The cover of Weird Science Fantasy #4, featuring a woman in a yellow jumpsuit fighting a large, tentacled creature. The title 'Weird Science Fantasy' is prominently displayed at the top, with the issue number '4' below it. The tagline 'The EC Archives' is visible at the bottom, along with the phrase 'Incredible Science-Fiction Stories!' and the names of the creators, including Evan Dorkin. The artwork is in a retro comic book style with a pink background.