The Amazing Spider-Ham 25th Anniversary Special Issue cover features a stylized Spider-Ham character in the center, with a dynamic pose and a red and blue costume. The background is filled with various Spider-Ham characters and web patterns, all rendered in a comic book style. The cover has a red and white color scheme, with the title 'The Amazing Spider-Ham' in bold, white letters at the top. The issue number '25' is prominently displayed in the bottom right corner.