The cover of the DVD 'Glenn Close in Disney's 101 Dalmatians' features a wide-screen image of Glenn Close as Cruella de Vil, surrounded by Dalmatian puppies. The title '101 Dalmatians' is prominently displayed in the center, with the word 'Disney's' above it and 'Glenn Close' below it. The background is a dark blue with a full moon, and the overall color scheme is a mix of red, black, and white.