "image_id": 28, "image_name": "11411.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1931.929, 2648.537, 1486.8159999999998, 600.2670000000003 ], "priority": 9, "parents": [ 647 ], "children": [ 657 ], "area": 5116785.437873, "iscrowd": 0, "segmentation": [] }, { "id": 657, "strid": "ad67793d-27fc-4f06-9726-e2a42f7f758e", "image_id": 28, "image_name": "11411.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1874.211, 3278.817, 1553.769, 117.74499999999989 ], "priority": 10, "parents": [ 656 ], "children": [], "area": 6145194.888387, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Microsatellite instability profiling workflow. Workflow can batch files case_id and then split tumor\nand normal (if present) samples. After that comes BWA alignment, and, finally, MSI profiling by MSIsensor and\nlobSTR. Besides the analysis of MSI, the workflow does FastQC analysis as well." }, { "id": 658, "strid": "2bd61bff-9b42-4c5b-afb4-7bd8d85ee164", "image_id": 28, "image_name": "11411.png", "category_id": 2, "category_name": "Figure", "bbox": [ 270.722, 3570.899, 743.403, 617.8929999999996 ], "priority": 11, "parents": [ 647 ], "children": [ 659 ], "area": 966720.9190779999, "iscrowd": 0, "segmentation": [] }, { "id": 659, "strid": "945ded03-83b5-4496-b06c-a2fcf2ab175b", "image_id": 28, "image_name": "11411.png", "category_id": 6, "category_name": "Caption", "bbox": [ 162.108, 4196.033, 955.8030000000001, 86.89099999999962 ], "priority": 12, "parents": [ 658 ], "children": [], "area": 680210.5175640001, "iscrowd": 0, "segmentation": [], "text": "Figure 2. MSlsensor results. All 592 cases sorted from smallest to\nlargest MSI score, featuring their actual MSI status as well." }, { "id": 660, "strid": "c7cebdd5-fee0-4479-aea7-a4b194fbd9ca", "image_id": 28, "image_name": "11411.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1422.031, 3578.14, 774.7799999999997, 610.6519999999996 ], "priority": 13, "parents": [ 647 ], "children": [ 661 ], "area": 5088226.002339999, "iscrowd": 0, "segmentation": [] }, { "id": 661, "strid": "72db79f1-7ff0-4dd0-b905-59d48b2d171d", "image_id": 28, "image_name": "11411.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1308.589, 4198.447, 912.3580000000002, 161.71399999999994 ], "priority": 14, "parents": [ 660 ], "children": [], "area": 5494041.561283, "iscrowd": 0, "segmentation": [], "text": "Figure 3. lobSTR results using both tumor and normal.\nTumor/normal ratios of total increase and decrease of length in\nrelation to reference genome are plotted on x and y axis, while\ntotal number of differences is presented with circle size." }, { "id": 662, "strid": "f6fab0dd-c6e2-40c7-97d3-c3d1d307dbb4", "image_id": 28, "image_name": "11411.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2563.684, 3582.967, 760.2979999999998, 598.5840000000003 ], "priority": 15, "parents": [ 647 ], "children": [ 663 ], "area": 9185595.170428, "iscrowd": 0, "segmentation": [] }, { "id": 663, "strid": "c5337b92-b3d5-489a-82c3-c3ce9d0762d3", "image_id": 28, "image_name": "11411.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2455.07, 4198.447, 972.6990000000001, 137.57800000000043 ], "priority": 16, "parents": [ 662 ], "children": [], "area": 10307481.276290001, "iscrowd": 0, "segmentation": [], "text": "Figure 4. lobSTR results using only tumor. Total increase and\ndecrease in length are plotted on x and y axis, and size of the circle\nrepresents total number of differences from the reference genome." }, { "id": 664, "strid": "c0a2c12b-3715-4055-b49d-d2e2935a8810", "image_id": 29, "image_name": "11463.png", "category_id": 9, "category_name": "Root", "bbox": [ 31.7, 218.07, 113.67999999999999, 109.75999999999999 ], "priority": -1, "parents": [], "children": [ 670, 671, 668, 674, 676, 669, 673, 684, 682, 675, 666, 665, 683, 678, 667, 681, 680 ], "area": 6912.8189999999995, "iscrowd": 0, "segmentation": [] }, { "id": 665, "strid": "15d9e1d3-66bd-47c1-bab2-474a57a4f835", "image_id": 29, "image_name": "11463.png", "category_id": 1, "category_name": "Title", "bbox": [ 79.236, 38.38, 1633.716, 163.495 ], "priority": 1, "parents": [ 664 ], "children": [], "area": 3041.0776800000003, "iscrowd": 0, "segmentation": [], "text": "Characterizing the structure of plant interaction\nnetworks ©" }, { "id": 666, "strid": "11ebd2b0-de44-4e99-bfa3-0670357119a3", "image_id": 29, "image_name": "11463.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 177.086, 215.501, 1445.448, 106.52000000000001 ], "priority": 2, "parents": [ 664 ], "children": [], "area": 38162.21008600001, "iscrowd": 0, "segmentation": [], "text": "~~ Nicole L. PRIS itch» y\nrtment of Ecology’& goa Na ge) / EN Se?" }, { "id": 667, "strid": "38512bab-aec1-4339-96e4-f0379751675d", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 48.639, 367.073, 811.282, 285.409 ], "priority": 3, "parents": [ 664 ], "children": [], "area": 17854.063647, "iscrowd": 0, "segmentation": [], "text": "Plant ecology has a rich history of plant interaction experiments to\nmeasure how plants interact in plant communities based on\nperformance in pairwise species combinations. We propose\nrepresenting these plant communities as networks of competitive\nand facilitative interactions. This is a powerful approach that allows\none to characterize community structure quantitatively using\nnetwork metrics including asymmetry, transitivity, and connectance.\nWe also have developed a novel methodology for synthesizing the\nstructure of multiple networks using meta-analysis." }, { "id": 668, "strid": "ab7c2c44-1fc0-4053-9761-9af2d0910a02", "image_id": 29, "image_name": "11463.png", "category_id": 4, "category_name": "List", "bbox": [ 49.591, 661.641, 813.313, 190.837 ], "priority": 4, "parents": [ 664 ], "children": [], "area": 32811.438831, "iscrowd": 0, "segmentation": [] }, { "id": 669, "strid": "c4dd247f-4072-4885-935e-b8977e30a5f2", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 47.863, 866.873, 813.443, 190.462 ], "priority": 5, "parents": [ 664 ], "children": [], "area": 41491.142399000004, "iscrowd": 0, "segmentation": [], "text": "Plant interaction experiments involve planting inter- or intraspecific combinations of species and\nMeasuring interaction strength using an index, e.g., Relative Interaction Intensity (RII) (2). The Rls for all\npairwise interactions in a community can be represented as a network (Fig. 1). As an example, we\nconducted a garden experiment to quantify interactions among woody plants in an old field community.\nThe results of this field experiment were included as one of the networks in the meta-analysis (Fig. 2).\n\nWe conducted a systematic review and identified 2,032 studies on Web of Science of which 31 met\nour selection criteria for inclusion in the meta-analysis. From each study, we built networks based on" }, { "id": 670, "strid": "3f47897e-ff53-48dc-9399-4c4ed2881e74", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 47.99, 1078.608, 803.742, 143.5530000000001 ], "priority": 6, "parents": [ 664 ], "children": [], "area": 51762.39792, "iscrowd": 0, "segmentation": [], "text": "Interactions are competitive on average, but some networks are\nweakly facilitative.\n\nInteractions were hypothesized to be mostly competitive, as plants share similar resource requirements.\nThe effect size we used was the mean strength, i.e., the sum of the interactions (Rlls) directed towards or\naway from a species, for each network." }, { "id": 671, "strid": "e2c44059-751b-4538-9e57-97003ae0fb96", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 44.603, 1223.029, 812.313, 296.13300000000004 ], "priority": 7, "parents": [ 664 ], "children": [ 672 ], "area": 54550.762487, "iscrowd": 0, "segmentation": [] }, { "id": 672, "strid": "cbb98f61-c4d4-4c16-9796-818f9cb02dc0", "image_id": 29, "image_name": "11463.png", "category_id": 6, "category_name": "Caption", "bbox": [ 49.362, 1519.98, 800.344, 31.286000000000058 ], "priority": 8, "parents": [ 671 ], "children": [], "area": 75029.25276, "iscrowd": 0, "segmentation": [], "text": "Figs. 3-6. Points represent mean values. On left, forest plots of study-specific metrics. Error bars are +1 SE. On right, grand means for metrics\nacross studies, including grand mean and groupwise means. Error bars are 95% credible intervals." }, { "id": 673, "strid": "1c3d67d6-06cd-407e-9fca-b3b9753d63a3", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 46.099, 1566.361, 833.229, 142.231 ], "priority": 9, "parents": [ 664 ], "children": [], "area": 72207.675739, "iscrowd": 0, "segmentation": [], "text": "Transitivity is the norm, but intransitivity does exist in plant networks.\nTransitivity is prevalent in individual plant communities, though transitive communities are theoretically\nunstable. Most networks were transitive, but studies with a true control treatment were often strongly\n\nintransitive. The effect size used was the Relative Intransitivity (RI) index (4), where a completely transitive\ncommunity has an RI of 0 and a maximally intransitive community has an RI of 1." }, { "id": 674, "strid": "49ee4b7d-8a31-4212-8e2d-c28552f81516", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 42.065, 1732.663, 813.558, 298.21399999999994 ], "priority": 10, "parents": [ 664 ], "children": [], "area": 72884.469095, "iscrowd": 0, "segmentation": [] }, { "id": 675, "strid": "6f0222e6-dc36-4b7d-9d7f-aaf40da9fd49", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 917.467, 367.009, 816.322, 221.86900000000003 ], "priority": 11, "parents": [ 664 ], "children": [], "area": 336718.646203, "iscrowd": 0, "segmentation": [], "text": "matrices of mean/SD Ril (one per study), and calculated mean/SD for each network metric of interest.\n\nThese network metrics, including mean strength, asymmetry, transitivity, and connectance, were\nused as the effect sizes in the study, and were then synthesized across studies using a Bayesian random\neffects meta-analysis to calculate the grand mean of each metric weighted by the variation within each\ncommunity. Groupwise meta-analyses were also fit to understand the influence of experiment type (true\ncontrol/monoculture control), habitat (old fields/other habitats), and experimental setting (greenhouse,\ngarden, or field) on network structure.\n\nGarden experiment: a plant interaction network of an old field shrub community" }, { "id": 676, "strid": "028c8b9f-28b3-4b7f-9b63-2e7a5cc5c32b", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 912.403, 589.508, 515.961, 473.106 ], "priority": 12, "parents": [ 664 ], "children": [ 677 ], "area": 537868.867724, "iscrowd": 0, "segmentation": [] }, { "id": 677, "strid": "e4e1059d-b48c-47d1-88eb-c3bf844f79be", "image_id": 29, "image_name": "11463.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1429.858, 874.878, 312.548, 89.69100000000003 ], "priority": 13, "parents": [ 676 ], "children": [], "area": 1250951.307324, "iscrowd": 0, "segmentation": [], "text": "Fig. 1 (left). Old field plant interaction network based\non fieldwork at Yale-Myers Forest, CT in summer 2016.\nEdge width is proportional to edge weight. Edge\nweight isthe Ril for each pairwise species combination\n(legend represents Ril range). Competitive interactions\nare red, facilitative are blue." }, { "id": 678, "strid": "24c906a1-0326-48bc-93f6-32234db84491", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1487.58, 591.4, 211.85500000000002, 281.788 ], "priority": 14, "parents": [ 664 ], "children": [ 679 ], "area": 879754.8119999999, "iscrowd": 0, "segmentation": [] }, { "id": 679, "strid": "0a59aed5-8edc-41ec-8d40-0d07d8419a16", "image_id": 29, "image_name": "11463.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1429.858, 972.794, 316.0730000000001, 86.16600000000005 ], "priority": 15, "parents": [ 678 ], "children": [], "area": 1390957.2832519999, "iscrowd": 0, "segmentation": [], "text": "ig. 2 (above). Set-up for pairwise plant interaction\nexperiments at Yale-Myers Forest. Target individuals are\nsurrounded by four neighbor individuals in intra- and\ninterspecific pairwise species combinations. Targets\nwere harvested Aug. 2016 and biomass was used to\ncalculate Ril indices for the network." }, { "id": 680, "strid": "7d94923b-7842-48e7-b7ab-ac2dc0293d68", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 918.038, 1079.901, 825.8510000000001, 143.93599999999992 ], "priority": 16, "parents": [ 664 ], "children": [], "area": 991390.154238, "iscrowd": 0, "segmentation": [], "text": "Asymmetric interactions are not ubiquitous.\n\nAsymmetry occurs when one species has a strong effect on the other with little reciprocal effect. Asymmetry\nwould be expected to be prevalent as initial differences in resource capture ability generate a positive\nfeedback (3). The effect size calculated was the correlation coefficient between interaction weights w; and\nw;. Interactions were weakly asymmetric on average, but this varied greatly among communities." }, { "id": 681, "strid": "4d0bb8e9-1345-4328-a2d7-e9e9d3015594", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 922.903, 1225.054, 805.9280000000001, 298.74199999999996 ], "priority": 17, "parents": [ 664 ], "children": [], "area": 1130606.0117620002, "iscrowd": 0, "segmentation": [] }, { "id": 682, "strid": "e8e0cc30-4e26-4890-bd7a-6f533cff4319", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 917.416, 1564.324, 812.619, 167.24299999999994 ], "priority": 18, "parents": [ 664 ], "children": [], "area": 1435135.866784, "iscrowd": 0, "segmentation": [], "text": "Plant communities are strongly connected.\n\nConnectance describes how strongly members interact with one another compared to a maximum level.\nCommunities varied in their connectance, but it was very high on average. We predicted plant networks\nwould have higher connectance than other ecological networks (which tend to fall in the range of 0.03 to\n0.3) (5), as co-occurring plants should interact strongly with one another. The effect size for connectance\nwas weighted quantitative connectance (6)." }, { "id": 683, "strid": "99039461-40c7-4167-a6f1-68611b7cc14f", "image_id": 29, "image_name": "11463.png", "category_id": 2, "category_name": "Figure", "bbox": [ 924.324, 1734.444, 806.429, 294.3710000000001 ], "priority": 19, "parents": [ 664 ], "children": [], "area": 1603188.2158559998, "iscrowd": 0, "segmentation": [] }, { "id": 684, "strid": "39281c7d-c12a-43b0-a439-0742b20725b9", "image_id": 29, "image_name": "11463.png", "category_id": 3, "category_name": "Text", "bbox": [ 48.011, 2045.595, 1668.806, 162.9219999999998 ], "priority": 20, "parents": [ 664 ], "children": [], "area": 98211.061545, "iscrowd": 0, "segmentation": [], "text": "By synthesizing structural metrics of multiple plant interaction communities using meta-analysis, we were able to make broad, quantitative\ngeneralizations about the nature of interactions in plant communities. Plant interaction networks are dominated by competitive interactions\nand are highly connected relative to other ecological networks. Interactions are not necessarily asymmetric, and intransitivity, or breaking\nfrom a hierarchy, is a feature of many communities. Network metrics differ based on whether the study had a true control treatment, but do\nnot differ based on the habitat or experimental setting of the study." }, { "id": 685, "strid": "a4f1ee40-0318-40f1-b18d-0cfb28a67c6b", "image_id": 30, "image_name": "11481.png", "category_id": 9, "category_name": "Root", "bbox": [ 2400.78, 95.85, 301.17999999999984, 231.67999999999998 ], "priority": -1, "parents": [], "children": [ 702, 698, 688, 690, 687, 704, 710, 689, 706, 700, 686, 693 ], "area": 230114.763, "iscrowd": 0, "segmentation": [] }, { "id": 686, "strid": "04180853-cdf8-46c0-93a1-f5cf1c53a955", "image_id": 30, "image_name": "11481.png", "category_id": 1, "category_name": "Title", "bbox": [ 110.765, 453.238, 2535.305, 140.16699999999997 ], "priority": 1, "parents": [ 685 ], "children": [], "area": 50202.90707, "iscrowd": 0, "segmentation": [], "text": "Human Islets~ Like Cell Aggregates (ICAs) Express Coxsackie~ Adenovirus receptors (CAR) and Decay\nAccelerating Factor (DAF or CD55) and Reveal A distinctive microRNA Diabetes~Associated Signature" }, { "id": 687, "strid": "0467d031-248e-4fdf-ac7a-95e5c3c1964d", "image_id": 30, "image_name": "11481.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 68.944, 788.769, 2634.403, 186.101 ], "priority": 2, "parents": [ 685 ], "children": [], "area": 54380.889936, "iscrowd": 0, "segmentation": [], "text": "Ammira S Alshabeeb Akil+2*, Anand Hardikar®, Allie Finlay1, Chi Nam Ignatius Pang>, Marc Wilkins>, William Rawlinson??> , Maria Craig?2:4\n\n1 Virology Research, Prince of Wales Hospital Research Laboratories, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney NSW 2031, 2School of Women’s and Children’s Health, Faculty\nof Medicine, University of New South Wales, Sydney NSW 2052, 3School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, 4Institute of Endocrinology and\nDiabetes, the Children’s Hospital at Westmead, Sydney NSW 2145, 5School of Biotechnology and Biomolecular Science, Faculty of Science, University of New South Wales, Sydney NSW 2052, NHMRC\n\nClinical Trials Centre, Sydney Medical School, University of Sydney, Sydney NSW 2006" }, { "id": 698, "strid": "4c062d55-b81a-44ad-bb27-ce65774d31d6", "image_id": 30, "image_name": "11481.png", "category_id": 5, "category_name": "Section", "bbox": [ 1291.162, 1034.789, 145.39100000000008, 26.528999999999996 ], "priority": 3, "parents": [ 685 ], "children": [ 699 ], "area": 1336080.234818, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 699, "strid": "99cbe842-4b60-47ef-809c-250e22dfd7fa", "image_id": 30, "image_name": "11481.png", "category_id": 3, "category_name": "Text", "bbox": [ 536.906, 1072.195, 1651.609, 295.3620000000001 ], "priority": 4, "parents": [ 698 ], "children": [], "area": 575667.9286699999, "iscrowd": 0, "segmentation": [], "text": "Human enterovirus (HEV) infections, specifically Coxsackievirus B (CVB), demonstrate -cell tropism and are\nassociated with type 1 diabetes (T1D).\n\nPrevious studies have shown that Coxsackie-Adenovirus receptors (CAR) and Decay Accelerating Factor (DAF) are\nboth required to initiate CVB infection in human and rodent models, but this has not been examined in Human Islets-\nLike Cells Aggregates (ICAs), which are derived from human islet progenitor cells.\n\nMicroRNAs function as translational repressors and are important regulators of key biological processes, although\ntheir role in virus induced —cell death has not been examined" }, { "id": 700, "strid": "064e3c03-02a7-4a2d-af9d-3163b301b6c8", "image_id": 30, "image_name": "11481.png", "category_id": 5, "category_name": "Section", "bbox": [ 1277.926, 1413.51, 171.21000000000004, 25.92599999999993 ], "priority": 5, "parents": [ 685 ], "children": [ 701 ], "area": 1806361.1802599998, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 701, "strid": "34940c1b-c65c-4c5b-a8ae-c1aebdade68c", "image_id": 30, "image_name": "11481.png", "category_id": 3, "category_name": "Text", "bbox": [ 537.466, 1450.589, 1650.864, 98.75600000000009 ], "priority": 6, "parents": [ 700 ], "children": [], "area": 779642.267474, "iscrowd": 0, "segmentation": [], "text": "We hypothesise that (i) CBV infection of HICS is associated with up-regulation of CAR and DAF receptors and down-\nregulation of insulin and pdx-1 genes; -cell death and (ii) CVB infection of HICS alters microRNA abundance, thereby\nregulating gene expression." }, { "id": 702, "strid": "cf302368-9926-434c-8e10-9c4e973cac92", "image_id": 30, "image_name": "11481.png", "category_id": 5, "category_name": "Section", "bbox": [ 1293.189, 1576.488, 142.43399999999997, 25.42599999999993 ], "priority": 7, "parents": [ 685 ], "children": [ 703 ], "area": 2038696.940232, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 703, "strid": "5e3b912a-05e8-4775-9d11-fabc3375b4fe", "image_id": 30, "image_name": "11481.png", "category_id": 4, "category_name": "List", "bbox": [ 537.859, 1614.82, 1653.185, 463.5930000000001 ], "priority": 8, "parents": [ 702 ], "children": [], "area": 868545.4703800001, "iscrowd": 0, "segmentation": [] }, { "id": 688, "strid": "5aff7adb-6fc8-4c01-b008-a819790130a0", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 39.722, 1002.595, 485.07000000000005, 1042.543 ], "priority": 9, "parents": [ 685 ], "children": [], "area": 39825.078590000005, "iscrowd": 0, "segmentation": [] }, { "id": 689, "strid": "fd899850-5dd4-41ec-88d7-f5f7379894c9", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 31.357, 2097.186, 465.659, 340.52599999999984 ], "priority": 10, "parents": [ 685 ], "children": [], "area": 65761.461402, "iscrowd": 0, "segmentation": [] }, { "id": 690, "strid": "3f590e32-0549-4893-8018-c201a2f1908b", "image_id": 30, "image_name": "11481.png", "category_id": 3, "category_name": "Text", "bbox": [ 31.818, 2469.462, 457.147, 262.587 ], "priority": 11, "parents": [ 685 ], "children": [], "area": 78573.341916, "iscrowd": 0, "segmentation": [], "text": "Cytopathic effects CPE following\nCVB-3 infection in insulin producing\nhuman &- cells. Uninfected control\nislets and islets infected with CVB-3 at 2,\n4, and 6 days post __ infection.\nMorphological changes were seen1-2\ndays post infection when the cells\nbecame more rounded and detached\nfrom the islet cluster into the medium." }, { "id": 710, "strid": "125e7c26-8e63-405f-805e-63796b660d90", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2209.706, 988.726, 509.68499999999995, 1022.147 ], "priority": 12, "parents": [ 685 ], "children": [], "area": 2184793.7745560003, "iscrowd": 0, "segmentation": [] }, { "id": 704, "strid": "29c975bf-3713-4acb-91a9-d34ae1ec21b5", "image_id": 30, "image_name": "11481.png", "category_id": 5, "category_name": "Section", "bbox": [ 1276.466, 2154.671, 118.54199999999992, 25.51000000000022 ], "priority": 13, "parents": [ 685 ], "children": [ 705, 708, 696, 713, 691, 711, 694 ], "area": 2750364.2726859995, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 705, "strid": "e722d998-7891-45a1-b954-2150068ee81e", "image_id": 30, "image_name": "11481.png", "category_id": 4, "category_name": "List", "bbox": [ 915.023, 2190.805, 842.3289999999998, 732.77 ], "priority": 14, "parents": [ 704 ], "children": [], "area": 2004636.963515, "iscrowd": 0, "segmentation": [] }, { "id": 708, "strid": "93b2b495-e6e0-4924-abf4-dd30d8ee9b7a", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1775.04, 2149.523, 413.9850000000001, 882.645 ], "priority": 15, "parents": [ 704 ], "children": [ 709 ], "area": 3815489.30592, "iscrowd": 0, "segmentation": [] }, { "id": 709, "strid": "80100e0e-7b44-43c9-ab50-6c10b41464f5", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1764.22, 3086.235, 433.7270000000001, 260.58500000000004 ], "priority": 16, "parents": [ 708 ], "children": [], "area": 5444797.511700001, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Heat map comparing expression\nof 105 microRNAs following infection of\nislets with CVB3, CVB4 or CVB5. The\nmiRNAs are clustered based on their fold-\nchange in expression using average\nlinkage clustering. The heat map shows\n23 miRNAs that are consistently up-\nregulated in CVB3, CVB4 and CVB5\ninfected cells." }, { "id": 696, "strid": "0251b0b2-7b08-43b6-a35a-ede1bf4b7c1a", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 525.956, 2779.346, 363.68899999999996, 370.7629999999999 ], "priority": 17, "parents": [ 704 ], "children": [ 697 ], "area": 1461813.704776, "iscrowd": 0, "segmentation": [] }, { "id": 697, "strid": "5078008e-0024-4efe-9248-5fe905af5290", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 529.072, 3166.507, 369.7320000000001, 354.7840000000001 ], "priority": 18, "parents": [ 696 ], "children": [], "area": 1675310.191504, "iscrowd": 0, "segmentation": [], "text": "Figure2.Up-regulated miRNA\nassociated with genes in the\nT1D protein interaction\nnetwork. The miRNAs with at least\nten-fold increase in expression\nfollowing infection of islets with\nCVB3, CVB4, or CVBS targeted 37\nT1D susceptibility genes. The protein\nproducts for 28 of these T1D\nsusceptibility genes and __ their\nphysical interaction partners form a\nhighly connected network as shown\nabove." }, { "id": 713, "strid": "e59d7f41-3e63-4ca3-b621-a61a823231bd", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2217.846, 2823.387, 517.4810000000002, 347.9209999999998 ], "priority": 19, "parents": [ 704 ], "children": [ 714 ], "area": 6261837.564402, "iscrowd": 0, "segmentation": [] }, { "id": 714, "strid": "4d4f8b75-0a55-4f67-9a45-7c076bef8d34", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2237.075, 3215.642, 486.80600000000004, 226.6619999999998 ], "priority": 20, "parents": [ 713 ], "children": [], "area": 7193632.327149999, "iscrowd": 0, "segmentation": [], "text": "Figure 3. Replication of CVBS clinical\nisolates in adult human R-cells. Floating\nislets were infected with high multiplicity\nof infection (MOI of 1/well) of CVB-2, CVB-\n3, CVB-4, and CVB-5 clinical isolate. The\nresults were shown as the mean + 95%\nconfidence intervals of three repeats." }, { "id": 691, "strid": "540039a1-1643-4acd-845c-e13d25f2250f", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 28.794, 2771.871, 486.34400000000005, 266.15700000000015 ], "priority": 21, "parents": [ 704 ], "children": [ 692 ], "area": 79813.253574, "iscrowd": 0, "segmentation": [] }, { "id": 692, "strid": "1360716a-bf26-4406-9685-45ebf8b513f5", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 32.53, 3066.546, 479.87800000000004, 298.7310000000002 ], "priority": 22, "parents": [ 691 ], "children": [], "area": 99754.74137999999, "iscrowd": 0, "segmentation": [], "text": "Figure 4. Effect of CVB3 and CVB5\ninfection on human insulin producing\ncells. CVB3/CVB5-infected and uninfected\ncontrol islets were harvested at 3 days\nafter infection and stained with insulin and\nvirus specific (VP1) antibodies. Infected\ncells are stained red (Alexa Fluor 594),\ninsulin stained with green (Alexa fluor 488)\nVirus-infected insulin- containing cells\nwere readily identified by their yellow color" }, { "id": 711, "strid": "8fe9c0b5-c18e-4c39-aed0-6cbf486369a4", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2196.727, 2067.958, 509.7040000000002, 379.9090000000001 ], "priority": 23, "parents": [ 704 ], "children": [ 712 ], "area": 4542739.173466, "iscrowd": 0, "segmentation": [] }, { "id": 712, "strid": "a315a45c-d50e-4cf0-8e5c-0d0f4ce242f9", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2229.252, 2496.785, 487.65599999999995, 266.4540000000002 ], "priority": 24, "parents": [ 711 ], "children": [], "area": 5565962.95482, "iscrowd": 0, "segmentation": [], "text": "Figure5. Effect of CVB3 and CVB5\ninfection on human insulin producing\ncells. CVB3/CVB5-infected and uninfected\ncontrol islets were harvested at 3 and 6\ndays after infection and stained with insulin\nand virus specific (VP1) antibodies. Virus-\ninfected insulin- containing cells were\nreadily identified by their yellow-orange\ncolor by using double fluorescent staining" }, { "id": 694, "strid": "53237af1-9476-4264-82ef-e3234f99ce10", "image_id": 30, "image_name": "11481.png", "category_id": 2, "category_name": "Figure", "bbox": [ 525.864, 2139.923, 366.26099999999997, 436.134 ], "priority": 25, "parents": [ 704 ], "children": [ 695 ], "area": 1125308.468472, "iscrowd": 0, "segmentation": [] }, { "id": 695, "strid": "280e9a9d-b249-404a-8dca-bc82ecf6f70c", "image_id": 30, "image_name": "11481.png", "category_id": 6, "category_name": "Caption", "bbox": [ 528.539, 2593.535, 350.9390000000001, 172.9920000000002 ], "priority": 26, "parents": [ 694 ], "children": [], "area": 1370784.395365, "iscrowd": 0, "segmentation": [], "text": "Figure 6: The changes in the\nexpression level of (CAR) and\n(DAF), EV-VP1, Insulin and PdX-1\nin the infected ICAs were analysed\nwith Immuno-fluorescent staining\nusing specific antibodies" }, { "id": 706, "strid": "70837843-4327-44d3-a93c-46518c918739", "image_id": 30, "image_name": "11481.png", "category_id": 5, "category_name": "Section", "bbox": [ 1226.25, 3007.452, 200.327, 25.802999999999884 ], "priority": 27, "parents": [ 685 ], "children": [ 707 ], "area": 3687888.015, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 707, "strid": "fd549fc3-e530-464c-8816-acbacf8f1a00", "image_id": 30, "image_name": "11481.png", "category_id": 3, "category_name": "Text", "bbox": [ 930.194, 3046.881, 806.0059999999999, 435.6709999999998 ], "priority": 28, "parents": [ 706 ], "children": [], "area": 2834190.4249139996, "iscrowd": 0, "segmentation": [], "text": "COXSACKEIVIRUS B (CVBs) infection to the Human Pancreatic\nIslets and Human Islets-Like Cell Aggregates (ICAs) lead to\nDYSREGULATION of multiple DIABETES- associated microRNAs\n\nDYSREGULATION of certain DIABETES associated microRNAs will:\n(1) Disrupt the protection of cellular integrity (2) Alterations in the\nImmune Response (3) Ultimate Pancreatic-B cell DEATH\n\nThe (ICAs STEM CELLS) are a NATURAL TARGET and\nRESERVOIRE for persistent CVB infection\n\nNO Effect on the INSULIN expression level at the early stages of viral\ninfection\n\nICAs STEM CELLS are a useful CELLULAR MODEL may further our\nunderstanding of the VIRUS induced DIABETES" }, { "id": 693, "strid": "ead796f8-74e6-41c4-a3cf-ca94768bebd8", "image_id": 30, "image_name": "11481.png", "category_id": 3, "category_name": "Text", "bbox": [ 34.714, 3395.77, 465.198, 116.30499999999984 ], "priority": 29, "parents": [ 685 ], "children": [], "area": 117880.75978, "iscrowd": 0, "segmentation": [], "text": "Australian Society of Medical\nResearch ASMR NSW\nScientific Meeting, 2014" }, { "id": 715, "strid": "dab5a73a-c96b-47f3-8d2a-10127c706cd2", "image_id": 31, "image_name": "11513.png", "category_id": 9, "category_name": "Root", "bbox": [ 50.56, 64.28, 241.37, 107.27000000000001 ], "priority": -1, "parents": [], "children": [ 721, 716, 717, 725, 722, 723, 728, 720, 718 ], "area": 3249.9968000000003, "iscrowd": 0, "segmentation": [] }, { "id": 716, "strid": "d387f32a-9d3c-4158-9dc6-f79726384bf3", "image_id": 31, "image_name": "11513.png", "category_id": 1, "category_name": "Title", "bbox": [ 1908.433, 89.754, 1280.9679999999998, 268.832 ], "priority": 1, "parents": [ 715 ], "children": [], "area": 171289.495482, "iscrowd": 0, "segmentation": [], "text": "Title: “Role of environmental filters\nin the restoration of degraded peri-\nurban ecosystems”" }, { "id": 717, "strid": "41bb8ee2-00df-43d9-851f-2b701f809273", "image_id": 31, "image_name": "11513.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 417.048, 45.192, 1298.194, 140.953 ], "priority": 2, "parents": [ 715 ], "children": [], "area": 18847.233216, "iscrowd": 0, "segmentation": [], "text": "Authors: Pawel Waryszak, Joseph B. Fontaine, Rachel J. Standish, Phil\nLadd and Neal J. Enright, Environmental & Conservation Sciences,\nMurdoch University, Perth, Western Australia" }, { "id": 718, "strid": "cdb0c8ea-9b06-43a7-bcb7-42d1acb86e50", "image_id": 31, "image_name": "11513.png", "category_id": 5, "category_name": "Section", "bbox": [ 204.943, 262.448, 315.44100000000003, 48.44900000000001 ], "priority": 3, "parents": [ 715 ], "children": [ 719 ], "area": 53786.880464, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 719, "strid": "0226c8bb-1049-4fb1-8822-1fbe4a71e865", "image_id": 31, "image_name": "11513.png", "category_id": 3, "category_name": "Text", "bbox": [ 201.59, 377.04, 694.379, 503.958 ], "priority": 4, "parents": [ 718 ], "children": [], "area": 76007.4936, "iscrowd": 0, "segmentation": [], "text": "“Ecological Filter” theory suggests that\nenvironmental filters influence the outcome\nof ecological restoration and ultimately\nlong-term restoration success. In this study,\nthree types of environmental filters:\ndispersal, biotic and abiotic, were\nmanipulated to improve understanding of\nhow to successfully re-establish native plant\ncommunities. The filters were manipulated\nwith use of transferred topsoil salvaged\nfrom under native Banksia Woodland." }, { "id": 720, "strid": "33f7388e-5cc4-45fc-8ca8-84c001bf60aa", "image_id": 31, "image_name": "11513.png", "category_id": 2, "category_name": "Figure", "bbox": [ 931.025, 273.218, 807.5119999999998, 609.5409999999999 ], "priority": 5, "parents": [ 715 ], "children": [], "area": 254372.78845000002, "iscrowd": 0, "segmentation": [] }, { "id": 721, "strid": "e316f8bb-ab1c-4da2-8c17-0fb93a75ae72", "image_id": 31, "image_name": "11513.png", "category_id": 2, "category_name": "Figure", "bbox": [ 176.333, 900.394, 1625.576, 2103.852 ], "priority": 6, "parents": [ 715 ], "children": [], "area": 158769.175202, "iscrowd": 0, "segmentation": [] }, { "id": 725, "strid": "ca413d97-f490-49fe-b865-55cfbf503dab", "image_id": 31, "image_name": "11513.png", "category_id": 5, "category_name": "Section", "bbox": [ 2488.565, 563.615, 233.58300000000008, 51.70600000000002 ], "priority": 7, "parents": [ 715 ], "children": [ 726, 727 ], "area": 1402592.562475, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 726, "strid": "e1b6b8a4-b883-4745-bbfd-aad1e77430e3", "image_id": 31, "image_name": "11513.png", "category_id": 7, "category_name": "Table", "bbox": [ 1810.744, 622.743, 970.383, 1133.087 ], "priority": 8, "parents": [ 725 ], "children": [], "area": 1127628.1507920001, "iscrowd": 0, "segmentation": [] }, { "id": 727, "strid": "37e0f2dd-cca5-48a0-9e0f-3a992b8c738c", "image_id": 31, "image_name": "11513.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2809.124, 642.08, 575.7060000000001, 1019.285 ], "priority": 9, "parents": [ 725 ], "children": [], "area": 1803682.33792, "iscrowd": 0, "segmentation": [] }, { "id": 728, "strid": "2b8d6bef-fe64-4212-a6bb-f3ab6123124e", "image_id": 31, "image_name": "11513.png", "category_id": 5, "category_name": "Section", "bbox": [ 2125.829, 1808.895, 983.9919999999997, 60.728000000000065 ], "priority": 10, "parents": [ 715 ], "children": [ 730, 729, 731 ], "area": 3845401.4489550004, "iscrowd": 0, "segmentation": [], "text": "Results (first year after topsoil transfer)" }, { "id": 729, "strid": "8d7e6ec6-da6d-42d7-ba09-fffd2252a215", "image_id": 31, "image_name": "11513.png", "category_id": 7, "category_name": "Table", "bbox": [ 1820.743, 1870.302, 1604.509, 1117.8749999999998 ], "priority": 11, "parents": [ 728 ], "children": [], "area": 3405339.274386, "iscrowd": 0, "segmentation": [] }, { "id": 730, "strid": "1cb0d58c-e302-4e3b-9931-11b2033c4fd2", "image_id": 31, "image_name": "11513.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1893.897, 3078.88, 1320.5429999999997, 584.5720000000001 ], "priority": 12, "parents": [ 728 ], "children": [], "area": 5831081.59536, "iscrowd": 0, "segmentation": [] }, { "id": 731, "strid": "5d76a1cd-33cd-4161-93d7-dd5008a9f7ad", "image_id": 31, "image_name": "11513.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1895.656, 3734.508, 1370.114, 726.4480000000003 ], "priority": 13, "parents": [ 728 ], "children": [], "area": 7079342.4972479995, "iscrowd": 0, "segmentation": [] }, { "id": 722, "strid": "b7892085-9ad3-4a33-afd0-279880e941bf", "image_id": 31, "image_name": "11513.png", "category_id": 4, "category_name": "List", "bbox": [ 396.267, 3096.287, 1295.652, 701.134 ], "priority": 14, "parents": [ 715 ], "children": [], "area": 1226956.360629, "iscrowd": 0, "segmentation": [] }, { "id": 723, "strid": "9bde1caa-07c4-4bf3-ae7d-a76a766a2cda", "image_id": 31, "image_name": "11513.png", "category_id": 5, "category_name": "Section", "bbox": [ 219.326, 4263.003, 498.48799999999994, 58.61800000000039 ], "priority": 15, "parents": [ 715 ], "children": [ 724 ], "area": 934987.3959779999, "iscrowd": 0, "segmentation": [], "text": "Acknowledgments" }, { "id": 724, "strid": "bec13a4c-2a3f-4316-8bd6-d6ffd6bc5e28", "image_id": 31, "image_name": "11513.png", "category_id": 3, "category_name": "Text", "bbox": [ 218.098, 4327.868, 1619.897, 114.35800000000017 ], "priority": 16, "parents": [ 723 ], "children": [], "area": 943899.3550640001, "iscrowd": 0, "segmentation": [], "text": "Many thanks to great co-workers and volunteers who helped me greatly with very extensive field work and vegetation\ndata: Billi Veber, William Fowler, Mark Brundrett, Anna Wisolith, Karen Taylor, Vanda Longman, Mark Gerlach, Amity\nWilliams, Christina Birnbaum, Niels Brouwers, and Megan Brown." }, { "id": 732, "strid": "22a4b2c4-80ae-4d83-841b-7c0bef4e5bb0", "image_id": 32, "image_name": "11531.png", "category_id": 9, "category_name": "Root", "bbox": [ 12.84, 244.15, 107.27, 248.07000000000002 ], "priority": -1, "parents": [], "children": [ 760, 736, 758, 738, 742, 733, 735, 734 ], "area": 3134.886, "iscrowd": 0, "segmentation": [] }, { "id": 733, "strid": "46639c77-a5e0-4021-9fd0-eadce568522b", "image_id": 32, "image_name": "11531.png", "category_id": 1, "category_name": "Title", "bbox": [ 193.073, 70.462, 2914.023, 235.829 ], "priority": 1, "parents": [ 732 ], "children": [], "area": 13604.309726000001, "iscrowd": 0, "segmentation": [], "text": "— The Overfitting Toolbox (TOT): See\n\nLarge-Scale Search in Model Space for Expected Neuroimaging Effects" }, { "id": 734, "strid": "c6f41611-dad1-4048-9796-a2b65425b446", "image_id": 32, "image_name": "11531.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 676.812, 365.638, 1960.3600000000001, 250.897 ], "priority": 2, "parents": [ 732 ], "children": [], "area": 247468.18605599998, "iscrowd": 0, "segmentation": [], "text": "Joram Soch'©°, Carsten Allefeld'*, John-Dylan Haynes?23:45:6\n\n1 Bernstein Center for Computational Neuroscience, Berlin, Germany 2 Berlin Center of Advanced Neuroimaging, Berlin, Germany\n3 Berlin School of Mind and Brain, Berlin, Germany 4 Excellence Cluster NeuroCure, Charité-Universitatsmedizin Berlin, Germany\n5 Department of Neurology, Charité-Universitatsmedizin Berlin, Germany ® Department of Psychology, Humboldt-Universitat zu Berlin, Germany\ne Bernstein Center for Computational Neuroscience, PhilippstraRe 13, Haus 6, 10115 Berlin, Germany / joram.soch@bccn-berlin.de" }, { "id": 735, "strid": "a4e09208-fc65-41c3-8d0c-d49ffb7c5ad8", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 189.306, 689.115, 2939.539, 58.36699999999996 ], "priority": 3, "parents": [ 732 ], "children": [], "area": 130453.60419000001, "iscrowd": 0, "segmentation": [], "text": "“Isla de Muerta (...) cannot be found except by those who already know where it is.” — Captain Jack Sparrow [4]" }, { "id": 736, "strid": "3c05f773-2847-4535-a397-9427cd74b36f", "image_id": 32, "image_name": "11531.png", "category_id": 5, "category_name": "Section", "bbox": [ 61.534, 825.07, 325.445, 47.35299999999995 ], "priority": 4, "parents": [ 732 ], "children": [ 737 ], "area": 50769.85738, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 737, "strid": "6f7c6913-eee3-4bf4-8dd9-1682455d5d51", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 59.765, 932.46, 1546.199, 435.76199999999994 ], "priority": 5, "parents": [ 736 ], "children": [], "area": 55728.471900000004, "iscrowd": 0, "segmentation": [], "text": "A common problem in experimental science is if the analysis of a data set yields no significant result\neven though there is a strong prior belief that the effect exists. In this case, overfitting can help, a\ntechnique that has become common practice in psychology [1] and neuroimaging [2]. Functional\nmagnetic resonance imaging (fMRI) is very suitable for overfitting, because general linear models\n(GLMs) allow to test a hypothesis at several ten thousand voxels, such that significant results are likely\nto be found. Furthermore, analysis pipelines have a high number of free parameters supporting a large\nmodel space. We present The Overfitting Toolbox (TOT), a set of computational tools that allow to\nsystematically exploit multiple model estimation, parallel statistical testing, varying statistical thresholds\nand other techniques that allow to increase the number of positive inferences." }, { "id": 738, "strid": "e1de3082-6f1f-4488-897a-374f60dc4ed5", "image_id": 32, "image_name": "11531.png", "category_id": 5, "category_name": "Section", "bbox": [ 1703.853, 826.445, 232.827, 47.51599999999996 ], "priority": 6, "parents": [ 732 ], "children": [ 741, 740, 739 ], "area": 1408140.7925850002, "iscrowd": 0, "segmentation": [], "text": "Features" }, { "id": 739, "strid": "207eb7b1-010e-4f4b-84e9-1c3861a32ac0", "image_id": 32, "image_name": "11531.png", "category_id": 4, "category_name": "List", "bbox": [ 1703.612, 932.645, 1142.335, 286.05899999999997 ], "priority": 7, "parents": [ 738 ], "children": [], "area": 1588865.21374, "iscrowd": 0, "segmentation": [] }, { "id": 740, "strid": "8d734749-7457-4623-bd3b-f5203bc8adf4", "image_id": 32, "image_name": "11531.png", "category_id": 4, "category_name": "List", "bbox": [ 1703.195, 1232.853, 1470.494, 85.41300000000001 ], "priority": 8, "parents": [ 738 ], "children": [], "area": 2099789.065335, "iscrowd": 0, "segmentation": [] }, { "id": 741, "strid": "b16424bc-6587-4a7d-ad82-a931f6597f3b", "image_id": 32, "image_name": "11531.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2911.945, 840.958, 325.154, 324.08299999999997 ], "priority": 9, "parents": [ 738 ], "children": [], "area": 2448823.44331, "iscrowd": 0, "segmentation": [] }, { "id": 742, "strid": "fd15513b-96a1-4c28-a694-de4f9cb2c7ab", "image_id": 32, "image_name": "11531.png", "category_id": 5, "category_name": "Section", "bbox": [ 987.101, 1461.301, 1342.8309999999997, 59.486000000000104 ], "priority": 10, "parents": [ 732 ], "children": [ 749, 746, 747, 748, 752, 754, 750, 755, 744, 751, 756, 757, 743, 753, 745 ], "area": 1442451.6784009999, "iscrowd": 0, "segmentation": [], "text": "Empirical Validation of the The Overfitting Toolbox" }, { "id": 743, "strid": "b03ccf21-3971-4628-a642-69e9e11ce383", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 89.152, 1489.764, 617.231, 206.93900000000008 ], "priority": 11, "parents": [ 742 ], "children": [], "area": 132815.440128, "iscrowd": 0, "segmentation": [], "text": "We analyze an SPM template\ndata set [5,6] which was based\non a 2 x 2 factorial design with\n4 experimental conditions:" }, { "id": 744, "strid": "af6de2ac-1be9-4a91-a8b8-cffdbc0b30cb", "image_id": 32, "image_name": "11531.png", "category_id": 7, "category_name": "Table", "bbox": [ 79.956, 1741.975, 634.106, 634.0589999999997 ], "priority": 12, "parents": [ 742 ], "children": [], "area": 139281.3531, "iscrowd": 0, "segmentation": [] }, { "id": 745, "strid": "d29bf3bf-118b-4a55-bdd7-d3d0b776ff11", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 788.444, 1553.665, 958.9090000000001, 164.80899999999997 ], "priority": 13, "parents": [ 742 ], "children": [], "area": 1224977.84726, "iscrowd": 0, "segmentation": [], "text": "We specify and estimate a very large\nmodel space consisting of 4,320 GLMs:" }, { "id": 746, "strid": "fbffc084-05c6-4526-85ec-cb928330a385", "image_id": 32, "image_name": "11531.png", "category_id": 7, "category_name": "Table", "bbox": [ 787.968, 1742.984, 949.0880000000001, 634.058 ], "priority": 14, "parents": [ 742 ], "children": [], "area": 1373415.6165119999, "iscrowd": 0, "segmentation": [] }, { "id": 747, "strid": "cacad8fe-90be-4dd2-bc44-e2312d465c4a", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 1811.948, 1553.672, 878.008, 164.86799999999994 ], "priority": 15, "parents": [ 742 ], "children": [], "area": 2815172.873056, "iscrowd": 0, "segmentation": [], "text": "The experimental design implies that\n4 different effects can be tested:" }, { "id": 748, "strid": "b62648ba-3c56-43ad-9c52-98060e6187ea", "image_id": 32, "image_name": "11531.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1811.956, 1741.966, 871.097, 634.056 ], "priority": 16, "parents": [ 742 ], "children": [], "area": 3156365.7454959997, "iscrowd": 0, "segmentation": [] }, { "id": 749, "strid": "fe07a67f-03aa-44dc-b436-eefe0086b684", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 2756.541, 1479.956, 479.28899999999976, 236.35400000000004 ], "priority": 17, "parents": [ 742 ], "children": [], "area": 4079559.392196, "iscrowd": 0, "segmentation": [], "text": "We look for\n\nthese effects\nin 90 different\nregions [7]:" }, { "id": 750, "strid": "9cdc2f13-a86f-4175-99f5-d428cab88d0c", "image_id": 32, "image_name": "11531.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2753.943, 1740.966, 482.13599999999997, 640.058 ], "priority": 18, "parents": [ 742 ], "children": [], "area": 4794521.128938, "iscrowd": 0, "segmentation": [] }, { "id": 751, "strid": "6cfd2707-d405-4414-8a72-e1bee27fe2ad", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 79.141, 2421.556, 801.761, 631.1570000000002 ], "priority": 19, "parents": [ 742 ], "children": [], "area": 191644.36339600003, "iscrowd": 0, "segmentation": [], "text": "When R = number of regions\nand M = number of models,\nthis gives us an R x M matrix\nfor each contrast indicating\nhow many voxels are activated\nwhen testing for this effect ina\nspecific region using a specific\nmodel. Here's this matrix for\nthe average effect of condition\n(AE Con) when not correcting\nfor multiple |§ comparisons\n(unc., p < 0.001, k = 10)." }, { "id": 752, "strid": "c0be9f73-f27d-43aa-ada4-b0b3fa033ebc", "image_id": 32, "image_name": "11531.png", "category_id": 2, "category_name": "Figure", "bbox": [ 903.93, 2423.958, 1135.1100000000001, 737.078 ], "priority": 20, "parents": [ 742 ], "children": [], "area": 2191088.35494, "iscrowd": 0, "segmentation": [] }, { "id": 753, "strid": "091728d2-5d67-461a-a7cc-d9ae79caef9d", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 81.05, 3204.778, 800.834, 582.701 ], "priority": 21, "parents": [ 742 ], "children": [], "area": 259747.25689999998, "iscrowd": 0, "segmentation": [], "text": "Let's say we ,know“~ that there\nis an interaction of familiarity\nand repetition (IA FxR) in left\nauditory cortex (AAL 79). The\ntoolbox can help us to identify\na model for which this effect\nbecomes significant in that\nregion. In fact, such a model\nexists, even when correcting\nfor multiple § comparisons\n(FWE, p < 0.05, k = 10)." }, { "id": 754, "strid": "bd0a055e-bf95-4ad3-8242-80b8b7bcf402", "image_id": 32, "image_name": "11531.png", "category_id": 2, "category_name": "Figure", "bbox": [ 901.955, 3211.943, 1135.3720000000003, 735.9520000000002 ], "priority": 22, "parents": [ 742 ], "children": [], "area": 2897028.0485650003, "iscrowd": 0, "segmentation": [] }, { "id": 755, "strid": "9467ca81-3f0b-4d68-b62d-f7c908743733", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 2108.454, 2413.566, 1117.542, 425.61799999999994 ], "priority": 23, "parents": [ 742 ], "children": [], "area": 5088892.886964, "iscrowd": 0, "segmentation": [], "text": "With TOT, we detected experimental effects in\nalmost every region using at least one model.\nThis was not the case when controlling for\nmultiple analyses using model selection [8] or\nmodel averaging [9]. In particular, the demons-\ntrated interaction of familiarity and repetition\n(IA FxR) in left auditory cortex (Step 6) was\nnot significant with cvBMS [8] and cvBMA [9]:" }, { "id": 756, "strid": "648dfeb2-82fb-4b36-882c-58bcd4b4772e", "image_id": 32, "image_name": "11531.png", "category_id": 7, "category_name": "Table", "bbox": [ 2104.951, 2890.989, 1126.0969999999998, 556.0570000000002 ], "priority": 24, "parents": [ 742 ], "children": [], "area": 6085390.186539, "iscrowd": 0, "segmentation": [] }, { "id": 757, "strid": "8d39c706-e2fd-494a-94e6-09e50afec34a", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 2111.454, 3519.177, 1114.2800000000002, 314.26200000000017 ], "priority": 25, "parents": [ 742 ], "children": [], "area": 7430580.3533580005, "iscrowd": 0, "segmentation": [], "text": "Your turn! Ask the presenter to identify a GLM\nthat makes your favorite effect significant!\nInput the expected effect (Step 3) and the\nr) desired region (Step 4) as well as statistical\n\nDS thresholds (Step 5/6) and TOT outputs models\nthat allow to detect this effect in that region." }, { "id": 758, "strid": "9050bb06-7af9-47f8-a35a-87c1182003dd", "image_id": 32, "image_name": "11531.png", "category_id": 5, "category_name": "Section", "bbox": [ 61.946, 4054.613, 297.31499999999994, 47.32500000000027 ], "priority": 26, "parents": [ 732 ], "children": [ 759 ], "area": 251167.05689799998, "iscrowd": 0, "segmentation": [], "text": "Discussion" }, { "id": 759, "strid": "e61f6d76-e114-4aa0-88ed-0dd487c91592", "image_id": 32, "image_name": "11531.png", "category_id": 3, "category_name": "Text", "bbox": [ 59.793, 4170.38, 1553.779, 435.9449999999997 ], "priority": 27, "parents": [ 758 ], "children": [], "area": 249359.53134000002, "iscrowd": 0, "segmentation": [], "text": "We have demonstrated the potential of overfitting in fMRI data analysis and how to turn it from a\nsubjective enterprise into an objective procedure. An important advantage over previous manual\noverfitting approaches is that TOT allows to automatically search through a large model space. These\nmethods could have improved some 40,000 fMRI studies and may have a large impact on the\ninterpretation of neuroimaging results [3]. As a next step, it would be desirable to reanalyze the entire\namount of previous fMRI studies to harvest the false-positive effects that might have been missed using\nconventional statistical techniques [1,2]. Widespread use of The Overfitting Toolbox (TOT) will allow\nresearchers to uncover literally unthinkable sorts of effects and lead to more spectacular findings and\nnews coverage for the entire fMRI community [3]." }, { "id": 760, "strid": "4a29cd13-50ae-45ec-a0df-25693c063052", "image_id": 32, "image_name": "11531.png", "category_id": 5, "category_name": "Section", "bbox": [ 1704.312, 4053.113, 299.0350000000001, 48.05899999999974 ], "priority": 28, "parents": [ 732 ], "children": [ 761 ], "area": 6907769.123256, "iscrowd": 0, "segmentation": [], "text": "References" }, { "id": 761, "strid": "0f59d128-83a3-4820-a89b-0a73466cfd7b", "image_id": 32, "image_name": "11531.png", "category_id": 4, "category_name": "List", "bbox": [ 1703.887, 4133.57, 1543.269, 477.02499999999964 ], "priority": 29, "parents": [ 760 ], "children": [], "area": 7043136.186589999, "iscrowd": 0, "segmentation": [] }, { "id": 762, "strid": "9172a923-96bd-470d-a9aa-42a4f1c49f29", "image_id": 33, "image_name": "11601.png", "category_id": 9, "category_name": "Root", "bbox": [ 2594.67, 432.38, 610.1300000000001, 174.32000000000005 ], "priority": -1, "parents": [], "children": [ 764, 769, 779, 773, 765, 763 ], "area": 1121883.4146, "iscrowd": 0, "segmentation": [] }, { "id": 763, "strid": "9565b282-fb00-428b-bcef-d24c98c4c937", "image_id": 33, "image_name": "11601.png", "category_id": 1, "category_name": "Title", "bbox": [ 120.056, 78.406, 2817.162, 245.74399999999997 ], "priority": 1, "parents": [ 762 ], "children": [], "area": 9413.110736, "iscrowd": 0, "segmentation": [], "text": "InterProScan: Protein sequence analysis and\nclassification 01>) oe)" }, { "id": 764, "strid": "51e47475-d631-4c63-804b-95bc233a16ef", "image_id": 33, "image_name": "11601.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 123.416, 347.414, 2106.756, 241.25299999999993 ], "priority": 2, "parents": [ 762 ], "children": [], "area": 42876.446224, "iscrowd": 0, "segmentation": [], "text": "Gift Nuka, Matthew Fraser, Alex Mitchell, Simon Potter, Siew-Yit Yong\n& Robert D. Finn\n\nEuropean Bioinformatics Institute (EMBL-EBI), United Kingdom" }, { "id": 765, "strid": "e55e42af-6ab0-4f00-a190-268c42a13dae", "image_id": 33, "image_name": "11601.png", "category_id": 5, "category_name": "Section", "bbox": [ 153.709, 751.0, 382.046, 48.03600000000006 ], "priority": 3, "parents": [ 762 ], "children": [ 767, 766 ], "area": 115435.459, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 766, "strid": "b6f1d7f4-563f-4e93-9888-a91169c2dabe", "image_id": 33, "image_name": "11601.png", "category_id": 3, "category_name": "Text", "bbox": [ 150.936, 811.744, 1457.395, 528.802 ], "priority": 4, "parents": [ 765 ], "children": [], "area": 122521.392384, "iscrowd": 0, "segmentation": [], "text": "InterPro (http://www.ebi.ac.uk/interpro/) is a freely\navailable database used to _ classify protein\nsequences into families and to predict the presence\nof important domains and sites. The resource is\nbased around diagnostic signatures, provided by\ndifferent member databases, against which protein\nsequences are searched to determine their\npotential functions." }, { "id": 767, "strid": "221b59b2-5455-45f3-a1d9-af91036fd811", "image_id": 33, "image_name": "11601.png", "category_id": 2, "category_name": "Figure", "bbox": [ 157.547, 1340.542, 1450.36, 929.9410000000003 ], "priority": 5, "parents": [ 765 ], "children": [ 768 ], "area": 211198.370474, "iscrowd": 0, "segmentation": [] }, { "id": 768, "strid": "2a5716f4-85b9-42c2-a12c-8e477866772b", "image_id": 33, "image_name": "11601.png", "category_id": 6, "category_name": "Caption", "bbox": [ 140.057, 2300.009, 1462.869, 218.70800000000008 ], "priority": 6, "parents": [ 767 ], "children": [], "area": 322132.360513, "iscrowd": 0, "segmentation": [], "text": "Figure 1: Fourteen different member databases with differing\nmethods of signature production and biological focuses make up\nthe InterPro resource. Databases with a v provide some form of\nresidue-specific annotation." }, { "id": 769, "strid": "8ea74c5e-1332-49fc-9a3e-5a80ee9fab53", "image_id": 33, "image_name": "11601.png", "category_id": 5, "category_name": "Section", "bbox": [ 137.185, 2562.1, 347.751, 53.572000000000116 ], "priority": 7, "parents": [ 762 ], "children": [ 771, 770 ], "area": 351481.6885, "iscrowd": 0, "segmentation": [], "text": "InterProScan" }, { "id": 770, "strid": "57646840-a4ce-4332-9f72-d25a0ad9a1d4", "image_id": 33, "image_name": "11601.png", "category_id": 3, "category_name": "Text", "bbox": [ 136.366, 2629.284, 1485.919, 530.5279999999998 ], "priority": 8, "parents": [ 769 ], "children": [], "area": 358544.9419440001, "iscrowd": 0, "segmentation": [], "text": "InterProScan (http://www.ebi.ac.uk/interpro/interproscan.html) is\nthe underlying software application that allows both protein\nand nucleic acid sequences to be scanned against\nInterPro's predictive models (profile hidden Markov\nmodels, profiles, position-specific scoring matrices and\nregular expressions), which are provided by the resource’s\nmember databases. InterProScan produces output in\ndifferent formats including tsv, xml, json and svg." }, { "id": 771, "strid": "74d2756a-5da6-43ed-981d-4806dcbe2a2f", "image_id": 33, "image_name": "11601.png", "category_id": 2, "category_name": "Figure", "bbox": [ 151.06, 3175.002, 1459.169, 975.011 ], "priority": 9, "parents": [ 769 ], "children": [ 772 ], "area": 479615.80212, "iscrowd": 0, "segmentation": [] }, { "id": 772, "strid": "cc197f32-fc05-4a8c-8dc3-52c54b900441", "image_id": 33, "image_name": "11601.png", "category_id": 6, "category_name": "Caption", "bbox": [ 179.365, 4163.158, 1467.063, 153.59100000000035 ], "priority": 10, "parents": [ 771 ], "children": [], "area": 746724.8346700001, "iscrowd": 0, "segmentation": [], "text": "Figure 2: InterProScan matches for UniProtKB protein Q3JCG5\nshowing predicted protein family membership, domains and\nsites." }, { "id": 773, "strid": "e52d7d92-8273-4804-88a8-cd4200c82d2b", "image_id": 33, "image_name": "11601.png", "category_id": 5, "category_name": "Section", "bbox": [ 1707.122, 747.94, 782.133, 53.08100000000002 ], "priority": 11, "parents": [ 762 ], "children": [ 777, 775, 774 ], "area": 1276824.82868, "iscrowd": 0, "segmentation": [], "text": "Residue-level annotation" }, { "id": 774, "strid": "d004f635-3eea-4519-8bf4-b5db23130dea", "image_id": 33, "image_name": "11601.png", "category_id": 3, "category_name": "Text", "bbox": [ 1703.827, 810.624, 1470.5490000000002, 395.23800000000006 ], "priority": 12, "parents": [ 773 ], "children": [], "area": 1381163.058048, "iscrowd": 0, "segmentation": [], "text": "Two recently added member databases, CDD and\nSFLD, provide specific residue-level annotation,\nenabling identification of important amino acids,\nsuch as those comprising ligand-binding or active\nsites. These provide an additional tier to the\nannotations provided by InterPro." }, { "id": 775, "strid": "130beabe-9e16-47be-bfcb-eb1cf9cc2a4e", "image_id": 33, "image_name": "11601.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1708.272, 1207.443, 1275.4409999999998, 726.137 ], "priority": 13, "parents": [ 773 ], "children": [ 776 ], "area": 2062641.0684959998, "iscrowd": 0, "segmentation": [] }, { "id": 776, "strid": "0f276eb9-285b-49c3-b4b4-05a482994de6", "image_id": 33, "image_name": "11601.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1713.403, 1955.761, 1436.7519999999997, 160.3739999999998 ], "priority": 14, "parents": [ 775 ], "children": [], "area": 3351006.764683, "iscrowd": 0, "segmentation": [], "text": "Figure 3: CDD and SFLD profiles are annotated with residue\ninformation for specific amino acids important for function,\nbinding, etc." }, { "id": 777, "strid": "fc204f93-2422-43fe-9754-dccc441cab64", "image_id": 33, "image_name": "11601.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1719.829, 2143.996, 1428.043, 629.2150000000001 ], "priority": 15, "parents": [ 773 ], "children": [ 778 ], "area": 3687306.496684, "iscrowd": 0, "segmentation": [] }, { "id": 778, "strid": "0688ec8f-3743-429e-8589-d74b9082a6ad", "image_id": 33, "image_name": "11601.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1708.038, 2820.095, 1443.4450000000002, 177.70499999999993 ], "priority": 16, "parents": [ 777 ], "children": [], "area": 4816829.42361, "iscrowd": 0, "segmentation": [], "text": "Figure 4: When a sequence matches a relevant profile\nin InterProScan, the appropriate matching amino acids\nare highlighted in the output." }, { "id": 779, "strid": "68a51e8d-9e11-4d57-b484-6c0420c7b4d2", "image_id": 33, "image_name": "11601.png", "category_id": 5, "category_name": "Section", "bbox": [ 1717.515, 3032.54, 1230.9690000000003, 66.7829999999999 ], "priority": 17, "parents": [ 762 ], "children": [ 781, 780 ], "area": 5208432.9381, "iscrowd": 0, "segmentation": [], "text": "Intrinsically disordered protein regions" }, { "id": 780, "strid": "dc7f29dc-3105-4d81-8dda-f9fb3d531e83", "image_id": 33, "image_name": "11601.png", "category_id": 3, "category_name": "Text", "bbox": [ 1710.264, 3105.072, 1477.077, 600.2960000000003 ], "priority": 18, "parents": [ 779 ], "children": [], "area": 5310492.859008, "iscrowd": 0, "segmentation": [], "text": "To complement the capability to annotate signal\npeptides, transmembrane regions and coiled-coils,\nInterPro has added prediction of intrinsically\ndisordered regions (IDRs) - polypeptide segments\nthat have little or no three-dimensional structure\n-through integration of MobiDB Lite. This tool\ncombines eight different prediction methods to\ngenerate consensus IDR annotations, focusing on\nlong disordered regions." }, { "id": 781, "strid": "dffd52e9-5a65-42e0-99c1-d042b1484cf2", "image_id": 33, "image_name": "11601.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1709.308, 3715.425, 1493.6279999999997, 357.7550000000001 ], "priority": 19, "parents": [ 779 ], "children": [ 782 ], "area": 6350805.6759, "iscrowd": 0, "segmentation": [] }, { "id": 782, "strid": "87397f87-8789-4654-9f29-7630f93e76b8", "image_id": 33, "image_name": "11601.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1730.884, 4101.525, 1489.373, 268.64599999999973 ], "priority": 20, "parents": [ 781 ], "children": [], "area": 7099263.9980999995, "iscrowd": 0, "segmentation": [], "text": "Figure 5: Other sequence features in InterPro, including MobiDB\nLite IDR annotations for UniParc sequence UPI0003464803. IDRs\nhave a wide range of potential functions, from acting as flexible\nlinkers between domains, to interacting with other proteins and\nmodifying their activity." }, { "id": 783, "strid": "e981c0c9-0d08-4237-9fc2-e204a340f680", "image_id": 34, "image_name": "11607.png", "category_id": 9, "category_name": "Root", "bbox": [ 2505.93, 55.32, 201.80000000000018, 209.57 ], "priority": -1, "parents": [], "children": [ 785, 809, 789, 799, 786, 784, 811 ], "area": 138628.0476, "iscrowd": 0, "segmentation": [] }, { "id": 784, "strid": "c0f734af-923c-48a0-a79f-ce44b66321fb", "image_id": 34, "image_name": "11607.png", "category_id": 1, "category_name": "Title", "bbox": [ 162.012, 82.9, 2219.116, 232.42 ], "priority": 1, "parents": [ 783 ], "children": [], "area": 13430.794800000001, "iscrowd": 0, "segmentation": [], "text": "Mathematical modelling of promoter occupancies\nin MYC-dependent gene regulation\"" }, { "id": 785, "strid": "74fe51dd-41f5-4754-a9db-4cbc5a1c939b", "image_id": 34, "image_name": "11607.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 160.085, 382.657, 2251.525, 244.28500000000003 ], "priority": 2, "parents": [ 783 ], "children": [], "area": 61257.645845, "iscrowd": 0, "segmentation": [], "text": "Uwe Benary’, Elmar Wolf?, Jana Wolf?\n\n \n\naMax Delbruck Center for Molecular Medicine (MDC), Berlin-Buch, Germany\nbDepartment of Biochemistry and Molecular Biology, Biocenter, University of Wurzburg, Wurzburg, Germany" }, { "id": 786, "strid": "a7c1d062-86e4-428b-b304-7735cc46b4e7", "image_id": 34, "image_name": "11607.png", "category_id": 5, "category_name": "Section", "bbox": [ 102.538, 726.658, 319.359, 42.22900000000004 ], "priority": 3, "parents": [ 783 ], "children": [ 787, 788 ], "area": 74510.058004, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 787, "strid": "394ff166-f75b-4005-94e7-9270a3250764", "image_id": 34, "image_name": "11607.png", "category_id": 4, "category_name": "List", "bbox": [ 99.885, 824.621, 738.029, 604.945 ], "priority": 4, "parents": [ 786 ], "children": [], "area": 82367.268585, "iscrowd": 0, "segmentation": [] }, { "id": 788, "strid": "a3d4ec72-3644-4aaa-9932-c5c106908b07", "image_id": 34, "image_name": "11607.png", "category_id": 4, "category_name": "List", "bbox": [ 915.777, 822.384, 816.3040000000001, 607.315 ], "priority": 5, "parents": [ 786 ], "children": [], "area": 753120.3523680001, "iscrowd": 0, "segmentation": [] }, { "id": 789, "strid": "01f36d04-a8ff-40d1-806f-57937f6808d4", "image_id": 34, "image_name": "11607.png", "category_id": 5, "category_name": "Section", "bbox": [ 101.928, 1532.639, 683.688, 55.66000000000008 ], "priority": 6, "parents": [ 783 ], "children": [ 794, 797, 790, 793, 795, 796, 792, 791, 798 ], "area": 156218.82799199998, "iscrowd": 0, "segmentation": [], "text": "Mathematical modelling\"" }, { "id": 790, "strid": "43e430c3-b014-485f-a66b-98a168834f1e", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 99.011, 1625.368, 1613.157, 115.45800000000008 ], "priority": 7, "parents": [ 789 ], "children": [], "area": 160929.31104799997, "iscrowd": 0, "segmentation": [], "text": "What is the relation between MYC DNA binding affinity anc\noccupancy?" }, { "id": 791, "strid": "4e2634a0-3b91-44e5-9f61-a91b8b526ba2", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 102.101, 1772.606, 776.548, 508.5820000000001 ], "priority": 8, "parents": [ 789 ], "children": [], "area": 180984.845206, "iscrowd": 0, "segmentation": [] }, { "id": 792, "strid": "111b525b-a4a5-45ef-8b1d-0c1b122600a3", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 978.51, 1853.636, 751.546, 399.433 ], "priority": 9, "parents": [ 789 ], "children": [], "area": 1813801.36236, "iscrowd": 0, "segmentation": [], "text": "The model describes the reversible binding of MYC\nto E-boxes and unspecific binding sites at random\nDNA sequences at steady state.\n\nAffinity is indirectly proportional to the dissociation\nconstant (KEbox, Ky)-\n\nOccupancy of E-boxes is the proportion of E-boxes\nbound by MYC in total number of E-boxes." }, { "id": 793, "strid": "42f711e4-c296-434e-9110-fc97276627a7", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 99.563, 2400.817, 1623.035, 114.28900000000021 ], "priority": 10, "parents": [ 789 ], "children": [], "area": 239032.54297100002, "iscrowd": 0, "segmentation": [], "text": "Does the number of MYC molecules permit high occupancies\nas observed in ChIP-sequencing experiments?" }, { "id": 794, "strid": "747546ad-ab71-4215-85f8-cc9a875c1279", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 98.883, 2542.78, 1627.628, 779.3040000000001 ], "priority": 11, "parents": [ 789 ], "children": [], "area": 251437.71474, "iscrowd": 0, "segmentation": [] }, { "id": 795, "strid": "3f1e9e27-eb6c-4d79-aac3-529434a12110", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 101.947, 3461.494, 1639.466, 114.7159999999999 ], "priority": 12, "parents": [ 789 ], "children": [], "area": 352888.928818, "iscrowd": 0, "segmentation": [], "text": "To what extent does affinity, karyotype and chromatin status\naffect occupancy?" }, { "id": 796, "strid": "ee921352-dfdb-45ab-9211-4d6d6b180118", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 99.527, 3609.321, 1645.955, 766.1499999999996 ], "priority": 13, "parents": [ 789 ], "children": [], "area": 359224.891167, "iscrowd": 0, "segmentation": [] }, { "id": 797, "strid": "076d12c8-57e1-4cf1-bf53-1e1ef534b4a8", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 211.025, 4408.205, 650.882, 57.136999999999716 ], "priority": 14, "parents": [ 789 ], "children": [], "area": 930241.460125, "iscrowd": 0, "segmentation": [], "text": "Simulations consider the genome size and number of\nE-boxes of U20S cells." }, { "id": 798, "strid": "263194b6-c29b-47de-82b6-d131f5633119", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1058.942, 4409.233, 650.337, 63.72099999999955 ], "priority": 15, "parents": [ 789 ], "children": [], "area": 4669122.011486, "iscrowd": 0, "segmentation": [], "text": "A particular set of published dissociation constants\nKEbox and Ky is assumed." }, { "id": 799, "strid": "31e0b269-dd86-4f10-a6cb-6fd125e52b83", "image_id": 34, "image_name": "11607.png", "category_id": 5, "category_name": "Section", "bbox": [ 1902.039, 717.249, 509.4419999999998, 53.5 ], "priority": 16, "parents": [ 783 ], "children": [ 803, 801, 802, 807, 808, 804, 805, 806, 800 ], "area": 1364235.5707110001, "iscrowd": 0, "segmentation": [], "text": "Experimental data\"" }, { "id": 800, "strid": "b2f1d66c-5395-48a6-9c48-93bbf562f205", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1900.448, 825.759, 947.9420000000002, 44.888000000000034 ], "priority": 17, "parents": [ 799 ], "children": [], "area": 1569312.040032, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 801, "strid": "f08d7ede-29bc-4716-8406-ca6e7d0e77d8", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1913.516, 922.55, 634.5819999999999, 33.33000000000004 ], "priority": 18, "parents": [ 799 ], "children": [], "area": 1765314.1858, "iscrowd": 0, "segmentation": [], "text": "MYC overexpression and knockdown (WB)" }, { "id": 802, "strid": "388c544d-94bb-4922-84dc-87e38a58a611", "image_id": 34, "image_name": "11607.png", "category_id": 7, "category_name": "Table", "bbox": [ 2003.883, 968.073, 1161.39, 308.3259999999999 ], "priority": 19, "parents": [ 799 ], "children": [], "area": 1939905.027459, "iscrowd": 0, "segmentation": [] }, { "id": 803, "strid": "2dcf8dd7-9020-467b-8b04-290819ad48d3", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1900.67, 1381.467, 1325.975, 114.08899999999994 ], "priority": 20, "parents": [ 799 ], "children": [], "area": 2625712.8828900005, "iscrowd": 0, "segmentation": [], "text": "ChiP-sequencing of wild-type and MYC overex-\npressing U2OS cells" }, { "id": 804, "strid": "8e0518e6-13a5-44a1-a90a-326e11a196a6", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1947.414, 1522.172, 1204.077, 387.26099999999997 ], "priority": 21, "parents": [ 799 ], "children": [], "area": 2964299.063208, "iscrowd": 0, "segmentation": [] }, { "id": 805, "strid": "ad0c453c-15e3-4731-b35d-fb665f1bc15a", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1900.775, 2005.527, 1312.299, 113.28099999999995 ], "priority": 22, "parents": [ 799 ], "children": [], "area": 3812055.5834250003, "iscrowd": 0, "segmentation": [], "text": "Promoter affinity stratifies distinct MYC regulated\nbiological processes at different MYC levels" }, { "id": 806, "strid": "de9edf62-fb9c-46e3-9159-01e6d1c96ef4", "image_id": 34, "image_name": "11607.png", "category_id": 4, "category_name": "List", "bbox": [ 1899.763, 2155.667, 364.92599999999993, 453.4870000000001 ], "priority": 23, "parents": [ 799 ], "children": [], "area": 4095256.4069209998, "iscrowd": 0, "segmentation": [] }, { "id": 807, "strid": "b1c15069-7d11-45f1-8462-9fe176f6eea5", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2091.266, 2178.71, 717.2449999999999, 615.7449999999999 ], "priority": 24, "parents": [ 799 ], "children": [], "area": 4556262.146860001, "iscrowd": 0, "segmentation": [] }, { "id": 808, "strid": "c6be2a2e-de35-464a-ac95-364c7f548078", "image_id": 34, "image_name": "11607.png", "category_id": 4, "category_name": "List", "bbox": [ 2858.144, 2155.187, 358.8000000000002, 614.5720000000001 ], "priority": 25, "parents": [ 799 ], "children": [], "area": 6159834.792927999, "iscrowd": 0, "segmentation": [] }, { "id": 809, "strid": "efe36076-df13-4b37-a20e-9e6f8fbb873b", "image_id": 34, "image_name": "11607.png", "category_id": 5, "category_name": "Section", "bbox": [ 1901.825, 2942.805, 291.77099999999996, 42.108000000000175 ], "priority": 26, "parents": [ 783 ], "children": [ 810 ], "area": 5596700.119125, "iscrowd": 0, "segmentation": [], "text": "Discussion" }, { "id": 810, "strid": "8191c4b1-9454-4c71-b0f0-9fbb1855f870", "image_id": 34, "image_name": "11607.png", "category_id": 4, "category_name": "List", "bbox": [ 1900.294, 3028.138, 1325.628, 587.8069999999998 ], "priority": 27, "parents": [ 809 ], "children": [], "area": 5754352.472572, "iscrowd": 0, "segmentation": [] }, { "id": 811, "strid": "fb939c8e-a7f5-4342-8148-b9c8df8404a7", "image_id": 34, "image_name": "11607.png", "category_id": 5, "category_name": "Section", "bbox": [ 1901.188, 3687.034, 298.759, 43.13599999999997 ], "priority": 28, "parents": [ 783 ], "children": [ 813, 812 ], "area": 7009744.796392, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 812, "strid": "f83fec86-8d8e-4196-9e22-005f0aad8a2a", "image_id": 34, "image_name": "11607.png", "category_id": 3, "category_name": "Text", "bbox": [ 1900.31, 3768.602, 1330.585, 80.25300000000016 ], "priority": 29, "parents": [ 811 ], "children": [], "area": 7161512.06662, "iscrowd": 0, "segmentation": [], "text": "Interactions of MYC with DNA-bound cofactors that increase its apparent binding affinity\ncan enhance occupancy." }, { "id": 813, "strid": "cad7b226-692b-4a67-9a9b-4bbf8036b93a", "image_id": 34, "image_name": "11607.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1905.172, 3887.832, 1321.975, 475.80700000000024 ], "priority": 30, "parents": [ 811 ], "children": [], "area": 7406988.667104, "iscrowd": 0, "segmentation": [] }, { "id": 814, "strid": "d68cb13e-ba54-463d-8385-f9d03adb29fc", "image_id": 35, "image_name": "11656.png", "category_id": 9, "category_name": "Root", "bbox": [ 37.15, 45.79, 73.91999999999999, 229.15 ], "priority": -1, "parents": [], "children": [ 817, 826, 841, 815, 830, 838, 834, 843, 816, 822, 819 ], "area": 1701.0984999999998, "iscrowd": 0, "segmentation": [] }, { "id": 815, "strid": "d89b0a7a-0946-4c87-a2cb-3c98c1097513", "image_id": 35, "image_name": "11656.png", "category_id": 1, "category_name": "Title", "bbox": [ 150.315, 117.472, 2324.515, 43.373000000000005 ], "priority": 1, "parents": [ 814 ], "children": [], "area": 17657.803679999997, "iscrowd": 0, "segmentation": [], "text": "CHANNHL CROSSTALK CORRECTION IN SUSPENSION & IMAGING\n\nMASS CYTOMETRY" }, { "id": 816, "strid": "aecf16c6-016a-460d-897d-8a16ea7595eb", "image_id": 35, "image_name": "11656.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 355.271, 184.729, 1913.3370000000002, 35.028999999999996 ], "priority": 2, "parents": [ 814 ], "children": [], "area": 65628.856559, "iscrowd": 0, "segmentation": [], "text": "Helena L Crowell\"*, Stéphane Chevrier’, Vito RT Zanotelli!:*, Stefanie Engler!, Mark D Robinson’, and Bernd Bodenmiller+" }, { "id": 817, "strid": "fc7ea781-f63d-4555-aed0-5766f354b54c", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 1145.783, 545.094, 1016.0880000000002, 38.38300000000004 ], "priority": 3, "parents": [ 814 ], "children": [ 818 ], "area": 624559.438602, "iscrowd": 0, "segmentation": [], "text": "Overview of bead-based compensation for mass cytometry data" }, { "id": 818, "strid": "b27124e3-b471-41c5-a5c6-e8237fa6297b", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 87.035, 607.944, 3150.924, 1025.195 ], "priority": 4, "parents": [ 817 ], "children": [], "area": 52912.406039999994, "iscrowd": 0, "segmentation": [] }, { "id": 819, "strid": "b9a1483d-97f7-41b1-b941-aabf5a0891d4", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 462.536, 1724.23, 769.1099999999999, 37.63000000000011 ], "priority": 5, "parents": [ 814 ], "children": [ 821, 820 ], "area": 797518.44728, "iscrowd": 0, "segmentation": [], "text": "Correction of spillover artefacts in Suspension..." }, { "id": 820, "strid": "637d8c68-6d97-4d95-911d-6774237ed278", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 80.157, 1785.823, 1542.185, 591.9840000000002 ], "priority": 6, "parents": [ 819 ], "children": [], "area": 143146.214211, "iscrowd": 0, "segmentation": [] }, { "id": 821, "strid": "29e1fe35-df79-4aeb-bdee-ea6a82633e90", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 75.879, 2402.49, 1545.083, 172.933 ], "priority": 7, "parents": [ 819 ], "children": [], "area": 182298.53871, "iscrowd": 0, "segmentation": [], "text": "A. t-SNE map displaying data on a subset of 20'000 PBMCs analyzed with a 36-antibody panel and colored by marker\nexpression for a pair of antibodies labeled with two different metal isotopes. The percentages of spillover affecting each\nchannel in the uncompensated dataset are indicated. B. Heat maps showing the marker expressions in different\nPhenoGraph clusters. Dashed boxes highlight regions that changed upon compensation. C. Correlation heatmaps across all\nmarkers for one exemplary cluster." }, { "id": 822, "strid": "1501ddd8-e78c-4bd8-b359-05da465f81d1", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 2198.45, 1727.675, 581.1109999999999, 35.605999999999995 ], "priority": 8, "parents": [ 814 ], "children": [ 824, 825, 823 ], "area": 3798207.10375, "iscrowd": 0, "segmentation": [], "text": "...and imaging mass cytometry (IMC)" }, { "id": 823, "strid": "532ecd64-29dd-413b-94ca-5415f96b350d", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1704.575, 1801.208, 1534.2539999999997, 381.0300000000002 ], "priority": 9, "parents": [ 822 ], "children": [], "area": 3070294.1266, "iscrowd": 0, "segmentation": [] }, { "id": 824, "strid": "8978677a-b22f-4d31-b3be-0434acf19ffd", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 1689.689, 2205.898, 1154.6120000000003, 368.1199999999999 ], "priority": 10, "parents": [ 822 ], "children": [], "area": 3727281.5857220003, "iscrowd": 0, "segmentation": [], "text": "A. Representative image of a breast cancer tissue sample imaged by IMC. Shown are\nimages of '®SEr (used to label antibody to carbonic anhydrase), '®’Er (no antibody labeled\nwith this metal), and 168Er (used to label anti-KI67). For visualization, a median filter was\nused to reduce noise. The spillover matrix was computed from pixel values of individually\nspotted heavy metals, and images were compensated at the pixel rather than the single-cell\nlevel. Red arrows indicate parts of the image where low signal was removed upon\ncompensation. B. Segmentation mask shown on the representative images described in\npanel A. The mean pixel intensities of the signals observed in the indicated channels per cell\nwere calculated using a customized CellProfiler module. C. Scatterplots of single cell\nsegmentation data from the IMC images. The arcsinh transformed ion counts (cofactor of 2)\nare shown. Spillover artifacts are largely removed upon compensation." }, { "id": 825, "strid": "46e441d3-dd35-47a5-b4aa-c9a4147aed02", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2863.383, 2186.292, 372.26099999999997, 379.5 ], "priority": 11, "parents": [ 822 ], "children": [], "area": 6260191.345836, "iscrowd": 0, "segmentation": [] }, { "id": 826, "strid": "33c5dc55-db06-4198-acbd-fb32b36271d5", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 248.384, 2662.227, 687.361, 65.57900000000018 ], "priority": 12, "parents": [ 814 ], "children": [ 829, 827, 828 ], "area": 661254.5911679999, "iscrowd": 0, "segmentation": [], "text": "NNLS compensation accounts for saturation effects\n& preserves mass cytometry data structure" }, { "id": 827, "strid": "70998f3f-4732-4fdb-9478-1d5fbdeb5ac2", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 88.1, 2740.067, 1020.677, 673.5280000000002 ], "priority": 13, "parents": [ 826 ], "children": [], "area": 241399.90269999998, "iscrowd": 0, "segmentation": [] }, { "id": 828, "strid": "07577327-2b1c-4f78-be7d-ac175c21b617", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 80.376, 3438.79, 1023.934, 347.299 ], "priority": 14, "parents": [ 826 ], "children": [], "area": 276396.18504, "iscrowd": 0, "segmentation": [], "text": "A. Dot plots showing the spillover for the indicated relationships assessed on cells\nstained with increasing amount of barcoding reagents. An increased amount of\nbarcoding was associated with a progressive decrease of spillover. B. Dot plots\nshowing the median counts in each channel potentially affected by spillover. For\neach dataset, the average sum of squares is shown on top. The relationship\ndemonstrated in panel A leads to a systematic overestimation in multiplexed\nstained cells. NNLS* compensation is robust to this effect. C. Scatter plots\nshowing signal due to anti-HLA-ABC labeled with '’?Yb and anti-CD3 labeled with\n173Yb from pooled single-stained beads and multiplexed-stained PBMCs. NNLS\ncompensation preserves the count abundance nature of mass cytometry data." }, { "id": 829, "strid": "88f15e5b-8ed5-4226-86fc-1c8dda697014", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 105.346, 3877.008, 903.158, 424.04299999999967 ], "priority": 15, "parents": [ 826 ], "children": [], "area": 408427.284768, "iscrowd": 0, "segmentation": [], "text": "*Estimation of real signal intensities using non-negative least squares (NNLS)\n\nThe intensity observed in a given channel j is a linear combination of real signal\nand contributions from a set of channels w, that spill into it:\n\nI j.observed = I jareat + S if 1 i, real\n\ni€w;\n\n \n\nMeasurement intensities may thence be viewed as the convolution of real intensities\nwith a spillover matrix capturing all interactions sj:\n\nI Lyeq° SM\n\nobserved ~ * real\n\nTo account for the fact that real signal would result in strictly non-negative counts, we solve\nfor real such that the least squares criterion is met under the constraint of non-negativity5®:\n\nMIN {Ly pcened — SM *Lyear)” *Corsered — SM *Lyeqy )¥ Site Teg =O" }, { "id": 830, "strid": "09b53d2a-fd84-4682-881c-a39fdad5a28d", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 1751.466, 2663.861, 915.634, 65.91400000000021 ], "priority": 16, "parents": [ 814 ], "children": [ 832, 833, 831 ], "area": 4665661.970225999, "iscrowd": 0, "segmentation": [], "text": "CATALYST (Cytometry dATa anALYSis Tools):\nAn R package & Shiny GUI for preprocessing of mass cytometry data" }, { "id": 831, "strid": "147850db-1724-4741-ace2-0fc3bb5fea9a", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1186.801, 2737.527, 747.0709999999999, 578.9270000000001 ], "priority": 17, "parents": [ 830 ], "children": [], "area": 3248899.7811269998, "iscrowd": 0, "segmentation": [] }, { "id": 832, "strid": "fe74c664-2bf9-4b6c-a10a-a506cb04c346", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1940.257, 2737.527, 1294.0719999999997, 810.9229999999998 ], "priority": 18, "parents": [ 830 ], "children": [], "area": 5311505.924439, "iscrowd": 0, "segmentation": [] }, { "id": 833, "strid": "82692bed-8395-48d5-8650-e243d279f98c", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 1189.213, 3339.603, 738.441, 202.83399999999983 ], "priority": 19, "parents": [ 830 ], "children": [], "area": 3971499.302439, "iscrowd": 0, "segmentation": [], "text": "A. Schematic overview of the workflow used in the\nCATALYST package to generate a compensated file based\non beads stained with single antibodies. The graphical\noutputs generated throughout the process are shown\nabove each step. B. Screenshots depicting a selection of\nfeatures available within the Shiny GUI." }, { "id": 834, "strid": "55c47d84-b2c4-46d4-a8e2-e8739ab33475", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 1412.707, 3634.351, 530.537, 68.01699999999983 ], "priority": 20, "parents": [ 814 ], "children": [ 837, 835, 836 ], "area": 5134273.098157001, "iscrowd": 0, "segmentation": [], "text": "Single-cell based estimation of spillover\nprevents overcompensation" }, { "id": 835, "strid": "65b13af2-30f2-429a-b84c-427ab06db56b", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1201.203, 3710.479, 377.0239999999999, 629.4119999999998 ], "priority": 21, "parents": [ 834 ], "children": [], "area": 4457038.506236999, "iscrowd": 0, "segmentation": [] }, { "id": 836, "strid": "e08bf17d-cda0-404e-a5f7-513b9d7e9008", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1593.806, 3710.479, 573.326, 303.8000000000002 ], "priority": 22, "parents": [ 834 ], "children": [], "area": 5913783.693074, "iscrowd": 0, "segmentation": [] }, { "id": 837, "strid": "9530b535-2bbc-4675-87da-4d6db7306964", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 1599.928, 4037.916, 571.075, 303.71799999999985 ], "priority": 23, "parents": [ 834 ], "children": [], "area": 6460374.8700480005, "iscrowd": 0, "segmentation": [], "text": "A. Median counts in each channel potentially\naffected by spillover. Assessing the spillover\nin single-stained beads using summary\nstatistics at the population level lead to\novercompensation, and spillover estimation\nwas more accurate when assessed at the\nsingle-bead level. B. Schematic description of\nspillover estimation at the population and the\nsingle-cell level." }, { "id": 838, "strid": "df3ef68f-6f8b-46bb-a69a-702bc2febfe7", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 2511.647, 3635.122, 456.163, 60.86299999999983 ], "priority": 24, "parents": [ 814 ], "children": [ 840, 839 ], "area": 9130143.265934, "iscrowd": 0, "segmentation": [], "text": "Spillover estimates are stable\nover stainings, time & instruments" }, { "id": 839, "strid": "4e44aff2-c51d-4dc2-b461-cefc69dfd433", "image_id": 35, "image_name": "11656.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2262.167, 3712.037, 973.719, 306.91600000000017 ], "priority": 25, "parents": [ 838 ], "children": [], "area": 8397247.604178999, "iscrowd": 0, "segmentation": [] }, { "id": 840, "strid": "5a049ecf-dc8d-4455-99ea-87282890815d", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 2249.356, 4038.143, 980.8299999999999, 302.04399999999987 ], "priority": 26, "parents": [ 838 ], "children": [], "area": 9083221.185908, "iscrowd": 0, "segmentation": [], "text": "A. Scatter plot displaying the means and standard deviations of the spillover\nmeasured on the same day (blue), after three days (green), and after four\nmonths (red). The origin of spillover (metal impurity vs. oxidation) is indicated.\nAlthough the spillover matrix could be stable over months, our results show\nthat for optimal compensation the spillover matrix should be acquired\nsimultaneously with the sample of interest. B. Scatter plot showing the total\namount of spillover in each individual channel for the seven matrices acquired\n4 months apart, for the four matrices acquired on two different machines, and\nfor the theoretical matrix provided by Fluidigm." }, { "id": 841, "strid": "200fbd76-3de3-4280-9dd0-90a71bf0476e", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 1445.999, 4430.785, 184.8219999999999, 24.10699999999997 ], "priority": 27, "parents": [ 814 ], "children": [ 842 ], "area": 6406910.679215, "iscrowd": 0, "segmentation": [], "text": "Acknowledgment" }, { "id": 842, "strid": "9dc5a081-8ffc-434a-b360-af94febd1017", "image_id": 35, "image_name": "11656.png", "category_id": 3, "category_name": "Text", "bbox": [ 380.902, 4459.896, 1252.627, 190.9979999999996 ], "priority": 28, "parents": [ 841 ], "children": [], "area": 1698783.306192, "iscrowd": 0, "segmentation": [], "text": "The authors thank Dr Hartland Jackson for providing the breast cancer tissue image, CyTOF facility of the University of Zurich\nfor providing us access to its instrument and, first and foremost, the Bodenmiller and Robinson laboratories for fruitful\ndiscussions and providing us with additional test data and feedback throughout the development of CATALYST.\n\nThis work was supported by the Swiss National Science Foundation (SNSF) R’Equip grant, a SNSF Assistant Professorship\ngrant PPOOP3-144874, the PhosphonetPPM and MetastasiX SystemsxX grant, and funding from the European Research\nCouncil (ERC) under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement\n\nn. 336921. S.C. was funded by a Roche Postdoctoral Fellowship." }, { "id": 843, "strid": "07bab0b3-c496-404e-a463-a569e1be2737", "image_id": 35, "image_name": "11656.png", "category_id": 5, "category_name": "Section", "bbox": [ 1681.225, 4432.864, 118.87400000000002, 18.75799999999981 ], "priority": 29, "parents": [ 814 ], "children": [ 844 ], "area": 7452641.778399999, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 844, "strid": "b55ee4db-cc2e-4893-a63e-ebacc82d7b66", "image_id": 35, "image_name": "11656.png", "category_id": 4, "category_name": "List", "bbox": [ 1681.348, 4467.322, 1195.279, 181.01800000000003 ], "priority": 30, "parents": [ 843 ], "children": [], "area": 7511122.910056, "iscrowd": 0, "segmentation": [] }, { "id": 845, "strid": "fff790bd-f071-4db7-b239-ff61deddc60d", "image_id": 36, "image_name": "116616.png", "category_id": 9, "category_name": "Root", "bbox": [ 144.51, 95.02, 270.44, 312.04 ], "priority": -1, "parents": [], "children": [ 866, 847, 864, 846, 850, 848, 854 ], "area": 13731.340199999999, "iscrowd": 0, "segmentation": [] }, { "id": 846, "strid": "e6ddc065-4316-4d0e-a569-590efac663bd", "image_id": 36, "image_name": "116616.png", "category_id": 1, "category_name": "Title", "bbox": [ 219.552, 491.048, 2903.861, 112.07899999999995 ], "priority": 1, "parents": [ 845 ], "children": [], "area": 107810.570496, "iscrowd": 0, "segmentation": [], "text": "Tolerability issues with Oral Anticlabetic Agents" }, { "id": 847, "strid": "a799724e-57ef-4c00-ba73-a52e32a4ff8c", "image_id": 36, "image_name": "116616.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 339.273, 629.77, 2667.978, 235.61900000000003 ], "priority": 2, "parents": [ 845 ], "children": [], "area": 213663.95721000002, "iscrowd": 0, "segmentation": [], "text": "Cambra, R. F.*; Cruz, R. S. **\n\n* Graduate Student of Pharmacy, College of Health Technology of Coimbra - Polytechnic Institute of Coimbra. Portugal\n** Department of Pharmacy, College of Health Technology of Coimbra - Polytechnic Institute of Coimbra. Portugal" }, { "id": 848, "strid": "3fe56f50-e6a7-49de-921c-dc52621b03be", "image_id": 36, "image_name": "116616.png", "category_id": 5, "category_name": "Section", "bbox": [ 1501.76, 953.922, 413.8120000000001, 52.321000000000026 ], "priority": 3, "parents": [ 845 ], "children": [ 849 ], "area": 1432561.9027200001, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 849, "strid": "9960217d-6849-4975-8c75-4541be82fdd7", "image_id": 36, "image_name": "116616.png", "category_id": 3, "category_name": "Text", "bbox": [ 280.521, 1051.15, 2814.698, 416.192 ], "priority": 4, "parents": [ 848 ], "children": [], "area": 294869.64915000007, "iscrowd": 0, "segmentation": [], "text": "As a general rule in type 2 diabetes can be a regular monitoring of blood glucose with oral antidiabetic agents. However, administration of\noral antidiabetic agents is often associated with adverse events for patients, influencing negatively either satisfaction, and treatment\nadherence. However, there are differences between antidiabetic classes of drugs, in consequence of their mechanisms of action. The\ntolerability is usually defined as the ability of the organism to sustain the effects of external agent.\n\nObjective: The purpose of this study was to analyze if oral therapy administered in patients with type II diabetes is well tolerated and its\ninfluence in the respective treatment tolerability." }, { "id": 850, "strid": "cfc2b8e2-d400-49ee-80b7-acd547ab45c5", "image_id": 36, "image_name": "116616.png", "category_id": 5, "category_name": "Section", "bbox": [ 1333.86, 1502.781, 752.2970000000003, 56.624000000000024 ], "priority": 5, "parents": [ 845 ], "children": [ 851, 852 ], "area": 2004499.4646599998, "iscrowd": 0, "segmentation": [], "text": "Materials and Methods" }, { "id": 851, "strid": "35b35ff2-b562-4b66-a136-2705e3337674", "image_id": 36, "image_name": "116616.png", "category_id": 3, "category_name": "Text", "bbox": [ 284.164, 1681.775, 1442.739, 412.2109999999998 ], "priority": 6, "parents": [ 850 ], "children": [], "area": 477899.9111, "iscrowd": 0, "segmentation": [], "text": "We conducted a systematic review of literature without meta-analyse\nfrom the MEDLINE, between 2004-2011 about tolerability issues on\noral antidiabetic agents in type 2 diabetes..\n\nThe selection of reports was performed according to a methodology\nfor analysis of the title and abstract, and according to the criteria of\ninclusion." }, { "id": 852, "strid": "cf2742e2-c8fb-44b1-a3d0-dc81c08e7710", "image_id": 36, "image_name": "116616.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1797.675, 1652.359, 1294.8700000000001, 541.4470000000001 ], "priority": 7, "parents": [ 850 ], "children": [ 853 ], "area": 2970404.4653249998, "iscrowd": 0, "segmentation": [] }, { "id": 853, "strid": "36a7d63e-5dd2-468c-8e80-213f01d3cb0a", "image_id": 36, "image_name": "116616.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2140.376, 1606.046, 606.2370000000001, 32.465999999999894 ], "priority": 8, "parents": [ 852 ], "children": [], "area": 3437542.3132960005, "iscrowd": 0, "segmentation": [], "text": "Figure 1: Stepwise literature search strategy" }, { "id": 854, "strid": "bda0e325-94c8-4757-a740-1f4bf27111e7", "image_id": 36, "image_name": "116616.png", "category_id": 5, "category_name": "Section", "bbox": [ 1585.944, 2243.109, 242.3209999999999, 55.01000000000022 ], "priority": 9, "parents": [ 845 ], "children": [ 858, 862, 855, 861, 857, 860 ], "area": 3557445.259896, "iscrowd": 0, "segmentation": [], "text": "PX RS" }, { "id": 855, "strid": "0178aa9d-73ee-4b3b-ae07-6bdd753b0849", "image_id": 36, "image_name": "116616.png", "category_id": 7, "category_name": "Table", "bbox": [ 77.933, 2339.508, 1619.107, 1894.5410000000002 ], "priority": 10, "parents": [ 854 ], "children": [ 856 ], "area": 182324.876964, "iscrowd": 0, "segmentation": [] }, { "id": 856, "strid": "3fd3434b-4a8f-4683-92bd-7d5ed42c5172", "image_id": 36, "image_name": "116616.png", "category_id": 6, "category_name": "Caption", "bbox": [ 459.147, 2362.944, 859.979, 38.215999999999894 ], "priority": 11, "parents": [ 855 ], "children": [], "area": 1084938.648768, "iscrowd": 0, "segmentation": [], "text": "Table 1: Reports used for analysis and discussion of results" }, { "id": 857, "strid": "103ec2e5-f1da-44a1-97f1-58c58d43826b", "image_id": 36, "image_name": "116616.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1713.336, 2443.403, 361.8459999999998, 443.3090000000002 ], "priority": 12, "parents": [ 854 ], "children": [], "area": 4186370.3224079995, "iscrowd": 0, "segmentation": [] }, { "id": 858, "strid": "67d03117-7825-4c4c-8beb-6b483ae61195", "image_id": 36, "image_name": "116616.png", "category_id": 7, "category_name": "Table", "bbox": [ 2076.82, 2354.222, 1198.897, 644.4769999999999 ], "priority": 13, "parents": [ 854 ], "children": [ 859 ], "area": 4889295.334040001, "iscrowd": 0, "segmentation": [] }, { "id": 859, "strid": "99db04e4-28fa-4385-b904-3fe35926ade1", "image_id": 36, "image_name": "116616.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2162.251, 2392.02, 1021.308, 40.327999999999975 ], "priority": 14, "parents": [ 858 ], "children": [], "area": 5172147.63702, "iscrowd": 0, "segmentation": [], "text": "Table 2: Incidence of tolerability inherent oral antidiabetics monotherapy" }, { "id": 860, "strid": "6132c953-b801-4da7-a5b4-0de1bc42e62a", "image_id": 36, "image_name": "116616.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2459.167, 3015.856, 411.77300000000014, 464.7739999999999 ], "priority": 15, "parents": [ 854 ], "children": [], "area": 7416493.551952001, "iscrowd": 0, "segmentation": [] }, { "id": 861, "strid": "70ca5490-48c7-44e0-b8a6-348b175df356", "image_id": 36, "image_name": "116616.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1707.451, 3614.662, 369.47800000000007, 406.81899999999996 ], "priority": 16, "parents": [ 854 ], "children": [], "area": 6171858.246561999, "iscrowd": 0, "segmentation": [] }, { "id": 862, "strid": "b25497f5-c6cb-44bc-95dc-2124bde81e38", "image_id": 36, "image_name": "116616.png", "category_id": 7, "category_name": "Table", "bbox": [ 2085.913, 3473.523, 1197.594, 641.3429999999998 ], "priority": 17, "parents": [ 854 ], "children": [ 863 ], "area": 7245466.781499, "iscrowd": 0, "segmentation": [] }, { "id": 863, "strid": "ecb086bf-0518-4eac-8a31-32a60b8b1247", "image_id": 36, "image_name": "116616.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2107.204, 3513.072, 1157.2909999999997, 35.72699999999986 ], "priority": 18, "parents": [ 862 ], "children": [], "area": 7402759.370688001, "iscrowd": 0, "segmentation": [], "text": "Table 3: Incidence of tolerability inherent oral antidiabetics in combination therapy" }, { "id": 864, "strid": "7a4ccd10-8c54-426e-88f6-39d47619d5f1", "image_id": 36, "image_name": "116616.png", "category_id": 5, "category_name": "Section", "bbox": [ 683.805, 4296.479, 360.0010000000001, 53.70600000000013 ], "priority": 19, "parents": [ 845 ], "children": [ 865 ], "area": 2937953.822595, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 865, "strid": "3cfc5828-9729-4a1a-87db-97f6d4452134", "image_id": 36, "image_name": "116616.png", "category_id": 3, "category_name": "Text", "bbox": [ 86.848, 4419.695, 1555.865, 173.46399999999994 ], "priority": 20, "parents": [ 864 ], "children": [], "area": 383841.67136, "iscrowd": 0, "segmentation": [], "text": "The oral hypoglycemic agents are associated with numerous adverse events,\nincluding hypoglycemia, edema, and gastrointestinal effects. These issues\naffect not only tolerability satisfaction, but also adherence to therapy." }, { "id": 866, "strid": "bf5d1caa-b15a-48fe-932f-eff22fe8630e", "image_id": 36, "image_name": "116616.png", "category_id": 5, "category_name": "Section", "bbox": [ 2339.277, 4168.881, 363.346, 57.78899999999976 ], "priority": 21, "parents": [ 845 ], "children": [ 867 ], "area": 9752167.439037, "iscrowd": 0, "segmentation": [], "text": "References" }, { "id": 867, "strid": "253a05ff-eb60-449a-9880-11346110ed85", "image_id": 36, "image_name": "116616.png", "category_id": 3, "category_name": "Text", "bbox": [ 1734.904, 4280.789, 1580.1150000000002, 388.52499999999964 ], "priority": 22, "parents": [ 866 ], "children": [], "area": 7426757.959256, "iscrowd": 0, "segmentation": [], "text": "1 - Belcher et al. Elsevier. 2005; 2 - Charbonnel et al. Diabetes UK. 2005; 3 - Charbonnel et al.\nDiabetologia. 2005; 4 - Fujioka et al. Diabetes Obes Metab. 2005; 5 - Garber et al. Diabetes\nObes Metab. 2005; 6 - Matthews et al. Diabetes Metab Res Rev. 2005; 7 - Roberts et al. Clinical\nTherapeutics. 2005; 8 - Kahn et al. N Engl J Med. 2006; 9 - Rosenstock et al. Diabetes Obes\nMetab. 2006; 10 - Chao et al. Excerpta Medica. 2007; 11 - Davidson et al. Clinical Therapeutics.\n2007; 12 - Lewin et al. Clinical Therapeutics. 2007; 13 - Asche et al. Diabetes Obes Metab. 2008;\n14 - Asche et al. Drugs Aging. 2008; 15 - Seufert et al. Elsevier. 2008; 16 - Vexiau et al. Diabetes\nObes Metab. 2008; 17 - Pollack et al. Elsevier. 2010." }, { "id": 868, "strid": "72f3e7c7-5b5c-433e-bb59-c722ee186551", "image_id": 37, "image_name": "116622.png", "category_id": 9, "category_name": "Root", "bbox": [ 35.72, 29.08, 44.64, 68.22 ], "priority": -1, "parents": [], "children": [ 896, 880, 893, 873, 871, 870, 869, 898 ], "area": 1038.7376, "iscrowd": 0, "segmentation": [] }, { "id": 869, "strid": "77e7b2ea-c8b0-4810-8013-e3970e250634", "image_id": 37, "image_name": "116622.png", "category_id": 1, "category_name": "Title", "bbox": [ 93.057, 46.891, 648.518, 58.45600000000001 ], "priority": 1, "parents": [ 868 ], "children": [], "area": 4363.535787, "iscrowd": 0, "segmentation": [], "text": "Effects of closure on the processing of invisible figures:\nAn ERP study" }, { "id": 870, "strid": "9b0ae99c-777f-468b-bebb-74ba610777db", "image_id": 37, "image_name": "116622.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 104.767, 105.91, 626.904, 32.952 ], "priority": 2, "parents": [ 868 ], "children": [], "area": 11095.872969999999, "iscrowd": 0, "segmentation": [], "text": "Weina Zhu®* & Yuanye Ma’\n4¥unnan Univérsity, Kunming, China, Kunming Inistitute of Zoology, Chinese Academly Of Science, Kunming, China" }, { "id": 871, "strid": "40dbe8cf-4229-4a29-84a3-548a8b0d7c16", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 165.38, 169.311, 83.11700000000002, 13.211000000000013 ], "priority": 3, "parents": [ 868 ], "children": [ 872 ], "area": 28000.65318, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 872, "strid": "1320c5f5-4fe7-4f9e-99d5-fbf4d830d3ef", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 21.625, 194.591, 370.811, 124.20400000000001 ], "priority": 4, "parents": [ 871 ], "children": [], "area": 4208.030375, "iscrowd": 0, "segmentation": [], "text": "‘The specific nature of closure is important for the computation of an\nobject representation. The discrimination of closuie is typically faster\nand easier than that of other geometrical features (Pomerantz, Sager\net al. 1977; Treisman and Paterson 1984).\n\nIn order’ to investigate whether the specific nature of closure\nrequires conscious perception, we recorded Event-Related Potentials\n(ERPs) during a Continuous Flashed Suppression paradigm (CFS)\n(Tsuchiya and Koch 2005)" }, { "id": 873, "strid": "9da78857-0398-4d80-af45-058f33fddfef", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 177.863, 326.672, 59.56, 13.728999999999985 ], "priority": 5, "parents": [ 868 ], "children": [ 876, 875, 877, 874, 878, 879 ], "area": 58102.861936, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 874, "strid": "80632b79-90a1-4481-be7a-efe78fcb3743", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 21.001, 358.1, 371.424, 69.50400000000002 ], "priority": 6, "parents": [ 873 ], "children": [], "area": 7520.458100000001, "iscrowd": 0, "segmentation": [], "text": "Continuous Flash Supeisssion paradiga (CFS)\n\nStimuli: six pairs of well controlled figures were used as target stimuli,\nand one of the two figures in each pair is closed (Zhu, Zhang et al\n2012)." }, { "id": 875, "strid": "d0e2d8c9-8e4d-4ec9-9c25-4e6b024472f2", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 21.886, 432.474, 367.44, 51.79599999999999 ], "priority": 7, "parents": [ 873 ], "children": [], "area": 9465.125963999999, "iscrowd": 0, "segmentation": [], "text": "Procedure: target stimuli and a flashedMondrian pattern were\ndisplayed separately in two eyes of the’ subjects. Subjects were\ngisttucted to respond when they seed of the figures." }, { "id": 876, "strid": "865edf34-10aa-4541-bb3d-ff6da6e3ae84", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 20.558, 489.582, 368.768, 91.63900000000001 ], "priority": 8, "parents": [ 873 ], "children": [], "area": 10064.826756, "iscrowd": 0, "segmentation": [], "text": "Rehevices! Experiment : Maid\nThe intensity of the target stimuli were changed from low to high\nduring the experiment, and the stimuli and flashed masks were on\nthe screen until the subjects responded. The reaction time and\naccuracy of the subjects were analyzed." }, { "id": 877, "strid": "7c34afde-0670-4508-bc08-8c7bbedd0226", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 20.991, 590.966, 124.687, 13.724000000000046 ], "priority": 9, "parents": [ 873 ], "children": [], "area": 12404.967306, "iscrowd": 0, "segmentation": [], "text": "ERP Experiment : N=24" }, { "id": 878, "strid": "b8be48c7-4d00-4e8a-aac7-518f9fabcbc8", "image_id": 37, "image_name": "116622.png", "category_id": 4, "category_name": "List", "bbox": [ 21.562, 610.769, 368.649, 237.39999999999998 ], "priority": 10, "parents": [ 873 ], "children": [], "area": 13169.401178, "iscrowd": 0, "segmentation": [] }, { "id": 879, "strid": "7d9f5c53-8778-4c8d-820d-9a7c80d9d51a", "image_id": 37, "image_name": "116622.png", "category_id": 2, "category_name": "Figure", "bbox": [ 20.988, 848.324, 378.77, 123.37599999999998 ], "priority": 11, "parents": [ 873 ], "children": [], "area": 17804.624111999998, "iscrowd": 0, "segmentation": [] }, { "id": 880, "strid": "7f3d4431-a6fe-43b2-9930-10d9b57592de", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 594.746, 168.738, 47.745000000000005, 13.900000000000006 ], "priority": 12, "parents": [ 868 ], "children": [ 885, 882, 889, 891, 887, 888, 881, 886, 883, 884, 890, 892 ], "area": 100356.250548, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 881, "strid": "79a4693d-3f86-43b4-8a77-372eb07a2130", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 442.096, 193.839, 102.85000000000002, 10.877999999999986 ], "priority": 13, "parents": [ 880 ], "children": [], "area": 85695.446544, "iscrowd": 0, "segmentation": [], "text": "Behavioral Experiment" }, { "id": 882, "strid": "54cbb63e-b3f4-4240-a307-6ea2eb98feec", "image_id": 37, "image_name": "116622.png", "category_id": 2, "category_name": "Figure", "bbox": [ 478.164, 212.829, 249.23699999999997, 91.76400000000001 ], "priority": 14, "parents": [ 880 ], "children": [], "area": 101767.165956, "iscrowd": 0, "segmentation": [] }, { "id": 883, "strid": "df3b0532-8324-41fe-a195-6a746532e3d1", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 655.176, 251.12, 128.08399999999995, 44.50400000000002 ], "priority": 15, "parents": [ 880 ], "children": [], "area": 164527.79712, "iscrowd": 0, "segmentation": [], "text": "Cleeed figaves took tess tine tobe\n(677m. 1953 ms ota\nbetter accuracy (99.1% vs.97 94." }, { "id": 884, "strid": "66b5f66e-6bf1-42c4-87fe-51d41e31b43a", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 431.522, 313.8, 363.796, 123.56099999999998 ], "priority": 16, "parents": [ 880 ], "children": [], "area": 135411.6036, "iscrowd": 0, "segmentation": [], "text": "ERP Experiment :\nthree areas: Occipital (02, 01, 02 and POZ}, Left Temporal-Occipital\n(1P7, POS, PO7, PS, P7, CB1) and Right Temporal-Occipital (TP8, POE,\nPOB, P6, P8, CB2) areas were analyzed,\n\n-the peak latency showed that closed figures (237ms) had shorter\nlatency than open figures (244ms).This was reflected in the\nbehavioral results.\n\nAnalysis of the area amplitude between 200ms and 300ms:" }, { "id": 885, "strid": "0bd2b9ca-e989-4ad4-bc17-1a0bba2d4f1a", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 441.007, 445.997, 53.488999999999976, 9.506000000000029 ], "priority": 17, "parents": [ 880 ], "children": [], "area": 196687.798979, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 886, "strid": "669eccc5-151f-44d4-bd03-3201ea854ffe", "image_id": 37, "image_name": "116622.png", "category_id": 2, "category_name": "Figure", "bbox": [ 440.998, 456.385, 359.372, 109.66700000000003 ], "priority": 18, "parents": [ 880 ], "children": [], "area": 201264.87222999998, "iscrowd": 0, "segmentation": [] }, { "id": 887, "strid": "97bb22dc-54a8-4c10-aaa7-6a6b3b03b19e", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 472.688, 568.928, 311.274, 21.936000000000035 ], "priority": 19, "parents": [ 880 ], "children": [], "area": 268925.438464, "iscrowd": 0, "segmentation": [], "text": "Crgneiale! sane, nn Mgaificent cainrace Retna pees and chen Rewres on\nGtr concious and unconscious conditions." }, { "id": 888, "strid": "283eb051-add0-45cd-9959-5c349e93e22f", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 437.832, 602.683, 107.96400000000006, 10.729000000000042 ], "priority": 20, "parents": [ 880 ], "children": [], "area": 263873.903256, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 889, "strid": "252451ab-0610-4b27-ae18-741e2f89df23", "image_id": 37, "image_name": "116622.png", "category_id": 2, "category_name": "Figure", "bbox": [ 439.136, 616.106, 360.434, 108.11599999999999 ], "priority": 21, "parents": [ 880 ], "children": [], "area": 270554.324416, "iscrowd": 0, "segmentation": [] }, { "id": 890, "strid": "04f64aa3-966d-40f3-a901-9be2a9c28f0e", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 437.623, 722.235, 113.20400000000001, 10.90300000000002 ], "priority": 22, "parents": [ 880 ], "children": [], "area": 316066.647405, "iscrowd": 0, "segmentation": [], "text": "Right Ternporal-Occipital area" }, { "id": 891, "strid": "00041042-adf8-4fc4-99ed-2fa73bce2287", "image_id": 37, "image_name": "116622.png", "category_id": 2, "category_name": "Figure", "bbox": [ 444.493, 737.76, 352.613, 97.71600000000001 ], "priority": 23, "parents": [ 880 ], "children": [], "area": 327929.15567999997, "iscrowd": 0, "segmentation": [] }, { "id": 892, "strid": "0374e898-c2d7-4d23-88ee-0e2f36d64812", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 458.142, 848.699, 322.715, 34.96100000000001 ], "priority": 24, "parents": [ 880 ], "children": [], "area": 388824.657258, "iscrowd": 0, "segmentation": [], "text": "Di the teENpOrEL- corti erenn, Kina cineed guns Inckiced! Mager eapateee\nthan open gues visible gues induced oppose resus: dosed figures induced\nsmaller amplitude then opap teres." }, { "id": 893, "strid": "bcdb54e1-dcd2-4173-83f2-e0124230b092", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 579.205, 897.124, 77.93999999999994, 14.200000000000045 ], "priority": 25, "parents": [ 868 ], "children": [ 894, 895 ], "area": 519618.70642000006, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 894, "strid": "3ad58ec3-a4e4-48d9-8f04-182d66de3820", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 432.93, 928.033, 354.98599999999993, 42.01999999999998 ], "priority": 26, "parents": [ 893 ], "children": [], "area": 401773.32669, "iscrowd": 0, "segmentation": [], "text": "Our results indikate that closure can be processed 4A the absence of\nawareness, and show a perceptional advantage of closed figures in\nboth behavioral and ERP results." }, { "id": 895, "strid": "4fdabef8-e5dd-4fb7-983e-c2d3baa8417f", "image_id": 37, "image_name": "116622.png", "category_id": 4, "category_name": "List", "bbox": [ 445.032, 973.079, 351.28799999999995, 92.10799999999995 ], "priority": 27, "parents": [ 893 ], "children": [], "area": 433051.29352799995, "iscrowd": 0, "segmentation": [] }, { "id": 896, "strid": "1c77c534-68ba-4bb3-941b-e98ec50605c0", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 429.157, 1073.024, 94.666, 11.814000000000078 ], "priority": 28, "parents": [ 868 ], "children": [ 897 ], "area": 460495.7607679999, "iscrowd": 0, "segmentation": [], "text": "Acknowledgements:" }, { "id": 897, "strid": "edc2a245-d38f-4940-8897-372e2f927dba", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 428.376, 1086.756, 374.31999999999994, 37.66399999999999 ], "priority": 29, "parents": [ 896 ], "children": [], "area": 465540.188256, "iscrowd": 0, "segmentation": [], "text": "Tee prodect wee eupportg is is Metionsl Neture Science Reundation of Cire (ELAgROE2,\n61005087), Yunnan Science and Technology Project (20090018), Yunnan Eduction\nDeparement Kay Progatenigone7)" }, { "id": 898, "strid": "4e8992c2-53dd-4201-bfaa-f56971b6c1f3", "image_id": 37, "image_name": "116622.png", "category_id": 5, "category_name": "Section", "bbox": [ 174.164, 988.722, 71.779, 14.104000000000042 ], "priority": 30, "parents": [ 868 ], "children": [ 899 ], "area": 172199.77840799998, "iscrowd": 0, "segmentation": [], "text": "3c) ict ecd sleek" }, { "id": 899, "strid": "672b54f7-f12a-477a-b1d9-f5705deff912", "image_id": 37, "image_name": "116622.png", "category_id": 3, "category_name": "Text", "bbox": [ 22.774, 1016.388, 373.602, 93.351 ], "priority": 31, "parents": [ 898 ], "children": [], "area": 23147.220312, "iscrowd": 0, "segmentation": [], "text": "Pomerantz, J. R., L. C. Sager, et al. (1977).<\"Perception of wholes and of their\ncomponent parts: some configural superiority effects.\" Exp Psychol Hum Percept\nPerform 3(3): 422-435,\n\nTreisman, A. and R. Paterson (1984)°\"Emergent features, attention, and objett\nperception.” E49 Peychol Hum Percept Perform 20(1): 12-31,\n\nZhu, W., J. Zhang, et al. (accepted). \"The time course ofthe perceptual processing\n\nof “hole” and “no-hole” figures! An ERP study.\" Neurosci Bull" }, { "id": 900, "strid": "34421469-0301-429c-84e5-df9e56d32c91", "image_id": 38, "image_name": "116639.png", "category_id": 9, "category_name": "Root", "bbox": [ 24.42, 6.85, 55.010000000000005, 114.60000000000001 ], "priority": -1, "parents": [], "children": [ 902, 911, 903, 905, 901, 908, 913 ], "area": 167.27700000000002, "iscrowd": 0, "segmentation": [] }, { "id": 901, "strid": "b8949cc3-6f82-4933-a51c-95b8018bb5af", "image_id": 38, "image_name": "116639.png", "category_id": 1, "category_name": "Title", "bbox": [ 271.257, 41.636, 1264.822, 41.531 ], "priority": 1, "parents": [ 900 ], "children": [], "area": 11294.056452, "iscrowd": 0, "segmentation": [], "text": "A rare case of Congenital Myasthenic Syndrome with diagnosis in adulthood" }, { "id": 902, "strid": "346f4836-4cb0-40e2-92a0-3c35ea375fc3", "image_id": 38, "image_name": "116639.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 232.89, 92.299, 1342.333, 32.831 ], "priority": 2, "parents": [ 900 ], "children": [], "area": 21495.51411, "iscrowd": 0, "segmentation": [], "text": "C S Agrawal, R Ranjan, P Correia, R Panchani. Dept. of Neurology, Sir Ganga Ram Hospital, New Delhi, India" }, { "id": 903, "strid": "ba83ed9e-b749-4527-8138-af2552e6382f", "image_id": 38, "image_name": "116639.png", "category_id": 5, "category_name": "Section", "bbox": [ 57.421, 176.659, 136.266, 25.670999999999992 ], "priority": 3, "parents": [ 900 ], "children": [ 904 ], "area": 10143.936439, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 904, "strid": "769c9b8f-4be4-4f2b-815b-73308bf36bbd", "image_id": 38, "image_name": "116639.png", "category_id": 4, "category_name": "List", "bbox": [ 55.939, 209.307, 1554.881, 160.10299999999998 ], "priority": 4, "parents": [ 903 ], "children": [], "area": 11708.424272999999, "iscrowd": 0, "segmentation": [] }, { "id": 905, "strid": "2665f3b7-9a00-4a7f-b7d4-548e12865083", "image_id": 38, "image_name": "116639.png", "category_id": 5, "category_name": "Section", "bbox": [ 40.053, 441.875, 121.65, 25.00799999999998 ], "priority": 5, "parents": [ 900 ], "children": [ 906, 914, 907, 915 ], "area": 17698.419374999998, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 906, "strid": "36b22d6c-5253-4315-9c29-11683c955ca0", "image_id": 38, "image_name": "116639.png", "category_id": 4, "category_name": "List", "bbox": [ 40.235, 474.547, 894.185, 301.70399999999995 ], "priority": 6, "parents": [ 905 ], "children": [], "area": 19093.398545, "iscrowd": 0, "segmentation": [] }, { "id": 914, "strid": "f06ede3d-4540-4b45-afc4-48509bed975f", "image_id": 38, "image_name": "116639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 974.98, 409.68, 669.9100000000001, 363.94 ], "priority": 7, "parents": [ 905 ], "children": [], "area": 243807.04540000003, "iscrowd": 0, "segmentation": [] }, { "id": 907, "strid": "f4d5f54b-6d70-49f3-96cd-19e9fd4aa19b", "image_id": 38, "image_name": "116639.png", "category_id": 4, "category_name": "List", "bbox": [ 528.462, 809.589, 1103.377, 227.976 ], "priority": 8, "parents": [ 905 ], "children": [], "area": 427837.022118, "iscrowd": 0, "segmentation": [] }, { "id": 915, "strid": "9fa84549-6fb2-404a-892f-52fe227e3984", "image_id": 38, "image_name": "116639.png", "category_id": 2, "category_name": "Figure", "bbox": [ 21.54, 797.11, 459.01, 268.43999999999994 ], "priority": 9, "parents": [ 905 ], "children": [], "area": 123216.64439999998, "iscrowd": 0, "segmentation": [] }, { "id": 908, "strid": "aa415540-281d-4f79-b592-f5894c3d0cb2", "image_id": 38, "image_name": "116639.png", "category_id": 5, "category_name": "Section", "bbox": [ 72.357, 1107.355, 120.822, 25.164999999999964 ], "priority": 10, "parents": [ 900 ], "children": [ 909, 910 ], "area": 80124.885735, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 909, "strid": "d0695dab-1cc7-4107-a291-0cf5aaba752e", "image_id": 38, "image_name": "116639.png", "category_id": 3, "category_name": "Text", "bbox": [ 193.166, 1109.77, 601.9580000000001, 22.472999999999956 ], "priority": 11, "parents": [ 908 ], "children": [], "area": 214369.83182, "iscrowd": 0, "segmentation": [], "text": "RUC Oe SAE oe PUEO ROG Ci SUe iota" }, { "id": 910, "strid": "9c7ce64a-ebcc-4f47-99e1-a17b5f3a3e95", "image_id": 38, "image_name": "116639.png", "category_id": 3, "category_name": "Text", "bbox": [ 72.603, 1134.435, 777.951, 303.6109999999999 ], "priority": 12, "parents": [ 908 ], "children": [], "area": 82363.38430499999, "iscrowd": 0, "segmentation": [], "text": "ymptoms occur in general €arly in life, usually in the first two years. Severity and\ncourse of disease are highly variable. Genetic defects occur in. molecules expressed at the\nneuromuscular junction\neC RUS MeN R Te ts\neran ir Carer Men ROe nee eV ene Cy\nNS OBES SUC uae Ue m LeUeP OCH be LLL\nSeren one out Rares cay Ome Tal\nFrom theMaghreb ( Algeria & Tunisia) : CHRNE mutation\nSU re ue ce ed\nBV ce cet eV MOO EO)\nNo response to treatment with AChE inhibitors: COLO or RAPSN’\nLimb-girdle phenotype : DOK7, COLO,GPPT1" }, { "id": 911, "strid": "d924ccd8-5e52-40fe-9fcb-4521d9ea20f4", "image_id": 38, "image_name": "116639.png", "category_id": 5, "category_name": "Section", "bbox": [ 72.351, 1449.572, 132.977, 25.861000000000104 ], "priority": 13, "parents": [ 900 ], "children": [ 912 ], "area": 104877.98377199999, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 912, "strid": "cead4edf-a3d7-4f63-b392-50710aacf28c", "image_id": 38, "image_name": "116639.png", "category_id": 4, "category_name": "List", "bbox": [ 73.443, 1482.547, 778.545, 149.558 ], "priority": 14, "parents": [ 911 ], "children": [], "area": 108882.699321, "iscrowd": 0, "segmentation": [] }, { "id": 913, "strid": "67ed1235-082c-4535-bd93-cd6cd5db0552", "image_id": 38, "image_name": "116639.png", "category_id": 7, "category_name": "Table", "bbox": [ 896.257, 1077.355, 755.1749999999998, 568.5729999999999 ], "priority": 15, "parents": [ 900 ], "children": [], "area": 965586.960235, "iscrowd": 0, "segmentation": [] }, { "id": 916, "strid": "9b784953-9c68-4a46-9c81-ee0855ea6d22", "image_id": 39, "image_name": "116674.png", "category_id": 9, "category_name": "Root", "bbox": [ 180.91, 178.89, 252.64000000000001, 260.79 ], "priority": -1, "parents": [], "children": [ 928, 918, 917, 921, 923, 919, 931 ], "area": 32362.989899999997, "iscrowd": 0, "segmentation": [] }, { "id": 917, "strid": "8a83ac91-a089-4bc4-8070-d2f948cd9634", "image_id": 39, "image_name": "116674.png", "category_id": 1, "category_name": "Title", "bbox": [ 685.975, 201.423, 1939.219, 88.01300000000003 ], "priority": 1, "parents": [ 916 ], "children": [], "area": 138171.142425, "iscrowd": 0, "segmentation": [], "text": "Genome-wide Enhanced Gene Regulatory Networks" }, { "id": 918, "strid": "6c7b59b0-da38-4c82-8a71-fa0792af8306", "image_id": 39, "image_name": "116674.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 839.717, 340.412, 1636.3089999999997, 116.344 ], "priority": 2, "parents": [ 916 ], "children": [], "area": 285849.74340399995, "iscrowd": 0, "segmentation": [], "text": "A. Benso, S.Di Carlo, G. Politano, A. Savino, and H. Ur Rehman\nPolitecnico di Torino, Department of Control and Computer Engineering, Italy" }, { "id": 919, "strid": "3e314137-b859-434c-9f86-ee82aad42d8c", "image_id": 39, "image_name": "116674.png", "category_id": 5, "category_name": "Section", "bbox": [ 280.169, 1003.635, 186.543, 40.365999999999985 ], "priority": 3, "parents": [ 916 ], "children": [ 920 ], "area": 281187.414315, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 920, "strid": "70a9168d-cac9-442b-869f-835c4ff255ed", "image_id": 39, "image_name": "116674.png", "category_id": 2, "category_name": "Figure", "bbox": [ 364.373, 1143.739, 1054.789, 982.6420000000003 ], "priority": 4, "parents": [ 919 ], "children": [], "area": 416747.610647, "iscrowd": 0, "segmentation": [] }, { "id": 921, "strid": "cdd52811-b178-43b4-a8cd-0ad62db520bd", "image_id": 39, "image_name": "116674.png", "category_id": 5, "category_name": "Section", "bbox": [ 1846.032, 1002.588, 261.28599999999983, 41.17800000000011 ], "priority": 5, "parents": [ 916 ], "children": [ 922 ], "area": 1850809.530816, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 922, "strid": "57b71abf-045b-483e-b3e9-0b2e503c9e01", "image_id": 39, "image_name": "116674.png", "category_id": 3, "category_name": "Text", "bbox": [ 1851.774, 1118.072, 1161.121, 1004.597 ], "priority": 6, "parents": [ 921 ], "children": [], "area": 2070416.6597279997, "iscrowd": 0, "segmentation": [], "text": "Often we are not only interested in the topological\nproperties of a network, but also in its dynamical\nproperties.\n\nDynamic processes take place on many networks. The\nnodes interact and their state changes as a result of\nthese interactions.\n\nOne of the simplest models of a dynamical network is\nthe Boolean network.\n\nA Boolean network is directed, and each node is in one\nof two states, 0 or 1.\n\nFurthermore, each node has a set of rules which tell it its\nstate depending on the states of its neighbours in the\nnetwork." }, { "id": 923, "strid": "786844b8-2913-44eb-becf-35a6c9b7700c", "image_id": 39, "image_name": "116674.png", "category_id": 5, "category_name": "Section", "bbox": [ 374.281, 2372.468, 386.16399999999993, 43.02500000000009 ], "priority": 7, "parents": [ 916 ], "children": [ 926, 925, 924, 927 ], "area": 887969.695508, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 924, "strid": "b04a8a4a-abd8-4cbb-8a48-be7d2b320342", "image_id": 39, "image_name": "116674.png", "category_id": 4, "category_name": "List", "bbox": [ 375.293, 2431.872, 978.4890000000001, 107.9050000000002 ], "priority": 8, "parents": [ 923 ], "children": [], "area": 912664.538496, "iscrowd": 0, "segmentation": [] }, { "id": 925, "strid": "05d0d6c8-4187-47c3-9453-f7515532a009", "image_id": 39, "image_name": "116674.png", "category_id": 4, "category_name": "List", "bbox": [ 373.547, 2607.998, 1248.071, 414.22299999999996 ], "priority": 9, "parents": [ 923 ], "children": [], "area": 974209.8289060001, "iscrowd": 0, "segmentation": [] }, { "id": 926, "strid": "70e5848a-cf96-4247-937b-14b525a05b65", "image_id": 39, "image_name": "116674.png", "category_id": 3, "category_name": "Text", "bbox": [ 602.227, 3089.152, 789.3960000000001, 111.84999999999991 ], "priority": 10, "parents": [ 923 ], "children": [], "area": 1860370.741504, "iscrowd": 0, "segmentation": [], "text": "Stability reached in certain conditions\nFree Energy Local minimum" }, { "id": 927, "strid": "0529b133-c075-4d04-89f4-5e35da3afcd6", "image_id": 39, "image_name": "116674.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1894.595, 2366.298, 1027.488, 903.9949999999999 ], "priority": 11, "parents": [ 923 ], "children": [], "area": 4483176.359309999, "iscrowd": 0, "segmentation": [] }, { "id": 928, "strid": "fdfc2845-482b-48f2-ba9e-ffa51e2745a8", "image_id": 39, "image_name": "116674.png", "category_id": 5, "category_name": "Section", "bbox": [ 355.329, 3587.56, 423.82300000000004, 38.90599999999995 ], "priority": 12, "parents": [ 916 ], "children": [ 929, 930 ], "area": 1274764.10724, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 929, "strid": "14c33e80-971d-4986-aad9-36d554804653", "image_id": 39, "image_name": "116674.png", "category_id": 3, "category_name": "Text", "bbox": [ 356.214, 3704.829, 1057.519, 170.08399999999983 ], "priority": 13, "parents": [ 928 ], "children": [], "area": 1319711.957406, "iscrowd": 0, "segmentation": [], "text": "Constraints PERMIT or DENY certain relations\n\nRegulatory Constraints consist of:" }, { "id": 930, "strid": "9cf3a8eb-4b0f-43a5-bcad-b4f379b0ae9e", "image_id": 39, "image_name": "116674.png", "category_id": 4, "category_name": "List", "bbox": [ 354.369, 3945.273, 1179.382, 349.9970000000003 ], "priority": 14, "parents": [ 928 ], "children": [], "area": 1398082.4477370002, "iscrowd": 0, "segmentation": [] }, { "id": 931, "strid": "ff1d4bde-591b-4e68-b1e4-4640811032ea", "image_id": 39, "image_name": "116674.png", "category_id": 5, "category_name": "Section", "bbox": [ 1621.704, 3588.073, 359.548, 38.103000000000065 ], "priority": 15, "parents": [ 916 ], "children": [ 932 ], "area": 5818792.336391999, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 932, "strid": "68b19b65-22a2-46a8-8b08-52ebd23adeac", "image_id": 39, "image_name": "116674.png", "category_id": 4, "category_name": "List", "bbox": [ 1620.216, 3705.073, 1452.295, 650.9569999999999 ], "priority": 16, "parents": [ 931 ], "children": [], "area": 6003018.555767999, "iscrowd": 0, "segmentation": [] }, { "id": 933, "strid": "c43f9624-093b-450c-9fd8-84247acc7c77", "image_id": 40, "image_name": "116709.png", "category_id": 9, "category_name": "Root", "bbox": [ 42.74, 69.73, 45.029999999999994, 42.209999999999994 ], "priority": -1, "parents": [], "children": [ 936, 948, 941, 934, 935, 939, 944, 946 ], "area": 2980.2602, "iscrowd": 0, "segmentation": [] }, { "id": 934, "strid": "9213ca0f-772b-4709-970f-9ee6d66e1e2a", "image_id": 40, "image_name": "116709.png", "category_id": 1, "category_name": "Title", "bbox": [ 125.269, 24.292, 826.356, 67.057 ], "priority": 1, "parents": [ 933 ], "children": [], "area": 3043.0345480000005, "iscrowd": 0, "segmentation": [], "text": "- The clinical and ethical practice of Deep Brain Stimulation:\nResults of an international survey of DBS experts and centers" }, { "id": 935, "strid": "1d0dae52-6f8c-4766-8eb3-362a74d342b7", "image_id": 40, "image_name": "116709.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 94.475, 103.031, 892.48, 38.00999999999999 ], "priority": 2, "parents": [ 933 ], "children": [], "area": 9733.853725, "iscrowd": 0, "segmentation": [], "text": "Markus Christen (University of Zurich, Switzerland & University of Notre Dame, USA; christen@ethik.uzh.ch), Merlin Bittlinger (Humboldt\nUniversitat Berlin, Germany), Christian Ineichen (University of Zurich), Sabine Muller (Charité-Universitatsmedizin Berlin, Germany)" }, { "id": 936, "strid": "a30dff03-6412-4313-97e7-753134d19db7", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 90.459, 180.328, 148.12, 17.455000000000013 ], "priority": 3, "parents": [ 933 ], "children": [ 937, 938 ], "area": 16312.290552, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 937, "strid": "80c00c5a-38ae-405c-9360-522fbbb0293b", "image_id": 40, "image_name": "116709.png", "category_id": 3, "category_name": "Text", "bbox": [ 53.359, 201.578, 220.77199999999996, 104.58599999999998 ], "priority": 4, "parents": [ 936 ], "children": [], "area": 10756.000502, "iscrowd": 0, "segmentation": [], "text": "Deep brain stimulation (D85} has become d standard\ntherapy for some forms of movement csorders ands\ninvestigated for other neurlogieal and psychiatric\ndisorders although many scent clinical and ethical\nissuesare stil open. Inorder to obtain an overview of\nthe global practice on DBS we have performed 2\nsurvey among researchers, dlnicians and DBS centers\nthat addresses clnial and ethical problems curently\nGacsssed a rOtIBS nenatore leceodinne" }, { "id": 938, "strid": "9916d9b0-f699-47e9-a5d2-330c1a074377", "image_id": 40, "image_name": "116709.png", "category_id": 4, "category_name": "List", "bbox": [ 57.328, 307.368, 216.064, 103.38799999999998 ], "priority": 5, "parents": [ 936 ], "children": [], "area": 17620.792704, "iscrowd": 0, "segmentation": [] }, { "id": 939, "strid": "d03a5734-1493-4015-b011-d2b8bbe3090f", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 117.11, 449.788, 95.06599999999999, 17.411999999999978 ], "priority": 6, "parents": [ 933 ], "children": [ 940 ], "area": 52674.67268, "iscrowd": 0, "segmentation": [], "text": "Methodology" }, { "id": 940, "strid": "ea027b56-d6c0-45c1-a9a8-5b9e244b1fb7", "image_id": 40, "image_name": "116709.png", "category_id": 3, "category_name": "Text", "bbox": [ 53.281, 474.973, 221.401, 326.186 ], "priority": 7, "parents": [ 939 ], "children": [], "area": 25307.036413, "iscrowd": 0, "segmentation": [], "text": "Researchers: The survey among DBS researchers and\ndlls was perforsed in two waves Between mid\n2011 and mid-2072 each of them induding two\nfllow-upsn thefist wave,esearchets identified ina\nlarge search pertormed by ust} were addressed who\npublished about DBS in Parkinson's esease since the\nearly 19905 The second wave addressed lniclans\nemerging fom a global search of DS centers tot\n712 persons were approached The survey question\npair was developed based on our previous seach\ninDBS [1-3] and has been rss-checked by abostdof\ninternational renowned DBS researchers The survey\nwas anonymized\n\nCenters‘The survey questionnaire or DBS centershas\nbeen pre-tstedn Delphi stud inciding al Swiss\ncentes (4. Using bblomety, ve have denied 12\ncounties that anked highest in lobal DBS research\ncompared tothe total research output in neurology\nand neuroscience Austla,Canada France, Germany,\nitaly Japan, Netherlands, Spain, Sweden, Sutzeland,\nUk.and USA For these counties we have performed\nanextended,nterne-bared serch to find cls tat\noffer DBS according to their webst;510 institutions\nhave been identied To thove centers ashort2-page\nquestionnaire hasbeen sent by postal malland two\nfllow-ups were performed (the second folow-upis\nSapling). The resus of this survey ere preliminary" }, { "id": 941, "strid": "0f3c1cff-f899-4ca3-815b-ad0033426a0b", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 351.495, 189.316, 404.044, 21.02799999999999 ], "priority": 8, "parents": [ 933 ], "children": [ 942, 943 ], "area": 66543.62742, "iscrowd": 0, "segmentation": [], "text": "The “ethical landscape” of DBS & related survey results" }, { "id": 942, "strid": "cc9ddc82-8c6f-4f21-ad66-dcb4043c8b9e", "image_id": 40, "image_name": "116709.png", "category_id": 2, "category_name": "Figure", "bbox": [ 321.67, 224.727, 468.392, 517.291 ], "priority": 9, "parents": [ 941 ], "children": [], "area": 72287.93409000001, "iscrowd": 0, "segmentation": [] }, { "id": 943, "strid": "59950d34-fabd-4245-9aef-2d72d02f0014", "image_id": 40, "image_name": "116709.png", "category_id": 4, "category_name": "List", "bbox": [ 331.592, 751.072, 438.40700000000004, 41.56299999999999 ], "priority": 10, "parents": [ 941 ], "children": [], "area": 249049.466624, "iscrowd": 0, "segmentation": [] }, { "id": 944, "strid": "9ec38704-a7f2-4646-bdda-058a47942c07", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 900.052, 183.857, 87.57100000000003, 13.742999999999995 ], "priority": 11, "parents": [ 933 ], "children": [ 945 ], "area": 165480.860564, "iscrowd": 0, "segmentation": [], "text": "Main Results" }, { "id": 945, "strid": "59787bbb-7e6a-4c4a-ae45-29e22c908c3e", "image_id": 40, "image_name": "116709.png", "category_id": 4, "category_name": "List", "bbox": [ 834.456, 202.728, 217.04200000000003, 338.964 ], "priority": 12, "parents": [ 944 ], "children": [], "area": 169167.595968, "iscrowd": 0, "segmentation": [] }, { "id": 946, "strid": "8fa57167-e9ef-4648-9ad8-f373d6bd1f51", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 902.019, 572.294, 83.53700000000003, 13.440000000000055 ], "priority": 13, "parents": [ 933 ], "children": [ 947 ], "area": 516220.06158599997, "iscrowd": 0, "segmentation": [], "text": "Conclusions" }, { "id": 947, "strid": "fc618012-378b-44fc-b346-a71f47689ac5", "image_id": 40, "image_name": "116709.png", "category_id": 3, "category_name": "Text", "bbox": [ 832.173, 588.709, 218.49800000000005, 81.23000000000002 ], "priority": 14, "parents": [ 946 ], "children": [], "area": 489907.73465699994, "iscrowd": 0, "segmentation": [], "text": "Our Survey expresses evaluations of experienced DBS\nexperts tht af optimistic with respect tothe curent\nuseand potential ofS. A mismatch of patent fears\nand isk az well asthe satisfaction gap cequite closer\ninvestigation. The proces of patient information and\nselection should be performed by mor interdscipin\nary teams which alse unclusie paychiateste." }, { "id": 948, "strid": "f948d01e-c4e9-4954-9160-a36d5bb42497", "image_id": 40, "image_name": "116709.png", "category_id": 5, "category_name": "Section", "bbox": [ 843.716, 699.61, 199.36, 16.865999999999985 ], "priority": 15, "parents": [ 933 ], "children": [ 949 ], "area": 590272.15076, "iscrowd": 0, "segmentation": [], "text": "Ongoing Research & Outlook" }, { "id": 949, "strid": "d19eae8e-6a75-40a1-bff4-d06165d4b000", "image_id": 40, "image_name": "116709.png", "category_id": 3, "category_name": "Text", "bbox": [ 831.704, 718.817, 220.164, 81.22900000000004 ], "priority": 16, "parents": [ 948 ], "children": [], "area": 597842.9741679999, "iscrowd": 0, "segmentation": [], "text": "We are currently finalizing Our center survey and we\nwillcommpement this esearch by biblometi studies\nFuture esearch Includes the ivectigation whether\nindications fora conservative assignment practice,\nwhich may disfavor stable patients are confined,\nOther sues are patient delsion making process in\nassignment, and psychosocial effects of DBS." }, { "id": 950, "strid": "e3689b61-0cbc-4999-8737-4467043e41c8", "image_id": 41, "image_name": "116768.png", "category_id": 9, "category_name": "Root", "bbox": [ 1603.11, 309.11, 257.3100000000002, 85.76999999999998 ], "priority": -1, "parents": [], "children": [ 952, 951, 958, 987, 969, 953 ], "area": 495537.3321, "iscrowd": 0, "segmentation": [] }, { "id": 951, "strid": "d942620d-a974-4419-9d60-856ccc5a7d68", "image_id": 41, "image_name": "116768.png", "category_id": 1, "category_name": "Title", "bbox": [ 75.062, 66.084, 1792.682, 186.832 ], "priority": 1, "parents": [ 950 ], "children": [], "area": 4960.397208, "iscrowd": 0, "segmentation": [], "text": "A Shape-based Approach to Biomodels: an _.\nExample for the Bone Remodelling Workbenc" }, { "id": 952, "strid": "3cc14063-71b6-40c0-a244-625542fbd2ac", "image_id": 41, "image_name": "116768.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 78.393, 292.994, 1124.588, 97.50799999999998 ], "priority": 2, "parents": [ 950 ], "children": [], "area": 22968.678642000003, "iscrowd": 0, "segmentation": [], "text": "Nicola Paoletti | ela Merelli | Luca Tesei - (Om\nSchool of Scie d Technology — CS division — University of Camerino" }, { "id": 953, "strid": "c585aeb6-07aa-4785-bac7-459fabcbc976", "image_id": 41, "image_name": "116768.png", "category_id": 5, "category_name": "Section", "bbox": [ 67.303, 451.494, 734.951, 58.661 ], "priority": 3, "parents": [ 950 ], "children": [ 956, 954, 955 ], "area": 30386.900682, "iscrowd": 0, "segmentation": [], "text": "Background and Motivation" }, { "id": 954, "strid": "862e4e75-188f-4eea-9d9b-4ef390421dc3", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 66.278, 545.509, 2222.627, 169.83400000000006 ], "priority": 4, "parents": [ 953 ], "children": [], "area": 36155.245502000005, "iscrowd": 0, "segmentation": [], "text": "Recently, computational methods in biology and biomedicine started to consider spatial aspects of biological entities such as the position, an interaction radius or a physical shape.\nIndeed, physical and spatial aspects of biological entities cannot be neglected. However, such systems can exhibit features hard to capture with classical quantitative\nobservables [4]. Interactions and collective functions can be driven not only by quantitative features (e.g., space and geometry), but also by higher-level, more abstract,\n\nqualitative relations, not directly expressible by the “natural” space-driven interactions." }, { "id": 955, "strid": "37692b40-7d7e-4f50-b02a-f529443cf120", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 66.092, 730.753, 1737.506, 311.13199999999995 ], "priority": 5, "parents": [ 953 ], "children": [], "area": 48296.927276, "iscrowd": 0, "segmentation": [], "text": "Therefore, a generalization is possible of the ways by which interactions among entities can be modelled, a concept that unifies the\ntreatment of quantitative and qualitative interactions. We define a formal language where processes are embedded in a\ngeneralized shape that, by means of a more general non-metrical notion of neighbourhood, regulates their communications and\ninteractions, so lifting the geometrical space to a more abstract level. Being so general, this concept of shape proves to be able to express\nclassical process algebras, as well as quantitative extensions of them. Further, we compare the expressiveness and the capabilities of the\nnew shape-based approach w.r.t. more common techniques in computational biology, by using as a workbench the process of bone\nremodelling (BR), a case study of high clinical and biological relevance." }, { "id": 956, "strid": "e0c138a0-cee3-4ba1-8884-fcd57b2fd3a7", "image_id": 41, "image_name": "116768.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1829.906, 726.033, 455.096, 261.014 ], "priority": 6, "parents": [ 953 ], "children": [ 957 ], "area": 1328572.142898, "iscrowd": 0, "segmentation": [] }, { "id": 957, "strid": "e472fa7f-a192-4875-b120-de3ab3644793", "image_id": 41, "image_name": "116768.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1839.687, 996.794, 435.654, 55.91700000000003 ], "priority": 7, "parents": [ 956 ], "children": [], "area": 1833788.963478, "iscrowd": 0, "segmentation": [], "text": "Figure |. Expressiveness of the shape-\nbased process algebra w.r-t. classical ones." }, { "id": 958, "strid": "a96114ed-085e-410f-8df3-0cdd8667dad6", "image_id": 41, "image_name": "116768.png", "category_id": 5, "category_name": "Section", "bbox": [ 65.807, 1103.39, 613.274, 62.36999999999989 ], "priority": 8, "parents": [ 950 ], "children": [ 960, 966, 959, 963, 961, 968, 965, 962, 964, 967 ], "area": 72610.78573, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 959, "strid": "4f369962-1d34-44c3-8df1-951ae400cbbf", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 99.125, 1228.784, 182.49, 32.221000000000004 ], "priority": 9, "parents": [ 958 ], "children": [], "area": 121803.214, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 960, "strid": "fd3c162f-5c85-4855-8271-ebcceb7bca15", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 98.189, 1293.911, 554.932, 33.499000000000024 ], "priority": 10, "parents": [ 958 ], "children": [], "area": 127047.827179, "iscrowd": 0, "segmentation": [], "text": "A shape-based system is a tuple (S, B), where" }, { "id": 961, "strid": "5f5f4bff-35b8-4419-89f6-eb7b8fd8938d", "image_id": 41, "image_name": "116768.png", "category_id": 4, "category_name": "List", "bbox": [ 99.717, 1340.595, 996.1740000000001, 34.75500000000011 ], "priority": 11, "parents": [ 958 ], "children": [], "area": 133680.111615, "iscrowd": 0, "segmentation": [] }, { "id": 962, "strid": "d64ebebf-bae2-45d6-a79e-89577cc5d44b", "image_id": 41, "image_name": "116768.png", "category_id": 2, "category_name": "Figure", "bbox": [ 255.622, 1387.159, 693.29, 126.36799999999994 ], "priority": 12, "parents": [ 958 ], "children": [], "area": 354588.35789800005, "iscrowd": 0, "segmentation": [] }, { "id": 963, "strid": "5257ecdd-f4eb-4f23-a13d-300d0b6784c1", "image_id": 41, "image_name": "116768.png", "category_id": 4, "category_name": "List", "bbox": [ 99.138, 1533.525, 924.779, 67.78899999999999 ], "priority": 13, "parents": [ 958 ], "children": [], "area": 152030.60145000002, "iscrowd": 0, "segmentation": [] }, { "id": 964, "strid": "3a584e87-6127-4dd2-a8da-9c342800c4f6", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 98.074, 1700.892, 624.812, 41.62799999999993 ], "priority": 14, "parents": [ 958 ], "children": [], "area": 166813.282008, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 965, "strid": "52b8f957-9d99-4748-9ec0-4d16f34ef112", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 98.017, 1770.433, 1010.3679999999999, 180.9949999999999 ], "priority": 15, "parents": [ 958 ], "children": [], "area": 173532.531361, "iscrowd": 0, "segmentation": [], "text": "Bone remodelling is activated by biomechanical signals, expressed by osteocytes\nthat are located inside the bone matrix and are connected by means of a\ncanaliculi network.When a micro-fracture breaks the network, osteocytes detect\nthe disruption and activate the remodelling event by secreting factors among\nwhich the RANKL protein." }, { "id": 966, "strid": "9d49cb45-24c4-4daa-8ac5-ee2b7f19b26f", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 106.738, 2004.816, 995.488, 143.4269999999999 ], "priority": 16, "parents": [ 958 ], "children": [], "area": 213990.050208, "iscrowd": 0, "segmentation": [], "text": "Actions: AS Mx{open, closed, RANKL}, s.t.an action a=(p, |) contains a position\np in a metric space M and a label | describing the biological function of the\nprocess: open if the canals with other osteocytes are open, closed in case of\nmicro-fracture, or RANKL if the osteocyte is producing RANKL." }, { "id": 967, "strid": "bfa88eb0-dbe8-49f2-a1c1-bfe73698fbb4", "image_id": 41, "image_name": "116768.png", "category_id": 3, "category_name": "Text", "bbox": [ 107.413, 2173.741, 990.5629999999999, 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Mawexbeyenchovin Ba 12-820." }, { "id": 1043, "strid": "03f5e535-c122-4dcd-853a-a3907a5cfb3c", "image_id": 43, "image_name": "116806.png", "category_id": 3, "category_name": "Text", "bbox": [ 410.409, 963.916, 59.07499999999999, 48.44200000000001 ], "priority": 34, "parents": [ 1009 ], "children": [], "area": 395599.801644, "iscrowd": 0, "segmentation": [], "text": "Pash" }, { "id": 1044, "strid": "a0f0b121-0240-41c0-87a2-4d2856806d25", "image_id": 44, "image_name": "116832.png", "category_id": 9, "category_name": "Root", "bbox": [ 10.6, 59.5, 87.12, 93.06 ], "priority": -1, "parents": [], "children": [ 1050, 1046, 1048, 1047, 1049, 1051, 1052, 1045 ], "area": 630.6999999999999, "iscrowd": 0, "segmentation": [] }, { "id": 1045, "strid": "634f1862-d083-488c-85f5-83e844dbdcd2", "image_id": 44, "image_name": "116832.png", "category_id": 1, "category_name": "Title", "bbox": [ 123.887, 83.26, 1176.901, 49.84000000000002 ], "priority": 1, "parents": [ 1044 ], "children": [], "area": 10314.83162, "iscrowd": 0, "segmentation": [], "text": "Coagulation Monitoring - not always Gold and Shining" }, { "id": 1046, "strid": "b8c3fcd1-bd79-466a-9839-e169adb3be69", "image_id": 44, "image_name": "116832.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 324.218, 158.02, 717.104, 43.496999999999986 ], "priority": 2, "parents": [ 1044 ], "children": [], "area": 51232.928360000005, "iscrowd": 0, "segmentation": [], "text": "Rolf Huet, Vlado Cernak, Christopher Gallandat\npt of Anesthesia, University Medical Center Groningen, Groningen, The Netherlan|" }, { "id": 1047, "strid": "1a95a2c0-d8c7-4a3e-9ae5-2a23b539be7a", "image_id": 44, "image_name": "116832.png", "category_id": 3, "category_name": "Text", "bbox": [ 110.368, 270.243, 1196.335, 78.935 ], "priority": 3, "parents": [ 1044 ], "children": [], "area": 29826.179423999998, "iscrowd": 0, "segmentation": [], "text": "Introduction. Thromboelastometry and Multiplate platelet function monitoring are both used for coagulation monitoring in cardiac surgery. The complementary value of the two\n\nmonitoring systems is not established. In the RoTEM full whole blood coagulation (ExTEM) as well as the plasmatic component (FibTEM, where Cytochalasin D inhibits platelet\n\nfunction) is measured. Subtraction of both measurements (ExTEM-FibTEM, panel A&B) should reflect the contribution of platelets to coagulation and clot strength. For this\nbservational study we assessed the contribution of platelets to maximum clot strength in relation to fibrinogen and the platelet aggregatory responses with the Multiplate® ." }, { "id": 1048, "strid": "bf715775-4ddf-45f5-8706-e0a9c1f09508", "image_id": 44, "image_name": "116832.png", "category_id": 3, "category_name": "Text", "bbox": [ 109.931, 369.974, 1188.334, 96.93900000000002 ], "priority": 4, "parents": [ 1044 ], "children": [], "area": 40671.611794, "iscrowd": 0, "segmentation": [], "text": "Methods. Twenty six elective cardiac surgery patients were included after informed consent and institutional review board approval. Clotting samples were assessed before and\nafter cardiopulmonary bypass. In the Multiplate three activators were used: 20 jl ADP, 50 1! Ristocetin (to test platelet adhesion) and 20 il TRAP. For comparison in the RoTEM\nclot strength, defined as maximum clot elasticity (MCE), was calculated from maximal clot firmness to accomodate for Hooke’s law. MCE = (100 x MCF)/(100-MCF) dyne cm\nin ExTEM and FibTEM!2. The platelet contribution to clot strength is then given by subtraction: MCEplaes = MCEextem - MCErisren (Lang, 2009). Patient samples after\ninduction (TO) and at the end of operation (T4) were included." }, { "id": 1049, "strid": "619fc2c4-79ab-467b-b921-2b2af372733d", "image_id": 44, "image_name": "116832.png", "category_id": 2, "category_name": "Figure", "bbox": [ 110.84, 489.656, 1203.232, 266.892 ], "priority": 5, "parents": [ 1044 ], "children": [], "area": 54273.471040000004, "iscrowd": 0, "segmentation": [] }, { "id": 1050, "strid": "d4179c7b-5a70-4af6-a221-4e9400d55de8", "image_id": 44, "image_name": "116832.png", "category_id": 3, "category_name": "Text", "bbox": [ 109.527, 791.774, 1201.675, 56.15499999999997 ], "priority": 6, "parents": [ 1044 ], "children": [], "area": 86720.630898, "iscrowd": 0, "segmentation": [], "text": "Results. We found no correlation between the MCEplatelets and any of the Multiplate activators (ADP r = 0.236, fig. 1, Risto r= 0.2, and TRAP 08). There was also no relation\nwith thrombocytes count (r=0.185, fig 2). However, we did find a strong relation between the fibrinogen level and the MCEpiaes both at the start and at the end of operation (r=\n0.80, P=<0.001, fig. 3). Platelet count decreased at the end of operation (202 +47 vs 133 + 35 10°/L)." }, { "id": 1051, "strid": "47723227-9388-4494-931c-cd1cadfce9b3", "image_id": 44, "image_name": "116832.png", "category_id": 3, "category_name": "Text", "bbox": [ 109.489, 883.002, 1179.021, 78.03399999999999 ], "priority": 7, "parents": [ 1044 ], "children": [], "area": 96679.005978, "iscrowd": 0, "segmentation": [], "text": "iscussion and Conclusion. |. We found no relation between platelet contribution to clot strength, as measured by ROTEM and platelet function testing with the Multiplate. 2.\nInterestingly, fibrinogen improved the platelet contribution of clot strength in RoOTEM measurements. It seems therefore doubtful whether the MCEpiacie, can be regarded as a\nmeasure of thrombocyte function. In ordinary cardiac surgery patients, we confirm the results as described by Lang et al? in vitro and in thrombopenic patients. In addition this\nstudy suggests, that to assess platelet function next to ROTEM measurements, a complementary platelet function test, ie. the Multiplate, will be necessary." }, { "id": 1052, "strid": "02103bac-26d8-4c1e-b88a-daa585dadae6", "image_id": 44, "image_name": "116832.png", "category_id": 3, "category_name": "Text", "bbox": [ 109.081, 1025.683, 815.504, 17.096000000000004 ], "priority": 8, "parents": [ 1044 ], "children": [], "area": 111882.527323, "iscrowd": 0, "segmentation": [], "text": "Literature |. Nielsen VG, et al Acta Anesthest Scand 2005: 49; 222-232. 2. Lang T et al. Anesth Analg 2009; 108: 751-8." }, { "id": 1053, "strid": "6c4c950f-eaa5-49c7-85cb-e6442b949274", "image_id": 45, "image_name": "116836.png", "category_id": 9, "category_name": "Root", "bbox": [ 115.71, 43.76, 444.96999999999997, 282.39 ], "priority": -1, "parents": [], "children": [ 1056, 1058, 1055, 1065, 1054, 1067 ], "area": 5063.469599999999, "iscrowd": 0, "segmentation": [] }, { "id": 1054, "strid": "1b7fa12a-148c-4b97-b534-bb0683d53732", "image_id": 45, "image_name": "116836.png", "category_id": 1, "category_name": "Title", "bbox": [ 383.558, 365.13, 2542.948, 106.048 ], "priority": 1, "parents": [ 1053 ], "children": [], "area": 140048.53254, "iscrowd": 0, "segmentation": [], "text": "Implementing a scientific debate in an enzymology lecture" }, { "id": 1055, "strid": "7c168a58-73ea-4f66-ada4-df4fdf3e3261", "image_id": 45, "image_name": "116836.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 567.549, 543.43, 2150.145, 223.087 ], "priority": 2, "parents": [ 1053 ], "children": [], "area": 308423.15306999994, "iscrowd": 0, "segmentation": [], "text": "Carmen Galiant, Christophe Durand? and Julien Douady?\n\n(\n' 1Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. :\n2Université Joseph Fourier (Grenoble |), Saint Martin d'Héres, France. carmen.galianb@gmail.com" }, { "id": 1056, "strid": "f7113742-9335-4db1-89de-116019bc704b", "image_id": 45, "image_name": "116836.png", "category_id": 5, "category_name": "Section", "bbox": [ 3024.002, 883.422, 42.6840000000002, 265.08500000000004 ], "priority": 3, "parents": [ 1053 ], "children": [ 1057 ], "area": 2671469.894844, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 1057, "strid": "4dfd9dae-fbed-4b51-b694-8220100a058d", "image_id": 45, "image_name": "116836.png", "category_id": 3, "category_name": "Text", "bbox": [ 324.129, 843.25, 2647.889, 430.597 ], "priority": 4, "parents": [ 1056 ], "children": [], "area": 273321.77925, "iscrowd": 0, "segmentation": [], "text": "This communication describes the application of a teaching method called here “scientific debate”, founded on constructivism and developed since the 1970's\nmainly by mathematics professor Marc Legrand in Grenoble (France). This method confronts students with troublesome knowledge in form of a multiple-choice\nquestion. Without help from their teacher, students choose an answer, defend their position in front of their pairs and engage into a debate. The role of the teacher is of\nthree kinds in this setup: (i) identifying a problematic notion and formulating an effective question, (ii) moderating the debate, (iii) settling the controversy by taking up\nall formulated ideas and “institutionalizing” the knowledge.\n\nTo address the notions of initial and maximum velocity of enzymatic reactions, | implemented a scientific debate in a Biochemistry undergraduate class at\nGrenoble University | (France). The preparation and evaluation of this debate session was the focus of a pre/in-service pedagogics training that involved 5 other\nyoung lecturers (PhD students) and 2 supervisors (senior lecturers) from the same University. This working group proved to be very useful to introduce us, new\nteachers, into the scientific debate method, motivate us to implement it and, importantly, perform a balanced assessment with help of video recording." }, { "id": 1058, "strid": "c936013e-eef4-4a4a-a4ac-0514343367a0", "image_id": 45, "image_name": "116836.png", "category_id": 5, "category_name": "Section", "bbox": [ 3015.015, 1668.347, 52.76200000000017, 183.14200000000005 ], "priority": 5, "parents": [ 1053 ], "children": [ 1060, 1063, 1062, 1061, 1064, 1059 ], "area": 5030091.230204999, "iscrowd": 0, "segmentation": [], "text": "Training" }, { "id": 1059, "strid": "9a4557d4-c20e-4c86-926f-00a268151b5f", "image_id": 45, "image_name": "116836.png", "category_id": 2, "category_name": "Figure", "bbox": [ 280.714, 1376.645, 1033.744, 541.0039999999999 ], "priority": 6, "parents": [ 1058 ], "children": [], "area": 386443.52453, "iscrowd": 0, "segmentation": [] }, { "id": 1060, "strid": "294e4fd2-be19-48e8-9ff2-c677e7c999d4", "image_id": 45, "image_name": "116836.png", "category_id": 3, "category_name": "Text", "bbox": [ 380.659, 1938.853, 828.5270000000002, 151.8710000000001 ], "priority": 7, "parents": [ 1058 ], "children": [], "area": 738041.844127, "iscrowd": 0, "segmentation": [], "text": "As graduate students, we were trained in the\nmethod of “scientific debate” and many of us\nwere tempted to adopt it in our lectures..." }, { "id": 1061, "strid": "3cc538d8-4eca-4fbe-a5f6-6fc95fa95bbd", "image_id": 45, "image_name": "116836.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1322.177, 1326.167, 728.233, 690.056 ], "priority": 8, "parents": [ 1058 ], "children": [], "area": 1753427.5055589997, "iscrowd": 0, "segmentation": [] }, { "id": 1062, "strid": "ae31f126-b5a0-4504-b44e-02e21ade8e2e", "image_id": 45, "image_name": "116836.png", "category_id": 3, "category_name": "Text", "bbox": [ 1376.034, 2019.264, 645.1019999999999, 94.85299999999984 ], "priority": 9, "parents": [ 1058 ], "children": [], "area": 2778575.918976, "iscrowd": 0, "segmentation": [], "text": "Alone, it appeared challenging and\nrisky, with low chances of success" }, { "id": 1063, "strid": "cebbef64-a505-4301-8081-60e91051ce79", "image_id": 45, "image_name": "116836.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2050.932, 1378.633, 982.5950000000003, 531.2059999999999 ], "priority": 10, "parents": [ 1058 ], "children": [], "area": 2827482.535956, "iscrowd": 0, "segmentation": [] }, { "id": 1064, "strid": "9594dd85-4fa1-4e64-bbcf-428051eed378", "image_id": 45, "image_name": "116836.png", "category_id": 3, "category_name": "Text", "bbox": [ 2067.998, 1939.215, 922.1880000000001, 150.8570000000002 ], "priority": 11, "parents": [ 1058 ], "children": [], "area": 4010292.74157, "iscrowd": 0, "segmentation": [], "text": "5 graduate students and 2 senior teachers started\na working group to plan and analyze a debate\nsession carried out by each of the 5 students" }, { "id": 1065, "strid": "1eabab5a-7c13-4b9e-9ade-24b22ea972f7", "image_id": 45, "image_name": "116836.png", "category_id": 5, "category_name": "Section", "bbox": [ 3023.914, 2978.699, 40.98900000000003, 164.48100000000022 ], "priority": 12, "parents": [ 1053 ], "children": [ 1066 ], "area": 9007329.607886001, "iscrowd": 0, "segmentation": [], "text": "Debate" }, { "id": 1066, "strid": "e03c7a15-cc21-4da2-8d34-e3e518c09d05", "image_id": 45, "image_name": "116836.png", "category_id": 2, "category_name": "Figure", "bbox": [ 280.385, 2148.88, 2734.407, 1517.842 ], "priority": 13, "parents": [ 1065 ], "children": [], "area": 602513.7188, "iscrowd": 0, "segmentation": [] }, { "id": 1067, "strid": "995ec3ec-ee7a-466f-ae2c-9d2fdeb5929c", "image_id": 45, "image_name": "116836.png", "category_id": 5, "category_name": "Section", "bbox": [ 3024.464, 4073.75, 40.76299999999992, 203.8130000000001 ], "priority": 14, "parents": [ 1053 ], "children": [ 1068, 1069, 1070 ], "area": 12320910.22, "iscrowd": 0, "segmentation": [], "text": "Ouicome" }, { "id": 1068, "strid": "49bf10dd-41ed-455b-864d-2c7991bed508", "image_id": 45, "image_name": "116836.png", "category_id": 4, "category_name": "List", "bbox": [ 303.605, 3719.715, 880.145, 633.018 ], "priority": 15, "parents": [ 1067 ], "children": [], "area": 1129324.072575, "iscrowd": 0, "segmentation": [] }, { "id": 1069, "strid": "7bd8e8e8-cb27-4047-8fd4-5d241718a330", "image_id": 45, "image_name": "116836.png", "category_id": 4, "category_name": "List", "bbox": [ 1255.821, 3721.977, 984.0160000000001, 622.2629999999999 ], "priority": 16, "parents": [ 1067 ], "children": [], "area": 4674136.878117, "iscrowd": 0, "segmentation": [] }, { "id": 1070, "strid": "cf12a84c-393d-4328-bcb8-44a6998164e1", "image_id": 45, "image_name": "116836.png", "category_id": 4, "category_name": "List", "bbox": [ 2287.469, 3722.031, 676.1700000000001, 620.0649999999996 ], "priority": 17, "parents": [ 1067 ], "children": [], "area": 8514030.529539, "iscrowd": 0, "segmentation": [] }, { "id": 1071, "strid": "1de1de49-ea69-4d2d-a860-37b6fb07a815", "image_id": 46, "image_name": "116860.png", "category_id": 9, "category_name": "Root", "bbox": [ 34.95, 28.49, 55.44, 41.57000000000001 ], "priority": -1, "parents": [], "children": [ 1076, 1072, 1073, 1080, 1074, 1090 ], "area": 995.7255, "iscrowd": 0, "segmentation": [] }, { "id": 1072, "strid": "a62ac566-f4fe-4ee3-8b2c-39f559693b00", "image_id": 46, "image_name": "116860.png", "category_id": 1, "category_name": "Title", "bbox": [ 116.066, 51.416, 630.016, 29.799000000000007 ], "priority": 1, "parents": [ 1071 ], "children": [], "area": 5967.649456, "iscrowd": 0, "segmentation": [], "text": "De ziekte van van Buchem, presentatie op de kinderleeftijd" }, { "id": 1073, "strid": "c1babbc9-1416-4226-8d70-aedfe6db9d30", "image_id": 46, "image_name": "116860.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 70.23, 92.763, 710.169, 61.638000000000005 ], "priority": 2, "parents": [ 1071 ], "children": [], "area": 6514.745490000001, "iscrowd": 0, "segmentation": [], "text": "ME. van Egmond', F.G. Dikkers?, A.M. Boot Brouwer\" om\n'Atdeling Neurologie, 7Afdeling oa Afdeling Kindergeneeskunde?, Universitair Medisch Centrum Groningen\n») Groningen i" }, { "id": 1074, "strid": "a58cab91-e2b1-489e-b977-fe4e3adede91", "image_id": 46, "image_name": "116860.png", "category_id": 5, "category_name": "Section", "bbox": [ 57.439, 212.262, 93.62200000000001, 18.144000000000005 ], "priority": 3, "parents": [ 1071 ], "children": [ 1075 ], "area": 12192.117018, "iscrowd": 0, "segmentation": [], "text": "Introductie" }, { "id": 1075, "strid": "35a41155-b4ec-4347-8e00-3ffdbc43ce6e", "image_id": 46, "image_name": "116860.png", "category_id": 3, "category_name": "Text", "bbox": [ 56.876, 259.389, 225.87699999999998, 195.151 ], "priority": 4, "parents": [ 1074 ], "children": [], "area": 14753.008764, "iscrowd": 0, "segmentation": [], "text": "Uitval van de ny facialis bij kinderen\nheeft een uitgebreide differentiaal\ndiagnose. Wij beschrijven rie\nkinder de zich presenteerden voor\nhet\\4* levensjaar_met een perifere\nzichtsverlamming, aanvankeli\néenzijdig, later bilateraal. Zij bleken\nallen de ziekte van Van Buchem te\nhebben, een ziekte die tot nu toe\nwereldwijd bij slechts\\~ circa 25\npatignten werd beschreven." }, { "id": 1076, "strid": "a309e6d9-3346-4d03-8bde-7dd5c532a8cc", "image_id": 46, "image_name": "116860.png", "category_id": 5, "category_name": "Section", "bbox": [ 55.625, 459.462, 48.495000000000005, 17.223000000000013 ], "priority": 5, "parents": [ 1071 ], "children": [ 1077, 1078 ], "area": 25557.57375, "iscrowd": 0, "segmentation": [], "text": "Casus" }, { "id": 1077, "strid": "73339d26-18a9-4300-b1b5-d734a19a5414", "image_id": 46, "image_name": "116860.png", "category_id": 3, "category_name": "Text", "bbox": [ 54.265, 506.266, 226.832, 283.58600000000007 ], "priority": 6, "parents": [ 1076 ], "children": [], "area": 27472.52449, "iscrowd": 0, "segmentation": [], "text": ". iént 1, een 4-jarige Gna patiént\n2, 2ijn\\G-jarige zus (consanguine\nou i en patiént 3, een 4jaar oud\nje, hadden vanaf de leeftijd vz\nresp. 9 maanden, 2 jaar en sre po\n\npartum meerdere spent\n\nperifere n. facialisuitval rechts of links.\nDe duur van de eee enige\nweken tot nee trad steeds\nslechts gedeeltelk” herstel op.\nInmiddels hee 2ij alle drie een\npermanente bilaterale uitval varigrend\nvan House:Brackmann gr. IV tot gr. VI.\nVardeg@bi al dhe elders Het\n\ngehoi rvees vastgesteld (conductief\n‘at. 1 en 2 en gemengd bij pat. 3).\n\net" }, { "id": 1078, "strid": "1a8ba1ce-9f35-47c5-8e62-e4a98efe625b", "image_id": 46, "image_name": "116860.png", "category_id": 2, "category_name": "Figure", "bbox": [ 303.611, 214.102, 241.96500000000003, 101.76500000000001 ], "priority": 7, "parents": [ 1076 ], "children": [ 1079 ], "area": 65003.722322, "iscrowd": 0, "segmentation": [] }, { "id": 1079, "strid": "a6f00a55-6528-4a79-bf1b-9e8420b5e287", "image_id": 46, "image_name": "116860.png", "category_id": 6, "category_name": "Caption", "bbox": [ 305.723, 321.349, 231.96600000000007, 59.29699999999997 ], "priority": 8, "parents": [ 1078 ], "children": [], "area": 98243.780327, "iscrowd": 0, "segmentation": [], "text": "Figuur 1. Gelaatsfoto's van patiént 1 (links) en\npaint 2 recht), in rust (A, C) en tidens z0\nPaclg nog ctinipen wn ope\n(8, D).*" }, { "id": 1080, "strid": "07118dfc-1b7e-41f8-9ce5-6c1916bf9159", "image_id": 46, "image_name": "116860.png", "category_id": 5, "category_name": "Section", "bbox": [ 301.177, 400.244, 77.68, 16.31400000000002 ], "priority": 9, "parents": [ 1071 ], "children": [ 1086, 1083, 1088, 1082, 1085, 1081 ], "area": 120544.28718800002, "iscrowd": 0, "segmentation": [], "text": "Discussie" }, { "id": 1081, "strid": "b3cef7ce-5b80-45a7-8475-e520142d81a3", "image_id": 46, "image_name": "116860.png", "category_id": 3, "category_name": "Text", "bbox": [ 301.531, 448.488, 246.45099999999996, 159.62899999999996 ], "priority": 10, "parents": [ 1080 ], "children": [], "area": 135233.035128, "iscrowd": 0, "segmentation": [], "text": "De ziekte varr Van Buchem, ofwel\nhyperostosis corticalis generalisata, is een\nautosomaal recessief overervende bot-\nsandoening, Verminderde functie van hi\nGP contin lat to ongereride\n\neoblastactviteit en daarmeé.» tot\nongebreidelde groei van botweefsel. De\noorzaak is een homozygote S2-kb deletie\nop chromosoom 17q. >." }, { "id": 1082, "strid": "38cc09c2-f02a-4790-bb62-4094c26d9b71", "image_id": 46, "image_name": "116860.png", "category_id": 4, "category_name": "List", "bbox": [ 300.667, 613.246, 247.12600000000003, 173.31499999999994 ], "priority": 11, "parents": [ 1080 ], "children": [], "area": 184382.83508199998, "iscrowd": 0, "segmentation": [] }, { "id": 1083, "strid": "aed1990a-3422-4c54-adb6-e4877ef8038a", "image_id": 46, "image_name": "116860.png", "category_id": 2, "category_name": "Figure", "bbox": [ 582.786, 520.546, 191.60400000000004, 145.88699999999994 ], "priority": 12, "parents": [ 1080 ], "children": [ 1084 ], "area": 303366.921156, "iscrowd": 0, "segmentation": [] }, { "id": 1084, "strid": "2bca453c-ac26-4554-8459-24bc85840ff2", "image_id": 46, "image_name": "116860.png", "category_id": 6, "category_name": "Caption", "bbox": [ 578.773, 676.322, 193.39199999999994, 72.72199999999998 ], "priority": 13, "parents": [ 1083 ], "children": [], "area": 391436.91290600004, "iscrowd": 0, "segmentation": [], "text": "Figuur 4 —Fenotype van een\nvolwassen patiént met de ziekte\nvan Van Buchem, Opvallend “a\nhyperostosis van de mandibul e\nbilaterale uitval van de n. facial" }, { "id": 1085, "strid": "c181dbaa-3509-4ea8-83bc-1b3316931367", "image_id": 46, "image_name": "116860.png", "category_id": 3, "category_name": "Text", "bbox": [ 579.575, 769.283, 193.976, 25.184999999999945 ], "priority": 14, "parents": [ 1080 ], "children": [], "area": 445857.19472500007, "iscrowd": 0, "segmentation": [], "text": "“Be Kates ven Appar 7 on SNS pee afeaeatt\namet toedtammi van bodghed" }, { "id": 1086, "strid": "1e598781-b55a-4f9b-b442-5decb98f63b4", "image_id": 46, "image_name": "116860.png", "category_id": 2, "category_name": "Figure", "bbox": [ 82.638, 807.02, 344.7919999999999, 206.87799999999993 ], "priority": 15, "parents": [ 1080 ], "children": [ 1087 ], "area": 66690.51876, "iscrowd": 0, "segmentation": [] }, { "id": 1087, "strid": "17af5119-0329-4e64-a8ed-30f441c2ee39", "image_id": 46, "image_name": "116860.png", "category_id": 6, "category_name": "Caption", "bbox": [ 85.134, 1016.371, 340.975, 59.372999999999934 ], "priority": 16, "parents": [ 1086 ], "children": [], "area": 86527.728714, "iscrowd": 0, "segmentation": [], "text": "Figuur 2. Beeldvorming van de schedel. CT-cerebrum, transversale\ncies hoop nt rey, lt 9 ops\nfi Inks) met forse vetdling von de shed Ter serge\n\nson CT-serehrumvan peperonde keeRildgenoot (rechis). ee" }, { "id": 1088, "strid": "a11cda01-c951-4783-b1cf-f9130c09abc4", "image_id": 46, "image_name": "116860.png", "category_id": 2, "category_name": "Figure", "bbox": [ 460.629, 806.755, 272.304, 203.88400000000001 ], "priority": 17, "parents": [ 1080 ], "children": [ 1089 ], "area": 371614.748895, "iscrowd": 0, "segmentation": [] }, { "id": 1089, "strid": "24d91b2f-9db4-400c-9524-39364c3544bf", "image_id": 46, "image_name": "116860.png", "category_id": 6, "category_name": "Caption", "bbox": [ 460.81, 1013.126, 269.54400000000004, 59.67800000000011 ], "priority": 18, "parents": [ 1088 ], "children": [], "area": 466858.59206, "iscrowd": 0, "segmentation": [], "text": "ur 3. Qvermatige botaanmank bi dysjakte van\nan Buchu, Weepscha met dog de sched\n\nvan gezonde personen (links) en eer chedel van een\n\npatiént met de ziekte van Van Buchem (rechts)." }, { "id": 1090, "strid": "8975fbb9-ff2c-4a65-baac-224678bd703d", "image_id": 46, "image_name": "116860.png", "category_id": 5, "category_name": "Section", "bbox": [ 562.835, 213.438, 81.30799999999999, 18.10900000000001 ], "priority": 19, "parents": [ 1071 ], "children": [ 1091 ], "area": 120130.37673, "iscrowd": 0, "segmentation": [], "text": "Conclusie" }, { "id": 1091, "strid": "de9ee95c-0980-4b03-99a0-b4f979c9d558", "image_id": 46, "image_name": "116860.png", "category_id": 3, "category_name": "Text", "bbox": [ 562.214, 259.28, 229.87099999999998, 250.957 ], "priority": 20, "parents": [ 1090 ], "children": [], "area": 145770.84592, "iscrowd": 0, "segmentation": [], "text": "2-ziekte van Van Buchem is\nzeldzame _botaandoening ie\nvoornamelik in Urk voo\ninderen presenteert de\nmeestal door perifere ui\nfacialis ten gevolge van\nde meatus acustict ternus.\nEen beter begrip van de onderliggende\npathofysiologische mechanismen van\nde ziekte leidt hopelijk in de toekomst\ntot fectieve behandeling. Er zijn\naanwijzingen dat patiénten met Van\njem baat hebben bij behandeling\n1et corticosteroiden. 7" }, { "id": 1092, "strid": "a2141ec1-ccd3-4e19-b75e-34ba018a5e54", "image_id": 47, "image_name": "116867.png", "category_id": 9, "category_name": "Root", "bbox": [ 19.26, 116.5, 66.71, 63.599999999999994 ], "priority": -1, "parents": [], "children": [ 1094, 1093, 1095, 1106, 1099, 1097 ], "area": 2243.79, "iscrowd": 0, "segmentation": [] }, { "id": 1093, "strid": "143878c6-1c70-4223-a792-760001ca8cff", "image_id": 47, "image_name": "116867.png", "category_id": 1, "category_name": "Title", "bbox": [ 38.98, 34.979, 1575.937, 65.469 ], "priority": 1, "parents": [ 1092 ], "children": [], "area": 1363.4814199999998, "iscrowd": 0, "segmentation": [], "text": "TENS Effectiveness: Have We Been Barking‘Up The Wrong RCT?" }, { "id": 1094, "strid": "8e68d1f6-cc45-4033-83d5-6e2f8c9c28d6", "image_id": 47, "image_name": "116867.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 178.705, 113.101, 1297.791, 28.147999999999996 ], "priority": 2, "parents": [ 1092 ], "children": [], "area": 20211.714205, "iscrowd": 0, "segmentation": [], "text": "Peter Gladwell, Specialist Physiotherapist Julie Bridson, Clinical Auditor North Bristol NHS Trust, Frenchay Hospital, Bristol, UK:" }, { "id": 1095, "strid": "33796a5d-b4f2-4760-92d5-7b8646bce072", "image_id": 47, "image_name": "116867.png", "category_id": 5, "category_name": "Section", "bbox": [ 38.912, 196.028, 203.521, 23.158999999999992 ], "priority": 3, "parents": [ 1092 ], "children": [ 1096 ], "area": 7627.841536, "iscrowd": 0, "segmentation": [], "text": "Aim ofiifvestigation:" }, { "id": 1096, "strid": "1d55fbd9-ddaf-42ce-b18e-6dc36aef9567", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 39.533, 221.811, 279.892, 51.647999999999996 ], "priority": 4, "parents": [ 1095 ], "children": [], "area": 8768.854263000001, "iscrowd": 0, "segmentation": [], "text": "To identify the types of benefit reported by long-term TENS\nSe ee ee coe\nTete a een\nin" }, { "id": 1097, "strid": "9ee719b2-8f22-487e-abd1-135f653f8653", "image_id": 47, "image_name": "116867.png", "category_id": 5, "category_name": "Section", "bbox": [ 40.124, 301.261, 121.97300000000001, 22.870000000000005 ], "priority": 5, "parents": [ 1092 ], "children": [ 1098 ], "area": 12087.796364000002, "iscrowd": 0, "segmentation": [], "text": "Background:" }, { "id": 1098, "strid": "7f8f56ca-cc66-4145-9e8c-288665291ada", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 39.642, 327.548, 287.562, 172.96000000000004 ], "priority": 6, "parents": [ 1097 ], "children": [], "area": 12984.657816, "iscrowd": 0, "segmentation": [], "text": "Laity el tncinahl ala cthhabiaclm tly aenalna chal\nees\nSe eed\nPeano\neo ee er\neee ee eee ee)\neee te ee\neee ee eters\nSe eee\ncontrast to the reports of benefit from significant Proportion\nof people with Chronic Pain who try TENS. This audi set out\neee een eee ee eri\nnachécaliatas base" }, { "id": 1099, "strid": "81378a3d-9c0d-49db-8d11-c58e5a48502d", "image_id": 47, "image_name": "116867.png", "category_id": 5, "category_name": "Section", "bbox": [ 40.551, 526.707, 73.546, 18.201000000000022 ], "priority": 7, "parents": [ 1092 ], "children": [ 1104, 1103, 1101, 1100, 1102, 1105 ], "area": 21358.495557000002, "iscrowd": 0, "segmentation": [], "text": "Method" }, { "id": 1100, "strid": "5fe1bed0-6612-4678-968a-159b2c33baa9", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 38.683, 552.933, 286.433, 253.279 ], "priority": 8, "parents": [ 1099 ], "children": [], "area": 21389.107239, "iscrowd": 0, "segmentation": [], "text": "sb immadpiiarsibebeanletibpet”.. “sthgrecbiaelasneniah Socata aasll\nappointment system withinyajwell-establshed TENS clinic was\npee eee TC eer!\nee ee eee\nee ee ees cee\nwere mare gipensive. The new system offered patients the\nce er eee te\nAppointment) The questionnaire found that this new system\nees\n\neee ee eed\nSee eee eee\nmeee eet kee ane aN\nmachine\n\neee eee ed\n\nSree\n\n“Because of my TENS machine | can." }, { "id": 1101, "strid": "d98bceaa-cf21-4e1e-8bc7-59a7de0c5975", "image_id": 47, "image_name": "116867.png", "category_id": 2, "category_name": "Figure", "bbox": [ 360.924, 196.832, 261.95399999999995, 198.62400000000002 ], "priority": 9, "parents": [ 1099 ], "children": [], "area": 71041.39276799999, "iscrowd": 0, "segmentation": [] }, { "id": 1102, "strid": "5d5df248-7595-493c-9046-2a9ccfb50d40", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 360.327, 405.248, 272.46299999999997, 54.31400000000002 ], "priority": 10, "parents": [ 1099 ], "children": [], "area": 146021.796096, "iscrowd": 0, "segmentation": [], "text": "Lich in: Meaghan: pipleenaahaner bane thi dengan nh:\nthan three years. Ths suggests that the sample were highly\nexperienced in using TENS, and had persisted in using TENS\n‘So aa ar py" }, { "id": 1103, "strid": "bf9585bc-f8ea-4a5b-a03e-fb3119483579", "image_id": 47, "image_name": "116867.png", "category_id": 2, "category_name": "Figure", "bbox": [ 360.511, 493.925, 284.47999999999996, 285.46199999999993 ], "priority": 11, "parents": [ 1099 ], "children": [], "area": 178065.395675, "iscrowd": 0, "segmentation": [] }, { "id": 1104, "strid": "e660e8d5-01bc-4988-816c-36d6615a608a", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 360.528, 812.811, 288.717, 39.313999999999965 ], "priority": 12, "parents": [ 1099 ], "children": [], "area": 293041.124208, "iscrowd": 0, "segmentation": [], "text": "Lede. daalnatdarl ealeeaeaaealeneshed salad nag\neee ores\nPan oni tare" }, { "id": 1105, "strid": "ccbe4fce-c073-4c32-a853-db35790ea0da", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": 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ee\neee ere\nPlease complete the sentence below\n\nee ee" }, { "id": 1108, "strid": "eb7d4f20-ceb6-4e92-8970-2b337c589a33", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 681.712, 347.581, 288.769, 502.025 ], "priority": 16, "parents": [ 1106 ], "children": [], "area": 236950.138672, "iscrowd": 0, "segmentation": [] }, { "id": 1109, "strid": "a0de2a22-998d-4856-8929-118bb8d4177c", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 681.877, 876.827, 274.38, 100.702 ], "priority": 17, "parents": [ 1106 ], "children": [], "area": 597888.1642789999, "iscrowd": 0, "segmentation": [], "text": "oe red\n“anes yanmar eerie\nseen ete es)\n\nca rey\n\neae ee" }, { "id": 1110, "strid": "1d5266c4-8309-4f4f-90ef-2b956a201740", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 681.331, 990.543, 277.519, 109.01799999999992 ], "priority": 18, "parents": [ 1106 ], "children": [], "area": 674887.652733, "iscrowd": 0, "segmentation": [] }, { "id": 1111, "strid": "4000584d-e07c-4b76-89b3-152d5934f526", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1003.128, 197.706, 283.55499999999995, 393.438 ], "priority": 19, "parents": [ 1106 ], "children": [], "area": 198324.424368, "iscrowd": 0, "segmentation": [] }, { "id": 1112, "strid": "29f1f520-36a2-4716-bd0c-f868e92a11db", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 1003.629, 604.009, 279.62800000000004, 78.34799999999996 ], "priority": 20, "parents": [ 1106 ], "children": [], "area": 606200.948661, "iscrowd": 0, "segmentation": [], "text": "ecraceiik eahabendlite indecent lae lmao hi shi na}\nhave been removed.\n\nSe ee eee eee\nrurvey, which should inform the choice of outcome measures\nsrelie ipier=lt tesserae raha" }, { "id": 1113, "strid": "d18e612d-f783-4146-a2f4-65a2efadf618", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1003.08, 697.139, 260.7869999999999, 85.89999999999998 ], "priority": 21, "parents": [ 1106 ], "children": [], "area": 699286.1881200001, "iscrowd": 0, "segmentation": [] }, { "id": 1114, "strid": "c80a9f5f-51fe-4b38-a4b2-5165825c5e75", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1002.86, 797.191, 210.57299999999998, 127.02599999999995 ], "priority": 22, "parents": [ 1106 ], "children": [], "area": 799470.96626, "iscrowd": 0, "segmentation": [] }, { "id": 1115, "strid": "253b4cc8-76b1-4f10-8db2-075e6fbc4c5f", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 1003.981, 937.557, 251.61799999999994, 27.60699999999997 ], "priority": 23, "parents": [ 1106 ], "children": [], "area": 941289.414417, "iscrowd": 0, "segmentation": [], "text": "arate, “ep mono nddimagen nme behind sienna\naren" }, { "id": 1116, "strid": "114b3664-e4a4-4b20-bd2e-349bb619fae6", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 1003.515, 990.127, 272.2789999999999, 24.27800000000002 ], "priority": 24, "parents": [ 1106 ], "children": [], "area": 993607.2964049999, "iscrowd": 0, "segmentation": [], "text": "i arent retell tel ell eee\nibe, ann eee" }, { "id": 1117, "strid": "5e7c118d-629c-46e1-a645-5dc984be813c", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1002.706, 1030.272, 288.60800000000006, 67.8309999999999 ], "priority": 25, "parents": [ 1106 ], "children": [], "area": 1033059.916032, "iscrowd": 0, "segmentation": [] }, { "id": 1118, "strid": "8fa7a6f4-626f-4964-93af-db4476cd2989", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1323.596, 196.898, 287.10300000000007, 333.961 ], "priority": 26, "parents": [ 1106 ], "children": [], "area": 260613.40520799998, "iscrowd": 0, "segmentation": [] }, { "id": 1119, "strid": "b86d9a64-8b61-4139-9e7e-f69df24235de", "image_id": 47, "image_name": "116867.png", "category_id": 3, "category_name": "Text", "bbox": [ 1324.392, 556.598, 287.672, 131.85000000000002 ], "priority": 27, "parents": [ 1106 ], "children": [], "area": 737153.938416, "iscrowd": 0, "segmentation": [], "text": "Summary\n\nInformation fromitines who successfully use TENS machines\ncan guide the choice of sensitive outcome measures, and\nincrease the likelipood of a meaningful outcome from research,\neee ee eee\nbe explained by the focus in previous TENS trials upon pain\nBe nee\nSee eee ee ey\n\na pea onnncis Sent dyeerunashume he," }, { "id": 1120, "strid": "863a2871-95c9-4262-858c-e6f5345ce3a0", "image_id": 47, "image_name": "116867.png", "category_id": 4, "category_name": "List", "bbox": [ 1324.675, 715.537, 286.317, 217.26800000000003 ], "priority": 28, "parents": [ 1106 ], "children": [], "area": 947853.975475, "iscrowd": 0, "segmentation": [] }, { "id": 1121, "strid": "dbb7ea20-807e-4833-b967-0daf3cf09cac", "image_id": 48, "image_name": "116917.png", "category_id": 9, "category_name": "Root", "bbox": [ 7.49, 20.95, 37.1, 78.58 ], "priority": -1, "parents": [], "children": [ 1124, 1134, 1133, 1123, 1126, 1122, 1132 ], "area": 156.9155, "iscrowd": 0, "segmentation": [] }, { "id": 1122, "strid": "133845ed-17d7-487b-a551-de904fd2702a", "image_id": 48, "image_name": "116917.png", "category_id": 1, "category_name": "Title", "bbox": [ 49.394, 24.072, 515.54, 50.72099999999999 ], "priority": 1, "parents": [ 1121 ], "children": [], "area": 1189.012368, "iscrowd": 0, "segmentation": [], "text": "PG Ns istr Vea tthe eco Cast ee CRTC Re tC es\ninside a psychotherapeutic relation" }, { "id": 1123, "strid": "4df0f345-6c7a-434f-9a1a-41b4ed5564e2", "image_id": 48, "image_name": "116917.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 50.51, 83.769, 253.23400000000004, 77.44900000000001 ], "priority": 2, "parents": [ 1121 ], "children": [], "area": 4231.17219, "iscrowd": 0, "segmentation": [], "text": "aa ee\n\nea\nSo renee eC (Egeahe a\nSeer eee\n\nMPG URC E teer ll" }, { "id": 1124, "strid": "291b851a-3f84-4128-953c-89937b39fe1f", "image_id": 48, "image_name": "116917.png", "category_id": 5, "category_name": "Section", "bbox": [ 106.448, 191.179, 173.084, 21.144000000000005 ], "priority": 3, "parents": [ 1121 ], "children": [ 1125 ], "area": 20350.622192, "iscrowd": 0, "segmentation": [], "text": "Intrenuction" }, { "id": 1125, "strid": "6c3b98f2-3171-4e0d-b049-c0c38190e21a", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 86.522, 219.638, 211.046, 295.155 ], "priority": 4, "parents": [ 1124 ], "children": [], "area": 19003.519036, "iscrowd": 0, "segmentation": [], "text": "Accordiagtadp ancient beliel the hee-\nling propertivs of humour have very au-\ncient dete If it wos trne for the past ~\neves sil wot all scientists have been\nrumpathetic towards the study of the\n\nGipinavined the langhtarta goseral = tt\n\n \n\nhas @ greater value at prerent days,\nwhere the health often matches with «\nfooling of well-being not only referred\nte the \"bios\", but also ta the paychalog:-\ngal aad social spheres,\n\nMy work, although, ts a rollection act\nsimply on how and how mach the comic\nmental side has advantageous potenti\nIntier for the individyal's health, bat\nmore Ia particular for the humour\nthet nadowbtedly” belongs td\n‘comie” mental\n\nshares the advantageous pecnliarities\nmentionddrahove - and for the relation\ni has with the psychotherapeutic envi-" }, { "id": 1126, "strid": "f7ff80ed-bfb3-49c3-9c01-3f008b0800dd", "image_id": 48, "image_name": "116917.png", "category_id": 5, "category_name": "Section", "bbox": [ 123.298, 539.79, 140.248, 19.32899999999995 ], "priority": 5, "parents": [ 1121 ], "children": [ 1127, 1130, 1131, 1128, 1129 ], "area": 66555.02742, "iscrowd": 0, "segmentation": [], "text": "Argument" }, { "id": 1127, "strid": "2df492e8-3c2b-4f11-b425-def759d3a603", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 85.761, 566.736, 212.739, 440.429 ], "priority": 6, "parents": [ 1126 ], "children": [], "area": 48603.846095999994, "iscrowd": 0, "segmentation": [], "text": "Departing point for my reflection waa\n\nthe question whether any kind of “ther.\n\npentie” humour might get some space\nrd siguilicance inside a thpebpSatic n\n\n \n\n \n\nlation 10 that it could hevtonsidered 0\nUerepentis tustrument qual « brawale\n\n \n\nmation factor,\nIf the humour, sith) all ite complexity\nthat makes it hotha mechs\n\nse /protection and ax ‘import\n\n \n\nism of det\n\n \n\n \n\n+ coping\nclement, js'ane of the mainstay my work\nis based on, the other topie to he taken\n\nteclepiderat\n\n \n\nyt the prgebntlns\n\n \n\nAs everybody knows, it dees not exist\n‘tke” psychotherapy, but different set-\nlings ~ therelore, different sets aad theo-\nretical and methodological (rames\nthrough which it can take place -a\nachtove a fulfillment\nDeliberately. in ma work, [do nat roler to\na specific way of conducting 4 paycho-\ntherepy, but I irted to-etplure and go\nthrough various fields, comsidering the\niqutty” axpoct of langhter aad\n\n \n\n \n\n \n\n \n\n \n\n \n\nbamout; thet rendh@Abens comma phe\n\n \n \n\nnomene to every men’s life\nThe following consideration, thea, has\nbees orgesized oa lwo fusdame\n\ncopts for tho psychotherapy attitude, In\norder ta establish some lendmarkes: the\n\n \n\n \n\nexe Seusing on the situation aud the\nSaber focusing on the process." }, { "id": 1128, "strid": "7f3c1008-5846-487e-8e80-f3a23545e79d", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 84.958, 1024.627, 212.40899999999996, 102.519 ], "priority": 7, "parents": [ 1126 ], "children": [], "area": 87050.26066599999, "iscrowd": 0, "segmentation": [], "text": "ty choth Utwatic\n\n \n\nThrough the analysis ofthe paychologicalbo-\nwith\nregard to the presonce aad fuaclich of the\noman i she piychotherapentic situation\nEven f rather late inthe if leginivation was\ninehdaiied, SMsals ta-seeiiebas. Vota Bees!\n\nrature some conlicting opiatoas om" }, { "id": 1129, "strid": "70c08a26-7ecf-4268-a298-1f6b3543638b", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 314.698, 314.044, 212.913, 474.07399999999996 ], "priority": 8, "parents": [ 1126 ], "children": [], "area": 98829.01871199999, "iscrowd": 0, "segmentation": [], "text": "“eed Pelee: ete very sowng ase Gaberelt\naod wore, on tho contrary, the objoctioas of\nse who excluded an eventual presence’ af\nhumour intide the therapeutic relat\nHe who is agetast the use of hemous taside the\nprychotheraps, like Kubie, jgtihed his ows\nviewpoint underlining the funetion of socal\nratios typical of the leugh ar well ex the fact\nthet is wight be asod at delonsive eittade, by\nsednee of altach the other, of even to check-\nmate the thesapeutte process. That would meas\nthat all the tsps typical of the tenslerence\nid eGgater-translerence aight be biddes\nbehinithe nse af hnmonr.\nly forthe husoer: the\nsherapiat cas, ia fact, bebave following his s2-\nistic or seductive tmpulror also boing silo,\n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\nBaths i wot dra\n\n \n\nhaving a clinical atttnde or without saying ®\nword. The soltion to the preblew, therelve, 8\nhe omelet\n\n \n\nany hemoritte peertbilty\n\n \n\n \n\nfrom the therapouticcelation,\nste the\n\nso thet i¢ ight be dose an use cousitent with\ntho therapeutic targot so a the base ofthe\n\n‘ts prosones,\n\n \n\nsary es)\n\n \n\nlation\nIf bumoae called s9tp action with awareness,\non the contrary, Ea futroduce ito the rela-\nsion the beneiiialstlets characterisie of the\nTanghs tagetheY” that ate a posible strong\nthoning éfhiho th\n\nsh ainie paint of view\nol te change owing to the\nMaliter peculiny to the Iaaghter, trom the\nSsorphooge é\n\ntie llience, fr\n\n \n\n \n\n \n\n fartheranee\n\n \n\nabrestive” pote" }, { "id": 1130, "strid": "700d49cf-b2d4-4ffb-8a4a-5ab58f184925", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 314.962, 796.429, 213.40200000000004, 331.60800000000006 ], "priority": 9, "parents": [ 1126 ], "children": [], "area": 250844.87069799998, "iscrowd": 0, "segmentation": [], "text": "Considering the characteristics\ntransformative potentialities inmate in\nthe humorous phenomenon, the paycho-\n\n \n\ntherapist might sevionaly talke trto eon\nsideration an ute of it, beGQuse he could\ncither make of ita therapeutic tnstew\nment able to evaluate the improvement\nof the patient and promote a change ~\nnot of course with a counter-trans\n\nEach therapeutic path consists, in fact,\nof emascipation from the suffering con-\nUitron.end the prucholoatcal stalemate\nthatcon arise for a given degree of r\nlity, stereotyping, sepetitio\nthese are all conditions that the comig\n\n \n\n \n\n \n\n \n\ndows ww be\n\n \n\n1-5, tu full the ovulate\nof the patient Gy.\n\n \n \n \n\n2 about the\nbeing eoudicton\nthet it being taken iia therapy can\nbe coustdeved « predictiva elpment lor the\nvesult of the prgchetbaany’ the humour," }, { "id": 1131, "strid": "29cef42f-d257-401a-8f6f-9e5fa73af9ec", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 548.819, 314.522, 212.83400000000006, 365.48600000000005 ], "priority": 10, "parents": [ 1126 ], "children": [], "area": 172615.649518, "iscrowd": 0, "segmentation": [], "text": "ARE Tas eras Waly lk cuanlnegs are eee,\n\nre mechanism and not a2 capging istremen(\n\ni sepreseats 4 high level deloase mateking\n\nwith a personality, that is suffering of couse,\n\nbut that hat also reached an higher evel\n9 level\n\nI the therapist. warts to wile the humour\n\\de tho prychotherapeutie setting for ox-\n\n \n\n \n\n \n\nIng tts igh transforgative potential, be\n0 dott pasta iach atention aad alwaye\nbestnning from ageing approach and also\nalways keopingiiy mind the distinction hetwe-\neu the devtoty laugh and a really empathic\nHe hey td keep sight of the seston\nthesapenti i\n\nspldvets could lend to a iaidity and steve\nsp, 2 tsa ofthe bs be\npagchotherapenticsteation into a superiicial\natniosphere sot prolestional anymore bul 6,\nJing to belittle For that reason 4 haa t@ be\n\n \n\n1 of the\ntion: if ii true that too much\n\n \n\n \n\n \n\na tration\n\n \n\n \n\n \n\n \n\n \n\ncusployed with good senso end gradual, ==\n(roduciag it ato the vetting st az bo used ac-\ntually considering tho\n\nthe methodelog\ntherapeuite path and the psychological seali-\nwebthesenbest" }, { "id": 1132, "strid": "6f7e2cc8-2911-43fd-b0d8-d59318cc1e13", "image_id": 48, "image_name": "116917.png", "category_id": 2, "category_name": "Figure", "bbox": [ 350.66, 189.032, 184.257, 109.172 ], "priority": 11, "parents": [ 1121 ], "children": [], "area": 66285.96112, "iscrowd": 0, "segmentation": [] }, { "id": 1133, "strid": "54834210-58a1-4b59-8d35-e12c009aaacb", "image_id": 48, "image_name": "116917.png", "category_id": 2, "category_name": "Figure", "bbox": [ 537.327, 188.977, 187.40499999999997, 108.614 ], "priority": 12, "parents": [ 1121 ], "children": [], "area": 101542.444479, "iscrowd": 0, "segmentation": [] }, { "id": 1134, "strid": "1ea4bbcb-af14-4e4e-a0cc-366046afa23e", "image_id": 48, "image_name": "116917.png", "category_id": 5, "category_name": "Section", "bbox": [ 576.681, 692.029, 153.894, 21.053999999999974 ], "priority": 13, "parents": [ 1121 ], "children": [ 1136, 1135 ], "area": 399079.97574900003, "iscrowd": 0, "segmentation": [], "text": "Contlusion" }, { "id": 1135, "strid": "8bcb52b5-1a1c-4cdf-b00d-173741eabcdb", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 550.565, 719.116, 207.66599999999994, 282.02199999999993 ], "priority": 14, "parents": [ 1134 ], "children": [], "area": 395920.10054, "iscrowd": 0, "segmentation": [], "text": "pn egpygiahe and wenn uae ok fhe\nbg aba bas\n\ngoals ab (facilitates the recovery of the\nrood parts of the Sell, being thew linked\nta the patient cognitive or emotional area\nThe therapeutic potential t owas, lies 1x\nthe fact that 1t possesses the Instruments\nto get out of the innate dichotomy sch as\nni\" Togtes to get aceesi to the\nlogical “et-ot\", which Jot bave «\n\n \n\ntcad Far theenpanttn\n\n \n\n \n\n \n\nwider comprehension of the pagehic\nite different dimes\n\nAlves\nterpretation ~ the most gawerln] transfor\nmative instrament the therapist possesses\n- the capability to create naw links able\nto tie up symptom ond unconscious, post\n\n \n \n\n \n\n1d proscgtelationality\n\n \n\nhe reploditter, as for the interpretation,\nis act HPit’s ated oF aot, but the uso ome\na bat it" }, { "id": 1136, "strid": "e6a3f3db-b07c-46fb-a917-291d1b87ab43", "image_id": 48, "image_name": "116917.png", "category_id": 3, "category_name": "Text", "bbox": [ 550.664, 1006.519, 207.15599999999995, 120.50099999999998 ], "priority": 15, "parents": [ 1134 ], "children": [], "area": 554253.778616, "iscrowd": 0, "segmentation": [], "text": "Comic! Sle D, Voll M2005), Reorder\ndre acoe Bele Borage, Tras\n\nRenner A 908, Lae della eeiann Rd\nlakhs. Rena 079\n\nKable LS, (0H) “The Danes Pinto er\nts Prchthempt-tn An} Poychet vol\npochic.Froven Angel Milano\n\nSpine A: 2000} vee che i Sg india" }, { "id": 1137, "strid": "e4b1236e-fa9c-439e-8363-3501038d5a4c", "image_id": 49, "image_name": "116969.png", "category_id": 9, "category_name": "Root", "bbox": [ 18.39, 12.65, 65.0, 32.5 ], "priority": -1, "parents": [], "children": [ 1156, 1145, 1153, 1149, 1139, 1155, 1154, 1142, 1151, 1140, 1138 ], "area": 232.63350000000003, "iscrowd": 0, "segmentation": [] }, { "id": 1138, "strid": "6baf3bc1-de25-45ec-a6d5-942a9c66089d", "image_id": 49, "image_name": "116969.png", "category_id": 1, "category_name": "Title", "bbox": [ 107.034, 66.255, 538.802, 47.33500000000001 ], "priority": 1, "parents": [ 1137 ], "children": [], "area": 7091.53767, "iscrowd": 0, "segmentation": [], "text": "Anovel méthod to confirm tracheal intubation based on\nairway préssures: validation in patients with lung disease." }, { "id": 1139, "strid": "a71236d6-432b-4757-aaf9-09b00391adb5", "image_id": 49, "image_name": "116969.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 19.944, 142.699, 711.342, 52.510999999999996 ], "priority": 2, "parents": [ 1137 ], "children": [], "area": 2845.988856, "iscrowd": 0, "segmentation": [], "text": "Arjarine Fontan othe G. Monsieurs?, Frank Luijmes', Willem Dieperink', Jan G. Zijlstra’, Alain F. Kalmar’\n»'Departmentiof Critigal Care, University of Groningen, University Medical Center Groningen, The Netherlands\n—@ © © @Department of Emergency Medicine, Antwerp University Hospital, Belgium" }, { "id": 1140, "strid": "e13f3e27-62fa-4a16-82ea-cc11533ba0bf", "image_id": 49, "image_name": "116969.png", "category_id": 5, "category_name": "Section", "bbox": [ 23.728, 231.673, 83.86099999999999, 15.24799999999999 ], "priority": 3, "parents": [ 1137 ], "children": [ 1141 ], "area": 5497.136944000001, "iscrowd": 0, "segmentation": [], "text": "Introduction" }, { "id": 1141, "strid": "95ac490f-ca7f-429d-8524-050820ae350d", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 23.665, 255.572, 333.526, 213.15300000000002 ], "priority": 4, "parents": [ 1140 ], "children": [], "area": 6048.11138, "iscrowd": 0, "segmentation": [], "text": "Emengency Ogovachssl ivubslion resus in gugvental\noesophageal intubation in up to 17% of patients often with\ndisastrous consequences. We have previously published a highly\nspecific and sensitive novel method to Wetect endotracheal\ninubation based on differences in ventilation pressure waveforms\nin the oesophagus and in the trachea’ in patients with healthy\nlungs[t]. A detection algorithm, based on differences. in\ncompliancelelasticty between the lung and the oesophagus,\ngenerated a \"D-value\" indicating tracheal intubation if D>0.5 and\noesophageal intubation if D<0.5. The aim of the current study was\nto validate the algorithm in patients with lung disease." }, { "id": 1142, "strid": "7b780638-31dd-42ab-a1fe-47747264c563", "image_id": 49, "image_name": "116969.png", "category_id": 5, "category_name": "Section", "bbox": [ 23.197, 476.393, 59.727999999999994, 15.454000000000008 ], "priority": 5, "parents": [ 1137 ], "children": [ 1143, 1144 ], "area": 11050.888421, "iscrowd": 0, "segmentation": [], "text": "Methods" }, { "id": 1143, "strid": "5280475b-f457-4e08-b36d-744701f759ae", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 22.865, 500.318, 333.926, 213.15300000000002 ], "priority": 6, "parents": [ 1142 ], "children": [], "area": 11439.771069999999, "iscrowd": 0, "segmentation": [], "text": "After obtaining institutional approval, twenty (iWiibated and\nventilated Intensive Care Unit patients were (included. Inclusion\ncfteria were controlled mechanical ventilation and at least mild to\nmoderate lung injury according to a MuiTay lung injury score >0.1\nA connecting piece was placed between the endotracheal tube\nand the ventilation bag. This piece comprised a thin air filed\ncatheter inserted through the tube lumen at 1 cm from the distal\nend, and a second catheter located at the proximal end of the\ntube, We performed three consecutive manual bag ventiltions\nwhile recording the pressure curves through both catheters. For\neach ventilation, a D-value was calculated." }, { "id": 1144, "strid": "90805d6a-2540-48a3-bfa6-2727c89b9059", "image_id": 49, "image_name": "116969.png", "category_id": 2, "category_name": "Figure", "bbox": [ 41.296, 725.323, 293.064, 126.61900000000003 ], "priority": 7, "parents": [ 1142 ], "children": [], "area": 29952.938608, "iscrowd": 0, "segmentation": [] }, { "id": 1145, "strid": "dc853d77-12b3-4fca-9e0a-0bcfc6a112c2", "image_id": 49, "image_name": "116969.png", "category_id": 5, "category_name": "Section", "bbox": [ 390.093, 231.381, 52.341999999999985, 16.441000000000003 ], "priority": 8, "parents": [ 1137 ], "children": [ 1147, 1146 ], "area": 90260.108433, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 1146, "strid": "7d03899b-6c56-4dce-8568-65ba1dbc4ffa", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 390.383, 255.067, 332.25499999999994, 192.062 ], "priority": 9, "parents": [ 1145 ], "children": [], "area": 99573.820661, "iscrowd": 0, "segmentation": [], "text": "Mean age (SD) of the patients was 60 (16) years, 60% was male.\nThe mean (SD) Murray score was 1.4 (0.6). Pathologies included\npulmonary oedema, pneumonia, atelectasis and traumatic-lung\ninjury. All 60 D-values are represented in Fig. 1. The median (IQR,\nrange) Dvalue was 38 (16-74, 0.8-1272). Our algorithm therefore\nconfirmed a high sensitivity tot detect correct’ endotracheal\nintabation also in patients with lung disease. Under the hypothesis\nthat oesophageal compliance does not increase significantly in\npatients with lung disease, the specificity of our algorithm will nt\nbe affected." }, { "id": 1147, "strid": "bd8ca4c7-4976-462b-a0d2-76c33e6fcf78", "image_id": 49, "image_name": "116969.png", "category_id": 2, "category_name": "Figure", "bbox": [ 388.118, 490.443, 332.723, 146.529 ], "priority": 10, "parents": [ 1145 ], "children": [ 1148 ], "area": 190349.75627399998, "iscrowd": 0, "segmentation": [] }, { "id": 1148, "strid": "ecb1c29b-cf18-4837-b625-3953653337c2", "image_id": 49, "image_name": "116969.png", "category_id": 6, "category_name": "Caption", "bbox": [ 390.121, 473.892, 55.891999999999996, 15.103999999999985 ], "priority": 11, "parents": [ 1147 ], "children": [], "area": 184875.220932, "iscrowd": 0, "segmentation": [], "text": "Figure 1" }, { "id": 1149, "strid": "e42de5f9-ae43-4736-bae2-6f0bbd5acd31", "image_id": 49, "image_name": "116969.png", "category_id": 5, "category_name": "Section", "bbox": [ 389.201, 665.312, 78.5, 15.130999999999972 ], "priority": 12, "parents": [ 1137 ], "children": [ 1150 ], "area": 258940.095712, "iscrowd": 0, "segmentation": [], "text": "Conclusion" }, { "id": 1150, "strid": "bb89de78-b01f-424a-804e-b1e81d2f17ea", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 388.865, 687.028, 331.07400000000007, 35.12699999999995 ], "priority": 13, "parents": [ 1149 ], "children": [], "area": 267161.14322, "iscrowd": 0, "segmentation": [], "text": "The algorithm to detect correct endotracheal intubation performed\nexcellent in patients with lung disease." }, { "id": 1151, "strid": "0ae24ca8-bbf5-495b-acad-abb818b54310", "image_id": 49, "image_name": "116969.png", "category_id": 5, "category_name": "Section", "bbox": [ 389.763, 746.777, 62.360000000000014, 13.725000000000023 ], "priority": 14, "parents": [ 1137 ], "children": [ 1152 ], "area": 291066.043851, "iscrowd": 0, "segmentation": [], "text": "References" }, { "id": 1152, "strid": "974f4848-c561-41ca-95e2-e2a16effb7cd", "image_id": 49, "image_name": "116969.png", "category_id": 4, "category_name": "List", "bbox": [ 391.697, 766.357, 265.59900000000005, 12.001999999999953 ], "priority": 15, "parents": [ 1151 ], "children": [], "area": 300179.737829, "iscrowd": 0, "segmentation": [] }, { "id": 1153, "strid": "d8aca3bf-30bd-43f7-bd65-cca6b4d9cbe2", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 139.072, 884.549, 150.04499999999996, 14.615999999999985 ], "priority": 16, "parents": [ 1137 ], "children": [], "area": 123015.998528, "iscrowd": 0, "segmentation": [], "text": "Tracheal ventilation" }, { "id": 1154, "strid": "f8268a3a-bffd-4e6b-ba62-74a975c717ac", "image_id": 49, "image_name": "116969.png", "category_id": 2, "category_name": "Figure", "bbox": [ 55.433, 908.665, 321.993, 167.04199999999992 ], "priority": 17, "parents": [ 1137 ], "children": [], "area": 50370.026945, "iscrowd": 0, "segmentation": [] }, { "id": 1155, "strid": "d0073d5e-3e96-4fcd-9d03-1bcb86766243", "image_id": 49, "image_name": "116969.png", "category_id": 3, "category_name": "Text", "bbox": [ 464.182, 884.487, 169.87699999999995, 18.58000000000004 ], "priority": 18, "parents": [ 1137 ], "children": [], "area": 410562.944634, "iscrowd": 0, "segmentation": [], "text": "Oesophageal ventilation" }, { "id": 1156, "strid": "be6423e3-d7e5-453d-97e2-9176b507d48e", "image_id": 49, "image_name": "116969.png", "category_id": 2, "category_name": "Figure", "bbox": [ 391.309, 910.904, 306.319, 167.04199999999992 ], "priority": 19, "parents": [ 1137 ], "children": [], "area": 356444.933336, "iscrowd": 0, "segmentation": [] }, { "id": 1157, "strid": "b476d8df-a84b-4a2a-a11a-d8c4c9b2f917", "image_id": 50, "image_name": "116971.png", "category_id": 9, "category_name": "Root", "bbox": [ 30.69, 26.08, 104.83000000000001, 42.879999999999995 ], "priority": -1, "parents": [], "children": [ 1190, 1160, 1161, 1159, 1158, 1165, 1176, 1168 ], "area": 800.3951999999999, "iscrowd": 0, "segmentation": [] }, { "id": 1158, "strid": "8c89adf0-9511-42ce-82d2-50de01249d7c", "image_id": 50, "image_name": "116971.png", "category_id": 1, "category_name": "Title", "bbox": [ 78.519, 86.198, 977.1090000000002, 218.61400000000003 ], "priority": 1, "parents": [ 1157 ], "children": [], "area": 6768.180762, "iscrowd": 0, "segmentation": [], "text": "Assessing searches in NICE\nSingle Technology Appraisals:\npractice and checklist" }, { "id": 1159, "strid": "718041d2-b7b7-47d4-84b6-a07e48e063d1", "image_id": 50, "image_name": "116971.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 66.611, 389.609, 821.466, 72.81900000000002 ], "priority": 2, "parents": [ 1157 ], "children": [], "area": 25952.245099, "iscrowd": 0, "segmentation": [], "text": "Ruth Wong, Suzy Paisley and Christopher Carroll\nScHARR, University of Sheffield, UK" }, { "id": 1160, "strid": "613a39e3-dcda-40b1-a16f-30127cf59677", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 96.483, 592.519, 377.935, 255.72800000000007 ], "priority": 3, "parents": [ 1157 ], "children": [], "area": 57168.010677000006, "iscrowd": 0, "segmentation": [], "text": "1. Analysis of the ERG\n(Evidence Review Group) reports\nof manufacturers’ submission\n(MS) searches shows what\nmanufacturers do in terms of\nsearching, what ERGs do in\nrelation to appraising searches\nand how they report on the\nappraisal process." }, { "id": 1161, "strid": "e24c92a8-a658-49f9-b27c-ccfc423019f6", "image_id": 50, "image_name": "116971.png", "category_id": 5, "category_name": "Section", "bbox": [ 1008.96, 692.361, 279.4569999999999, 57.97799999999995 ], "priority": 4, "parents": [ 1157 ], "children": [ 1162, 1164, 1163 ], "area": 698564.55456, "iscrowd": 0, "segmentation": [], "text": "Approach" }, { "id": 1162, "strid": "010eb6c7-bf4c-4f1d-8deb-fc989718d1a6", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1017.558, 786.012, 368.88300000000004, 141.44299999999998 ], "priority": 5, "parents": [ 1161 ], "children": [], "area": 799812.7986959999, "iscrowd": 0, "segmentation": [], "text": "2. Limitations from search\ncritiques in 83 (94%) of the 88\nERG reports between 2006 and\nMay 2011 were extracted and\ngrouped into themes." }, { "id": 1163, "strid": "7053696d-1058-44b0-b202-7d985ac99a2c", "image_id": 50, "image_name": "116971.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1133.944, 142.786, 616.113, 574.0729999999999 ], "priority": 6, "parents": [ 1161 ], "children": [], "area": 161911.327984, "iscrowd": 0, "segmentation": [] }, { "id": 1164, "strid": "e0f53ece-934f-4d02-944d-af44bd347d25", "image_id": 50, "image_name": "116971.png", "category_id": 2, "category_name": "Figure", "bbox": [ 542.821, 530.422, 527.6040000000002, 424.05500000000006 ], "priority": 7, "parents": [ 1161 ], "children": [], "area": 287924.20046200004, "iscrowd": 0, "segmentation": [] }, { "id": 1165, "strid": "705b2932-1758-4d33-9372-c9700ff73f51", "image_id": 50, "image_name": "116971.png", "category_id": 5, "category_name": "Section", "bbox": [ 75.505, 913.839, 243.51, 52.18100000000004 ], "priority": 8, "parents": [ 1157 ], "children": [ 1167, 1166 ], "area": 68999.413695, "iscrowd": 0, "segmentation": [], "text": "Themes" }, { "id": 1166, "strid": "f749fd59-9461-4f63-bb3c-03821dd1ccc9", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 107.798, 986.295, 1454.031, 69.024 ], "priority": 9, "parents": [ 1165 ], "children": [], "area": 106320.62840999999, "iscrowd": 0, "segmentation": [], "text": "3. Twelve themes were identified, six themes closely related to the search strategy theme with the most\nlimitations." }, { "id": 1167, "strid": "67c4d220-9616-42b9-91b8-2ad880d29a72", "image_id": 50, "image_name": "116971.png", "category_id": 2, "category_name": "Figure", "bbox": [ 82.812, 1063.969, 1609.839, 177.788 ], "priority": 10, "parents": [ 1165 ], "children": [], "area": 88109.400828, "iscrowd": 0, "segmentation": [] }, { "id": 1168, "strid": "5d889de6-514b-4518-96c6-3c72b8f22536", "image_id": 50, "image_name": "116971.png", "category_id": 5, "category_name": "Section", "bbox": [ 708.726, 1247.18, 394.4119999999999, 57.190000000000055 ], "priority": 11, "parents": [ 1157 ], "children": [ 1173, 1175, 1171, 1174, 1172, 1169, 1170 ], "area": 883908.89268, "iscrowd": 0, "segmentation": [], "text": "Comparisons" }, { "id": 1169, "strid": "1bb71dd6-8009-490c-85ad-c86d7c8b7639", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 697.003, 1315.895, 417.79499999999996, 68.13499999999999 ], "priority": 12, "parents": [ 1168 ], "children": [], "area": 917182.7626850001, "iscrowd": 0, "segmentation": [], "text": "Limitations reported in the\nMS searches by the ERGs" }, { "id": 1170, "strid": "55281a70-7678-4f80-a0d8-b0051ca57c78", "image_id": 50, "image_name": "116971.png", "category_id": 2, "category_name": "Figure", "bbox": [ 29.232, 1387.885, 651.485, 656.356 ], "priority": 13, "parents": [ 1168 ], "children": [], "area": 40570.65432, "iscrowd": 0, "segmentation": [] }, { "id": 1171, "strid": "4a5ca3bf-80f7-4153-8bea-b637117308f2", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 727.029, 1486.998, 420.47900000000004, 197.25 ], "priority": 14, "parents": [ 1168 ], "children": [], "area": 1081090.668942, "iscrowd": 0, "segmentation": [], "text": "4. Key limitations relate to either\nomissions (comprehensiveness of\nsearch) and missing full strategies\n(lack transparency and careful\ndocumentation of the MS’s search\nprocess): common in both clinical\nand cost effectiveness reviews." }, { "id": 1172, "strid": "62c0b4d8-6107-44d6-8a30-22727f9c1539", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 709.709, 1829.54, 432.98799999999994, 252.0949999999998 ], "priority": 15, "parents": [ 1168 ], "children": [], "area": 1298441.0038599998, "iscrowd": 0, "segmentation": [], "text": "5. Search strategy theme: the most\nfrequent limitations relate to the\nfailure to use subject headings or\nthesauri, missing free-text terms,\nerrors in database syntax and errors\nin the combination of lines in\nstatements which will have an\nimpact on the recall and/or precision\nof the search." }, { "id": 1173, "strid": "21c8985e-b33f-454c-a6c3-1101de9b0262", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 709.709, 2181.703, 428.177, 167.42200000000003 ], "priority": 16, "parents": [ 1168 ], "children": [], "area": 1548374.254427, "iscrowd": 0, "segmentation": [], "text": "7. The appraisal should consist of\ntwo key elements: an assessment of\nthe actual reporting of the searches\nundertaken and a structured critical\nappraisal of the actual strategy\n(including sources)." }, { "id": 1174, "strid": "c3c07ac5-dfa1-4a14-8819-fd4797739789", "image_id": 50, "image_name": "116971.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1197.034, 1378.143, 540.672, 589.3809999999999 ], "priority": 17, "parents": [ 1168 ], "children": [], "area": 1649684.0278620003, "iscrowd": 0, "segmentation": [] }, { "id": 1175, "strid": "090b8038-d664-481f-a26b-0b19615f1c68", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1247.576, 2061.429, 335.80600000000004, 194.36299999999983 ], "priority": 18, "parents": [ 1168 ], "children": [], "area": 2571789.346104, "iscrowd": 0, "segmentation": [], "text": "6. The wide range of\nlimitations identified reflects\nthe importance of the\ninformation specialists’ role\nwithin the ERG team in\nassessing the quality of the\nmanufacturers’ searches." }, { "id": 1176, "strid": "4c0c6716-c79f-48ee-826d-70e464e44aaf", "image_id": 50, "image_name": "116971.png", "category_id": 5, "category_name": "Section", "bbox": [ 63.285, 2167.367, 290.946, 47.791999999999916 ], "priority": 19, "parents": [ 1157 ], "children": [ 1188, 1185, 1177, 1180, 1187, 1183, 1182, 1181, 1178, 1179, 1189, 1184, 1186 ], "area": 137161.820595, "iscrowd": 0, "segmentation": [], "text": "Checklist" }, { "id": 1177, "strid": "50913b6c-2ac8-4cac-ab54-92ee75118d69", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 56.169, 2255.694, 447.552, 166.91100000000006 ], "priority": 20, "parents": [ 1176 ], "children": [], "area": 126700.076286, "iscrowd": 0, "segmentation": [], "text": "8. A checklist based on the themes\ndeveloped from this study that\nincorporates both search strategy and\nreporting elements was created. Below\nare examples of questions from each\ntheme." }, { "id": 1178, "strid": "94354bef-2c09-4502-9658-0f2abd078afc", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 137.701, 2454.711, 218.04099999999997, 90.62699999999995 ], "priority": 21, "parents": [ 1176 ], "children": [], "area": 338016.159411, "iscrowd": 0, "segmentation": [], "text": "Reporting: Were\nstrategies as described\nin methods fully\nprovided?" }, { "id": 1179, "strid": "a0e0bf64-f4a7-42fe-b158-185834716fff", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 137.734, 2591.393, 216.00299999999996, 49.0920000000001 ], "priority": 22, "parents": [ 1176 ], "children": [], "area": 356922.92346200004, "iscrowd": 0, "segmentation": [], "text": "Overall strategy: Was\nthe strategy clear?" }, { "id": 1180, "strid": "f9770201-1547-4d34-8c01-bae5755f9d72", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 137.734, 2704.304, 171.00199999999998, 96.54700000000003 ], "priority": 23, "parents": [ 1176 ], "children": [], "area": 372474.60713600006, "iscrowd": 0, "segmentation": [], "text": "PICO and terms:\nWere terms used\ncorrectly and\nnecessary?" }, { "id": 1181, "strid": "c51b9bd2-63eb-4464-9751-be177ea4f6a6", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 428.192, 2452.3, 223.36699999999996, 72.0010000000002 ], "priority": 24, "parents": [ 1176 ], "children": [], "area": 1050055.2416, "iscrowd": 0, "segmentation": [], "text": "Free-text terms: Were\nthere free-text terms\nmissing?" }, { "id": 1182, "strid": "ccbd4267-df89-4dce-9a49-ce195bd99c75", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 426.556, 2576.666, 238.094, 95.72899999999981 ], "priority": 25, "parents": [ 1176 ], "children": [], "area": 1099092.342296, "iscrowd": 0, "segmentation": [], "text": "Subject headings: Were\nany subject\nheadings/thesauri\nmissing?" }, { "id": 1183, "strid": "0dd2a84b-6c6c-44fa-b808-2d14242a77a8", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 431.465, 2723.122, 216.82099999999997, 47.45499999999993 ], "priority": 26, "parents": [ 1176 ], "children": [], "area": 1174931.8337299998, "iscrowd": 0, "segmentation": [], "text": "Syntax: Was the\nsyntax used correctly?" }, { "id": 1184, "strid": "fa52b291-4a21-4bf0-9c40-7a99fa19ccf0", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 730.106, 2454.755, 176.73000000000002, 72.0010000000002 ], "priority": 27, "parents": [ 1176 ], "children": [], "area": 1792231.35403, "iscrowd": 0, "segmentation": [], "text": "Structure: Were\nBoolean operators\nused correctly?" }, { "id": 1185, "strid": "8053f6f8-5b18-49fc-963e-8abcbda0481e", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 730.106, 2582.393, 212.73000000000002, 67.90999999999985 ], "priority": 28, "parents": [ 1176 ], "children": [], "area": 1885420.623658, "iscrowd": 0, "segmentation": [], "text": "Source: Were sources\nmissing in the\nmethods?" }, { "id": 1186, "strid": "d43d5917-6ad6-4419-92c4-36c16b57c069", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 724.379, 2708.395, 189.00300000000004, 69.54599999999982 ], "priority": 29, "parents": [ 1176 ], "children": [], "area": 1961904.4617050001, "iscrowd": 0, "segmentation": [], "text": "Limits: Were limits\napplied appropriate\nand justified?" }, { "id": 1187, "strid": "ef952ddc-0db5-4614-a62c-6dcc2f1b2fe0", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1027.564, 2459.091, 207.6579999999999, 64.96000000000004 ], "priority": 30, "parents": [ 1176 ], "children": [], "area": 2526873.384324, "iscrowd": 0, "segmentation": [], "text": "Filters: Was the filter\napplied appropriate\nand sensitive?" }, { "id": 1188, "strid": "bf4f7db5-2f4c-4454-8798-718be1f934e5", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1021.175, 2591.495, 191.32899999999995, 64.25 ], "priority": 31, "parents": [ 1176 ], "children": [], "area": 2646369.906625, "iscrowd": 0, "segmentation": [], "text": "Translation: Was\ntranslation between\ndatabases correct?" }, { "id": 1189, "strid": "4dcf74e9-f259-4491-9915-e54ab17e2319", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1014.785, 2704.73, 218.3069999999999, 66.02500000000009 ], "priority": 32, "parents": [ 1176 ], "children": [], "area": 2744719.43305, "iscrowd": 0, "segmentation": [], "text": "Missing studies: Were\nany missing studies\nfound?" }, { "id": 1190, "strid": "3cc19bf5-1d53-4191-9744-19bb6f58b207", "image_id": 50, "image_name": "116971.png", "category_id": 5, "category_name": "Section", "bbox": [ 1313.595, 2355.445, 292.31999999999994, 294.45899999999983 ], "priority": 33, "parents": [ 1157 ], "children": [ 1192, 1191 ], "area": 3094100.7747750003, "iscrowd": 0, "segmentation": [], "text": "&\nWS 9. Man\n\nagencies, i:\nenecialicts" }, { "id": 1191, "strid": "ec089b9a-3133-46d2-97b8-7e5da4434759", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1434.708, 2576.153, 301.952, 255.19799999999987 ], "priority": 34, "parents": [ 1190 ], "children": [], "area": 3696027.318324, "iscrowd": 0, "segmentation": [], "text": "9. Manufacturers,\nagencies, information\nspecialists involved in\nHTAs will be aware of\n\npotential limitations\nrelating to the search\nmethodology - this would\nimprove the efficiency of\nthe STA process." }, { "id": 1192, "strid": "00d0fa85-ee47-4f1f-91ca-75dba9f85833", "image_id": 50, "image_name": "116971.png", "category_id": 3, "category_name": "Text", "bbox": [ 1184.38, 2845.962, 547.4099999999999, 85.7159999999999 ], "priority": 35, "parents": [ 1190 ], "children": [], "area": 3370700.4735600003, "iscrowd": 0, "segmentation": [], "text": "10, This study provides a checklist for HTA\npractice in the UK and other countries such as\nFrance, Australia and Canada." }, { "id": 1193, "strid": "ace50a53-bdc2-4ce7-a52c-59b57ca81bd3", "image_id": 51, "image_name": "117011.png", "category_id": 9, "category_name": "Root", "bbox": [ 483.84, 29.32, 410.26000000000005, 170.11 ], "priority": -1, "parents": [], "children": [ 1196, 1228, 1222, 1205, 1209, 1230, 1195, 1194, 1226, 1201, 1215 ], "area": 14186.1888, "iscrowd": 0, "segmentation": [] }, { "id": 1194, "strid": "e618a3aa-a9d5-4be0-9236-a7543cea53e8", "image_id": 51, "image_name": "117011.png", "category_id": 1, "category_name": "Title", "bbox": [ 1066.369, 65.927, 2466.308, 65.01299999999999 ], "priority": 1, "parents": [ 1193 ], "children": [], "area": 70302.509063, "iscrowd": 0, "segmentation": [], "text": "Efficacy of Clevidipine in Controlling Perioperative Hypertension in Neurosurgical Patients" }, { "id": 1195, "strid": "8056b87f-495d-438f-9b05-ba5223440f95", "image_id": 51, "image_name": "117011.png", "category_id": 0, "category_name": "Author Info", "bbox": [ 839.424, 266.935, 2921.547, 116.51299999999998 ], "priority": 2, "parents": [ 1193 ], "children": [], "area": 224071.64544, "iscrowd": 0, "segmentation": [], "text": "Sorosch Didehvar MD, Sunmi Kim MD, Beatriz Nistal-Nuno MD, Alice Chu MD, Hyelin Kim, Michael Haile MD, Alex Bekker MD, PhD\nDepartment of Anesthesiology, New York University Medical Center, New York, NY, United States" }, { "id": 1196, "strid": "1ea9098a-c96d-4729-9a5c-5ba914cc4c8f", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 413.218, 471.188, 144.52000000000004, 33.30500000000001 ], "priority": 3, "parents": [ 1193 ], "children": [ 1200, 1197, 1198, 1199 ], "area": 194703.362984, "iscrowd": 0, "segmentation": [], "text": "Abstract" }, { "id": 1197, "strid": "bc863158-b346-46a7-9537-32f3768fc23e", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 100.832, 556.425, 767.319, 332.813 ], "priority": 4, "parents": [ 1196 ], "children": [], "area": 56105.44559999999, "iscrowd": 0, "segmentation": [], "text": "Background:\n\nAcute blood pressure (BP) elevations in neurosurgical patients\nare associated with serious neurologic, cardiovascular, or\nsurgical site complications. Clevidipine, an ultra-short-acting\ndihydropyridine calcium antagonist, has been shown to be\nefficacious and safe for acute hypertension in cardiac surgery.\nThis study assessed the efficacy and safety of clevidipine in\ncontrolling perioperative hypertension in the neurosurgical\nsetting." }, { "id": 1198, "strid": "63f40f37-0512-4e63-b0cf-f0193cef5fb0", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 97.429, 927.751, 781.589, 443.4269999999999 ], "priority": 5, "parents": [ 1196 ], "children": [], "area": 90389.852179, "iscrowd": 0, "segmentation": [], "text": "Methods:\n\nThis study was a prospective, open-label, observational trial.\nIRB approval was obtained and patients scheduled for\nintracranial surgery were prospectively enrolled after giving\nconsent. Clevidipine (0.5 mg/ml in 20% lipid solution, which\nwas to be initiated at 10 mg/h and titrated to effect) was\nadministered as the primary antihypertensive agent for\nperioperative hypertension, with target BPs of <130 mmHg.\nOther vasoactive drugs were administered as needed for\ntreating systolic BP (SBP) <90 mmHg or >130 mmHg. The\nprimary end point was the proportion of patients not requiring\nrescue antihypertensive to maintain target SBP (<130 mmHg)." }, { "id": 1199, "strid": "de754eb5-9f56-4925-a901-b916980840f6", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 101.641, 1410.193, 768.874, 436.25400000000013 ], "priority": 6, "parents": [ 1196 ], "children": [], "area": 143333.426713, "iscrowd": 0, "segmentation": [], "text": "Results:\n\nTwenty-two patients were enrolled. One patient did not\nrequire antihypertensive therapy. Seventeen patients (17 of\n21, 81%) were treated with clevidipine alone; one received\nclevidipine in the postanesthesia care unit only. Twenty-eight\nhypertensive episodes (defined as any new acute BP elevation\nrequiring clevidipine initiation) were documented. SBP was\nreduced to target level within 15 minutes in 22 of 28 episodes\n(78.6%). Two mild hypotensive episodes occurred after the\ninitiation of clevidipine infusion; these transient decreases in\nBP were treated with vasoactive drugs and resolved within 5\nminutes." }, { "id": 1200, "strid": "f6d2e853-fb8c-4e07-b92e-58dc54ff4a3a", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 99.697, 1890.162, 775.761, 187.19299999999998 ], "priority": 7, "parents": [ 1196 ], "children": [], "area": 188443.480914, "iscrowd": 0, "segmentation": [], "text": "Conclusions:\n\nClevidipine is effective and safe for perioperative hypertension\nin patients undergoing intracranial procedures. Rapid control\nof BP is possible with higher starting doses. Drug effects\nresolved rapidly after drug discontinuation." }, { "id": 1201, "strid": "14320a35-cfe8-4c77-84f7-dd1628972045", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 1267.653, 471.441, 202.952, 39.00600000000003 ], "priority": 8, "parents": [ 1193 ], "children": [ 1203, 1204, 1202 ], "area": 597623.597973, "iscrowd": 0, "segmentation": [], "text": "Background" }, { "id": 1202, "strid": "9cef9da4-0ae8-406c-9af5-c281b94c44c1", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 986.249, 555.065, 748.6879999999999, 289.337 ], "priority": 9, "parents": [ 1201 ], "children": [], "area": 547432.3011850001, "iscrowd": 0, "segmentation": [] }, { "id": 1203, "strid": "533a4b09-5c23-4ca5-a198-7ba514d81925", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 986.407, 875.682, 742.679, 218.79999999999995 ], "priority": 10, "parents": [ 1201 ], "children": [], "area": 863778.854574, "iscrowd": 0, "segmentation": [] }, { "id": 1204, "strid": "056ac008-1cfb-4b32-b00c-e1c08c50aa77", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 985.829, 1124.705, 769.7439999999999, 172.21000000000004 ], "priority": 11, "parents": [ 1201 ], "children": [], "area": 1108766.8054449998, "iscrowd": 0, "segmentation": [] }, { "id": 1205, "strid": "e9cf1be4-c4db-4b26-b577-89de1a1fea3f", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 1275.531, 1406.172, 187.6479999999999, 30.266000000000076 ], "priority": 12, "parents": [ 1193 ], "children": [ 1206, 1207, 1208 ], "area": 1793615.977332, "iscrowd": 0, "segmentation": [], "text": "Methods-1" }, { "id": 1206, "strid": "e189748d-c706-4e55-a320-0ec36f15f45c", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 978.837, 1487.709, 716.3910000000001, 102.51299999999992 ], "priority": 13, "parents": [ 1205 ], "children": [], "area": 1456224.614433, "iscrowd": 0, "segmentation": [] }, { "id": 1207, "strid": "cdce6af3-8eda-47ec-b452-f62e34ef92ef", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 979.032, 1614.806, 632.965, 179.63300000000004 ], "priority": 14, "parents": [ 1205 ], "children": [], "area": 1580946.7477920002, "iscrowd": 0, "segmentation": [] }, { "id": 1208, "strid": "655bac9b-e87e-4aee-aeab-9c53f6669a4f", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 980.167, 1817.104, 789.5500000000001, 255.44299999999998 ], "priority": 15, "parents": [ 1205 ], "children": [], "area": 1781065.3763680002, "iscrowd": 0, "segmentation": [] }, { "id": 1209, "strid": "2602a311-ce04-49c6-b193-579c407a300b", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 2167.669, 472.075, 189.49699999999984, 31.583000000000027 ], "priority": 16, "parents": [ 1193 ], "children": [ 1210, 1211, 1213, 1212 ], "area": 1023302.3431749999, "iscrowd": 0, "segmentation": [], "text": "" }, { "id": 1210, "strid": "ba382438-bec5-48d0-bc55-8d9f2c347186", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 1860.68, 555.691, 737.51, 100.15200000000004 ], "priority": 17, "parents": [ 1209 ], "children": [], "area": 1033963.1298800001, "iscrowd": 0, "segmentation": [], "text": "Primary Study Endpoint\n\nProportion of patients not requiring additional antihypertensives besides\nclevidipine for BP control (SBP <130 mm Hg)" }, { "id": 1211, "strid": "0a134c92-a6e3-4e9b-aa65-c7fbff5c35a3", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 1857.74, 696.337, 624.3120000000001, 154.39200000000005 ], "priority": 18, "parents": [ 1209 ], "children": [], "area": 1293613.09838, "iscrowd": 0, "segmentation": [] }, { "id": 1212, "strid": "8dd2ff9b-4e69-40f7-95a7-1c11b49820cd", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 1861.538, 890.611, 791.5140000000001, 881.6620000000001 ], "priority": 19, "parents": [ 1209 ], "children": [], "area": 1657906.219718, "iscrowd": 0, "segmentation": [] }, { "id": 1213, "strid": "a1876400-8c5b-49b0-9a71-ae4aaf6d8baf", "image_id": 51, "image_name": "117011.png", "category_id": 2, "category_name": "Figure", "bbox": [ 1863.221, 1871.867, 759.6109999999999, 199.03799999999978 ], "priority": 20, "parents": [ 1209 ], "children": [ 1214 ], "area": 3487701.903607, "iscrowd": 0, "segmentation": [] }, { "id": 1214, "strid": "6fdd655d-6042-43dc-b196-5cbecaf37c7a", "image_id": 51, "image_name": "117011.png", "category_id": 6, "category_name": "Caption", "bbox": [ 1861.558, 1828.312, 263.7080000000001, 23.126999999999953 ], "priority": 21, "parents": [ 1213 ], "children": [], "area": 3403508.830096, "iscrowd": 0, "segmentation": [], "text": "Figure 1. Study Schematic" }, { "id": 1215, "strid": "7d5cbaca-93c8-4806-9d07-d5cd1525c791", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 3130.68, 471.56, 123.03600000000006, 32.750999999999976 ], "priority": 22, "parents": [ 1193 ], "children": [ 1217, 1221, 1216, 1219, 1218 ], "area": 1476303.4608, "iscrowd": 0, "segmentation": [], "text": "Results" }, { "id": 1216, "strid": "a5e149a9-062e-414c-b5e9-e2392ada0eb6", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 2780.66, 581.812, 788.7280000000001, 162.481 ], "priority": 23, "parents": [ 1215 ], "children": [], "area": 1617821.35592, "iscrowd": 0, "segmentation": [] }, { "id": 1217, "strid": "f1926c06-4aa7-4c4f-956a-afa3e9243628", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 2785.042, 766.39, 838.3470000000002, 378.831 ], "priority": 24, "parents": [ 1215 ], "children": [], "area": 2134428.33838, "iscrowd": 0, "segmentation": [] }, { "id": 1218, "strid": "89052b8a-a153-411c-85ab-040db520a391", "image_id": 51, "image_name": "117011.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2783.013, 1164.919, 809.1930000000002, 363.87799999999993 ], "priority": 25, "parents": [ 1215 ], "children": [], "area": 3241984.720947, "iscrowd": 0, "segmentation": [] }, { "id": 1219, "strid": "01269e86-5596-46e9-bf6e-646ccec0c183", "image_id": 51, "image_name": "117011.png", "category_id": 2, "category_name": "Figure", "bbox": [ 2884.297, 1659.455, 560.127, 354.68100000000004 ], "priority": 26, "parents": [ 1215 ], "children": [ 1220 ], "area": 4786361.078135, "iscrowd": 0, "segmentation": [] }, { "id": 1220, "strid": "caba6264-a384-4aea-aff9-4a6a30c36cba", "image_id": 51, "image_name": "117011.png", "category_id": 6, "category_name": "Caption", "bbox": [ 2783.974, 1619.542, 646.3159999999998, 23.060999999999922 ], "priority": 27, "parents": [ 1219 ], "children": [], "area": 4508762.819908, "iscrowd": 0, "segmentation": [], "text": "Figure 3: SBP changes and clevidipine infusion rates in the PACU" }, { "id": 1221, "strid": "7f7a7dcd-5f8d-4c6a-8236-57248610f85e", "image_id": 51, "image_name": "117011.png", "category_id": 4, "category_name": "List", "bbox": [ 2784.847, 2033.015, 827.0230000000001, 81.60400000000004 ], "priority": 28, "parents": [ 1215 ], "children": [], "area": 5661635.723705, "iscrowd": 0, "segmentation": [] }, { "id": 1222, "strid": "c7234fb6-cff1-451c-9d7d-c523f29b9b85", "image_id": 51, "image_name": "117011.png", "category_id": 5, "category_name": "Section", "bbox": [ 4030.561, 472.094, 157.7220000000002, 31.24000000000001 ], "priority": 29, "parents": [ 1193 ], "children": [ 1225, 1223, 1224 ], "area": 1902803.664734, "iscrowd": 0, "segmentation": [], "text": "Results-2" }, { "id": 1223, "strid": "2f3e103d-fd9d-407b-ab00-9514432b15d2", "image_id": 51, "image_name": "117011.png", "category_id": 3, "category_name": "Text", "bbox": [ 3713.615, 559.401, 771.8950000000004, 85.481 ], "priority": 30, "parents": [ 1222 ], "children": [], "area": 2077399.9446149997, "iscrowd": 0, "segmentation": [], "text": "22 episodes of transient hypotension (